LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MFS_1_like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS_1_like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3W4_LEIMU
TriTrypDb:
LmxM.32.1290
Length:
591

Annotations

LeishMANIAdb annotations

Appears to be a transporter, related to vertebrate MFSD6 proteins (whose function is likewise unexplored).. Only expanded in Leptomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9B3W4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3W4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0022857 transmembrane transporter activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.742
CLV_C14_Caspase3-7 329 333 PF00656 0.420
CLV_C14_Caspase3-7 91 95 PF00656 0.701
CLV_NRD_NRD_1 10 12 PF00675 0.523
CLV_NRD_NRD_1 200 202 PF00675 0.410
CLV_NRD_NRD_1 466 468 PF00675 0.543
CLV_NRD_NRD_1 526 528 PF00675 0.575
CLV_NRD_NRD_1 544 546 PF00675 0.623
CLV_NRD_NRD_1 567 569 PF00675 0.494
CLV_NRD_NRD_1 88 90 PF00675 0.446
CLV_PCSK_FUR_1 8 12 PF00082 0.523
CLV_PCSK_KEX2_1 10 12 PF00082 0.555
CLV_PCSK_KEX2_1 200 202 PF00082 0.410
CLV_PCSK_KEX2_1 312 314 PF00082 0.307
CLV_PCSK_KEX2_1 544 546 PF00082 0.623
CLV_PCSK_KEX2_1 566 568 PF00082 0.486
CLV_PCSK_KEX2_1 87 89 PF00082 0.455
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.342
CLV_PCSK_SKI1_1 200 204 PF00082 0.474
CLV_PCSK_SKI1_1 313 317 PF00082 0.323
CLV_PCSK_SKI1_1 467 471 PF00082 0.451
CLV_PCSK_SKI1_1 528 532 PF00082 0.407
DEG_APCC_DBOX_1 295 303 PF00400 0.549
DEG_SPOP_SBC_1 107 111 PF00917 0.538
DEG_SPOP_SBC_1 234 238 PF00917 0.370
DEG_SPOP_SBC_1 81 85 PF00917 0.638
DOC_CDC14_PxL_1 161 169 PF14671 0.407
DOC_MAPK_gen_1 173 182 PF00069 0.506
DOC_MAPK_gen_1 200 208 PF00069 0.169
DOC_MAPK_gen_1 293 301 PF00069 0.507
DOC_MAPK_gen_1 312 318 PF00069 0.477
DOC_MAPK_gen_1 566 572 PF00069 0.695
DOC_MAPK_MEF2A_6 293 301 PF00069 0.521
DOC_MAPK_MEF2A_6 377 384 PF00069 0.482
DOC_MAPK_MEF2A_6 399 406 PF00069 0.337
DOC_MAPK_NFAT4_5 399 407 PF00069 0.280
DOC_MAPK_RevD_3 185 201 PF00069 0.233
DOC_PP1_RVXF_1 304 310 PF00149 0.416
DOC_USP7_MATH_1 188 192 PF00917 0.279
DOC_USP7_MATH_1 538 542 PF00917 0.719
DOC_USP7_MATH_1 548 552 PF00917 0.682
DOC_USP7_MATH_1 81 85 PF00917 0.650
DOC_USP7_MATH_1 93 97 PF00917 0.723
DOC_WW_Pin1_4 142 147 PF00397 0.207
DOC_WW_Pin1_4 175 180 PF00397 0.483
DOC_WW_Pin1_4 99 104 PF00397 0.754
LIG_14-3-3_CanoR_1 235 240 PF00244 0.539
LIG_14-3-3_CanoR_1 494 499 PF00244 0.461
LIG_AP2alpha_1 330 334 PF02296 0.420
LIG_BRCT_BRCA1_1 123 127 PF00533 0.444
LIG_BRCT_BRCA1_1 135 139 PF00533 0.320
LIG_BRCT_BRCA1_1 257 261 PF00533 0.388
LIG_BRCT_BRCA1_1 30 34 PF00533 0.717
LIG_BRCT_BRCA1_1 425 429 PF00533 0.440
LIG_BRCT_BRCA1_1 64 68 PF00533 0.694
LIG_CaM_IQ_9 481 496 PF13499 0.465
LIG_CSL_BTD_1 417 420 PF09270 0.370
LIG_CtBP_PxDLS_1 179 183 PF00389 0.178
LIG_CtBP_PxDLS_1 53 57 PF00389 0.553
LIG_EH1_1 146 154 PF00400 0.342
LIG_eIF4E_1 147 153 PF01652 0.342
LIG_FHA_1 108 114 PF00498 0.700
LIG_FHA_1 267 273 PF00498 0.169
