Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3X3_LEIMU

TriTrypDb:

LmxM.32.1360

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.513
CLV_C14_Caspase3-7	51	55	PF00656	0.631
CLV_NRD_NRD_1	285	287	PF00675	0.440
CLV_PCSK_KEX2_1	219	221	PF00082	0.655
CLV_PCSK_KEX2_1	285	287	PF00082	0.440
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.618
CLV_PCSK_SKI1_1	251	255	PF00082	0.430
CLV_PCSK_SKI1_1	288	292	PF00082	0.420
CLV_PCSK_SKI1_1	340	344	PF00082	0.632
CLV_PCSK_SKI1_1	403	407	PF00082	0.514
CLV_PCSK_SKI1_1	419	423	PF00082	0.632
DEG_APCC_DBOX_1	248	256	PF00400	0.510
DEG_SCF_FBW7_1	394	400	PF00400	0.665
DEG_SPOP_SBC_1	228	232	PF00917	0.580
DEG_SPOP_SBC_1	79	83	PF00917	0.565
DOC_ANK_TNKS_1	350	357	PF00023	0.487
DOC_CKS1_1	304	309	PF01111	0.658
DOC_CKS1_1	394	399	PF01111	0.608
DOC_CYCLIN_RxL_1	246	259	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.550
DOC_MAPK_gen_1	246	255	PF00069	0.523
DOC_MAPK_gen_1	285	292	PF00069	0.460
DOC_PP2B_LxvP_1	107	110	PF13499	0.591
DOC_PP2B_LxvP_1	194	197	PF13499	0.508
DOC_PP4_FxxP_1	187	190	PF00568	0.490
DOC_USP7_MATH_1	110	114	PF00917	0.473
DOC_USP7_MATH_1	182	186	PF00917	0.583
DOC_USP7_MATH_1	201	205	PF00917	0.588
DOC_USP7_MATH_1	227	231	PF00917	0.634
DOC_USP7_MATH_1	299	303	PF00917	0.574
DOC_USP7_MATH_1	366	370	PF00917	0.627
DOC_USP7_MATH_1	395	399	PF00917	0.632
DOC_USP7_MATH_1	91	95	PF00917	0.566
DOC_WW_Pin1_4	153	158	PF00397	0.439
DOC_WW_Pin1_4	167	172	PF00397	0.482
DOC_WW_Pin1_4	220	225	PF00397	0.818
DOC_WW_Pin1_4	231	236	PF00397	0.491
DOC_WW_Pin1_4	303	308	PF00397	0.667
DOC_WW_Pin1_4	312	317	PF00397	0.671
DOC_WW_Pin1_4	341	346	PF00397	0.470
DOC_WW_Pin1_4	393	398	PF00397	0.608
DOC_WW_Pin1_4	94	99	PF00397	0.576
LIG_14-3-3_CanoR_1	131	138	PF00244	0.478
LIG_14-3-3_CanoR_1	24	30	PF00244	0.597
LIG_14-3-3_CanoR_1	415	421	PF00244	0.674
LIG_14-3-3_CanoR_1	445	451	PF00244	0.728
LIG_Actin_WH2_2	387	405	PF00022	0.495
LIG_Clathr_ClatBox_1	252	256	PF01394	0.435
LIG_FHA_1	242	248	PF00498	0.600
LIG_FHA_1	360	366	PF00498	0.706
LIG_FHA_1	378	384	PF00498	0.493
LIG_FHA_1	447	453	PF00498	0.578
LIG_FHA_1	81	87	PF00498	0.678
LIG_FHA_2	26	32	PF00498	0.605
LIG_FHA_2	49	55	PF00498	0.627
LIG_FHA_2	60	66	PF00498	0.502
LIG_LIR_Apic_2	185	190	PF02991	0.489
LIG_LIR_Apic_2	259	265	PF02991	0.463
LIG_LIR_Apic_2	398	404	PF02991	0.642
LIG_LIR_Gen_1	324	331	PF02991	0.485
LIG_LIR_Gen_1	68	77	PF02991	0.447
LIG_LIR_Nem_3	324	329	PF02991	0.485
LIG_LIR_Nem_3	65	70	PF02991	0.455
LIG_MYND_1	171	175	PF01753	0.451
LIG_SH2_CRK	326	330	PF00017	0.539
LIG_SH2_NCK_1	309	313	PF00017	0.620
LIG_SH2_PTP2	70	73	PF00017	0.427
LIG_SH2_STAP1	29	33	PF00017	0.599
LIG_SH2_STAP1	309	313	PF00017	0.628
LIG_SH2_STAP1	326	330	PF00017	0.440
LIG_SH2_STAT3	144	147	PF00017	0.582
LIG_SH2_STAT5	401	404	PF00017	0.672
LIG_SH2_STAT5	70	73	PF00017	0.427
LIG_SH3_3	122	128	PF00018	0.682
LIG_SH3_3	151	157	PF00018	0.513
LIG_SH3_3	17	23	PF00018	0.573
LIG_SH3_3	187	193	PF00018	0.679
LIG_SH3_3	287	293	PF00018	0.509
LIG_SH3_3	301	307	PF00018	0.514
LIG_SH3_3	313	319	PF00018	0.712
LIG_SH3_3	339	345	PF00018	0.475
