Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3X8_LEIMU

TriTrypDb:

LmxM.32.1410

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000421	autophagosome membrane	6	1
GO:0005774	vacuolar membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9B3X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3X8

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	11
GO:0006996	organelle organization	4	11
GO:0007033	vacuole organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:1905037	autophagosome organization	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.438
CLV_C14_Caspase3-7	527	531	PF00656	0.649
CLV_NRD_NRD_1	208	210	PF00675	0.457
CLV_NRD_NRD_1	391	393	PF00675	0.425
CLV_NRD_NRD_1	428	430	PF00675	0.428
CLV_PCSK_KEX2_1	207	209	PF00082	0.463
CLV_PCSK_KEX2_1	226	228	PF00082	0.708
CLV_PCSK_KEX2_1	390	392	PF00082	0.465
CLV_PCSK_KEX2_1	428	430	PF00082	0.428
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.667
CLV_PCSK_SKI1_1	180	184	PF00082	0.456
CLV_PCSK_SKI1_1	293	297	PF00082	0.280
CLV_PCSK_SKI1_1	396	400	PF00082	0.390
CLV_PCSK_SKI1_1	429	433	PF00082	0.541
CLV_PCSK_SKI1_1	442	446	PF00082	0.257
CLV_PCSK_SKI1_1	471	475	PF00082	0.447
CLV_PCSK_SKI1_1	539	543	PF00082	0.512
CLV_PCSK_SKI1_1	99	103	PF00082	0.504
DEG_APCC_DBOX_1	391	399	PF00400	0.485
DEG_Nend_UBRbox_3	1	3	PF02207	0.638
DEG_SCF_FBW7_1	239	244	PF00400	0.468
DOC_CYCLIN_RxL_1	471	479	PF00134	0.505
DOC_MAPK_MEF2A_6	509	518	PF00069	0.417
DOC_USP7_MATH_1	265	269	PF00917	0.578
DOC_USP7_MATH_1	36	40	PF00917	0.560
DOC_USP7_MATH_1	431	435	PF00917	0.512
DOC_USP7_MATH_1	504	508	PF00917	0.402
DOC_USP7_MATH_1	528	532	PF00917	0.691
DOC_USP7_MATH_1	543	547	PF00917	0.570
DOC_USP7_MATH_1	575	579	PF00917	0.474
DOC_USP7_MATH_1	82	86	PF00917	0.576
DOC_WW_Pin1_4	237	242	PF00397	0.768
DOC_WW_Pin1_4	246	251	PF00397	0.697
DOC_WW_Pin1_4	256	261	PF00397	0.614
DOC_WW_Pin1_4	531	536	PF00397	0.602
DOC_WW_Pin1_4	8	13	PF00397	0.660
LIG_14-3-3_CanoR_1	167	173	PF00244	0.589
LIG_14-3-3_CanoR_1	195	200	PF00244	0.522
LIG_14-3-3_CanoR_1	227	231	PF00244	0.459
LIG_14-3-3_CanoR_1	269	273	PF00244	0.543
LIG_14-3-3_CanoR_1	309	317	PF00244	0.442
LIG_14-3-3_CanoR_1	442	449	PF00244	0.395
LIG_14-3-3_CanoR_1	509	516	PF00244	0.464
LIG_14-3-3_CanoR_1	70	78	PF00244	0.564
LIG_Actin_WH2_2	19	37	PF00022	0.573
LIG_CaM_IQ_9	148	164	PF13499	0.546
LIG_DLG_GKlike_1	391	398	PF00625	0.481
LIG_FHA_1	146	152	PF00498	0.553
LIG_FHA_1	358	364	PF00498	0.511
LIG_FHA_1	381	387	PF00498	0.436
LIG_FHA_1	472	478	PF00498	0.457
LIG_FHA_1	508	514	PF00498	0.381
LIG_FHA_1	70	76	PF00498	0.464
LIG_FHA_2	169	175	PF00498	0.495
LIG_FHA_2	182	188	PF00498	0.495
