Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B3V7_LEIMU

TriTrypDb:

LmxM.32.1230

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0035869	ciliary transition zone	2	1

Expansion

Sequence features

E9B3V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.399
CLV_NRD_NRD_1	116	118	PF00675	0.394
CLV_NRD_NRD_1	253	255	PF00675	0.437
CLV_NRD_NRD_1	420	422	PF00675	0.529
CLV_NRD_NRD_1	430	432	PF00675	0.484
CLV_NRD_NRD_1	609	611	PF00675	0.681
CLV_NRD_NRD_1	77	79	PF00675	0.588
CLV_PCSK_KEX2_1	116	118	PF00082	0.357
CLV_PCSK_KEX2_1	403	405	PF00082	0.524
CLV_PCSK_KEX2_1	430	432	PF00082	0.575
CLV_PCSK_KEX2_1	609	611	PF00082	0.681
CLV_PCSK_KEX2_1	77	79	PF00082	0.588
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.553
CLV_PCSK_SKI1_1	158	162	PF00082	0.275
CLV_PCSK_SKI1_1	17	21	PF00082	0.519
CLV_PCSK_SKI1_1	374	378	PF00082	0.510
CLV_Separin_Metazoa	427	431	PF03568	0.592
DEG_APCC_DBOX_1	373	381	PF00400	0.433
DEG_APCC_DBOX_1	429	437	PF00400	0.468
DEG_SPOP_SBC_1	497	501	PF00917	0.618
DOC_CDC14_PxL_1	573	581	PF14671	0.565
DOC_CKS1_1	466	471	PF01111	0.465
DOC_MAPK_gen_1	233	242	PF00069	0.480
DOC_MAPK_gen_1	421	428	PF00069	0.524
DOC_MAPK_gen_1	77	87	PF00069	0.500
DOC_PP2B_LxvP_1	537	540	PF13499	0.707
DOC_USP7_MATH_1	10	14	PF00917	0.553
DOC_USP7_MATH_1	139	143	PF00917	0.393
DOC_USP7_MATH_1	176	180	PF00917	0.487
DOC_USP7_MATH_1	439	443	PF00917	0.455
DOC_USP7_MATH_1	450	454	PF00917	0.711
DOC_USP7_MATH_1	455	459	PF00917	0.710
DOC_USP7_MATH_1	493	497	PF00917	0.731
DOC_USP7_MATH_1	510	514	PF00917	0.671
DOC_USP7_UBL2_3	399	403	PF12436	0.570
DOC_WW_Pin1_4	465	470	PF00397	0.662
DOC_WW_Pin1_4	499	504	PF00397	0.749
DOC_WW_Pin1_4	532	537	PF00397	0.619
DOC_WW_Pin1_4	551	556	PF00397	0.784
DOC_WW_Pin1_4	8	13	PF00397	0.693
LIG_14-3-3_CanoR_1	249	254	PF00244	0.395
LIG_14-3-3_CanoR_1	421	427	PF00244	0.599
LIG_14-3-3_CanoR_1	511	516	PF00244	0.679
LIG_14-3-3_CanoR_1	550	555	PF00244	0.734
LIG_14-3-3_CterR_2	609	613	PF00244	0.725
LIG_Actin_WH2_2	239	256	PF00022	0.496
LIG_APCC_ABBA_1	106	111	PF00400	0.464
LIG_BRCT_BRCA1_1	140	144	PF00533	0.324
LIG_BRCT_BRCA1_1	192	196	PF00533	0.270
LIG_EVH1_1	537	541	PF00568	0.506
LIG_EVH1_1	576	580	PF00568	0.662
LIG_FHA_1	183	189	PF00498	0.453
LIG_FHA_1	338	344	PF00498	0.686
LIG_FHA_1	410	416	PF00498	0.453
LIG_FHA_1	421	427	PF00498	0.455
LIG_FHA_1	43	49	PF00498	0.441
LIG_FHA_1	435	441	PF00498	0.456
LIG_FHA_1	60	66	PF00498	0.439
LIG_FHA_2	592	598	PF00498	0.694
LIG_LIR_Gen_1	44	55	PF02991	0.509
LIG_LIR_Gen_1	86	95	PF02991	0.441
LIG_LIR_Nem_3	566	572	PF02991	0.716
