Expression-site associated gene (ESAG3),putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3), putative

Species:

Leishmania mexicana

UniProt:

E9B3W7_LEIMU

TriTrypDb:

LmxM.32.1310

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B3W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.593
CLV_NRD_NRD_1	155	157	PF00675	0.567
CLV_NRD_NRD_1	199	201	PF00675	0.604
CLV_NRD_NRD_1	237	239	PF00675	0.492
CLV_NRD_NRD_1	400	402	PF00675	0.543
CLV_NRD_NRD_1	501	503	PF00675	0.609
CLV_NRD_NRD_1	629	631	PF00675	0.610
CLV_NRD_NRD_1	76	78	PF00675	0.735
CLV_NRD_NRD_1	98	100	PF00675	0.591
CLV_PCSK_FUR_1	131	135	PF00082	0.564
CLV_PCSK_FUR_1	153	157	PF00082	0.575
CLV_PCSK_KEX2_1	133	135	PF00082	0.593
CLV_PCSK_KEX2_1	155	157	PF00082	0.563
CLV_PCSK_KEX2_1	199	201	PF00082	0.592
CLV_PCSK_KEX2_1	286	288	PF00082	0.603
CLV_PCSK_KEX2_1	29	31	PF00082	0.463
CLV_PCSK_KEX2_1	386	388	PF00082	0.606
CLV_PCSK_KEX2_1	501	503	PF00082	0.609
CLV_PCSK_KEX2_1	610	612	PF00082	0.715
CLV_PCSK_KEX2_1	629	631	PF00082	0.575
CLV_PCSK_KEX2_1	76	78	PF00082	0.751
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.608
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.487
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.606
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.717
CLV_PCSK_SKI1_1	287	291	PF00082	0.581
CLV_PCSK_SKI1_1	358	362	PF00082	0.635
CLV_PCSK_SKI1_1	42	46	PF00082	0.467
CLV_PCSK_SKI1_1	574	578	PF00082	0.670
CLV_PCSK_SKI1_1	610	614	PF00082	0.592
DEG_APCC_DBOX_1	41	49	PF00400	0.687
DEG_APCC_DBOX_1	461	469	PF00400	0.358
DOC_ANK_TNKS_1	489	496	PF00023	0.379
DOC_CKS1_1	480	485	PF01111	0.386
DOC_CKS1_1	566	571	PF01111	0.434
DOC_CYCLIN_RxL_1	197	211	PF00134	0.350
DOC_CYCLIN_RxL_1	284	293	PF00134	0.275
DOC_MAPK_gen_1	153	161	PF00069	0.350
DOC_MAPK_gen_1	199	207	PF00069	0.349
DOC_MAPK_gen_1	401	409	PF00069	0.333
DOC_MAPK_gen_1	501	508	PF00069	0.396
DOC_MAPK_gen_1	99	105	PF00069	0.310
DOC_MAPK_MEF2A_6	401	409	PF00069	0.437
DOC_MAPK_MEF2A_6	52	61	PF00069	0.471
DOC_MAPK_MEF2A_6	591	600	PF00069	0.311
DOC_MAPK_MEF2A_6	641	648	PF00069	0.361
DOC_MAPK_RevD_3	61	77	PF00069	0.328
DOC_PP1_RVXF_1	156	162	PF00149	0.378
DOC_PP1_RVXF_1	201	208	PF00149	0.343
DOC_PP2B_LxvP_1	87	90	PF13499	0.463
DOC_PP4_FxxP_1	104	107	PF00568	0.353
DOC_PP4_FxxP_1	184	187	PF00568	0.340
DOC_SPAK_OSR1_1	160	164	PF12202	0.274
DOC_USP7_MATH_1	109	113	PF00917	0.494
DOC_USP7_MATH_1	175	179	PF00917	0.287
DOC_USP7_MATH_1	20	24	PF00917	0.621
DOC_USP7_MATH_1	385	389	PF00917	0.440
DOC_USP7_MATH_1	604	608	PF00917	0.453
DOC_USP7_MATH_1	631	635	PF00917	0.443
DOC_USP7_MATH_1	90	94	PF00917	0.448
DOC_WW_Pin1_4	241	246	PF00397	0.381
DOC_WW_Pin1_4	290	295	PF00397	0.248
DOC_WW_Pin1_4	36	41	PF00397	0.611
DOC_WW_Pin1_4	376	381	PF00397	0.444
DOC_WW_Pin1_4	433	438	PF00397	0.408
DOC_WW_Pin1_4	479	484	PF00397	0.441
DOC_WW_Pin1_4	565	570	PF00397	0.431
LIG_14-3-3_CanoR_1	133	139	PF00244	0.335
LIG_14-3-3_CanoR_1	501	508	PF00244	0.399
LIG_14-3-3_CanoR_1	52	58	PF00244	0.532
LIG_14-3-3_CanoR_1	611	619	PF00244	0.399