LIG_SH3_3	383	389	PF00018	0.525
LIG_SH3_3	87	93	PF00018	0.670
LIG_SUMO_SIM_anti_2	434	441	PF11976	0.662
LIG_SUMO_SIM_par_1	251	256	PF11976	0.434
LIG_SUMO_SIM_par_1	390	396	PF11976	0.655
LIG_TRAF2_1	63	66	PF00917	0.564
LIG_TYR_ITSM	322	329	PF00017	0.514
MOD_CDC14_SPxK_1	234	237	PF00782	0.598
MOD_CDK_SPxK_1	231	237	PF00069	0.600
MOD_CDK_SPxxK_3	94	101	PF00069	0.613
MOD_CK1_1	113	119	PF00069	0.513
MOD_CK1_1	176	182	PF00069	0.617
MOD_CK1_1	204	210	PF00069	0.730
MOD_CK1_1	211	217	PF00069	0.597
MOD_CK1_1	231	237	PF00069	0.665
MOD_CK1_1	266	272	PF00069	0.403
MOD_CK1_1	300	306	PF00069	0.614
MOD_CK1_1	308	314	PF00069	0.601
MOD_CK1_1	315	321	PF00069	0.545
MOD_CK1_1	393	399	PF00069	0.618
MOD_CK1_1	432	438	PF00069	0.655
MOD_CK1_1	94	100	PF00069	0.646
MOD_CK2_1	153	159	PF00069	0.440
MOD_CK2_1	41	47	PF00069	0.603
MOD_CK2_1	59	65	PF00069	0.446
MOD_CK2_1	99	105	PF00069	0.537
MOD_GlcNHglycan	270	273	PF01048	0.457
MOD_GlcNHglycan	368	371	PF01048	0.601
MOD_GlcNHglycan	54	57	PF01048	0.619
MOD_GlcNHglycan	74	77	PF01048	0.433
MOD_GSK3_1	165	172	PF00069	0.447
MOD_GSK3_1	200	207	PF00069	0.746
MOD_GSK3_1	227	234	PF00069	0.751
MOD_GSK3_1	266	273	PF00069	0.435
MOD_GSK3_1	299	306	PF00069	0.597
MOD_GSK3_1	308	315	PF00069	0.611
MOD_GSK3_1	321	328	PF00069	0.457
MOD_GSK3_1	393	400	PF00069	0.612
MOD_GSK3_1	415	422	PF00069	0.586
MOD_GSK3_1	425	432	PF00069	0.619
MOD_GSK3_1	446	453	PF00069	0.493
MOD_GSK3_1	48	55	PF00069	0.595
MOD_GSK3_1	80	87	PF00069	0.636
MOD_N-GLC_1	300	305	PF02516	0.470
MOD_N-GLC_1	335	340	PF02516	0.555
MOD_N-GLC_2	333	335	PF02516	0.586
MOD_N-GLC_2	50	52	PF02516	0.499
MOD_NEK2_1	111	116	PF00069	0.627
MOD_NEK2_1	325	330	PF00069	0.557
MOD_NEK2_1	414	419	PF00069	0.644
MOD_NEK2_1	59	64	PF00069	0.446
MOD_NEK2_2	321	326	PF00069	0.526
MOD_PIKK_1	201	207	PF00454	0.644
MOD_PKA_2	13	19	PF00069	0.595
MOD_PKA_2	23	29	PF00069	0.593
MOD_PKA_2	366	372	PF00069	0.615
MOD_PKA_2	414	420	PF00069	0.646
MOD_Plk_1	182	188	PF00069	0.535
MOD_Plk_1	300	306	PF00069	0.527
MOD_Plk_2-3	99	105	PF00069	0.537
MOD_Plk_4	183	189	PF00069	0.629
MOD_Plk_4	300	306	PF00069	0.527
MOD_Plk_4	321	327	PF00069	0.524
MOD_Plk_4	397	403	PF00069	0.649
MOD_Plk_4	432	438	PF00069	0.611
MOD_Plk_4	446	452	PF00069	0.558
MOD_Plk_4	91	97	PF00069	0.638
MOD_ProDKin_1	153	159	PF00069	0.440
MOD_ProDKin_1	167	173	PF00069	0.490
MOD_ProDKin_1	220	226	PF00069	0.818
MOD_ProDKin_1	231	237	PF00069	0.492
MOD_ProDKin_1	303	309	PF00069	0.670
MOD_ProDKin_1	312	318	PF00069	0.665
MOD_ProDKin_1	341	347	PF00069	0.469
MOD_ProDKin_1	393	399	PF00069	0.608
MOD_ProDKin_1	94	100	PF00069	0.566
TRG_DiLeu_BaEn_2	158	164	PF01217	0.426
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.448
TRG_ENDOCYTIC_2	326	329	PF00928	0.543
TRG_ENDOCYTIC_2	70	73	PF00928	0.427
TRG_ER_diArg_1	249	252	PF00400	0.517
TRG_ER_diArg_1	285	288	PF00400	0.453
TRG_NLS_MonoExtN_4	216	223	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L8	Leptomonas seymouri	38%	81%
A0A3S7X6N2	Leishmania donovani	85%	100%
A4HLJ8	Leishmania braziliensis	70%	100%
A4I908	Leishmania infantum	85%	100%
Q4Q451	Leishmania major	85%	100%