Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Y0_LEIMU

TriTrypDb:

LmxM.32.1430

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.466
CLV_NRD_NRD_1	297	299	PF00675	0.525
CLV_NRD_NRD_1	311	313	PF00675	0.520
CLV_NRD_NRD_1	464	466	PF00675	0.560
CLV_NRD_NRD_1	5	7	PF00675	0.672
CLV_PCSK_FUR_1	295	299	PF00082	0.457
CLV_PCSK_FUR_1	3	7	PF00082	0.668
CLV_PCSK_KEX2_1	193	195	PF00082	0.463
CLV_PCSK_KEX2_1	24	26	PF00082	0.466
CLV_PCSK_KEX2_1	295	297	PF00082	0.576
CLV_PCSK_KEX2_1	311	313	PF00082	0.509
CLV_PCSK_KEX2_1	464	466	PF00082	0.560
CLV_PCSK_KEX2_1	5	7	PF00082	0.672
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.463
CLV_PCSK_PC7_1	307	313	PF00082	0.487
CLV_PCSK_SKI1_1	200	204	PF00082	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.604
DEG_SCF_FBW7_2	328	334	PF00400	0.630
DEG_SPOP_SBC_1	408	412	PF00917	0.467
DEG_SPOP_SBC_1	448	452	PF00917	0.487
DOC_CDC14_PxL_1	257	265	PF14671	0.486
DOC_CDC14_PxL_1	555	563	PF14671	0.457
DOC_CKS1_1	328	333	PF01111	0.641
DOC_CKS1_1	81	86	PF01111	0.517
DOC_MAPK_DCC_7	512	520	PF00069	0.490
DOC_PP2B_LxvP_1	355	358	PF13499	0.627
DOC_PP4_FxxP_1	177	180	PF00568	0.591
DOC_USP7_MATH_1	155	159	PF00917	0.591
DOC_USP7_MATH_1	221	225	PF00917	0.651
DOC_USP7_MATH_1	287	291	PF00917	0.511
DOC_USP7_MATH_1	448	452	PF00917	0.496
DOC_USP7_MATH_1	478	482	PF00917	0.273
DOC_USP7_MATH_1	82	86	PF00917	0.603
DOC_USP7_MATH_1	9	13	PF00917	0.489
DOC_WW_Pin1_4	120	125	PF00397	0.706
DOC_WW_Pin1_4	184	189	PF00397	0.543
DOC_WW_Pin1_4	202	207	PF00397	0.528
DOC_WW_Pin1_4	327	332	PF00397	0.629
DOC_WW_Pin1_4	336	341	PF00397	0.783
DOC_WW_Pin1_4	444	449	PF00397	0.616
DOC_WW_Pin1_4	67	72	PF00397	0.572
DOC_WW_Pin1_4	80	85	PF00397	0.560
LIG_14-3-3_CanoR_1	25	35	PF00244	0.511
LIG_14-3-3_CanoR_1	271	275	PF00244	0.552
LIG_14-3-3_CanoR_1	44	49	PF00244	0.683
LIG_14-3-3_CanoR_1	541	546	PF00244	0.481
LIG_BIR_III_4	102	106	PF00653	0.535
LIG_BRCT_BRCA1_1	186	190	PF00533	0.478
LIG_deltaCOP1_diTrp_1	191	199	PF00928	0.467
LIG_eIF4E_1	258	264	PF01652	0.395
LIG_FHA_1	184	190	PF00498	0.640
LIG_FHA_1	203	209	PF00498	0.475
LIG_FHA_1	215	221	PF00498	0.652
LIG_FHA_1	265	271	PF00498	0.521
LIG_FHA_1	457	463	PF00498	0.676
LIG_FHA_1	5	11	PF00498	0.501
LIG_FHA_2	313	319	PF00498	0.577
LIG_FHA_2	351	357	PF00498	0.624
LIG_FHA_2	498	504	PF00498	0.383
LIG_FHA_2	68	74	PF00498	0.619
LIG_Integrin_RGD_1	488	490	PF01839	0.411
LIG_IRF3_LxIS_1	331	338	PF10401	0.488
LIG_LIR_Gen_1	359	368	PF02991	0.603
LIG_LIR_Gen_1	480	487	PF02991	0.363
LIG_LIR_Gen_1	495	503	PF02991	0.360
LIG_LIR_Nem_3	254	260	PF02991	0.482
LIG_LIR_Nem_3	359	363	PF02991	0.669
LIG_LIR_Nem_3	480	485	PF02991	0.367
LIG_LIR_Nem_3	495	501	PF02991	0.370
LIG_LIR_Nem_3	504	510	PF02991	0.383
LIG_LYPXL_yS_3	558	561	PF13949	0.439
LIG_SH2_CRK	106	110	PF00017	0.549
LIG_SH2_CRK	482	486	PF00017	0.359
LIG_SH2_CRK	556	560	PF00017	0.519
LIG_SH2_PTP2	420	423	PF00017	0.583
LIG_SH2_SRC	342	345	PF00017	0.477
LIG_SH2_SRC	420	423	PF00017	0.648
LIG_SH2_STAP1	482	486	PF00017	0.359
LIG_SH2_STAT5	258	261	PF00017	0.404
LIG_SH2_STAT5	420	423	PF00017	0.585
LIG_SH2_STAT5	537	540	PF00017	0.339
LIG_SH3_3	215	221	PF00018	0.646
LIG_SH3_3	383	389	PF00018	0.604
LIG_SH3_3	455	461	PF00018	0.613
LIG_SUMO_SIM_par_1	266	273	PF11976	0.434
