Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 family protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3W5_LEIMU

TriTrypDb:

LmxM.32.1300

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4
GO:0005576	extracellular region	2	2

Expansion

Sequence features

E9B3W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3W5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	479	483	PF00656	0.309
CLV_C14_Caspase3-7	553	557	PF00656	0.273
CLV_NRD_NRD_1	125	127	PF00675	0.503
CLV_NRD_NRD_1	14	16	PF00675	0.210
CLV_NRD_NRD_1	180	182	PF00675	0.462
CLV_NRD_NRD_1	214	216	PF00675	0.469
CLV_NRD_NRD_1	373	375	PF00675	0.461
CLV_NRD_NRD_1	431	433	PF00675	0.643
CLV_NRD_NRD_1	594	596	PF00675	0.416
CLV_NRD_NRD_1	605	607	PF00675	0.394
CLV_NRD_NRD_1	9	11	PF00675	0.298
CLV_PCSK_KEX2_1	14	16	PF00082	0.184
CLV_PCSK_KEX2_1	236	238	PF00082	0.463
CLV_PCSK_KEX2_1	286	288	PF00082	0.456
CLV_PCSK_KEX2_1	373	375	PF00082	0.424
CLV_PCSK_KEX2_1	431	433	PF00082	0.595
CLV_PCSK_KEX2_1	486	488	PF00082	0.588
CLV_PCSK_KEX2_1	605	607	PF00082	0.382
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.474
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.456
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.588
CLV_PCSK_PC7_1	10	16	PF00082	0.293
CLV_PCSK_SKI1_1	111	115	PF00082	0.428
CLV_PCSK_SKI1_1	204	208	PF00082	0.451
CLV_PCSK_SKI1_1	239	243	PF00082	0.484
CLV_PCSK_SKI1_1	260	264	PF00082	0.466
CLV_PCSK_SKI1_1	286	290	PF00082	0.442
CLV_PCSK_SKI1_1	424	428	PF00082	0.578
CLV_PCSK_SKI1_1	43	47	PF00082	0.470
CLV_PCSK_SKI1_1	560	564	PF00082	0.602
CLV_PCSK_SKI1_1	75	79	PF00082	0.614
CLV_Separin_Metazoa	425	429	PF03568	0.425
DEG_APCC_DBOX_1	494	502	PF00400	0.371
DEG_SPOP_SBC_1	323	327	PF00917	0.271
DOC_CKS1_1	345	350	PF01111	0.248
DOC_CKS1_1	57	62	PF01111	0.386
DOC_CYCLIN_RxL_1	108	115	PF00134	0.304
DOC_CYCLIN_RxL_1	201	211	PF00134	0.317
DOC_CYCLIN_RxL_1	254	266	PF00134	0.238
DOC_CYCLIN_RxL_1	557	566	PF00134	0.440
DOC_MAPK_gen_1	352	361	PF00069	0.208
DOC_MAPK_gen_1	40	48	PF00069	0.327
DOC_MAPK_gen_1	431	440	PF00069	0.370
DOC_MAPK_MEF2A_6	135	144	PF00069	0.273
DOC_MAPK_MEF2A_6	243	250	PF00069	0.320
DOC_MAPK_MEF2A_6	83	91	PF00069	0.292
DOC_PP1_RVXF_1	202	208	PF00149	0.245
DOC_PP1_RVXF_1	348	354	PF00149	0.310
DOC_PP2B_LxvP_1	162	165	PF13499	0.310
DOC_PP2B_LxvP_1	248	251	PF13499	0.256
DOC_PP4_FxxP_1	207	210	PF00568	0.207
DOC_PP4_FxxP_1	540	543	PF00568	0.280
DOC_PP4_FxxP_1	57	60	PF00568	0.395
DOC_USP7_MATH_1	148	152	PF00917	0.207
DOC_USP7_MATH_1	166	170	PF00917	0.288
DOC_USP7_MATH_1	256	260	PF00917	0.256