LIG_FHA_1 443 449 PF00498 0.440
LIG_FHA_1 476 482 PF00498 0.438
LIG_FHA_1 567 573 PF00498 0.705
LIG_FHA_2 14 20 PF00498 0.706
LIG_FHA_2 33 39 PF00498 0.712
LIG_LIR_Gen_1 236 247 PF02991 0.516
LIG_LIR_Gen_1 264 275 PF02991 0.348
LIG_LIR_Gen_1 31 39 PF02991 0.740
LIG_LIR_Gen_1 326 336 PF02991 0.327
LIG_LIR_Gen_1 398 409 PF02991 0.291
LIG_LIR_Gen_1 413 424 PF02991 0.254
LIG_LIR_Gen_1 459 469 PF02991 0.307
LIG_LIR_Gen_1 65 74 PF02991 0.661
LIG_LIR_Nem_3 236 242 PF02991 0.500
LIG_LIR_Nem_3 244 248 PF02991 0.312
LIG_LIR_Nem_3 264 270 PF02991 0.308
LIG_LIR_Nem_3 31 37 PF02991 0.783
LIG_LIR_Nem_3 326 331 PF02991 0.329
LIG_LIR_Nem_3 332 337 PF02991 0.255
LIG_LIR_Nem_3 398 404 PF02991 0.293
LIG_LIR_Nem_3 413 419 PF02991 0.310
LIG_LIR_Nem_3 459 464 PF02991 0.307
LIG_LIR_Nem_3 57 61 PF02991 0.614
LIG_LIR_Nem_3 65 71 PF02991 0.648
LIG_Pex14_2 123 127 PF04695 0.310
LIG_Pex14_2 330 334 PF04695 0.327
LIG_Pex14_2 414 418 PF04695 0.291
LIG_PTB_Apo_2 330 337 PF02174 0.420
LIG_PTB_Apo_2 67 74 PF02174 0.663
LIG_SH2_CRK 135 139 PF00017 0.264
LIG_SH2_CRK 245 249 PF00017 0.178
LIG_SH2_CRK 283 287 PF00017 0.378
LIG_SH2_CRK 394 398 PF00017 0.291
LIG_SH2_CRK 461 465 PF00017 0.305
LIG_SH2_NCK_1 135 139 PF00017 0.320
LIG_SH2_NCK_1 245 249 PF00017 0.178
LIG_SH2_NCK_1 291 295 PF00017 0.470
LIG_SH2_NCK_1 461 465 PF00017 0.342
LIG_SH2_SRC 147 150 PF00017 0.353
LIG_SH2_STAP1 135 139 PF00017 0.356
LIG_SH2_STAT5 122 125 PF00017 0.263
LIG_SH2_STAT5 169 172 PF00017 0.482
LIG_SH2_STAT5 195 198 PF00017 0.439
LIG_SH2_STAT5 241 244 PF00017 0.526
LIG_SH2_STAT5 263 266 PF00017 0.310
LIG_SH2_STAT5 283 286 PF00017 0.150
LIG_SH2_STAT5 461 464 PF00017 0.320
LIG_SH3_3 214 220 PF00018 0.269
LIG_SH3_3 284 290 PF00018 0.383
LIG_SH3_3 496 502 PF00018 0.656
LIG_SUMO_SIM_anti_2 181 187 PF11976 0.262
LIG_SUMO_SIM_anti_2 529 535 PF11976 0.601
LIG_SUMO_SIM_anti_2 569 576 PF11976 0.627
LIG_SUMO_SIM_par_1 353 360 PF11976 0.309
LIG_SUMO_SIM_par_1 401 407 PF11976 0.345
LIG_SUMO_SIM_par_1 568 576 PF11976 0.687
LIG_TRAF2_1 41 44 PF00917 0.592
LIG_TYR_ITIM 133 138 PF00017 0.178
LIG_TYR_ITIM 281 286 PF00017 0.420
LIG_TYR_ITSM 324 331 PF00017 0.402
LIG_TYR_ITSM 457 464 PF00017 0.420
LIG_UBA3_1 226 232 PF00899 0.470
LIG_WRC_WIRS_1 122 127 PF05994 0.181
LIG_WRC_WIRS_1 578 583 PF05994 0.574
MOD_CK1_1 181 187 PF00069 0.343
MOD_CK1_1 22 28 PF00069 0.763
MOD_CK1_1 237 243 PF00069 0.549
MOD_CK1_1 540 546 PF00069 0.722
MOD_CK1_1 69 75 PF00069 0.736
MOD_CK2_1 142 148 PF00069 0.320
MOD_CK2_1 32 38 PF00069 0.655
MOD_Cter_Amidation 198 201 PF01082 0.370
MOD_Cter_Amidation 564 567 PF01082 0.437
MOD_Cter_Amidation 8 11 PF01082 0.523
MOD_GlcNHglycan 153 156 PF01048 0.333
MOD_GlcNHglycan 197 200 PF01048 0.398
MOD_GlcNHglycan 21 24 PF01048 0.461
MOD_GlcNHglycan 435 438 PF01048 0.298
MOD_GlcNHglycan 445 448 PF01048 0.318
MOD_GlcNHglycan 540 543 PF01048 0.594
MOD_GlcNHglycan 545 548 PF01048 0.610
MOD_GlcNHglycan 64 67 PF01048 0.497
MOD_GlcNHglycan 97 100 PF01048 0.538
MOD_GSK3_1 102 109 PF00069 0.733
MOD_GSK3_1 15 22 PF00069 0.717