LIG_SUMO_SIM_par_1	353	359	PF11976	0.780
LIG_SUMO_SIM_par_1	474	481	PF11976	0.410
LIG_TRFH_1	257	261	PF08558	0.472
LIG_TRFH_1	262	266	PF08558	0.468
LIG_TYR_ITIM	418	423	PF00017	0.647
LIG_ULM_U2AF65_1	295	300	PF00076	0.455
LIG_WRC_WIRS_1	357	362	PF05994	0.666
MOD_CDK_SPK_2	336	341	PF00069	0.561
MOD_CDK_SPxxK_3	67	74	PF00069	0.509
MOD_CK1_1	120	126	PF00069	0.633
MOD_CK1_1	169	175	PF00069	0.712
MOD_CK1_1	211	217	PF00069	0.605
MOD_CK1_1	30	36	PF00069	0.548
MOD_CK1_1	426	432	PF00069	0.622
MOD_CK1_1	435	441	PF00069	0.689
MOD_CK1_1	447	453	PF00069	0.545
MOD_CK1_1	456	462	PF00069	0.560
MOD_CK1_1	47	53	PF00069	0.768
MOD_CK1_1	540	546	PF00069	0.497
MOD_CK1_1	57	63	PF00069	0.644
MOD_CK2_1	120	126	PF00069	0.669
MOD_CK2_1	221	227	PF00069	0.625
MOD_CK2_1	277	283	PF00069	0.485
MOD_CK2_1	312	318	PF00069	0.592
MOD_CK2_1	350	356	PF00069	0.592
MOD_CK2_1	67	73	PF00069	0.682
MOD_GlcNHglycan	126	130	PF01048	0.537
MOD_GlcNHglycan	150	153	PF01048	0.800
MOD_GlcNHglycan	168	171	PF01048	0.751
MOD_GlcNHglycan	223	226	PF01048	0.775
MOD_GlcNHglycan	289	292	PF01048	0.531
MOD_GlcNHglycan	32	35	PF01048	0.576
MOD_GlcNHglycan	411	414	PF01048	0.555
MOD_GlcNHglycan	56	59	PF01048	0.564
MOD_GSK3_1	116	123	PF00069	0.632
MOD_GSK3_1	207	214	PF00069	0.698
MOD_GSK3_1	216	223	PF00069	0.611
MOD_GSK3_1	26	33	PF00069	0.489
MOD_GSK3_1	314	321	PF00069	0.629
MOD_GSK3_1	423	430	PF00069	0.600
MOD_GSK3_1	442	449	PF00069	0.499
MOD_GSK3_1	456	463	PF00069	0.575
MOD_GSK3_1	497	504	PF00069	0.380
MOD_GSK3_1	537	544	PF00069	0.521
MOD_GSK3_1	57	64	PF00069	0.620
MOD_GSK3_1	76	83	PF00069	0.555
MOD_N-GLC_1	541	546	PF02516	0.481
MOD_NEK2_1	19	24	PF00069	0.483
MOD_NEK2_1	216	221	PF00069	0.689
MOD_NEK2_1	250	255	PF00069	0.584
MOD_NEK2_1	277	282	PF00069	0.723
MOD_NEK2_1	335	340	PF00069	0.724
MOD_NEK2_1	491	496	PF00069	0.418
MOD_NEK2_1	501	506	PF00069	0.465
MOD_PIKK_1	251	257	PF00454	0.534
MOD_PIKK_1	270	276	PF00454	0.572
MOD_PIKK_1	4	10	PF00454	0.499
MOD_PIKK_1	435	441	PF00454	0.638
MOD_PK_1	322	328	PF00069	0.594
MOD_PKA_2	26	32	PF00069	0.499
MOD_PKA_2	270	276	PF00069	0.466
MOD_PKA_2	318	324	PF00069	0.549
MOD_PKA_2	4	10	PF00069	0.499
MOD_PKA_2	540	546	PF00069	0.497
MOD_PKB_1	25	33	PF00069	0.509
MOD_Plk_1	541	547	PF00069	0.485
MOD_Plk_2-3	394	400	PF00069	0.645
MOD_Plk_4	350	356	PF00069	0.582
MOD_Plk_4	541	547	PF00069	0.527
MOD_ProDKin_1	120	126	PF00069	0.708
MOD_ProDKin_1	184	190	PF00069	0.536
MOD_ProDKin_1	202	208	PF00069	0.540
MOD_ProDKin_1	327	333	PF00069	0.630
MOD_ProDKin_1	336	342	PF00069	0.782
MOD_ProDKin_1	444	450	PF00069	0.615
MOD_ProDKin_1	67	73	PF00069	0.572
MOD_ProDKin_1	80	86	PF00069	0.557
MOD_SUMO_rev_2	57	63	PF00179	0.645
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.499
TRG_ENDOCYTIC_2	257	260	PF00928	0.506
TRG_ENDOCYTIC_2	420	423	PF00928	0.610
TRG_ENDOCYTIC_2	482	485	PF00928	0.360
TRG_ENDOCYTIC_2	558	561	PF00928	0.439
TRG_ER_diArg_1	2	5	PF00400	0.670
TRG_ER_diArg_1	23	25	PF00400	0.557
TRG_ER_diArg_1	295	298	PF00400	0.581
TRG_ER_diArg_1	512	515	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L4	Leptomonas seymouri	37%	100%
A0A3Q8IEV6	Leishmania donovani	83%	97%
A4HLK4	Leishmania braziliensis	66%	99%
A4I915	Leishmania infantum	83%	94%
Q4Q444	Leishmania major	81%	100%