F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3V6_LEIMU

TriTrypDb:

LmxM.32.1220

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	644	648	PF00656	0.550
CLV_MEL_PAP_1	346	352	PF00089	0.677
CLV_NRD_NRD_1	124	126	PF00675	0.518
CLV_NRD_NRD_1	177	179	PF00675	0.805
CLV_NRD_NRD_1	196	198	PF00675	0.338
CLV_NRD_NRD_1	467	469	PF00675	0.583
CLV_NRD_NRD_1	535	537	PF00675	0.714
CLV_NRD_NRD_1	793	795	PF00675	0.683
CLV_PCSK_FUR_1	791	795	PF00082	0.762
CLV_PCSK_KEX2_1	124	126	PF00082	0.518
CLV_PCSK_KEX2_1	196	198	PF00082	0.537
CLV_PCSK_KEX2_1	535	537	PF00082	0.714
CLV_PCSK_KEX2_1	791	793	PF00082	0.680
CLV_PCSK_SKI1_1	530	534	PF00082	0.654
CLV_PCSK_SKI1_1	715	719	PF00082	0.515
DEG_ODPH_VHL_1	718	730	PF01847	0.530
DEG_SCF_FBW7_1	694	701	PF00400	0.517
DEG_SPOP_SBC_1	317	321	PF00917	0.775
DOC_CDC14_PxL_1	716	724	PF14671	0.525
DOC_CKS1_1	341	346	PF01111	0.802
DOC_CYCLIN_RxL_1	705	714	PF00134	0.583
DOC_MAPK_gen_1	530	539	PF00069	0.681
DOC_PP2B_LxvP_1	290	293	PF13499	0.685
DOC_PP2B_LxvP_1	615	618	PF13499	0.653
DOC_PP2B_LxvP_1	83	86	PF13499	0.572
DOC_PP4_FxxP_1	717	720	PF00568	0.524
DOC_USP7_MATH_1	108	112	PF00917	0.548
DOC_USP7_MATH_1	184	188	PF00917	0.461
DOC_USP7_MATH_1	266	270	PF00917	0.737
DOC_USP7_MATH_1	281	285	PF00917	0.628
DOC_USP7_MATH_1	291	295	PF00917	0.694
DOC_USP7_MATH_1	339	343	PF00917	0.775
DOC_USP7_MATH_1	387	391	PF00917	0.770
DOC_USP7_MATH_1	403	407	PF00917	0.646
DOC_USP7_MATH_1	458	462	PF00917	0.793
DOC_USP7_MATH_1	481	485	PF00917	0.753
DOC_USP7_MATH_1	645	649	PF00917	0.525
DOC_USP7_MATH_1	681	685	PF00917	0.830
DOC_WW_Pin1_4	12	17	PF00397	0.699
DOC_WW_Pin1_4	149	154	PF00397	0.662
DOC_WW_Pin1_4	237	242	PF00397	0.767
DOC_WW_Pin1_4	253	258	PF00397	0.546
DOC_WW_Pin1_4	270	275	PF00397	0.753
DOC_WW_Pin1_4	292	297	PF00397	0.612
DOC_WW_Pin1_4	304	309	PF00397	0.754
DOC_WW_Pin1_4	329	334	PF00397	0.810
DOC_WW_Pin1_4	340	345	PF00397	0.705
DOC_WW_Pin1_4	36	41	PF00397	0.684
DOC_WW_Pin1_4	399	404	PF00397	0.603
DOC_WW_Pin1_4	436	441	PF00397	0.821
DOC_WW_Pin1_4	577	582	PF00397	0.848
DOC_WW_Pin1_4	651	656	PF00397	0.810
DOC_WW_Pin1_4	669	674	PF00397	0.695
DOC_WW_Pin1_4	694	699	PF00397	0.560
DOC_WW_Pin1_4	701	706	PF00397	0.775
DOC_WW_Pin1_4	753	758	PF00397	0.662
LIG_14-3-3_CanoR_1	124	130	PF00244	0.594
LIG_14-3-3_CanoR_1	178	186	PF00244	0.515
LIG_14-3-3_CanoR_1	425	429	PF00244	0.675
LIG_14-3-3_CanoR_1	511	519	PF00244	0.625
LIG_14-3-3_CanoR_1	7	16	PF00244	0.686
LIG_AP2alpha_2	245	247	PF02296	0.702
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	274	278	PF00533	0.711
LIG_Clathr_ClatBox_1	730	734	PF01394	0.499
LIG_Clathr_ClatBox_1	739	743	PF01394	0.550
LIG_CSL_BTD_1	702	705	PF09270	0.498
LIG_deltaCOP1_diTrp_1	120	130	PF00928	0.489