LIG_14-3-3_CanoR_1	99	107	PF00244	0.359
LIG_BRCT_BRCA1_1	100	104	PF00533	0.341
LIG_BRCT_BRCA1_1	223	227	PF00533	0.318
LIG_BRCT_BRCA1_1	30	34	PF00533	0.624
LIG_BRCT_BRCA1_1	308	312	PF00533	0.380
LIG_BRCT_BRCA1_1	581	585	PF00533	0.520
LIG_Clathr_ClatBox_1	496	500	PF01394	0.404
LIG_CSL_BTD_1	32	35	PF09270	0.681
LIG_CtBP_PxDLS_1	477	481	PF00389	0.365
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.364
LIG_deltaCOP1_diTrp_1	645	654	PF00928	0.366
LIG_eIF4E_1	491	497	PF01652	0.373
LIG_FHA_1	121	127	PF00498	0.477
LIG_FHA_1	297	303	PF00498	0.289
LIG_FHA_1	36	42	PF00498	0.611
LIG_FHA_1	395	401	PF00498	0.441
LIG_FHA_1	404	410	PF00498	0.404
LIG_FHA_1	480	486	PF00498	0.443
LIG_FHA_1	539	545	PF00498	0.436
LIG_FHA_1	56	62	PF00498	0.396
LIG_FHA_1	566	572	PF00498	0.442
LIG_FHA_1	634	640	PF00498	0.398
LIG_FHA_1	68	74	PF00498	0.405
LIG_FHA_2	117	123	PF00498	0.436
LIG_FHA_2	227	233	PF00498	0.387
LIG_FHA_2	575	581	PF00498	0.489
LIG_LIR_Apic_2	101	107	PF02991	0.330
LIG_LIR_Apic_2	488	494	PF02991	0.423
LIG_LIR_Gen_1	193	201	PF02991	0.412
LIG_LIR_Gen_1	202	208	PF02991	0.390
LIG_LIR_Gen_1	343	352	PF02991	0.320
LIG_LIR_Gen_1	5	11	PF02991	0.669
LIG_LIR_Gen_1	651	660	PF02991	0.383
LIG_LIR_Nem_3	193	198	PF02991	0.420
LIG_LIR_Nem_3	202	207	PF02991	0.394
LIG_LIR_Nem_3	232	236	PF02991	0.330
LIG_LIR_Nem_3	343	347	PF02991	0.432
LIG_LIR_Nem_3	5	10	PF02991	0.668
LIG_LIR_Nem_3	651	657	PF02991	0.357
LIG_PCNA_yPIPBox_3	358	372	PF02747	0.334
LIG_PCNA_yPIPBox_3	453	464	PF02747	0.301
LIG_Pex14_1	74	78	PF04695	0.437
LIG_Pex14_2	236	240	PF04695	0.458
LIG_SH2_CRK	344	348	PF00017	0.392
LIG_SH2_CRK	491	495	PF00017	0.376
LIG_SH2_CRK	603	607	PF00017	0.407
LIG_SH2_CRK	78	82	PF00017	0.443
LIG_SH2_NCK_1	603	607	PF00017	0.400
LIG_SH2_SRC	145	148	PF00017	0.334
LIG_SH2_STAP1	487	491	PF00017	0.408
LIG_SH2_STAP1	619	623	PF00017	0.377
LIG_SH2_STAP1	78	82	PF00017	0.370
LIG_SH2_STAT3	381	384	PF00017	0.426
LIG_SH2_STAT5	145	148	PF00017	0.412
LIG_SH2_STAT5	204	207	PF00017	0.386
LIG_SH2_STAT5	431	434	PF00017	0.398
LIG_SH2_STAT5	460	463	PF00017	0.349
LIG_SH2_STAT5	524	527	PF00017	0.446
LIG_SH3_3	282	288	PF00018	0.447
LIG_SH3_3	310	316	PF00018	0.370
LIG_SH3_3	504	510	PF00018	0.384
LIG_SH3_3	564	570	PF00018	0.402
LIG_SH3_3	593	599	PF00018	0.414
LIG_SUMO_SIM_anti_2	62	71	PF11976	0.251
LIG_SUMO_SIM_par_1	215	225	PF11976	0.368
LIG_SUMO_SIM_par_1	56	62	PF11976	0.389
LIG_SUMO_SIM_par_1	63	71	PF11976	0.402
MOD_CDC14_SPxK_1	244	247	PF00782	0.274
MOD_CDC14_SPxK_1	39	42	PF00782	0.603
MOD_CDK_SPxK_1	241	247	PF00069	0.271
MOD_CDK_SPxK_1	36	42	PF00069	0.611
MOD_CK1_1	193	199	PF00069	0.372
MOD_CK1_1	403	409	PF00069	0.435
MOD_CK1_1	479	485	PF00069	0.438
MOD_CK1_1	6	12	PF00069	0.675
MOD_CK2_1	116	122	PF00069	0.511
MOD_CMANNOS	535	538	PF00535	0.636
MOD_Cter_Amidation	27	30	PF01082	0.485
MOD_GlcNHglycan	100	103	PF01048	0.551
MOD_GlcNHglycan	13	16	PF01048	0.462
MOD_GlcNHglycan	177	180	PF01048	0.562
MOD_GlcNHglycan	25	29	PF01048	0.452
MOD_GlcNHglycan	30	33	PF01048	0.441
MOD_GlcNHglycan	574	577	PF01048	0.674
