Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3V8_LEIMU

TriTrypDb:

LmxM.32.1240

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

E9B3V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.290
CLV_C14_Caspase3-7	39	43	PF00656	0.423
CLV_C14_Caspase3-7	414	418	PF00656	0.473
CLV_NRD_NRD_1	165	167	PF00675	0.494
CLV_NRD_NRD_1	57	59	PF00675	0.503
CLV_NRD_NRD_1	796	798	PF00675	0.615
CLV_NRD_NRD_1	816	818	PF00675	0.489
CLV_PCSK_KEX2_1	466	468	PF00082	0.585
CLV_PCSK_KEX2_1	57	59	PF00082	0.503
CLV_PCSK_KEX2_1	796	798	PF00082	0.615
CLV_PCSK_KEX2_1	815	817	PF00082	0.499
CLV_PCSK_KEX2_1	854	856	PF00082	0.608
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.549
CLV_PCSK_PC1ET2_1	854	856	PF00082	0.608
CLV_PCSK_SKI1_1	110	114	PF00082	0.364
CLV_PCSK_SKI1_1	854	858	PF00082	0.615
CLV_Separin_Metazoa	54	58	PF03568	0.480
DEG_APCC_DBOX_1	487	495	PF00400	0.472
DEG_APCC_DBOX_1	816	824	PF00400	0.629
DEG_SPOP_SBC_1	580	584	PF00917	0.578
DEG_SPOP_SBC_1	856	860	PF00917	0.599
DEG_SPOP_SBC_1	867	871	PF00917	0.582
DOC_CYCLIN_RxL_1	104	117	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	554	560	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	599	605	PF00134	0.581
DOC_MAPK_DCC_7	556	565	PF00069	0.517
DOC_MAPK_DCC_7	815	825	PF00069	0.629
DOC_MAPK_gen_1	402	412	PF00069	0.359
DOC_MAPK_gen_1	815	825	PF00069	0.629
DOC_MAPK_MEF2A_6	488	495	PF00069	0.472
DOC_MAPK_MEF2A_6	556	565	PF00069	0.517
DOC_MAPK_MEF2A_6	816	825	PF00069	0.631
DOC_MAPK_NFAT4_5	488	496	PF00069	0.477
DOC_PP1_RVXF_1	347	354	PF00149	0.415
DOC_PP2B_LxvP_1	113	116	PF13499	0.406
DOC_PP2B_LxvP_1	20	23	PF13499	0.440
DOC_PP2B_LxvP_1	493	496	PF13499	0.525
DOC_PP2B_LxvP_1	558	561	PF13499	0.632
DOC_PP2B_LxvP_1	575	578	PF13499	0.599
DOC_PP2B_LxvP_1	597	600	PF13499	0.676
DOC_PP2B_LxvP_1	629	632	PF13499	0.485
DOC_SPAK_OSR1_1	349	353	PF12202	0.404
DOC_USP7_MATH_1	142	146	PF00917	0.573
DOC_USP7_MATH_1	171	175	PF00917	0.411
DOC_USP7_MATH_1	224	228	PF00917	0.523
DOC_USP7_MATH_1	370	374	PF00917	0.512
DOC_USP7_MATH_1	570	574	PF00917	0.786
DOC_USP7_MATH_1	581	585	PF00917	0.661
DOC_USP7_MATH_1	591	595	PF00917	0.501
DOC_USP7_MATH_1	61	65	PF00917	0.432
DOC_USP7_MATH_1	619	623	PF00917	0.669
DOC_USP7_MATH_1	634	638	PF00917	0.538
DOC_USP7_MATH_1	647	651	PF00917	0.489
DOC_USP7_MATH_1	71	75	PF00917	0.529
DOC_USP7_MATH_1	749	753	PF00917	0.486