LIG_deltaCOP1_diTrp_1	206	209	PF00928	0.572
LIG_FHA_1	143	149	PF00498	0.592
LIG_FHA_1	222	228	PF00498	0.683
LIG_FHA_1	341	347	PF00498	0.801
LIG_FHA_1	380	386	PF00498	0.643
LIG_FHA_1	39	45	PF00498	0.729
LIG_FHA_1	695	701	PF00498	0.690
LIG_FHA_1	702	708	PF00498	0.690
LIG_FHA_1	92	98	PF00498	0.446
LIG_FHA_2	512	518	PF00498	0.593
LIG_FHA_2	601	607	PF00498	0.583
LIG_FHA_2	642	648	PF00498	0.797
LIG_FHA_2	652	658	PF00498	0.610
LIG_FHA_2	776	782	PF00498	0.600
LIG_LIR_Apic_2	701	706	PF02991	0.702
LIG_LIR_Apic_2	714	720	PF02991	0.520
LIG_LIR_Apic_2	753	757	PF02991	0.663
LIG_LIR_Apic_2	781	787	PF02991	0.498
LIG_LIR_Gen_1	128	137	PF02991	0.596
LIG_LIR_Gen_1	187	193	PF02991	0.501
LIG_LIR_Gen_1	206	215	PF02991	0.588
LIG_LIR_Gen_1	30	38	PF02991	0.698
LIG_LIR_Gen_1	622	632	PF02991	0.581
LIG_LIR_Gen_1	687	695	PF02991	0.802
LIG_LIR_Gen_1	725	735	PF02991	0.489
LIG_LIR_Gen_1	780	789	PF02991	0.671
LIG_LIR_Gen_1	98	105	PF02991	0.532
LIG_LIR_Nem_3	111	116	PF02991	0.360
LIG_LIR_Nem_3	187	192	PF02991	0.500
LIG_LIR_Nem_3	206	212	PF02991	0.581
LIG_LIR_Nem_3	30	34	PF02991	0.696
LIG_LIR_Nem_3	622	627	PF02991	0.562
LIG_LIR_Nem_3	66	71	PF02991	0.527
LIG_LIR_Nem_3	687	691	PF02991	0.815
LIG_LIR_Nem_3	725	730	PF02991	0.491
LIG_LIR_Nem_3	780	785	PF02991	0.650
LIG_LIR_Nem_3	93	99	PF02991	0.532
LIG_MYND_1	333	337	PF01753	0.709
LIG_MYND_1	344	348	PF01753	0.708
LIG_MYND_1	705	709	PF01753	0.760
LIG_Pex14_2	249	253	PF04695	0.684
LIG_Pex14_2	712	716	PF04695	0.555
LIG_REV1ctd_RIR_1	190	201	PF16727	0.522
LIG_REV1ctd_RIR_1	710	719	PF16727	0.556
LIG_SH2_CRK	636	640	PF00017	0.724
LIG_SH2_CRK	782	786	PF00017	0.663
LIG_SH2_PTP2	727	730	PF00017	0.470
LIG_SH2_PTP2	784	787	PF00017	0.682
LIG_SH2_SRC	630	633	PF00017	0.698
LIG_SH2_SRC	784	787	PF00017	0.517
LIG_SH2_STAP1	189	193	PF00017	0.500
LIG_SH2_STAT3	75	78	PF00017	0.707
LIG_SH2_STAT3	772	775	PF00017	0.627
LIG_SH2_STAT5	129	132	PF00017	0.513
LIG_SH2_STAT5	199	202	PF00017	0.540
LIG_SH2_STAT5	422	425	PF00017	0.606
LIG_SH2_STAT5	727	730	PF00017	0.470
LIG_SH2_STAT5	777	780	PF00017	0.616
LIG_SH2_STAT5	784	787	PF00017	0.682
LIG_SH2_STAT5	96	99	PF00017	0.499
LIG_SH3_1	437	443	PF00018	0.650
LIG_SH3_2	786	791	PF14604	0.712
LIG_SH3_3	144	150	PF00018	0.590
LIG_SH3_3	290	296	PF00018	0.707
LIG_SH3_3	298	304	PF00018	0.727
LIG_SH3_3	338	344	PF00018	0.719
LIG_SH3_3	347	353	PF00018	0.678
LIG_SH3_3	437	443	PF00018	0.728
LIG_SH3_3	445	451	PF00018	0.648
LIG_SH3_3	579	585	PF00018	0.743
LIG_SH3_3	688	694	PF00018	0.835
LIG_SH3_3	703	709	PF00018	0.653
LIG_SH3_3	783	789	PF00018	0.669
LIG_SUMO_SIM_anti_2	488	495	PF11976	0.603
LIG_SUMO_SIM_par_1	223	229	PF11976	0.686
LIG_SUMO_SIM_par_1	488	495	PF11976	0.603
LIG_SUMO_SIM_par_1	598	604	PF11976	0.606