LIG_FHA_2	195	201	PF00498	0.417
LIG_FHA_2	401	407	PF00498	0.411
LIG_FHA_2	422	428	PF00498	0.453
LIG_FHA_2	87	93	PF00498	0.536
LIG_LIR_Gen_1	157	165	PF02991	0.429
LIG_LIR_Gen_1	42	52	PF02991	0.546
LIG_LIR_Nem_3	114	120	PF02991	0.431
LIG_LIR_Nem_3	157	161	PF02991	0.428
LIG_LIR_Nem_3	163	168	PF02991	0.427
LIG_LIR_Nem_3	39	44	PF02991	0.580
LIG_NRBOX	394	400	PF00104	0.494
LIG_Pex14_2	564	568	PF04695	0.464
LIG_SH2_CRK	117	121	PF00017	0.426
LIG_SH2_CRK	158	162	PF00017	0.428
LIG_SH2_CRK	165	169	PF00017	0.431
LIG_SH2_CRK	44	48	PF00017	0.543
LIG_SH2_STAT5	158	161	PF00017	0.548
LIG_SH2_STAT5	178	181	PF00017	0.539
LIG_SH2_STAT5	255	258	PF00017	0.765
LIG_SH2_STAT5	317	320	PF00017	0.488
LIG_SH2_STAT5	333	336	PF00017	0.436
LIG_SH2_STAT5	44	47	PF00017	0.551
LIG_SH3_3	477	483	PF00018	0.245
LIG_SUMO_SIM_anti_2	510	517	PF11976	0.414
LIG_SUMO_SIM_par_1	462	469	PF11976	0.444
LIG_SUMO_SIM_par_1	575	580	PF11976	0.445
LIG_TRAF2_1	125	128	PF00917	0.439
MOD_CDC14_SPxK_1	259	262	PF00782	0.541
MOD_CDK_SPxK_1	256	262	PF00069	0.544
MOD_CK1_1	11	17	PF00069	0.635
MOD_CK1_1	268	274	PF00069	0.541
MOD_CK1_1	319	325	PF00069	0.311
MOD_CK1_1	379	385	PF00069	0.278
MOD_CK1_1	394	400	PF00069	0.329
MOD_CK1_1	43	49	PF00069	0.600
MOD_CK1_1	507	513	PF00069	0.475
MOD_CK1_1	531	537	PF00069	0.637
MOD_CK1_1	546	552	PF00069	0.558
MOD_CK1_1	556	562	PF00069	0.560
MOD_CK1_1	69	75	PF00069	0.511
MOD_CK1_1	86	92	PF00069	0.633
MOD_CK2_1	168	174	PF00069	0.540
MOD_CK2_1	181	187	PF00069	0.498
MOD_CK2_1	194	200	PF00069	0.369
MOD_CK2_1	226	232	PF00069	0.456
MOD_CK2_1	86	92	PF00069	0.541
MOD_GlcNHglycan	297	300	PF01048	0.297
MOD_GlcNHglycan	310	313	PF01048	0.469
MOD_GlcNHglycan	370	373	PF01048	0.270
MOD_GlcNHglycan	4	8	PF01048	0.643
MOD_GlcNHglycan	415	418	PF01048	0.277
MOD_GlcNHglycan	433	436	PF01048	0.373
MOD_GlcNHglycan	449	452	PF01048	0.258
MOD_GlcNHglycan	498	501	PF01048	0.456
MOD_GlcNHglycan	506	509	PF01048	0.486
MOD_GlcNHglycan	530	533	PF01048	0.599
MOD_GlcNHglycan	543	546	PF01048	0.585
MOD_GlcNHglycan	550	553	PF01048	0.556
MOD_GlcNHglycan	555	558	PF01048	0.619
MOD_GSK3_1	237	244	PF00069	0.683
MOD_GSK3_1	36	43	PF00069	0.597
MOD_GSK3_1	376	383	PF00069	0.272
MOD_GSK3_1	427	434	PF00069	0.492
MOD_GSK3_1	492	499	PF00069	0.459
MOD_GSK3_1	504	511	PF00069	0.401
MOD_GSK3_1	526	533	PF00069	0.748
MOD_GSK3_1	82	89	PF00069	0.625
MOD_LATS_1	116	122	PF00433	0.294
MOD_LATS_1	440	446	PF00433	0.373
MOD_N-GLC_1	278	283	PF02516	0.335
MOD_N-GLC_1	546	551	PF02516	0.562
MOD_N-GLC_1	83	88	PF02516	0.586
MOD_NEK2_1	295	300	PF00069	0.297
MOD_NEK2_1	327	332	PF00069	0.340
MOD_NEK2_1	354	359	PF00069	0.336
