Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3X4_LEIMU

TriTrypDb:

LmxM.32.1370

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.727
CLV_C14_Caspase3-7	422	426	PF00656	0.612
CLV_NRD_NRD_1	173	175	PF00675	0.601
CLV_NRD_NRD_1	206	208	PF00675	0.748
CLV_NRD_NRD_1	296	298	PF00675	0.768
CLV_NRD_NRD_1	349	351	PF00675	0.635
CLV_NRD_NRD_1	416	418	PF00675	0.620
CLV_PCSK_KEX2_1	142	144	PF00082	0.563
CLV_PCSK_KEX2_1	206	208	PF00082	0.663
CLV_PCSK_KEX2_1	296	298	PF00082	0.811
CLV_PCSK_KEX2_1	348	350	PF00082	0.646
CLV_PCSK_KEX2_1	416	418	PF00082	0.620
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.535
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.663
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.646
CLV_PCSK_SKI1_1	120	124	PF00082	0.667
CLV_PCSK_SKI1_1	355	359	PF00082	0.531
DEG_SPOP_SBC_1	100	104	PF00917	0.599
DEG_SPOP_SBC_1	357	361	PF00917	0.531
DOC_CKS1_1	70	75	PF01111	0.532
DOC_USP7_MATH_1	100	104	PF00917	0.561
DOC_USP7_MATH_1	177	181	PF00917	0.674
DOC_USP7_MATH_1	192	196	PF00917	0.660
DOC_USP7_MATH_1	247	251	PF00917	0.805
DOC_USP7_MATH_1	265	269	PF00917	0.520
DOC_USP7_MATH_1	65	69	PF00917	0.543
DOC_USP7_UBL2_3	171	175	PF12436	0.609
DOC_WW_Pin1_4	224	229	PF00397	0.691
DOC_WW_Pin1_4	257	262	PF00397	0.715
DOC_WW_Pin1_4	348	353	PF00397	0.719
DOC_WW_Pin1_4	388	393	PF00397	0.630
DOC_WW_Pin1_4	395	400	PF00397	0.757
DOC_WW_Pin1_4	43	48	PF00397	0.443
DOC_WW_Pin1_4	69	74	PF00397	0.555
LIG_14-3-3_CanoR_1	18	22	PF00244	0.557
LIG_14-3-3_CanoR_1	223	228	PF00244	0.745
LIG_14-3-3_CanoR_1	296	305	PF00244	0.739
LIG_14-3-3_CanoR_1	319	328	PF00244	0.512
LIG_14-3-3_CanoR_1	393	402	PF00244	0.772
LIG_14-3-3_CanoR_1	411	416	PF00244	0.627
LIG_14-3-3_CanoR_1	43	47	PF00244	0.659
LIG_14-3-3_CanoR_1	76	80	PF00244	0.584
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BIR_III_4	64	68	PF00653	0.535
LIG_Clathr_ClatBox_1	60	64	PF01394	0.476
LIG_FHA_1	257	263	PF00498	0.719
LIG_FHA_1	379	385	PF00498	0.620
LIG_FHA_1	410	416	PF00498	0.699
LIG_FHA_1	76	82	PF00498	0.605
LIG_FHA_2	265	271	PF00498	0.747
LIG_FHA_2	381	387	PF00498	0.616
LIG_FHA_2	420	426	PF00498	0.616
LIG_LIR_Nem_3	20	24	PF02991	0.615
LIG_SH2_CRK	77	81	PF00017	0.493
LIG_SH2_STAP1	77	81	PF00017	0.493
LIG_SH2_STAT3	318	321	PF00017	0.710
LIG_SH2_STAT5	5	8	PF00017	0.502
LIG_SH2_STAT5	77	80	PF00017	0.658
LIG_SH3_2	291	296	PF14604	0.623
LIG_SH3_3	122	128	PF00018	0.744
LIG_SH3_3	141	147	PF00018	0.795
LIG_SH3_3	156	162	PF00018	0.525
LIG_SH3_3	259	265	PF00018	0.714
LIG_SH3_3	286	292	PF00018	0.654
LIG_SH3_3	324	330	PF00018	0.665
LIG_SH3_3	368	374	PF00018	0.718
LIG_SH3_3	381	387	PF00018	0.597
LIG_SH3_3	56	62	PF00018	0.515
LIG_SH3_3	67	73	PF00018	0.494
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.591
LIG_SUMO_SIM_par_1	78	85	PF11976	0.501
LIG_TRAF2_1	181	184	PF00917	0.679
LIG_TRAF2_1	335	338	PF00917	0.738
MOD_CDC14_SPxK_1	398	401	PF00782	0.726
MOD_CDK_SPK_2	388	393	PF00069	0.539
MOD_CDK_SPxK_1	395	401	PF00069	0.730
MOD_CDK_SPxxK_3	348	355	PF00069	0.713
MOD_CDK_SPxxK_3	388	395	PF00069	0.527
MOD_CDK_SPxxK_3	69	76	PF00069	0.623
MOD_CK1_1	104	110	PF00069	0.720
MOD_CK1_1	226	232	PF00069	0.652
MOD_CK1_1	236	242	PF00069	0.771