LIG_SUMO_SIM_par_1	729	734	PF11976	0.489
LIG_SUMO_SIM_par_1	738	745	PF11976	0.577
LIG_TRFH_1	716	720	PF08558	0.517
LIG_TYR_ITIM	505	510	PF00017	0.715
LIG_TYR_ITIM	634	639	PF00017	0.712
LIG_TYR_ITIM	97	102	PF00017	0.517
MOD_CDK_SPK_2	651	656	PF00069	0.810
MOD_CDK_SPxxK_3	701	708	PF00069	0.781
MOD_CK1_1	15	21	PF00069	0.692
MOD_CK1_1	152	158	PF00069	0.737
MOD_CK1_1	240	246	PF00069	0.684
MOD_CK1_1	295	301	PF00069	0.762
MOD_CK1_1	32	38	PF00069	0.515
MOD_CK1_1	321	327	PF00069	0.838
MOD_CK1_1	328	334	PF00069	0.743
MOD_CK1_1	399	405	PF00069	0.815
MOD_CK1_1	412	418	PF00069	0.508
MOD_CK1_1	436	442	PF00069	0.728
MOD_CK1_1	461	467	PF00069	0.544
MOD_CK1_1	6	12	PF00069	0.677
MOD_CK1_1	648	654	PF00069	0.593
MOD_CK1_1	672	678	PF00069	0.611
MOD_CK1_1	684	690	PF00069	0.830
MOD_CK2_1	15	21	PF00069	0.655
MOD_CK2_1	184	190	PF00069	0.523
MOD_CK2_1	200	206	PF00069	0.549
MOD_CK2_1	281	287	PF00069	0.724
MOD_CK2_1	424	430	PF00069	0.684
MOD_CK2_1	511	517	PF00069	0.594
MOD_CK2_1	600	606	PF00069	0.597
MOD_CK2_1	651	657	PF00069	0.740
MOD_CK2_1	775	781	PF00069	0.600
MOD_GlcNHglycan	17	20	PF01048	0.725
MOD_GlcNHglycan	186	189	PF01048	0.538
MOD_GlcNHglycan	242	245	PF01048	0.668
MOD_GlcNHglycan	249	252	PF01048	0.724
MOD_GlcNHglycan	253	256	PF01048	0.735
MOD_GlcNHglycan	268	271	PF01048	0.641
MOD_GlcNHglycan	320	323	PF01048	0.737
MOD_GlcNHglycan	35	38	PF01048	0.537
MOD_GlcNHglycan	407	410	PF01048	0.774
MOD_GlcNHglycan	411	414	PF01048	0.725
MOD_GlcNHglycan	44	47	PF01048	0.687
MOD_GlcNHglycan	461	464	PF01048	0.737
MOD_GlcNHglycan	530	533	PF01048	0.649
MOD_GlcNHglycan	564	567	PF01048	0.725
MOD_GlcNHglycan	573	576	PF01048	0.758
MOD_GlcNHglycan	59	62	PF01048	0.604
MOD_GlcNHglycan	647	650	PF01048	0.528
MOD_GlcNHglycan	663	666	PF01048	0.461
MOD_GlcNHglycan	674	677	PF01048	0.640
MOD_GlcNHglycan	683	686	PF01048	0.762
MOD_GlcNHglycan	797	800	PF01048	0.768
MOD_GSK3_1	15	22	PF00069	0.690
MOD_GSK3_1	152	159	PF00069	0.660
MOD_GSK3_1	217	224	PF00069	0.655
MOD_GSK3_1	247	254	PF00069	0.747
MOD_GSK3_1	266	273	PF00069	0.575
MOD_GSK3_1	29	36	PF00069	0.760
MOD_GSK3_1	291	298	PF00069	0.759
MOD_GSK3_1	3	10	PF00069	0.666
MOD_GSK3_1	304	311	PF00069	0.592
MOD_GSK3_1	317	324	PF00069	0.826
MOD_GSK3_1	325	332	PF00069	0.744
MOD_GSK3_1	38	45	PF00069	0.670
MOD_GSK3_1	399	406	PF00069	0.734
MOD_GSK3_1	432	439	PF00069	0.698
MOD_GSK3_1	481	488	PF00069	0.648
MOD_GSK3_1	495	502	PF00069	0.590
MOD_GSK3_1	567	574	PF00069	0.784
MOD_GSK3_1	641	648	PF00069	0.530
MOD_GSK3_1	661	668	PF00069	0.753
MOD_GSK3_1	672	679	PF00069	0.564
MOD_GSK3_1	680	687	PF00069	0.749
MOD_GSK3_1	694	701	PF00069	0.604
MOD_GSK3_1	91	98	PF00069	0.611
MOD_LATS_1	316	322	PF00433	0.851
MOD_LATS_1	509	515	PF00433	0.622
MOD_N-GLC_1	279	284	PF02516	0.553
MOD_N-GLC_1	324	329	PF02516	0.735
MOD_N-GLC_1	499	504	PF02516	0.625
MOD_N-GLC_1	511	516	PF02516	0.443
MOD_NEK2_1	142	147	PF00069	0.591
MOD_NEK2_1	247	252	PF00069	0.747
MOD_NEK2_1	33	38	PF00069	0.486
MOD_NEK2_1	525	530	PF00069	0.623
MOD_NEK2_1	571	576	PF00069	0.809
MOD_NEK2_1	661	666	PF00069	0.653
MOD_NEK2_1	8	13	PF00069	0.677
MOD_PIKK_1	299	305	PF00454	0.750
MOD_PIKK_1	310	316	PF00454	0.616
MOD_PIKK_1	461	467	PF00454	0.832
MOD_PIKK_1	676	682	PF00454	0.738
MOD_PKA_1	178	184	PF00069	0.553
MOD_PKA_1	793	799	PF00069	0.760
MOD_PKA_2	317	323	PF00069	0.842
MOD_PKA_2	424	430	PF00069	0.677
MOD_PKA_2	523	529	PF00069	0.631
MOD_PKA_2	6	12	PF00069	0.677
MOD_PKA_2	793	799	PF00069	0.779
MOD_PKB_1	791	799	PF00069	0.761
MOD_Plk_1	29	35	PF00069	0.698
MOD_Plk_1	387	393	PF00069	0.631
MOD_Plk_1	656	662	PF00069	0.758
MOD_Plk_1	76	82	PF00069	0.450
MOD_Plk_4	118	124	PF00069	0.451
MOD_Plk_4	125	131	PF00069	0.458
MOD_Plk_4	610	616	PF00069	0.556
MOD_Plk_4	656	662	PF00069	0.622
MOD_Plk_4	95	101	PF00069	0.554
MOD_ProDKin_1	12	18	PF00069	0.697
MOD_ProDKin_1	149	155	PF00069	0.671
MOD_ProDKin_1	237	243	PF00069	0.766
MOD_ProDKin_1	253	259	PF00069	0.547
MOD_ProDKin_1	270	276	PF00069	0.751
MOD_ProDKin_1	292	298	PF00069	0.613
MOD_ProDKin_1	304	310	PF00069	0.759
MOD_ProDKin_1	329	335	PF00069	0.836
MOD_ProDKin_1	340	346	PF00069	0.804
MOD_ProDKin_1	36	42	PF00069	0.686
MOD_ProDKin_1	399	405	PF00069	0.601
MOD_ProDKin_1	436	442	PF00069	0.821
MOD_ProDKin_1	577	583	PF00069	0.849
MOD_ProDKin_1	651	657	PF00069	0.810
MOD_ProDKin_1	669	675	PF00069	0.698
MOD_ProDKin_1	694	700	PF00069	0.562
MOD_ProDKin_1	701	707	PF00069	0.770
MOD_ProDKin_1	753	759	PF00069	0.661
MOD_SUMO_rev_2	211	220	PF00179	0.597
TRG_DiLeu_BaEn_2	516	522	PF01217	0.589
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.799
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.658
TRG_DiLeu_LyEn_5	357	362	PF01217	0.620
TRG_ENDOCYTIC_2	131	134	PF00928	0.628
TRG_ENDOCYTIC_2	189	192	PF00928	0.498
TRG_ENDOCYTIC_2	507	510	PF00928	0.594
TRG_ENDOCYTIC_2	636	639	PF00928	0.724
TRG_ENDOCYTIC_2	688	691	PF00928	0.818
TRG_ENDOCYTIC_2	727	730	PF00928	0.470
TRG_ENDOCYTIC_2	782	785	PF00928	0.609
TRG_ENDOCYTIC_2	99	102	PF00928	0.496
TRG_ER_diArg_1	123	125	PF00400	0.514
TRG_ER_diArg_1	196	198	PF00400	0.537
TRG_ER_diArg_1	362	365	PF00400	0.727
TRG_ER_diArg_1	471	474	PF00400	0.667
TRG_ER_diArg_1	535	537	PF00400	0.714
TRG_ER_diArg_1	791	794	PF00400	0.746
TRG_NES_CRM1_1	418	430	PF08389	0.606
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH7	Leptomonas seymouri	50%	97%
A0A3Q8IK34	Leishmania donovani	91%	100%
A4HLH7	Leishmania braziliensis	76%	97%
A4I8Y7	Leishmania infantum	90%	100%
Q4Q468	Leishmania major	89%	98%