MOD_NEK2_1	368	373	PF00069	0.306
MOD_NEK2_1	399	404	PF00069	0.391
MOD_NEK2_1	455	460	PF00069	0.378
MOD_NEK2_1	47	52	PF00069	0.473
MOD_NEK2_1	473	478	PF00069	0.317
MOD_NEK2_1	541	546	PF00069	0.493
MOD_NEK2_1	66	71	PF00069	0.516
MOD_NEK2_2	36	41	PF00069	0.561
MOD_NEK2_2	410	415	PF00069	0.393
MOD_PIKK_1	34	40	PF00454	0.523
MOD_PK_1	226	232	PF00069	0.456
MOD_PKA_1	226	232	PF00069	0.657
MOD_PKA_1	391	397	PF00069	0.438
MOD_PKA_2	111	117	PF00069	0.488
MOD_PKA_2	168	174	PF00069	0.540
MOD_PKA_2	194	200	PF00069	0.366
MOD_PKA_2	226	232	PF00069	0.657
MOD_PKA_2	268	274	PF00069	0.513
MOD_PKA_2	308	314	PF00069	0.482
MOD_PKA_2	391	397	PF00069	0.441
MOD_PKA_2	427	433	PF00069	0.402
MOD_PKA_2	447	453	PF00069	0.464
MOD_PKA_2	492	498	PF00069	0.369
MOD_PKA_2	508	514	PF00069	0.416
MOD_PKA_2	553	559	PF00069	0.381
MOD_PKA_2	69	75	PF00069	0.547
MOD_Plk_1	156	162	PF00069	0.506
MOD_Plk_1	278	284	PF00069	0.265
MOD_Plk_1	380	386	PF00069	0.267
MOD_Plk_1	405	411	PF00069	0.441
MOD_Plk_1	546	552	PF00069	0.486
MOD_Plk_1	66	72	PF00069	0.584
MOD_Plk_1	83	89	PF00069	0.630
MOD_Plk_4	268	274	PF00069	0.478
MOD_Plk_4	36	42	PF00069	0.544
MOD_Plk_4	410	416	PF00069	0.331
MOD_Plk_4	47	53	PF00069	0.487
MOD_Plk_4	473	479	PF00069	0.428
MOD_Plk_4	483	489	PF00069	0.348
MOD_ProDKin_1	237	243	PF00069	0.763
MOD_ProDKin_1	246	252	PF00069	0.697
MOD_ProDKin_1	256	262	PF00069	0.615
MOD_ProDKin_1	531	537	PF00069	0.588
MOD_ProDKin_1	8	14	PF00069	0.656
MOD_SUMO_for_1	214	217	PF00179	0.500
MOD_SUMO_rev_2	121	126	PF00179	0.425
MOD_SUMO_rev_2	176	185	PF00179	0.552
MOD_SUMO_rev_2	290	295	PF00179	0.391
TRG_DiLeu_BaEn_1	23	28	PF01217	0.566
TRG_DiLeu_BaEn_4	128	134	PF01217	0.430
TRG_ENDOCYTIC_2	117	120	PF00928	0.424
TRG_ENDOCYTIC_2	158	161	PF00928	0.409
TRG_ENDOCYTIC_2	165	168	PF00928	0.411
TRG_ENDOCYTIC_2	44	47	PF00928	0.545
TRG_ER_diArg_1	167	170	PF00400	0.545
TRG_ER_diArg_1	206	209	PF00400	0.508
TRG_ER_diArg_1	389	392	PF00400	0.443
TRG_ER_diArg_1	61	64	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK2	Leptomonas seymouri	68%	100%
A0A0S4IUZ3	Bodo saltans	24%	100%
A0A1X0NWL7	Trypanosomatidae	37%	100%
A0A1X0P716	Trypanosomatidae	21%	99%
A0A3S7X6T5	Leishmania donovani	92%	100%
A0A422NYX2	Trypanosoma rangeli	36%	100%
A4HLK2	Leishmania braziliensis	82%	100%
A4I913	Leishmania infantum	92%	100%
D0A7L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q09406	Caenorhabditis elegans	23%	100%
Q19124	Caenorhabditis elegans	24%	100%
Q4Q446	Leishmania major	90%	100%
Q5RAC9	Pongo abelii	26%	97%
Q676U5	Homo sapiens	26%	97%
Q6NNP0	Arabidopsis thaliana	27%	100%
Q8C0J2	Mus musculus	26%	97%
V5BW76	Trypanosoma cruzi	39%	100%