LIG_LIR_Nem_3	86	91	PF02991	0.434
LIG_LYPXL_SIV_4	344	352	PF13949	0.585
LIG_NRBOX	358	364	PF00104	0.373
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.339
LIG_SH2_CRK	88	92	PF00017	0.508
LIG_SH2_SRC	171	174	PF00017	0.462
LIG_SH2_SRC	569	572	PF00017	0.621
LIG_SH2_STAP1	109	113	PF00017	0.463
LIG_SH2_STAP1	339	343	PF00017	0.521
LIG_SH2_STAT3	339	342	PF00017	0.620
LIG_SH2_STAT5	109	112	PF00017	0.503
LIG_SH2_STAT5	127	130	PF00017	0.327
LIG_SH2_STAT5	166	169	PF00017	0.444
LIG_SH2_STAT5	270	273	PF00017	0.437
LIG_SH2_STAT5	303	306	PF00017	0.428
LIG_SH2_STAT5	339	342	PF00017	0.570
LIG_SH2_STAT5	345	348	PF00017	0.542
LIG_SH2_STAT5	556	559	PF00017	0.480
LIG_SH3_1	444	450	PF00018	0.647
LIG_SH3_2	539	544	PF14604	0.559
LIG_SH3_3	444	450	PF00018	0.672
LIG_SH3_3	463	469	PF00018	0.682
LIG_SH3_3	479	485	PF00018	0.664
LIG_SH3_3	487	493	PF00018	0.614
LIG_SH3_3	506	512	PF00018	0.628
LIG_SH3_3	517	523	PF00018	0.658
LIG_SH3_3	533	539	PF00018	0.670
LIG_SH3_3	540	546	PF00018	0.619
LIG_SH3_3	574	580	PF00018	0.645
LIG_SH3_3	581	587	PF00018	0.602
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.521
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.573
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.578
LIG_SUMO_SIM_par_1	361	367	PF11976	0.489
LIG_SUMO_SIM_par_1	83	89	PF11976	0.393
LIG_WRC_WIRS_1	373	378	PF05994	0.565
LIG_WRC_WIRS_1	66	71	PF05994	0.376
LIG_WW_2	577	580	PF00397	0.465
LIG_WW_3	508	512	PF00397	0.554
MOD_CDK_SPxxK_3	8	15	PF00069	0.547
MOD_CK1_1	142	148	PF00069	0.350
MOD_CK1_1	181	187	PF00069	0.453
MOD_CK1_1	289	295	PF00069	0.463
MOD_CK1_1	366	372	PF00069	0.551
MOD_CK1_1	41	47	PF00069	0.496
MOD_CK1_1	465	471	PF00069	0.503
MOD_CK1_1	496	502	PF00069	0.644
MOD_CK2_1	376	382	PF00069	0.487
MOD_CK2_1	591	597	PF00069	0.558
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.551
MOD_GlcNHglycan	102	105	PF01048	0.480
MOD_GlcNHglycan	123	126	PF01048	0.411
MOD_GlcNHglycan	178	181	PF01048	0.253
MOD_GlcNHglycan	192	195	PF01048	0.365
MOD_GlcNHglycan	206	209	PF01048	0.473
MOD_GlcNHglycan	210	213	PF01048	0.330
MOD_GlcNHglycan	221	224	PF01048	0.277
MOD_GlcNHglycan	225	228	PF01048	0.456
MOD_GlcNHglycan	263	266	PF01048	0.436
MOD_GlcNHglycan	291	294	PF01048	0.464
MOD_GlcNHglycan	306	309	PF01048	0.422
MOD_GlcNHglycan	366	369	PF01048	0.577
MOD_GlcNHglycan	441	444	PF01048	0.689
MOD_GlcNHglycan	452	455	PF01048	0.717
MOD_GlcNHglycan	457	460	PF01048	0.702
MOD_GlcNHglycan	494	498	PF01048	0.718
MOD_GlcNHglycan	516	519	PF01048	0.644
MOD_GSK3_1	117	124	PF00069	0.539