DOC_USP7_MATH_1	769	773	PF00917	0.560
DOC_USP7_MATH_1	801	805	PF00917	0.599
DOC_WW_Pin1_4	387	392	PF00397	0.523
DOC_WW_Pin1_4	515	520	PF00397	0.670
DOC_WW_Pin1_4	799	804	PF00397	0.604
DOC_WW_Pin1_4	834	839	PF00397	0.604
LIG_14-3-3_CanoR_1	166	175	PF00244	0.383
LIG_14-3-3_CanoR_1	296	301	PF00244	0.394
LIG_14-3-3_CanoR_1	329	337	PF00244	0.427
LIG_14-3-3_CanoR_1	425	431	PF00244	0.505
LIG_14-3-3_CanoR_1	5	10	PF00244	0.552
LIG_14-3-3_CanoR_1	501	507	PF00244	0.545
LIG_14-3-3_CanoR_1	847	852	PF00244	0.567
LIG_BIR_III_4	271	275	PF00653	0.371
LIG_BRCT_BRCA1_1	427	431	PF00533	0.505
LIG_deltaCOP1_diTrp_1	34	40	PF00928	0.380
LIG_EVH1_1	575	579	PF00568	0.549
LIG_EVH1_1	597	601	PF00568	0.679
LIG_FHA_1	156	162	PF00498	0.473
LIG_FHA_1	167	173	PF00498	0.330
LIG_FHA_1	231	237	PF00498	0.493
LIG_FHA_1	313	319	PF00498	0.380
LIG_FHA_1	401	407	PF00498	0.562
LIG_FHA_1	50	56	PF00498	0.515
LIG_FHA_1	509	515	PF00498	0.576
LIG_FHA_1	518	524	PF00498	0.614
LIG_FHA_1	536	542	PF00498	0.587
LIG_FHA_1	581	587	PF00498	0.584
LIG_FHA_1	640	646	PF00498	0.677
LIG_FHA_1	74	80	PF00498	0.538
LIG_FHA_1	753	759	PF00498	0.482
LIG_FHA_1	805	811	PF00498	0.598
LIG_FHA_1	862	868	PF00498	0.626
LIG_FHA_2	29	35	PF00498	0.387
LIG_FHA_2	337	343	PF00498	0.323
LIG_FHA_2	37	43	PF00498	0.344
LIG_FHA_2	485	491	PF00498	0.421
LIG_FHA_2	508	514	PF00498	0.613
LIG_FHA_2	838	844	PF00498	0.645
LIG_FHA_2	856	862	PF00498	0.512
LIG_LIR_Gen_1	34	45	PF02991	0.520
LIG_LIR_Gen_1	367	377	PF02991	0.586
LIG_LIR_Gen_1	447	454	PF02991	0.353
LIG_LIR_LC3C_4	17	22	PF02991	0.448
LIG_LIR_Nem_3	122	128	PF02991	0.492
LIG_LIR_Nem_3	177	181	PF02991	0.381
LIG_LIR_Nem_3	34	40	PF02991	0.452
LIG_LIR_Nem_3	389	395	PF02991	0.526
LIG_LIR_Nem_3	447	452	PF02991	0.356
LIG_MAD2	18	26	PF02301	0.397
LIG_NRBOX	160	166	PF00104	0.431
LIG_REV1ctd_RIR_1	202	209	PF16727	0.332
LIG_SH2_SRC	181	184	PF00017	0.326
LIG_SH2_SRC	219	222	PF00017	0.493
LIG_SH2_STAP1	201	205	PF00017	0.355
LIG_SH2_STAT5	181	184	PF00017	0.408
LIG_SH2_STAT5	249	252	PF00017	0.490
LIG_SH2_STAT5	517	520	PF00017	0.592
LIG_SH2_STAT5	793	796	PF00017	0.607
LIG_SH3_3	19	25	PF00018	0.399
LIG_SH3_3	338	344	PF00018	0.475
LIG_SH3_3	542	548	PF00018	0.688
LIG_SH3_3	554	560	PF00018	0.660
LIG_SH3_3	573	579	PF00018	0.495
LIG_SH3_3	585	591	PF00018	0.626
LIG_SH3_3	592	598	PF00018	0.596
LIG_SH3_3	603	609	PF00018	0.654
LIG_SH3_3	613	619	PF00018	0.795
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.314
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.452
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.367
LIG_SUMO_SIM_par_1	111	117	PF11976	0.462
LIG_UBA3_1	161	167	PF00899	0.426
MOD_CDK_SPxK_1	387	393	PF00069	0.525
MOD_CDK_SPxxK_3	799	806	PF00069	0.604
MOD_CK1_1	157	163	PF00069	0.390
MOD_CK1_1	309	315	PF00069	0.398
MOD_CK1_1	387	393	PF00069	0.573
MOD_CK1_1	552	558	PF00069	0.543
MOD_CK1_1	621	627	PF00069	0.774
MOD_CK1_1	630	636	PF00069	0.565
MOD_CK1_1	69	75	PF00069	0.620
MOD_CK1_1	752	758	PF00069	0.485
MOD_CK1_1	8	14	PF00069	0.662
MOD_CK1_1	804	810	PF00069	0.595
MOD_CK1_1	837	843	PF00069	0.608
MOD_CK1_1	846	852	PF00069	0.557
MOD_CK1_1	99	105	PF00069	0.485
MOD_CK2_1	141	147	PF00069	0.520
MOD_CK2_1	171	177	PF00069	0.359
MOD_CK2_1	181	187	PF00069	0.288
MOD_CK2_1	336	342	PF00069	0.369
MOD_CK2_1	370	376	PF00069	0.552
MOD_CK2_1	38	44	PF00069	0.378
MOD_CK2_1	431	437	PF00069	0.587
MOD_CK2_1	484	490	PF00069	0.418
MOD_CK2_1	837	843	PF00069	0.643
MOD_CK2_1	855	861	PF00069	0.514
MOD_DYRK1A_RPxSP_1	834	838	PF00069	0.575
MOD_GlcNHglycan	144	147	PF01048	0.648
MOD_GlcNHglycan	183	186	PF01048	0.336
MOD_GlcNHglycan	226	229	PF01048	0.310
MOD_GlcNHglycan	253	256	PF01048	0.501
MOD_GlcNHglycan	268	271	PF01048	0.358
MOD_GlcNHglycan	272	275	PF01048	0.402
MOD_GlcNHglycan	293	296	PF01048	0.510
MOD_GlcNHglycan	308	311	PF01048	0.333
MOD_GlcNHglycan	322	325	PF01048	0.458
MOD_GlcNHglycan	355	358	PF01048	0.514
MOD_GlcNHglycan	372	375	PF01048	0.493
MOD_GlcNHglycan	386	389	PF01048	0.528
MOD_GlcNHglycan	528	531	PF01048	0.618
MOD_GlcNHglycan	567	570	PF01048	0.743
MOD_GlcNHglycan	572	575	PF01048	0.606
MOD_GlcNHglycan	63	66	PF01048	0.511
MOD_GlcNHglycan	649	652	PF01048	0.519
MOD_GlcNHglycan	68	71	PF01048	0.594
MOD_GlcNHglycan	73	76	PF01048	0.624
MOD_GlcNHglycan	770	774	PF01048	0.523
MOD_GlcNHglycan	85	88	PF01048	0.549
MOD_GlcNHglycan	98	101	PF01048	0.513
MOD_GSK3_1	137	144	PF00069	0.476
MOD_GSK3_1	146	153	PF00069	0.591
MOD_GSK3_1	166	173	PF00069	0.387
MOD_GSK3_1	226	233	PF00069	0.513
MOD_GSK3_1	266	273	PF00069	0.384
MOD_GSK3_1	308	315	PF00069	0.367
MOD_GSK3_1	380	387	PF00069	0.524
MOD_GSK3_1	561	568	PF00069	0.656
MOD_GSK3_1	61	68	PF00069	0.480
MOD_GSK3_1	630	637	PF00069	0.539
MOD_GSK3_1	69	76	PF00069	0.553
MOD_GSK3_1	801	808	PF00069	0.598
MOD_GSK3_1	830	837	PF00069	0.619
MOD_GSK3_1	843	850	PF00069	0.577
MOD_GSK3_1	855	862	PF00069	0.553
MOD_GSK3_1	90	97	PF00069	0.579
MOD_N-GLC_1	150	155	PF02516	0.526
MOD_N-GLC_1	535	540	PF02516	0.530
MOD_N-GLC_1	830	835	PF02516	0.527
MOD_N-GLC_2	130	132	PF02516	0.398
MOD_NEK2_1	126	131	PF00069	0.492
MOD_NEK2_1	204	209	PF00069	0.366
MOD_NEK2_1	244	249	PF00069	0.401
MOD_NEK2_1	28	33	PF00069	0.456
MOD_NEK2_1	431	436	PF00069	0.513
MOD_NEK2_1	484	489	PF00069	0.448
MOD_NEK2_1	525	530	PF00069	0.694
MOD_NEK2_1	783	788	PF00069	0.583
MOD_PIKK_1	249	255	PF00454	0.391
MOD_PIKK_1	400	406	PF00454	0.505
MOD_PIKK_1	415	421	PF00454	0.378
MOD_PK_1	5	11	PF00069	0.488
MOD_PK_1	847	853	PF00069	0.524
MOD_PKA_1	166	172	PF00069	0.395
MOD_PKA_1	854	860	PF00069	0.600
MOD_PKA_2	154	160	PF00069	0.508
MOD_PKA_2	244	250	PF00069	0.458
MOD_PKA_2	328	334	PF00069	0.402
MOD_PKA_2	415	421	PF00069	0.356
MOD_PKA_2	47	53	PF00069	0.553
MOD_PKA_2	783	789	PF00069	0.583
MOD_PKA_2	805	811	PF00069	0.598
MOD_PKA_2	846	852	PF00069	0.571
MOD_PKA_2	854	860	PF00069	0.593
MOD_PKB_1	830	838	PF00069	0.607
MOD_Plk_1	146	152	PF00069	0.503
MOD_Plk_1	230	236	PF00069	0.508
MOD_Plk_2-3	380	386	PF00069	0.514
MOD_Plk_4	157	163	PF00069	0.434
MOD_Plk_4	380	386	PF00069	0.545
MOD_Plk_4	426	432	PF00069	0.550
MOD_Plk_4	601	607	PF00069	0.535
MOD_Plk_4	862	868	PF00069	0.596
MOD_ProDKin_1	387	393	PF00069	0.525
MOD_ProDKin_1	515	521	PF00069	0.669
MOD_ProDKin_1	799	805	PF00069	0.603
MOD_ProDKin_1	834	840	PF00069	0.607
MOD_SUMO_for_1	811	814	PF00179	0.603
MOD_SUMO_for_1	823	826	PF00179	0.565
MOD_SUMO_rev_2	837	846	PF00179	0.629
TRG_DiLeu_BaEn_1	221	226	PF01217	0.566
TRG_DiLeu_BaEn_1	490	495	PF01217	0.478
TRG_ENDOCYTIC_2	201	204	PF00928	0.369
TRG_ENDOCYTIC_2	369	372	PF00928	0.548
TRG_ENDOCYTIC_2	392	395	PF00928	0.516
TRG_ER_diArg_1	56	58	PF00400	0.524
TRG_ER_diArg_1	796	798	PF00400	0.615
TRG_ER_diArg_1	815	817	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0X2	Trypanosomatidae	32%	100%
A0A3Q8IGU1	Leishmania donovani	31%	100%
A0A3S7X6R5	Leishmania donovani	87%	100%
A4HLH8	Leishmania braziliensis	32%	100%
A4HLH9	Leishmania braziliensis	76%	100%
A4I8Y8	Leishmania infantum	29%	100%
A4I8Y9	Leishmania infantum	88%	100%
Q4Q466	Leishmania major	87%	100%
Q4Q467	Leishmania major	32%	100%