RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Y1_LEIMU

TriTrypDb:

LmxM.32.1440

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Y1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.684
CLV_C14_Caspase3-7	38	42	PF00656	0.678
CLV_C14_Caspase3-7	608	612	PF00656	0.601
CLV_NRD_NRD_1	511	513	PF00675	0.688
CLV_NRD_NRD_1	572	574	PF00675	0.684
CLV_NRD_NRD_1	653	655	PF00675	0.516
CLV_PCSK_KEX2_1	490	492	PF00082	0.543
CLV_PCSK_KEX2_1	511	513	PF00082	0.688
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.543
CLV_PCSK_PC7_1	507	513	PF00082	0.651
CLV_PCSK_SKI1_1	501	505	PF00082	0.736
CLV_PCSK_SKI1_1	516	520	PF00082	0.470
CLV_PCSK_SKI1_1	554	558	PF00082	0.330
CLV_Separin_Metazoa	152	156	PF03568	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DEG_SPOP_SBC_1	227	231	PF00917	0.693
DEG_SPOP_SBC_1	97	101	PF00917	0.659
DOC_CKS1_1	345	350	PF01111	0.669
DOC_CKS1_1	405	410	PF01111	0.596
DOC_CKS1_1	91	96	PF01111	0.580
DOC_MAPK_gen_1	511	521	PF00069	0.569
DOC_PP1_RVXF_1	514	521	PF00149	0.550
DOC_PP2B_LxvP_1	27	30	PF13499	0.516
DOC_PP4_FxxP_1	91	94	PF00568	0.566
DOC_USP7_MATH_1	140	144	PF00917	0.519
DOC_USP7_MATH_1	162	166	PF00917	0.675
DOC_USP7_MATH_1	180	184	PF00917	0.605
DOC_USP7_MATH_1	21	25	PF00917	0.686
DOC_USP7_MATH_1	227	231	PF00917	0.693
DOC_USP7_MATH_1	248	252	PF00917	0.630
DOC_USP7_MATH_1	290	294	PF00917	0.748
DOC_USP7_MATH_1	35	39	PF00917	0.683
DOC_USP7_MATH_1	389	393	PF00917	0.684
DOC_USP7_MATH_1	395	399	PF00917	0.617
DOC_USP7_MATH_1	467	471	PF00917	0.729
DOC_USP7_MATH_1	531	535	PF00917	0.590
DOC_USP7_MATH_1	64	68	PF00917	0.542
DOC_USP7_MATH_1	98	102	PF00917	0.669
DOC_USP7_UBL2_3	550	554	PF12436	0.590
DOC_WW_Pin1_4	234	239	PF00397	0.697
DOC_WW_Pin1_4	257	262	PF00397	0.567
DOC_WW_Pin1_4	310	315	PF00397	0.704
DOC_WW_Pin1_4	344	349	PF00397	0.669
DOC_WW_Pin1_4	404	409	PF00397	0.616
DOC_WW_Pin1_4	419	424	PF00397	0.612
DOC_WW_Pin1_4	90	95	PF00397	0.635
LIG_14-3-3_CanoR_1	195	205	PF00244	0.646
LIG_14-3-3_CanoR_1	206	210	PF00244	0.646
LIG_14-3-3_CanoR_1	225	233	PF00244	0.506
LIG_14-3-3_CanoR_1	253	261	PF00244	0.667
LIG_14-3-3_CanoR_1	501	509	PF00244	0.652
LIG_14-3-3_CanoR_1	584	588	PF00244	0.331
LIG_BRCT_BRCA1_1	533	537	PF00533	0.590
LIG_deltaCOP1_diTrp_1	79	87	PF00928	0.600
LIG_FHA_1	121	127	PF00498	0.721
LIG_FHA_1	206	212	PF00498	0.710
LIG_FHA_1	24	30	PF00498	0.550
LIG_FHA_1	340	346	PF00498	0.612
LIG_FHA_1	362	368	PF00498	0.742
LIG_FHA_1	504	510	PF00498	0.678
LIG_FHA_1	622	628	PF00498	0.544
LIG_FHA_2	527	533	PF00498	0.602
