RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9B3Y3_LEIMU

TriTrypDb:

LmxM.32.1460partial

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Y3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.510
DOC_CKS1_1	135	140	PF01111	0.477
DOC_USP7_MATH_1	152	156	PF00917	0.495
DOC_USP7_MATH_1	25	29	PF00917	0.425
DOC_USP7_MATH_1	57	61	PF00917	0.522
DOC_WW_Pin1_4	134	139	PF00397	0.475
LIG_14-3-3_CanoR_1	80	87	PF00244	0.625
LIG_BIR_II_1	1	5	PF00653	0.300
LIG_BRCT_BRCA1_1	11	15	PF00533	0.425
LIG_FHA_1	77	83	PF00498	0.372
LIG_FHA_2	112	118	PF00498	0.511
LIG_FHA_2	45	51	PF00498	0.422
LIG_LIR_Gen_1	154	163	PF02991	0.494
LIG_LIR_Nem_3	154	159	PF02991	0.494
LIG_LIR_Nem_3	161	166	PF02991	0.467
LIG_LIR_Nem_3	21	26	PF02991	0.512
LIG_MLH1_MIPbox_1	11	15	PF16413	0.425
LIG_Pex14_2	11	15	PF04695	0.425
LIG_Pex14_2	156	160	PF04695	0.502
LIG_SH2_CRK	26	30	PF00017	0.425
LIG_TRAF2_1	148	151	PF00917	0.505
LIG_WRPW_2	23	26	PF00400	0.425
MOD_CK1_1	128	134	PF00069	0.478
MOD_CK1_1	155	161	PF00069	0.497
MOD_CK1_1	167	173	PF00069	0.453
MOD_CK1_1	60	66	PF00069	0.425
MOD_CK1_1	76	82	PF00069	0.342
MOD_CK2_1	145	151	PF00069	0.511
MOD_CK2_1	44	50	PF00069	0.422
MOD_GlcNHglycan	105	109	PF01048	0.519
MOD_GlcNHglycan	165	169	PF01048	0.469
MOD_GlcNHglycan	82	85	PF01048	0.435
MOD_GSK3_1	100	107	PF00069	0.482
MOD_GSK3_1	121	128	PF00069	0.494
MOD_GSK3_1	151	158	PF00069	0.496
MOD_GSK3_1	41	48	PF00069	0.437
MOD_GSK3_1	76	83	PF00069	0.502
MOD_GSK3_1	88	95	PF00069	0.542
MOD_N-GLC_1	126	131	PF02516	0.481
MOD_N-GLC_1	152	157	PF02516	0.494
MOD_NEK2_1	126	131	PF00069	0.481
MOD_NEK2_1	139	144	PF00069	0.477
MOD_NEK2_1	159	164	PF00069	0.454
MOD_PIKK_1	65	71	PF00454	0.406
MOD_Plk_1	152	158	PF00069	0.494
MOD_Plk_4	155	161	PF00069	0.497
MOD_Plk_4	25	31	PF00069	0.425
MOD_ProDKin_1	134	140	PF00069	0.478
TRG_DiLeu_BaEn_1	115	120	PF01217	0.511
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.382
TRG_ENDOCYTIC_2	163	166	PF00928	0.479
TRG_ENDOCYTIC_2	26	29	PF00928	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMA7	Leishmania donovani	39%	100%
A4HLK8	Leishmania braziliensis	42%	100%
A4I919	Leishmania infantum	41%	100%
E9B3Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q440	Leishmania major	41%	100%