DOC_USP7_MATH_1	330	334	PF00917	0.224
DOC_USP7_MATH_1	502	506	PF00917	0.281
DOC_USP7_MATH_2	63	69	PF00917	0.329
DOC_USP7_UBL2_3	486	490	PF12436	0.393
DOC_USP7_UBL2_3	7	11	PF12436	0.523
DOC_WW_Pin1_4	144	149	PF00397	0.365
DOC_WW_Pin1_4	344	349	PF00397	0.350
DOC_WW_Pin1_4	453	458	PF00397	0.363
DOC_WW_Pin1_4	56	61	PF00397	0.325
LIG_14-3-3_CanoR_1	215	219	PF00244	0.298
LIG_14-3-3_CanoR_1	287	293	PF00244	0.256
LIG_14-3-3_CanoR_1	331	340	PF00244	0.135
LIG_14-3-3_CanoR_1	40	46	PF00244	0.288
LIG_14-3-3_CanoR_1	495	503	PF00244	0.288
LIG_14-3-3_CanoR_1	598	603	PF00244	0.710
LIG_Actin_WH2_2	357	375	PF00022	0.310
LIG_Actin_WH2_2	433	450	PF00022	0.317
LIG_Actin_WH2_2	582	600	PF00022	0.601
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_4	294	298	PF00653	0.250
LIG_BRCT_BRCA1_1	565	569	PF00533	0.354
LIG_Clathr_ClatBox_1	262	266	PF01394	0.213
LIG_CSL_BTD_1	160	163	PF09270	0.310
LIG_CtBP_PxDLS_1	63	67	PF00389	0.426
LIG_eIF4E_1	257	263	PF01652	0.274
LIG_eIF4E_1	355	361	PF01652	0.310
LIG_eIF4E_1	579	585	PF01652	0.299
LIG_FHA_1	105	111	PF00498	0.316
LIG_FHA_1	18	24	PF00498	0.253
LIG_FHA_1	185	191	PF00498	0.308
LIG_FHA_1	37	43	PF00498	0.279
LIG_FHA_2	131	137	PF00498	0.262
LIG_FHA_2	215	221	PF00498	0.238
LIG_FHA_2	289	295	PF00498	0.243
LIG_FHA_2	406	412	PF00498	0.321
LIG_FHA_2	517	523	PF00498	0.414
LIG_FHA_2	551	557	PF00498	0.272
LIG_FHA_2	60	66	PF00498	0.323
LIG_LIR_Apic_2	54	60	PF02991	0.270
LIG_LIR_Gen_1	105	114	PF02991	0.181
LIG_LIR_Gen_1	138	149	PF02991	0.220
LIG_LIR_Gen_1	290	301	PF02991	0.241
LIG_LIR_Gen_1	333	343	PF02991	0.314
LIG_LIR_Gen_1	385	395	PF02991	0.271
LIG_LIR_Gen_1	403	412	PF02991	0.311
LIG_LIR_Gen_1	508	517	PF02991	0.366
LIG_LIR_Gen_1	549	559	PF02991	0.427
LIG_LIR_Gen_1	578	589	PF02991	0.308
LIG_LIR_Gen_1	85	95	PF02991	0.256
LIG_LIR_Nem_3	105	109	PF02991	0.176
LIG_LIR_Nem_3	138	144	PF02991	0.245
LIG_LIR_Nem_3	189	194	PF02991	0.212
LIG_LIR_Nem_3	290	296	PF02991	0.241
LIG_LIR_Nem_3	333	339	PF02991	0.314
LIG_LIR_Nem_3	385	390	PF02991	0.278
LIG_LIR_Nem_3	403	407	PF02991	0.302
LIG_LIR_Nem_3	504	509	PF02991	0.428
LIG_LIR_Nem_3	549	555	PF02991	0.391
LIG_LIR_Nem_3	556	562	PF02991	0.317
LIG_LIR_Nem_3	578	584	PF02991	0.308
LIG_LIR_Nem_3	85	91	PF02991	0.278
LIG_MAD2	111	119	PF02301	0.310
LIG_NRBOX	109	115	PF00104	0.278
LIG_NRBOX	201	207	PF00104	0.310
LIG_NRBOX	41	47	PF00104	0.275
LIG_NRBOX	563	569	PF00104	0.300
LIG_PCNA_yPIPBox_3	260	268	PF02747	0.254
LIG_Pex14_2	238	242	PF04695	0.310
LIG_Pex14_2	301	305	PF04695	0.218
LIG_Pex14_2	361	365	PF04695	0.274
LIG_Rb_pABgroove_1	201	209	PF01858	0.310