MOD_GSK3_1	11	18	PF00069	0.676
MOD_GSK3_1	116	123	PF00069	0.549
MOD_GSK3_1	171	178	PF00069	0.334
MOD_GSK3_1	182	189	PF00069	0.278
MOD_GSK3_1	2	9	PF00069	0.657
MOD_GSK3_1	20	27	PF00069	0.632
MOD_GSK3_1	336	343	PF00069	0.339
MOD_GSK3_1	376	383	PF00069	0.441
MOD_GSK3_1	427	434	PF00069	0.379
MOD_GSK3_1	51	58	PF00069	0.481
MOD_GSK3_1	662	669	PF00069	0.431
MOD_N-GLC_1	191	196	PF02516	0.546
MOD_N-GLC_1	395	400	PF02516	0.625
MOD_N-GLC_1	538	543	PF02516	0.639
MOD_N-GLC_1	655	660	PF02516	0.648
MOD_NEK2_1	11	16	PF00069	0.744
MOD_NEK2_1	191	196	PF00069	0.373
MOD_NEK2_1	336	341	PF00069	0.344
MOD_NEK2_1	356	361	PF00069	0.353
MOD_NEK2_1	394	399	PF00069	0.516
MOD_NEK2_1	413	418	PF00069	0.350
MOD_NEK2_1	424	429	PF00069	0.388
MOD_NEK2_1	558	563	PF00069	0.429
MOD_NEK2_1	572	577	PF00069	0.499
MOD_PIKK_1	20	26	PF00454	0.643
MOD_PIKK_1	380	386	PF00454	0.427
MOD_PIKK_1	444	450	PF00454	0.413
MOD_PIKK_1	500	506	PF00454	0.351
MOD_PKA_1	610	616	PF00069	0.370
MOD_PKA_2	109	115	PF00069	0.346
MOD_PKA_2	11	17	PF00069	0.748
MOD_PKA_2	154	160	PF00069	0.350
MOD_PKA_2	400	406	PF00069	0.366
MOD_PKA_2	500	506	PF00069	0.403
MOD_PKA_2	51	57	PF00069	0.470
MOD_PKA_2	610	616	PF00069	0.395
MOD_PKA_2	631	637	PF00069	0.427
MOD_PKA_2	98	104	PF00069	0.346
MOD_Plk_1	191	197	PF00069	0.405
MOD_Plk_1	395	401	PF00069	0.426
MOD_Plk_1	655	661	PF00069	0.400
MOD_Plk_2-3	246	252	PF00069	0.385
MOD_Plk_4	308	314	PF00069	0.284
MOD_Plk_4	395	401	PF00069	0.460
MOD_Plk_4	403	409	PF00069	0.420
MOD_Plk_4	427	433	PF00069	0.339
MOD_Plk_4	59	65	PF00069	0.487
MOD_Plk_4	6	12	PF00069	0.686
MOD_Plk_4	662	668	PF00069	0.445
MOD_ProDKin_1	241	247	PF00069	0.387
MOD_ProDKin_1	290	296	PF00069	0.247
MOD_ProDKin_1	36	42	PF00069	0.611
MOD_ProDKin_1	376	382	PF00069	0.447
MOD_ProDKin_1	433	439	PF00069	0.416
MOD_ProDKin_1	479	485	PF00069	0.438
MOD_ProDKin_1	565	571	PF00069	0.435
MOD_SUMO_rev_2	165	172	PF00179	0.260
MOD_SUMO_rev_2	260	268	PF00179	0.375
TRG_DiLeu_BaEn_1	662	667	PF01217	0.331
TRG_DiLeu_BaEn_2	649	655	PF01217	0.370
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.404
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.412
TRG_ENDOCYTIC_2	195	198	PF00928	0.411
TRG_ENDOCYTIC_2	204	207	PF00928	0.386
TRG_ENDOCYTIC_2	344	347	PF00928	0.408
TRG_ENDOCYTIC_2	619	622	PF00928	0.387
TRG_ENDOCYTIC_2	78	81	PF00928	0.512
TRG_ER_diArg_1	131	134	PF00400	0.368
TRG_ER_diArg_1	155	158	PF00400	0.314
TRG_ER_diArg_1	198	200	PF00400	0.398
TRG_ER_diArg_1	461	464	PF00400	0.350
TRG_ER_diArg_1	629	632	PF00400	0.363
TRG_ER_diArg_1	75	77	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	61%	100%
A0A3Q8ID98	Leishmania donovani	33%	100%
A0A3Q8IM92	Leishmania donovani	91%	100%
A4H7X2	Leishmania braziliensis	32%	100%
A4HLI8	Leishmania braziliensis	79%	100%
A4HLJ0	Leishmania braziliensis	76%	100%
A4HLJ2	Leishmania braziliensis	80%	100%
A4HW99	Leishmania infantum	33%	100%
A4I8Z8	Leishmania infantum	91%	100%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q457	Leishmania major	88%	100%
Q4QFI2	Leishmania major	31%	100%