MOD_GSK3_1 233 240 PF00069 0.526
MOD_GSK3_1 251 258 PF00069 0.402
MOD_GSK3_1 28 35 PF00069 0.770
MOD_GSK3_1 319 326 PF00069 0.363
MOD_GSK3_1 38 45 PF00069 0.738
MOD_GSK3_1 528 535 PF00069 0.740
MOD_GSK3_1 572 579 PF00069 0.743
MOD_GSK3_1 62 69 PF00069 0.738
MOD_GSK3_1 77 84 PF00069 0.686
MOD_GSK3_1 93 100 PF00069 0.768
MOD_N-GLC_1 19 24 PF02516 0.582
MOD_N-GLC_1 54 59 PF02516 0.566
MOD_N-GLC_1 61 66 PF02516 0.503
MOD_N-GLC_1 69 74 PF02516 0.511
MOD_NEK2_1 123 128 PF00069 0.327
MOD_NEK2_1 159 164 PF00069 0.385
MOD_NEK2_1 186 191 PF00069 0.368
MOD_NEK2_1 193 198 PF00069 0.318
MOD_NEK2_1 209 214 PF00069 0.414
MOD_NEK2_1 255 260 PF00069 0.370
MOD_NEK2_1 261 266 PF00069 0.484
MOD_NEK2_1 319 324 PF00069 0.350
MOD_NEK2_1 364 369 PF00069 0.500
MOD_NEK2_1 433 438 PF00069 0.498
MOD_NEK2_1 440 445 PF00069 0.300
MOD_NEK2_1 456 461 PF00069 0.264
MOD_NEK2_1 46 51 PF00069 0.774
MOD_NEK2_1 577 582 PF00069 0.573
MOD_NEK2_1 61 66 PF00069 0.676
MOD_NEK2_2 188 193 PF00069 0.267
MOD_PIKK_1 520 526 PF00454 0.727
MOD_PK_1 494 500 PF00069 0.464
MOD_PKA_1 566 572 PF00069 0.639
MOD_PKA_1 87 93 PF00069 0.595
MOD_PKA_2 234 240 PF00069 0.530
MOD_PKA_2 46 52 PF00069 0.687
MOD_PKA_2 538 544 PF00069 0.794
MOD_PKA_2 566 572 PF00069 0.771
MOD_PKA_2 87 93 PF00069 0.745
MOD_Plk_1 42 48 PF00069 0.716
MOD_Plk_1 528 534 PF00069 0.659
MOD_Plk_1 54 60 PF00069 0.709
MOD_Plk_1 69 75 PF00069 0.741
MOD_Plk_4 159 165 PF00069 0.348
MOD_Plk_4 178 184 PF00069 0.192
MOD_Plk_4 188 194 PF00069 0.340
MOD_Plk_4 251 257 PF00069 0.394
MOD_Plk_4 319 325 PF00069 0.378
MOD_Plk_4 326 332 PF00069 0.321
MOD_Plk_4 456 462 PF00069 0.360
MOD_Plk_4 46 52 PF00069 0.728
MOD_Plk_4 476 482 PF00069 0.150
MOD_Plk_4 494 500 PF00069 0.452
MOD_Plk_4 54 60 PF00069 0.684
MOD_ProDKin_1 142 148 PF00069 0.207
MOD_ProDKin_1 175 181 PF00069 0.483
MOD_ProDKin_1 99 105 PF00069 0.753
TRG_DiLeu_BaEn_1 148 153 PF01217 0.365
TRG_DiLeu_BaEn_1 303 308 PF01217 0.530
TRG_DiLeu_BaEn_2 53 59 PF01217 0.553
TRG_DiLeu_BaLyEn_6 154 159 PF01217 0.420
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.420
TRG_ENDOCYTIC_2 122 125 PF00928 0.185
TRG_ENDOCYTIC_2 135 138 PF00928 0.327
TRG_ENDOCYTIC_2 245 248 PF00928 0.178
TRG_ENDOCYTIC_2 283 286 PF00928 0.354
TRG_ENDOCYTIC_2 291 294 PF00928 0.497
TRG_ENDOCYTIC_2 328 331 PF00928 0.310
TRG_ENDOCYTIC_2 394 397 PF00928 0.291
TRG_ENDOCYTIC_2 461 464 PF00928 0.264
TRG_ER_diArg_1 200 202 PF00400 0.210
TRG_ER_diArg_1 566 568 PF00400 0.696
TRG_ER_diArg_1 7 10 PF00400 0.724
TRG_ER_diArg_1 87 89 PF00400 0.592
TRG_NES_CRM1_1 346 360 PF08389 0.370
TRG_NES_CRM1_1 488 501 PF08389 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U9 Leptomonas seymouri 57% 100%
A0A0S4J6V2 Bodo saltans 35% 100%
A0A0S4JFI6 Bodo saltans 31% 100%
A0A1X0P0X3 Trypanosomatidae 41% 100%
A0A3R7NAF7 Trypanosoma rangeli 35% 100%
A0A3S7X6L2 Leishmania donovani 85% 100%
A4HLI5 Leishmania braziliensis 68% 100%
A4I8Z5 Leishmania infantum 85% 100%
Q4Q460 Leishmania major 82% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS