LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3Y6_LEIMU
TriTrypDb:
LmxM.32.1500
Length:
851

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0035869 ciliary transition zone 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B3Y6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Y6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 153 157 PF00656 0.447
CLV_C14_Caspase3-7 465 469 PF00656 0.284
CLV_C14_Caspase3-7 506 510 PF00656 0.453
CLV_MEL_PAP_1 367 373 PF00089 0.500
CLV_MEL_PAP_1 9 15 PF00089 0.397
CLV_NRD_NRD_1 309 311 PF00675 0.525
CLV_NRD_NRD_1 436 438 PF00675 0.413
CLV_NRD_NRD_1 519 521 PF00675 0.450
CLV_NRD_NRD_1 550 552 PF00675 0.402
CLV_NRD_NRD_1 806 808 PF00675 0.544
CLV_PCSK_FUR_1 131 135 PF00082 0.612
CLV_PCSK_KEX2_1 133 135 PF00082 0.641
CLV_PCSK_KEX2_1 309 311 PF00082 0.525
CLV_PCSK_KEX2_1 436 438 PF00082 0.411
CLV_PCSK_KEX2_1 440 442 PF00082 0.407
CLV_PCSK_KEX2_1 46 48 PF00082 0.447
CLV_PCSK_KEX2_1 519 521 PF00082 0.450
CLV_PCSK_KEX2_1 552 554 PF00082 0.400
CLV_PCSK_KEX2_1 806 808 PF00082 0.507
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.611
CLV_PCSK_PC1ET2_1 440 442 PF00082 0.467
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.447
CLV_PCSK_PC1ET2_1 552 554 PF00082 0.474
CLV_PCSK_PC7_1 436 442 PF00082 0.428
CLV_PCSK_SKI1_1 183 187 PF00082 0.421
CLV_PCSK_SKI1_1 285 289 PF00082 0.395
CLV_PCSK_SKI1_1 310 314 PF00082 0.405
CLV_PCSK_SKI1_1 437 441 PF00082 0.544
CLV_PCSK_SKI1_1 455 459 PF00082 0.290
CLV_PCSK_SKI1_1 553 557 PF00082 0.361
CLV_PCSK_SKI1_1 572 576 PF00082 0.418
CLV_PCSK_SKI1_1 74 78 PF00082 0.490
CLV_PCSK_SKI1_1 796 800 PF00082 0.399
DEG_APCC_DBOX_1 805 813 PF00400 0.527
DEG_SPOP_SBC_1 105 109 PF00917 0.512
DEG_SPOP_SBC_1 238 242 PF00917 0.615
DEG_SPOP_SBC_1 654 658 PF00917 0.503
DEG_SPOP_SBC_1 732 736 PF00917 0.484
DEG_SPOP_SBC_1 749 753 PF00917 0.447
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.433
DOC_CYCLIN_yCln2_LP_2 584 590 PF00134 0.548
DOC_CYCLIN_yCln2_LP_2 620 626 PF00134 0.459
DOC_MAPK_gen_1 806 812 PF00069 0.523
DOC_MAPK_MEF2A_6 12 21 PF00069 0.510
DOC_MAPK_MEF2A_6 325 333 PF00069 0.554
DOC_MAPK_MEF2A_6 355 364 PF00069 0.444
DOC_MAPK_RevD_3 295 310 PF00069 0.304
DOC_MAPK_RevD_3 31 47 PF00069 0.408
DOC_PP1_RVXF_1 344 351 PF00149 0.399
DOC_PP2B_LxvP_1 113 116 PF13499 0.663
DOC_PP2B_LxvP_1 333 336 PF13499 0.450
DOC_PP2B_LxvP_1 584 587 PF13499 0.517
DOC_PP2B_LxvP_1 605 608 PF13499 0.564
DOC_PP2B_LxvP_1 737 740 PF13499 0.557
DOC_PP4_FxxP_1 288 291 PF00568 0.558
DOC_SPAK_OSR1_1 774 778 PF12202 0.523
DOC_USP7_MATH_1 105 109 PF00917 0.589