LIG_Rb_pABgroove_1	287	295	PF01858	0.274
LIG_SH2_CRK	196	200	PF00017	0.218
LIG_SH2_CRK	336	340	PF00017	0.310
LIG_SH2_CRK	357	361	PF00017	0.207
LIG_SH2_CRK	454	458	PF00017	0.257
LIG_SH2_CRK	559	563	PF00017	0.349
LIG_SH2_CRK	581	585	PF00017	0.274
LIG_SH2_NCK_1	404	408	PF00017	0.348
LIG_SH2_NCK_1	478	482	PF00017	0.262
LIG_SH2_NCK_1	509	513	PF00017	0.348
LIG_SH2_PTP2	88	91	PF00017	0.275
LIG_SH2_SRC	355	358	PF00017	0.310
LIG_SH2_SRC	404	407	PF00017	0.347
LIG_SH2_STAP1	106	110	PF00017	0.363
LIG_SH2_STAP1	196	200	PF00017	0.292
LIG_SH2_STAP1	357	361	PF00017	0.207
LIG_SH2_STAP1	509	513	PF00017	0.348
LIG_SH2_STAT3	610	613	PF00017	0.510
LIG_SH2_STAT5	106	109	PF00017	0.265
LIG_SH2_STAT5	249	252	PF00017	0.218
LIG_SH2_STAT5	257	260	PF00017	0.218
LIG_SH2_STAT5	27	30	PF00017	0.275
LIG_SH2_STAT5	484	487	PF00017	0.268
LIG_SH2_STAT5	552	555	PF00017	0.275
LIG_SH2_STAT5	579	582	PF00017	0.387
LIG_SH2_STAT5	88	91	PF00017	0.250
LIG_SH3_3	115	121	PF00018	0.218
LIG_SH3_3	177	183	PF00018	0.218
LIG_SH3_3	57	63	PF00018	0.385
LIG_Sin3_3	622	629	PF02671	0.498
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.254
LIG_SUMO_SIM_par_1	261	266	PF11976	0.220
LIG_SUMO_SIM_par_1	337	342	PF11976	0.207
LIG_TRAF2_1	505	508	PF00917	0.293
LIG_TRAF2_1	62	65	PF00917	0.328
LIG_UBA3_1	199	204	PF00899	0.285
LIG_UBA3_1	360	369	PF00899	0.322
LIG_UBA3_1	386	394	PF00899	0.311
LIG_UBA3_1	426	435	PF00899	0.351
MOD_CDK_SPK_2	56	61	PF00069	0.294
MOD_CDK_SPxK_1	344	350	PF00069	0.248
MOD_CDK_SPxxK_3	453	460	PF00069	0.363
MOD_CK1_1	186	192	PF00069	0.310
MOD_CK1_1	214	220	PF00069	0.310
MOD_CK1_1	363	369	PF00069	0.274
MOD_CK1_1	41	47	PF00069	0.301
MOD_CK1_1	516	522	PF00069	0.433
MOD_CK1_1	68	74	PF00069	0.287
MOD_CK2_1	130	136	PF00069	0.254
MOD_CK2_1	166	172	PF00069	0.312
MOD_CK2_1	400	406	PF00069	0.334
MOD_CK2_1	464	470	PF00069	0.333
MOD_CK2_1	502	508	PF00069	0.292
MOD_CK2_1	516	522	PF00069	0.400
MOD_CK2_1	59	65	PF00069	0.327
MOD_Cter_Amidation	12	15	PF01082	0.264
MOD_GlcNHglycan	150	153	PF01048	0.407
MOD_GlcNHglycan	169	172	PF01048	0.407
MOD_GlcNHglycan	466	469	PF01048	0.505
MOD_GlcNHglycan	514	518	PF01048	0.598
MOD_GSK3_1	144	151	PF00069	0.348
MOD_GSK3_1	194	201	PF00069	0.306
MOD_GSK3_1	226	233	PF00069	0.256
MOD_GSK3_1	321	328	PF00069	0.215
MOD_GSK3_1	34	41	PF00069	0.296
MOD_GSK3_1	51	58	PF00069	0.249
MOD_GSK3_1	546	553	PF00069	0.437
MOD_GSK3_1	64	71	PF00069	0.304
MOD_N-GLC_1	331	336	PF02516	0.335
MOD_NEK2_1	17	22	PF00069	0.284
MOD_NEK2_1	195	200	PF00069	0.271
MOD_NEK2_1	230	235	PF00069	0.351
MOD_NEK2_1	3	8	PF00069	0.603
MOD_NEK2_1	360	365	PF00069	0.236
MOD_NEK2_1	38	43	PF00069	0.306
MOD_NEK2_1	386	391	PF00069	0.294
MOD_NEK2_1	464	469	PF00069	0.345
MOD_NEK2_1	563	568	PF00069	0.424
MOD_PIKK_1	184	190	PF00454	0.256
MOD_PIKK_1	541	547	PF00454	0.373
MOD_PKA_2	214	220	PF00069	0.247
MOD_PKA_2	330	336	PF00069	0.309
MOD_Plk_1	226	232	PF00069	0.250
MOD_Plk_1	34	40	PF00069	0.320
MOD_Plk_1	64	70	PF00069	0.406
MOD_Plk_2-3	508	514	PF00069	0.359
MOD_Plk_2-3	550	556	PF00069	0.277
MOD_Plk_4	186	192	PF00069	0.285
MOD_Plk_4	195	201	PF00069	0.232
MOD_Plk_4	288	294	PF00069	0.214
MOD_Plk_4	360	366	PF00069	0.221
MOD_Plk_4	508	514	PF00069	0.321
MOD_Plk_4	550	556	PF00069	0.402
MOD_Plk_4	563	569	PF00069	0.239
MOD_Plk_4	580	586	PF00069	0.211
MOD_ProDKin_1	144	150	PF00069	0.365
MOD_ProDKin_1	344	350	PF00069	0.350
MOD_ProDKin_1	453	459	PF00069	0.364
MOD_ProDKin_1	56	62	PF00069	0.325
MOD_SUMO_for_1	82	85	PF00179	0.292
MOD_SUMO_rev_2	278	288	PF00179	0.275
TRG_ENDOCYTIC_2	106	109	PF00928	0.265
TRG_ENDOCYTIC_2	196	199	PF00928	0.222
TRG_ENDOCYTIC_2	336	339	PF00928	0.310
TRG_ENDOCYTIC_2	357	360	PF00928	0.207
TRG_ENDOCYTIC_2	404	407	PF00928	0.340
TRG_ENDOCYTIC_2	478	481	PF00928	0.294
TRG_ENDOCYTIC_2	509	512	PF00928	0.405
TRG_ENDOCYTIC_2	552	555	PF00928	0.373
TRG_ENDOCYTIC_2	559	562	PF00928	0.313
TRG_ENDOCYTIC_2	581	584	PF00928	0.268
TRG_ENDOCYTIC_2	88	91	PF00928	0.250
TRG_ER_diArg_1	350	353	PF00400	0.310
TRG_ER_diArg_1	372	374	PF00400	0.224
TRG_ER_diArg_1	430	432	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML7	Leptomonas seymouri	29%	100%
A0A0N1PA82	Leptomonas seymouri	67%	100%
A0A0S4KEI7	Bodo saltans	28%	100%
A0A0S4KLC8	Bodo saltans	41%	100%
A0A179HKZ8	Purpureocillium lilacinum	30%	100%
A0A1X0P192	Trypanosomatidae	46%	99%
A0A3R7KBH2	Trypanosoma rangeli	44%	97%
A0A3R7KJM1	Trypanosoma rangeli	32%	100%
A0A3S5H636	Leishmania donovani	30%	100%
A0A3S5H7U4	Leishmania donovani	91%	96%
A4H590	Leishmania braziliensis	30%	100%
A4HLI6	Leishmania braziliensis	82%	100%
A4HTH4	Leishmania infantum	30%	100%
A4I8Z6	Leishmania infantum	90%	96%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9AMA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q46189	Clostridium pasteurianum	26%	100%
Q4Q459	Leishmania major	92%	100%
Q4QIE6	Leishmania major	32%	100%
Q54P00	Dictyostelium discoideum	32%	91%
Q54TR5	Dictyostelium discoideum	27%	94%
Q5M7P6	Xenopus tropicalis	32%	100%
Q6INL7	Xenopus laevis	31%	100%
Q80V03	Mus musculus	29%	100%
Q9D0L4	Mus musculus	31%	100%
Q9W133	Drosophila melanogaster	28%	100%
V5AX60	Trypanosoma cruzi	30%	100%
V5BCS0	Trypanosoma cruzi	47%	99%