MOD_CK1_1	250	256	PF00069	0.594
MOD_CK1_1	257	263	PF00069	0.618
MOD_CK1_1	268	274	PF00069	0.598
MOD_CK1_1	280	286	PF00069	0.582
MOD_CK1_1	298	304	PF00069	0.787
MOD_CK1_1	31	37	PF00069	0.588
MOD_CK1_1	322	328	PF00069	0.709
MOD_CK1_1	353	359	PF00069	0.706
MOD_CK1_1	361	367	PF00069	0.616
MOD_CK1_1	410	416	PF00069	0.730
MOD_CK2_1	148	154	PF00069	0.712
MOD_CK2_1	167	173	PF00069	0.661
MOD_CK2_1	177	183	PF00069	0.622
MOD_CK2_1	264	270	PF00069	0.753
MOD_CK2_1	280	286	PF00069	0.584
MOD_CK2_1	348	354	PF00069	0.726
MOD_CK2_1	380	386	PF00069	0.620
MOD_GlcNHglycan	103	106	PF01048	0.660
MOD_GlcNHglycan	112	115	PF01048	0.563
MOD_GlcNHglycan	149	153	PF01048	0.677
MOD_GlcNHglycan	179	182	PF01048	0.721
MOD_GlcNHglycan	235	238	PF01048	0.658
MOD_GlcNHglycan	267	270	PF01048	0.751
MOD_GlcNHglycan	321	324	PF01048	0.615
MOD_GlcNHglycan	360	363	PF01048	0.745
MOD_GlcNHglycan	395	398	PF01048	0.690
MOD_GlcNHglycan	55	58	PF01048	0.444
MOD_GSK3_1	100	107	PF00069	0.676
MOD_GSK3_1	193	200	PF00069	0.649
MOD_GSK3_1	223	230	PF00069	0.626
MOD_GSK3_1	248	255	PF00069	0.648
MOD_GSK3_1	264	271	PF00069	0.622
MOD_GSK3_1	27	34	PF00069	0.751
MOD_GSK3_1	273	280	PF00069	0.632
MOD_GSK3_1	295	302	PF00069	0.752
MOD_GSK3_1	353	360	PF00069	0.703
MOD_GSK3_1	361	368	PF00069	0.741
MOD_GSK3_1	402	409	PF00069	0.669
MOD_GSK3_1	419	426	PF00069	0.582
MOD_GSK3_1	65	72	PF00069	0.539
MOD_N-GLC_1	167	172	PF02516	0.653
MOD_N-GLC_1	224	229	PF02516	0.533
MOD_N-GLC_1	32	37	PF02516	0.573
MOD_N-GLC_2	42	44	PF02516	0.650
MOD_NEK2_1	27	32	PF00069	0.587
MOD_NEK2_1	295	300	PF00069	0.583
MOD_PIKK_1	214	220	PF00454	0.551
MOD_PIKK_1	248	254	PF00454	0.688
MOD_PIKK_1	322	328	PF00454	0.679
MOD_PKA_1	142	148	PF00069	0.598
MOD_PKA_2	142	148	PF00069	0.530
MOD_PKA_2	17	23	PF00069	0.551
MOD_PKA_2	177	183	PF00069	0.580
MOD_PKA_2	248	254	PF00069	0.664
MOD_PKA_2	295	301	PF00069	0.661
MOD_PKA_2	340	346	PF00069	0.792
MOD_PKA_2	410	416	PF00069	0.637
MOD_PKA_2	42	48	PF00069	0.652
MOD_PKA_2	75	81	PF00069	0.542
MOD_PKA_2	82	88	PF00069	0.502
MOD_Plk_1	337	343	PF00069	0.682
MOD_Plk_2-3	421	427	PF00069	0.617
MOD_Plk_4	284	290	PF00069	0.612
MOD_Plk_4	65	71	PF00069	0.536
MOD_Plk_4	75	81	PF00069	0.504
MOD_ProDKin_1	224	230	PF00069	0.691
MOD_ProDKin_1	257	263	PF00069	0.719
MOD_ProDKin_1	348	354	PF00069	0.720
MOD_ProDKin_1	388	394	PF00069	0.630
MOD_ProDKin_1	395	401	PF00069	0.759
MOD_ProDKin_1	43	49	PF00069	0.440
MOD_ProDKin_1	69	75	PF00069	0.557
MOD_SUMO_rev_2	113	122	PF00179	0.595
MOD_SUMO_rev_2	170	177	PF00179	0.594
MOD_SUMO_rev_2	325	335	PF00179	0.675
TRG_ENDOCYTIC_2	77	80	PF00928	0.514
TRG_ER_diArg_1	207	210	PF00400	0.542
TRG_ER_diArg_1	295	297	PF00400	0.620
TRG_ER_diArg_1	415	417	PF00400	0.628
TRG_NLS_MonoCore_2	204	209	PF00514	0.655
TRG_NLS_MonoCore_2	346	351	PF00514	0.678
TRG_NLS_MonoExtC_3	204	209	PF00514	0.652
TRG_NLS_MonoExtC_3	347	352	PF00514	0.657
TRG_NLS_MonoExtN_4	203	210	PF00514	0.643
TRG_NLS_MonoExtN_4	347	352	PF00514	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS2	Leptomonas seymouri	38%	100%
A0A3S7X6S8	Leishmania donovani	87%	100%
A4I909	Leishmania infantum	87%	100%
E9AIV5	Leishmania braziliensis	66%	97%
Q4Q450	Leishmania major	85%	100%