DOC_USP7_MATH_1 124 128 PF00917 0.544
DOC_USP7_MATH_1 238 242 PF00917 0.644
DOC_USP7_MATH_1 244 248 PF00917 0.643
DOC_USP7_MATH_1 323 327 PF00917 0.555
DOC_USP7_MATH_1 337 341 PF00917 0.390
DOC_USP7_MATH_1 424 428 PF00917 0.620
DOC_USP7_MATH_1 503 507 PF00917 0.404
DOC_USP7_MATH_1 639 643 PF00917 0.463
DOC_USP7_MATH_1 654 658 PF00917 0.607
DOC_USP7_MATH_1 715 719 PF00917 0.708
DOC_USP7_MATH_1 722 726 PF00917 0.654
DOC_USP7_MATH_1 742 746 PF00917 0.661
DOC_USP7_MATH_1 749 753 PF00917 0.688
DOC_USP7_MATH_1 767 771 PF00917 0.588
DOC_USP7_UBL2_3 80 84 PF12436 0.478
DOC_WW_Pin1_4 166 171 PF00397 0.561
DOC_WW_Pin1_4 177 182 PF00397 0.619
DOC_WW_Pin1_4 184 189 PF00397 0.601
DOC_WW_Pin1_4 246 251 PF00397 0.708
DOC_WW_Pin1_4 48 53 PF00397 0.564
LIG_14-3-3_CanoR_1 138 147 PF00244 0.400
LIG_14-3-3_CanoR_1 258 262 PF00244 0.396
LIG_14-3-3_CanoR_1 285 291 PF00244 0.499
LIG_14-3-3_CanoR_1 370 376 PF00244 0.535
LIG_14-3-3_CanoR_1 464 468 PF00244 0.510
LIG_14-3-3_CanoR_1 553 562 PF00244 0.428
LIG_14-3-3_CanoR_1 625 632 PF00244 0.751
LIG_14-3-3_CanoR_1 684 692 PF00244 0.595
LIG_14-3-3_CanoR_1 780 787 PF00244 0.525
LIG_14-3-3_CanoR_1 806 810 PF00244 0.554
LIG_14-3-3_CanoR_1 814 820 PF00244 0.535
LIG_14-3-3_CanoR_1 832 836 PF00244 0.570
LIG_Actin_WH2_2 610 627 PF00022 0.450
LIG_BIR_II_1 1 5 PF00653 0.580
LIG_BRCT_BRCA1_1 276 280 PF00533 0.350
LIG_BRCT_BRCA1_1 50 54 PF00533 0.433
LIG_BRCT_BRCA1_1 746 750 PF00533 0.498
LIG_EVH1_1 333 337 PF00568 0.461
LIG_FHA_1 105 111 PF00498 0.628
LIG_FHA_1 26 32 PF00498 0.425
LIG_FHA_1 264 270 PF00498 0.490
LIG_FHA_1 273 279 PF00498 0.434
LIG_FHA_1 366 372 PF00498 0.449
LIG_FHA_1 61 67 PF00498 0.563
LIG_FHA_1 660 666 PF00498 0.496
LIG_FHA_1 734 740 PF00498 0.509
LIG_FHA_1 814 820 PF00498 0.403
LIG_FHA_2 101 107 PF00498 0.555
LIG_FHA_2 274 280 PF00498 0.364
LIG_FHA_2 463 469 PF00498 0.291
LIG_FHA_2 485 491 PF00498 0.491
LIG_FHA_2 587 593 PF00498 0.523
LIG_LIR_Apic_2 347 353 PF02991 0.473
LIG_LIR_Gen_1 146 155 PF02991 0.476
LIG_LIR_Gen_1 213 224 PF02991 0.359
LIG_LIR_Gen_1 398 406 PF02991 0.693
LIG_LIR_Gen_1 536 544 PF02991 0.382
LIG_LIR_Gen_1 556 567 PF02991 0.402
LIG_LIR_Nem_3 146 150 PF02991 0.489
LIG_LIR_Nem_3 163 168 PF02991 0.576
LIG_LIR_Nem_3 212 217 PF02991 0.367
LIG_LIR_Nem_3 398 403 PF02991 0.634
LIG_LIR_Nem_3 536 540 PF02991 0.358
LIG_LIR_Nem_3 556 562 PF02991 0.408
LIG_LIR_Nem_3 564 570 PF02991 0.376
LIG_LIR_Nem_3 657 663 PF02991 0.448
LIG_LIR_Nem_3 704 708 PF02991 0.480
LIG_NRBOX 361 367 PF00104 0.441
LIG_Pex14_2 750 754 PF04695 0.442
LIG_Pex14_2 96 100 PF04695 0.469
LIG_SH2_CRK 420 424 PF00017 0.501
LIG_SH2_NCK_1 4 8 PF00017 0.529
LIG_SH2_SRC 400 403 PF00017 0.547
LIG_SH2_SRC 420 423 PF00017 0.346
LIG_SH2_STAP1 274 278 PF00017 0.366
LIG_SH2_STAP1 578 582 PF00017 0.365
LIG_SH2_STAT5 268 271 PF00017 0.453
LIG_SH2_STAT5 274 277 PF00017 0.351
LIG_SH2_STAT5 533 536 PF00017 0.449
LIG_SH2_STAT5 537 540 PF00017 0.465
LIG_SH2_STAT5 573 576 PF00017 0.361
LIG_SH3_3 164 170 PF00018 0.536
LIG_SH3_3 288 294 PF00018 0.564
LIG_SH3_3 317 323 PF00018 0.481
LIG_SH3_3 326 332 PF00018 0.378
LIG_SH3_3 378 384 PF00018 0.537
LIG_SH3_3 388 394 PF00018 0.579
LIG_SH3_3 410 416 PF00018 0.514
LIG_SUMO_SIM_anti_2 222 227 PF11976 0.552
LIG_SUMO_SIM_par_1 148 154 PF11976 0.328
LIG_SUMO_SIM_par_1 363 368 PF11976 0.496
LIG_SUMO_SIM_par_1 586 593 PF11976 0.510
LIG_SUMO_SIM_par_1 613 619 PF11976 0.495
LIG_SUMO_SIM_par_1 844 849 PF11976 0.422
LIG_SxIP_EBH_1 803 814 PF03271 0.388
LIG_TRAF2_1 527 530 PF00917 0.493
LIG_TRAF2_1 68 71 PF00917 0.516
LIG_TRAF2_1 758 761 PF00917 0.574
LIG_TYR_ITIM 535 540 PF00017 0.355
LIG_UBA3_1 365 374 PF00899 0.454
MOD_CDC14_SPxK_1 180 183 PF00782 0.419
MOD_CDK_SPK_2 184 189 PF00069 0.348
MOD_CDK_SPxK_1 177 183 PF00069 0.573
MOD_CK1_1 108 114 PF00069 0.651
MOD_CK1_1 15 21 PF00069 0.560
MOD_CK1_1 242 248 PF00069 0.648
MOD_CK1_1 316 322 PF00069 0.490
MOD_CK1_1 656 662 PF00069 0.342
MOD_CK1_1 813 819 PF00069 0.524
MOD_CK2_1 100 106 PF00069 0.529
MOD_CK2_1 273 279 PF00069 0.375
MOD_CK2_1 586 592 PF00069 0.504
MOD_Cter_Amidation 131 134 PF01082 0.637
MOD_GlcNHglycan 126 129 PF01048 0.709
MOD_GlcNHglycan 153 156 PF01048 0.371
MOD_GlcNHglycan 241 244 PF01048 0.633
MOD_GlcNHglycan 246 249 PF01048 0.625
MOD_GlcNHglycan 302 305 PF01048 0.545
MOD_GlcNHglycan 339 342 PF01048 0.647
MOD_GlcNHglycan 376 379 PF01048 0.681
MOD_GlcNHglycan 478 481 PF01048 0.505
MOD_GlcNHglycan 609 612 PF01048 0.714
MOD_GlcNHglycan 642 645 PF01048 0.666
MOD_GlcNHglycan 708 711 PF01048 0.641
MOD_GlcNHglycan 740 743 PF01048 0.630
MOD_GlcNHglycan 746 749 PF01048 0.684
MOD_GlcNHglycan 841 844 PF01048 0.578
MOD_GSK3_1 104 111 PF00069 0.570
MOD_GSK3_1 151 158 PF00069 0.501
MOD_GSK3_1 238 245 PF00069 0.656
MOD_GSK3_1 253 260 PF00069 0.350
MOD_GSK3_1 365 372 PF00069 0.447
MOD_GSK3_1 48 55 PF00069 0.732
MOD_GSK3_1 586 593 PF00069 0.512
MOD_GSK3_1 635 642 PF00069 0.610
MOD_GSK3_1 649 656 PF00069 0.584
MOD_GSK3_1 72 79 PF00069 0.584
MOD_GSK3_1 727 734 PF00069 0.542
MOD_GSK3_1 738 745 PF00069 0.513
MOD_GSK3_1 749 756 PF00069 0.642
MOD_GSK3_1 815 822 PF00069 0.548
MOD_GSK3_1 96 103 PF00069 0.518
MOD_N-GLC_1 124 129 PF02516 0.722
MOD_N-GLC_1 15 20 PF02516 0.436
MOD_N-GLC_1 96 101 PF02516 0.464
MOD_NEK2_1 239 244 PF00069 0.638
MOD_NEK2_1 25 30 PF00069 0.507
MOD_NEK2_1 257 262 PF00069 0.337
MOD_NEK2_1 295 300 PF00069 0.411
MOD_NEK2_1 313 318 PF00069 0.288
MOD_NEK2_1 365 370 PF00069 0.377
MOD_NEK2_1 462 467 PF00069 0.343
MOD_NEK2_1 54 59 PF00069 0.686
MOD_NEK2_1 624 629 PF00069 0.465
MOD_NEK2_1 675 680 PF00069 0.393
MOD_NEK2_1 731 736 PF00069 0.584
MOD_NEK2_1 750 755 PF00069 0.556
MOD_NEK2_1 96 101 PF00069 0.483
MOD_NEK2_2 155 160 PF00069 0.284
MOD_NEK2_2 815 820 PF00069 0.492
MOD_PIKK_1 407 413 PF00454 0.711
MOD_PIKK_1 424 430 PF00454 0.450
MOD_PIKK_1 637 643 PF00454 0.653
MOD_PK_1 673 679 PF00069 0.407
MOD_PKA_2 257 263 PF00069 0.370
MOD_PKA_2 369 375 PF00069 0.491
MOD_PKA_2 463 469 PF00069 0.515
MOD_PKA_2 624 630 PF00069 0.751
MOD_PKA_2 683 689 PF00069 0.577
MOD_PKA_2 805 811 PF00069 0.580
MOD_PKA_2 813 819 PF00069 0.537
MOD_PKA_2 831 837 PF00069 0.574
MOD_PKB_1 551 559 PF00069 0.419
MOD_Plk_1 105 111 PF00069 0.518
MOD_Plk_1 15 21 PF00069 0.382
MOD_Plk_1 540 546 PF00069 0.469
MOD_Plk_1 590 596 PF00069 0.623
MOD_Plk_1 767 773 PF00069 0.378
MOD_Plk_1 96 102 PF00069 0.422
MOD_Plk_4 140 146 PF00069 0.589
MOD_Plk_4 155 161 PF00069 0.538
MOD_Plk_4 257 263 PF00069 0.370
MOD_Plk_4 316 322 PF00069 0.531
MOD_Plk_4 727 733 PF00069 0.486
MOD_ProDKin_1 166 172 PF00069 0.567
MOD_ProDKin_1 177 183 PF00069 0.619
MOD_ProDKin_1 184 190 PF00069 0.605
MOD_ProDKin_1 246 252 PF00069 0.696
MOD_ProDKin_1 48 54 PF00069 0.574
MOD_SUMO_for_1 698 701 PF00179 0.494
MOD_SUMO_rev_2 545 554 PF00179 0.468
TRG_DiLeu_BaEn_1 550 555 PF01217 0.457
TRG_DiLeu_BaEn_3 529 535 PF01217 0.460
TRG_ENDOCYTIC_2 165 168 PF00928 0.566
TRG_ENDOCYTIC_2 400 403 PF00928 0.579
TRG_ENDOCYTIC_2 420 423 PF00928 0.346
TRG_ENDOCYTIC_2 537 540 PF00928 0.401
TRG_ENDOCYTIC_2 567 570 PF00928 0.493
TRG_ENDOCYTIC_2 838 841 PF00928 0.485
TRG_ER_diArg_1 308 310 PF00400 0.531
TRG_ER_diArg_1 518 520 PF00400 0.400
TRG_ER_diArg_1 551 554 PF00400 0.427
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.311
TRG_Pf-PMV_PEXEL_1 437 442 PF00026 0.526
TRG_Pf-PMV_PEXEL_1 455 459 PF00026 0.324

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HW62 Leptomonas seymouri 63% 99%
A0A1X0P2J7 Trypanosomatidae 40% 100%
A0A3S7X6N7 Leishmania donovani 94% 100%
A0A422NG65 Trypanosoma rangeli 40% 100%
A4HLL0 Leishmania braziliensis 84% 100%
A4I922 Leishmania infantum 93% 100%
D0A522 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
Q4Q438 Leishmania major 93% 100%
V5AXC5 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS