Pre-mRNA-splicing factor CWC15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3W6_LEIMU

TriTrypDb:

LmxM.32.1305

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3W6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.347
CLV_NRD_NRD_1	188	190	PF00675	0.433
CLV_NRD_NRD_1	19	21	PF00675	0.536
CLV_PCSK_FUR_1	113	117	PF00082	0.335
CLV_PCSK_KEX2_1	115	117	PF00082	0.376
CLV_PCSK_KEX2_1	17	19	PF00082	0.534
CLV_PCSK_KEX2_1	186	188	PF00082	0.631
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.534
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.571
CLV_PCSK_SKI1_1	105	109	PF00082	0.416
CLV_PCSK_SKI1_1	209	213	PF00082	0.561
DEG_SPOP_SBC_1	142	146	PF00917	0.414
DEG_SPOP_SBC_1	80	84	PF00917	0.335
DOC_PP4_FxxP_1	169	172	PF00568	0.171
DOC_USP7_MATH_1	132	136	PF00917	0.301
DOC_USP7_MATH_1	148	152	PF00917	0.348
DOC_USP7_MATH_1	66	70	PF00917	0.343
DOC_USP7_MATH_1	80	84	PF00917	0.338
DOC_USP7_UBL2_3	186	190	PF12436	0.574
DOC_USP7_UBL2_3	209	213	PF12436	0.397
DOC_USP7_UBL2_3	72	76	PF12436	0.335
DOC_WW_Pin1_4	144	149	PF00397	0.480
LIG_14-3-3_CanoR_1	58	62	PF00244	0.177
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	200	204	PF00533	0.508
LIG_eIF4E_1	163	169	PF01652	0.289
LIG_FHA_2	180	186	PF00498	0.566
LIG_LIR_Apic_2	166	172	PF02991	0.171
LIG_LIR_Nem_3	201	207	PF02991	0.440
LIG_Pex14_2	207	211	PF04695	0.517
LIG_REV1ctd_RIR_1	209	213	PF16727	0.530
LIG_SH2_STAP1	163	167	PF00017	0.404
LIG_SH3_3	60	66	PF00018	0.171
MOD_CK1_1	127	133	PF00069	0.317
MOD_CK1_1	146	152	PF00069	0.301
MOD_CK1_1	178	184	PF00069	0.506
MOD_CK1_1	68	74	PF00069	0.216
MOD_CK1_1	82	88	PF00069	0.370
MOD_CK2_1	179	185	PF00069	0.593
MOD_GlcNHglycan	1	4	PF01048	0.674
MOD_GlcNHglycan	127	130	PF01048	0.272
MOD_GlcNHglycan	134	137	PF01048	0.297
MOD_GlcNHglycan	148	151	PF01048	0.348
MOD_GlcNHglycan	62	66	PF01048	0.404
MOD_GlcNHglycan	68	71	PF01048	0.403
MOD_GlcNHglycan	73	76	PF01048	0.336
MOD_GSK3_1	120	127	PF00069	0.268
MOD_GSK3_1	128	135	PF00069	0.301
MOD_GSK3_1	142	149	PF00069	0.243
MOD_GSK3_1	175	182	PF00069	0.645
MOD_GSK3_1	20	27	PF00069	0.628
MOD_GSK3_1	53	60	PF00069	0.406
MOD_GSK3_1	61	68	PF00069	0.344
MOD_GSK3_1	79	86	PF00069	0.258
MOD_N-GLC_1	195	200	PF02516	0.489
MOD_PIKK_1	195	201	PF00454	0.516
MOD_PIKK_1	20	26	PF00454	0.610
MOD_PK_1	190	196	PF00069	0.548
MOD_PKA_2	57	63	PF00069	0.207
MOD_PKA_2	80	86	PF00069	0.420
MOD_PKB_1	18	26	PF00069	0.673
MOD_Plk_4	190	196	PF00069	0.690
MOD_ProDKin_1	144	150	PF00069	0.480
TRG_ER_diArg_1	113	116	PF00400	0.349
TRG_ER_diArg_1	18	20	PF00400	0.540
TRG_NLS_MonoCore_2	16	21	PF00514	0.537
TRG_NLS_MonoExtC_3	16	22	PF00514	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U6	Leptomonas seymouri	44%	100%
A0A1X0P239	Trypanosomatidae	28%	100%
A0A3R7RIF0	Trypanosoma rangeli	28%	100%
A0A3S7X6R7	Leishmania donovani	84%	99%
A4HLI7	Leishmania braziliensis	77%	100%
A4I8Z7	Leishmania infantum	85%	100%
D0A4Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q458	Leishmania major	83%	100%
V5BLV0	Trypanosoma cruzi	29%	100%