MOD_GSK3_1	138	145	PF00069	0.392
MOD_GSK3_1	17	24	PF00069	0.560
MOD_GSK3_1	178	185	PF00069	0.510
MOD_GSK3_1	204	211	PF00069	0.419
MOD_GSK3_1	215	222	PF00069	0.397
MOD_GSK3_1	306	313	PF00069	0.414
MOD_GSK3_1	37	44	PF00069	0.458
MOD_GSK3_1	372	379	PF00069	0.470
MOD_GSK3_1	405	412	PF00069	0.594
MOD_GSK3_1	493	500	PF00069	0.692
MOD_GSK3_1	510	517	PF00069	0.636
MOD_GSK3_1	528	535	PF00069	0.644
MOD_GSK3_1	561	568	PF00069	0.728
MOD_GSK3_1	605	612	PF00069	0.708
MOD_N-GLC_1	289	294	PF02516	0.240
MOD_N-GLC_1	42	47	PF02516	0.511
MOD_NEK2_1	144	149	PF00069	0.433
MOD_NEK2_1	304	309	PF00069	0.421
MOD_NEK2_1	363	368	PF00069	0.562
MOD_NEK2_1	376	381	PF00069	0.495
MOD_NEK2_1	38	43	PF00069	0.444
MOD_NEK2_1	498	503	PF00069	0.742
MOD_NEK2_1	528	533	PF00069	0.566
MOD_NEK2_1	99	104	PF00069	0.355
MOD_NEK2_2	83	88	PF00069	0.372
MOD_PIKK_1	144	150	PF00454	0.439
MOD_PIKK_1	338	344	PF00454	0.633
MOD_PKA_2	383	389	PF00069	0.546
MOD_PKA_2	420	426	PF00069	0.562
MOD_PKA_2	434	440	PF00069	0.498
MOD_PKA_2	510	516	PF00069	0.725
MOD_PKA_2	549	555	PF00069	0.583
MOD_Plk_1	142	148	PF00069	0.417
MOD_Plk_1	17	23	PF00069	0.587
MOD_Plk_1	181	187	PF00069	0.455
MOD_Plk_1	275	281	PF00069	0.507
MOD_Plk_1	289	295	PF00069	0.355
MOD_Plk_1	310	316	PF00069	0.438
MOD_Plk_1	42	48	PF00069	0.473
MOD_Plk_1	493	499	PF00069	0.755
MOD_Plk_4	275	281	PF00069	0.472
MOD_Plk_4	42	48	PF00069	0.507
MOD_Plk_4	511	517	PF00069	0.664
MOD_Plk_4	83	89	PF00069	0.385
MOD_ProDKin_1	465	471	PF00069	0.664
MOD_ProDKin_1	499	505	PF00069	0.746
MOD_ProDKin_1	532	538	PF00069	0.613
MOD_ProDKin_1	551	557	PF00069	0.784
MOD_ProDKin_1	8	14	PF00069	0.692
MOD_SUMO_rev_2	24	29	PF00179	0.471
MOD_SUMO_rev_2	416	423	PF00179	0.455
TRG_DiLeu_BaEn_1	173	178	PF01217	0.549
TRG_DiLeu_BaEn_1	358	363	PF01217	0.519
TRG_ENDOCYTIC_2	200	203	PF00928	0.521
TRG_ENDOCYTIC_2	391	394	PF00928	0.488
TRG_ENDOCYTIC_2	569	572	PF00928	0.621
TRG_ENDOCYTIC_2	88	91	PF00928	0.504
TRG_ER_diArg_1	115	117	PF00400	0.357
TRG_ER_diArg_1	429	431	PF00400	0.464
TRG_ER_diArg_1	444	447	PF00400	0.517
TRG_ER_diArg_1	609	611	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	69%	89%
A0A0S4IK48	Bodo saltans	24%	73%
A0A0S4JA89	Bodo saltans	37%	70%
A0A1X0P0X2	Trypanosomatidae	41%	92%
A0A1X0P178	Trypanosomatidae	37%	100%
A0A3Q8IGU1	Leishmania donovani	89%	99%
A0A422N1N7	Trypanosoma rangeli	22%	71%
A4HLH8	Leishmania braziliensis	73%	98%
A4HLH9	Leishmania braziliensis	30%	79%
A4I8Y8	Leishmania infantum	89%	99%
D0A4Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	83%
Q4Q467	Leishmania major	90%	100%