LIG_FHA_2	583	589	PF00498	0.541
LIG_LIR_Apic_2	470	476	PF02991	0.756
LIG_LIR_Apic_2	538	543	PF02991	0.590
LIG_LIR_Apic_2	89	94	PF02991	0.569
LIG_LIR_Gen_1	297	306	PF02991	0.705
LIG_LIR_Gen_1	85	96	PF02991	0.682
LIG_LIR_Nem_3	534	540	PF02991	0.595
LIG_LIR_Nem_3	578	583	PF02991	0.583
LIG_LIR_Nem_3	628	633	PF02991	0.369
LIG_LIR_Nem_3	85	91	PF02991	0.686
LIG_PCNA_PIPBox_1	396	405	PF02747	0.605
LIG_PCNA_yPIPBox_3	393	403	PF02747	0.602
LIG_Pex14_2	87	91	PF04695	0.687
LIG_SH2_CRK	420	424	PF00017	0.673
LIG_SH2_CRK	540	544	PF00017	0.600
LIG_SH2_NCK_1	420	424	PF00017	0.523
LIG_SH2_SRC	366	369	PF00017	0.750
LIG_SH2_STAP1	263	267	PF00017	0.688
LIG_SH2_STAP1	384	388	PF00017	0.533
LIG_SH2_STAT3	402	405	PF00017	0.692
LIG_SH2_STAT3	484	487	PF00017	0.708
LIG_SH2_STAT3	620	623	PF00017	0.538
LIG_SH2_STAT5	283	286	PF00017	0.679
LIG_SH2_STAT5	366	369	PF00017	0.750
LIG_SH2_STAT5	403	406	PF00017	0.748
LIG_SH3_1	17	23	PF00018	0.532
LIG_SH3_3	17	23	PF00018	0.532
LIG_SH3_3	276	282	PF00018	0.665
LIG_SH3_3	300	306	PF00018	0.706
LIG_SH3_3	640	646	PF00018	0.609
LIG_SH3_3	91	97	PF00018	0.577
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.685
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.590
LIG_SUMO_SIM_par_1	545	551	PF11976	0.590
LIG_SxIP_EBH_1	381	394	PF03271	0.693
LIG_TRAF2_1	76	79	PF00917	0.699
LIG_TRFH_1	402	406	PF08558	0.690
LIG_WRC_WIRS_1	163	168	PF05994	0.537
LIG_WRC_WIRS_1	627	632	PF05994	0.303
LIG_WRC_WIRS_1	88	93	PF05994	0.519
MOD_CDK_SPxxK_3	310	317	PF00069	0.543
MOD_CK1_1	164	170	PF00069	0.702
MOD_CK1_1	172	178	PF00069	0.729
MOD_CK1_1	198	204	PF00069	0.698
MOD_CK1_1	251	257	PF00069	0.657
MOD_CK1_1	358	364	PF00069	0.721
MOD_CK1_1	380	386	PF00069	0.695
MOD_CK1_1	422	428	PF00069	0.630
MOD_CK1_1	449	455	PF00069	0.708
MOD_CK1_1	456	462	PF00069	0.681
MOD_CK1_1	565	571	PF00069	0.641
MOD_CK1_1	89	95	PF00069	0.513
MOD_CK2_1	582	588	PF00069	0.545
MOD_CK2_1	638	644	PF00069	0.532
MOD_Cter_Amidation	488	491	PF01082	0.532
MOD_GlcNHglycan	100	103	PF01048	0.738
MOD_GlcNHglycan	134	137	PF01048	0.707
MOD_GlcNHglycan	200	203	PF01048	0.728
MOD_GlcNHglycan	211	214	PF01048	0.622
MOD_GlcNHglycan	266	270	PF01048	0.748
MOD_GlcNHglycan	299	302	PF01048	0.651
MOD_GlcNHglycan	359	363	PF01048	0.694
MOD_GlcNHglycan	469	472	PF01048	0.670
MOD_GlcNHglycan	564	567	PF01048	0.711
MOD_GlcNHglycan	577	580	PF01048	0.378
MOD_GlcNHglycan	66	69	PF01048	0.698
MOD_GSK3_1	121	128	PF00069	0.700
MOD_GSK3_1	141	148	PF00069	0.492
MOD_GSK3_1	161	168	PF00069	0.585
MOD_GSK3_1	196	203	PF00069	0.756
MOD_GSK3_1	205	212	PF00069	0.661
MOD_GSK3_1	21	28	PF00069	0.699
MOD_GSK3_1	228	235	PF00069	0.681
MOD_GSK3_1	242	249	PF00069	0.624
MOD_GSK3_1	251	258	PF00069	0.600
MOD_GSK3_1	261	268	PF00069	0.513
MOD_GSK3_1	270	277	PF00069	0.545
MOD_GSK3_1	290	297	PF00069	0.695
MOD_GSK3_1	308	315	PF00069	0.640
MOD_GSK3_1	380	387	PF00069	0.721
MOD_GSK3_1	418	425	PF00069	0.725
MOD_GSK3_1	42	49	PF00069	0.644
MOD_GSK3_1	445	452	PF00069	0.576
MOD_GSK3_1	455	462	PF00069	0.604
MOD_GSK3_1	531	538	PF00069	0.619
MOD_GSK3_1	575	582	PF00069	0.577
MOD_GSK3_1	621	628	PF00069	0.539
MOD_GSK3_1	82	89	PF00069	0.789
MOD_LATS_1	193	199	PF00433	0.700
MOD_N-GLC_1	169	174	PF02516	0.766
MOD_N-GLC_1	428	433	PF02516	0.696
MOD_N-GLC_1	434	439	PF02516	0.622
MOD_N-GLC_1	46	51	PF02516	0.565
MOD_NEK2_1	121	126	PF00069	0.705
MOD_NEK2_1	142	147	PF00069	0.709
MOD_NEK2_1	166	171	PF00069	0.708
MOD_NEK2_1	209	214	PF00069	0.657
MOD_NEK2_1	246	251	PF00069	0.690
MOD_NEK2_1	25	30	PF00069	0.524
MOD_NEK2_1	450	455	PF00069	0.538
MOD_NEK2_1	616	621	PF00069	0.514
MOD_NEK2_1	626	631	PF00069	0.406
MOD_NEK2_1	638	643	PF00069	0.504
MOD_NEK2_1	87	92	PF00069	0.687
MOD_NEK2_2	248	253	PF00069	0.607
MOD_PIKK_1	107	113	PF00454	0.612
MOD_PIKK_1	172	178	PF00454	0.742
MOD_PIKK_1	290	296	PF00454	0.762
MOD_PIKK_1	42	48	PF00454	0.511
MOD_PIKK_1	531	537	PF00454	0.590
MOD_PK_1	542	548	PF00069	0.590
MOD_PKA_2	205	211	PF00069	0.662
MOD_PKA_2	252	258	PF00069	0.520
MOD_PKA_2	316	322	PF00069	0.524
MOD_PKA_2	583	589	PF00069	0.308
MOD_Plk_1	46	52	PF00069	0.583
MOD_Plk_1	531	537	PF00069	0.638
MOD_Plk_2-3	480	486	PF00069	0.750
MOD_Plk_4	121	127	PF00069	0.701
MOD_Plk_4	228	234	PF00069	0.698
MOD_Plk_4	242	248	PF00069	0.617
MOD_Plk_4	319	325	PF00069	0.687
MOD_Plk_4	35	41	PF00069	0.749
MOD_Plk_4	446	452	PF00069	0.723
MOD_Plk_4	46	52	PF00069	0.709
MOD_Plk_4	542	548	PF00069	0.590
MOD_ProDKin_1	234	240	PF00069	0.697
MOD_ProDKin_1	257	263	PF00069	0.569
MOD_ProDKin_1	310	316	PF00069	0.700
MOD_ProDKin_1	344	350	PF00069	0.670
MOD_ProDKin_1	404	410	PF00069	0.617
MOD_ProDKin_1	419	425	PF00069	0.613
MOD_ProDKin_1	90	96	PF00069	0.634
TRG_ENDOCYTIC_2	163	166	PF00928	0.771
TRG_ENDOCYTIC_2	2	5	PF00928	0.626
TRG_ENDOCYTIC_2	299	302	PF00928	0.726
TRG_ENDOCYTIC_2	58	61	PF00928	0.512
TRG_ENDOCYTIC_2	88	91	PF00928	0.686
TRG_ER_diArg_1	511	514	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6N3	Leishmania donovani	80%	97%
A4HLK5	Leishmania braziliensis	55%	98%
A4I916	Leishmania infantum	80%	97%
Q4Q443	Leishmania major	77%	100%