AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania mexicana

UniProt:

E9B3V4_LEIMU

TriTrypDb:

LmxM.32.1200

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B3V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3V4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.597
CLV_C14_Caspase3-7	381	385	PF00656	0.737
CLV_C14_Caspase3-7	410	414	PF00656	0.535
CLV_C14_Caspase3-7	429	433	PF00656	0.742
CLV_C14_Caspase3-7	450	454	PF00656	0.780
CLV_C14_Caspase3-7	58	62	PF00656	0.682
CLV_C14_Caspase3-7	613	617	PF00656	0.748
CLV_NRD_NRD_1	439	441	PF00675	0.543
CLV_PCSK_FUR_1	437	441	PF00082	0.571
CLV_PCSK_KEX2_1	351	353	PF00082	0.316
CLV_PCSK_KEX2_1	439	441	PF00082	0.547
CLV_PCSK_KEX2_1	507	509	PF00082	0.552
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.343
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.510
CLV_PCSK_SKI1_1	326	330	PF00082	0.369
CLV_PCSK_SKI1_1	352	356	PF00082	0.328
CLV_PCSK_SKI1_1	370	374	PF00082	0.328
CLV_PCSK_SKI1_1	485	489	PF00082	0.600
CLV_PCSK_SKI1_1	591	595	PF00082	0.437
CLV_PCSK_SKI1_1	83	87	PF00082	0.435
CLV_PCSK_SKI1_1	92	96	PF00082	0.466
CLV_Separin_Metazoa	645	649	PF03568	0.649
DEG_Nend_UBRbox_2	1	3	PF02207	0.453
DEG_SPOP_SBC_1	448	452	PF00917	0.587
DEG_SPOP_SBC_1	60	64	PF00917	0.667
DOC_CYCLIN_RxL_1	192	203	PF00134	0.730
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.588
DOC_MAPK_gen_1	351	359	PF00069	0.516
DOC_PP2B_LxvP_1	106	109	PF13499	0.741
DOC_SPAK_OSR1_1	376	380	PF12202	0.660
DOC_SPAK_OSR1_1	97	101	PF12202	0.738
DOC_USP7_MATH_1	176	180	PF00917	0.791
DOC_USP7_MATH_1	200	204	PF00917	0.680
DOC_USP7_MATH_1	227	231	PF00917	0.725
DOC_USP7_MATH_1	286	290	PF00917	0.667
DOC_USP7_MATH_1	32	36	PF00917	0.425
DOC_USP7_MATH_1	449	453	PF00917	0.689
DOC_USP7_MATH_1	614	618	PF00917	0.763
DOC_USP7_UBL2_3	206	210	PF12436	0.667
DOC_USP7_UBL2_3	313	317	PF12436	0.642
DOC_USP7_UBL2_3	378	382	PF12436	0.683
DOC_USP7_UBL2_3	383	387	PF12436	0.734
DOC_USP7_UBL2_3	503	507	PF12436	0.768
DOC_WW_Pin1_4	129	134	PF00397	0.709
DOC_WW_Pin1_4	623	628	PF00397	0.557
LIG_14-3-3_CanoR_1	140	147	PF00244	0.777
LIG_14-3-3_CanoR_1	148	152	PF00244	0.680
LIG_14-3-3_CanoR_1	361	369	PF00244	0.516
LIG_14-3-3_CanoR_1	52	57	PF00244	0.665
LIG_14-3-3_CanoR_1	574	584	PF00244	0.655
LIG_14-3-3_CanoR_1	83	93	PF00244	0.649
LIG_Actin_WH2_2	1	19	PF00022	0.478
LIG_Actin_WH2_2	134	150	PF00022	0.767
LIG_Actin_WH2_2	538	553	PF00022	0.650
LIG_BRCT_BRCA1_1	294	298	PF00533	0.554
LIG_BRCT_BRCA1_1	373	377	PF00533	0.644
LIG_BRCT_BRCA1_1	63	67	PF00533	0.724
LIG_CSL_BTD_1	44	47	PF09270	0.682
LIG_eIF4E_1	253	259	PF01652	0.638
LIG_eIF4E_1	349	355	PF01652	0.527
LIG_FHA_1	118	124	PF00498	0.728
LIG_FHA_1	140	146	PF00498	0.738
LIG_FHA_1	16	22	PF00498	0.411
LIG_FHA_1	413	419	PF00498	0.625
LIG_FHA_1	486	492	PF00498	0.794
LIG_FHA_1	519	525	PF00498	0.589
LIG_FHA_1	537	543	PF00498	0.565
LIG_FHA_1	554	560	PF00498	0.554
LIG_FHA_1	578	584	PF00498	0.642
LIG_FHA_1	605	611	PF00498	0.761
LIG_FHA_1	79	85	PF00498	0.689
LIG_FHA_1	89	95	PF00498	0.687
LIG_FHA_2	150	156	PF00498	0.770
LIG_FHA_2	202	208	PF00498	0.754
LIG_FHA_2	246	252	PF00498	0.634
LIG_FHA_2	348	354	PF00498	0.546
LIG_FHA_2	427	433	PF00498	0.738
LIG_FHA_2	448	454	PF00498	0.798
LIG_FHA_2	495	501	PF00498	0.738
LIG_FHA_2	637	643	PF00498	0.576
LIG_LIR_Apic_2	315	321	PF02991	0.591
LIG_LIR_Gen_1	102	113	PF02991	0.694
LIG_LIR_Gen_1	2	12	PF02991	0.417
LIG_LIR_Gen_1	292	300	PF02991	0.531
LIG_LIR_Nem_3	102	108	PF02991	0.701
LIG_LIR_Nem_3	189	193	PF02991	0.730
LIG_LIR_Nem_3	2	7	PF02991	0.425
LIG_LIR_Nem_3	292	296	PF02991	0.527
LIG_LIR_Nem_3	44	49	PF02991	0.614
LIG_MLH1_MIPbox_1	294	298	PF16413	0.553
LIG_NRBOX	326	332	PF00104	0.457
LIG_NRBOX	589	595	PF00104	0.648
LIG_PCNA_PIPBox_1	570	579	PF02747	0.548
LIG_Pex14_2	293	297	PF04695	0.517
LIG_Pex14_2	373	377	PF04695	0.627
LIG_PTB_Apo_2	122	129	PF02174	0.734
LIG_PTB_Apo_2	6	13	PF02174	0.439
LIG_SH2_CRK	126	130	PF00017	0.743
LIG_SH2_CRK	255	259	PF00017	0.592
LIG_SH2_CRK	318	322	PF00017	0.644
LIG_SH2_NCK_1	318	322	PF00017	0.644
LIG_SH2_PTP2	4	7	PF00017	0.331
LIG_SH2_SRC	318	321	PF00017	0.637
LIG_SH2_STAP1	119	123	PF00017	0.715
LIG_SH2_STAT3	253	256	PF00017	0.567
LIG_SH2_STAT5	105	108	PF00017	0.735
LIG_SH2_STAT5	119	122	PF00017	0.696
LIG_SH2_STAT5	126	129	PF00017	0.666
LIG_SH2_STAT5	196	199	PF00017	0.676
LIG_SH2_STAT5	253	256	PF00017	0.573
LIG_SH2_STAT5	349	352	PF00017	0.456
LIG_SH2_STAT5	4	7	PF00017	0.446
LIG_SH2_STAT5	40	43	PF00017	0.582
LIG_SH2_STAT5	407	410	PF00017	0.533
LIG_SH2_STAT5	56	59	PF00017	0.593
LIG_SH2_STAT5	576	579	PF00017	0.634
LIG_SH2_STAT5	89	92	PF00017	0.587
LIG_SH3_1	318	324	PF00018	0.642
LIG_SH3_2	321	326	PF14604	0.596
LIG_SH3_3	296	302	PF00018	0.613
LIG_SH3_3	318	324	PF00018	0.586
LIG_SH3_3	90	96	PF00018	0.704
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.473
LIG_SUMO_SIM_anti_2	641	648	PF11976	0.589
LIG_TRAF2_1	175	178	PF00917	0.792
LIG_TRAF2_1	364	367	PF00917	0.470
LIG_TRAF2_1	639	642	PF00917	0.620
LIG_TYR_ITIM	103	108	PF00017	0.729
LIG_UBA3_1	304	313	PF00899	0.594
MOD_CDC14_SPxK_1	132	135	PF00782	0.708
MOD_CDK_SPxK_1	129	135	PF00069	0.710
MOD_CK1_1	15	21	PF00069	0.411
MOD_CK1_1	170	176	PF00069	0.783
MOD_CK1_1	179	185	PF00069	0.769
MOD_CK1_1	208	214	PF00069	0.678
MOD_CK1_1	289	295	PF00069	0.562
MOD_CK1_1	394	400	PF00069	0.666
MOD_CK1_1	451	457	PF00069	0.775
MOD_CK1_1	55	61	PF00069	0.690
MOD_CK1_1	578	584	PF00069	0.650
MOD_CK2_1	227	233	PF00069	0.727
MOD_CK2_1	361	367	PF00069	0.469
MOD_CK2_1	454	460	PF00069	0.772
MOD_CK2_1	494	500	PF00069	0.738
MOD_CK2_1	589	595	PF00069	0.633
MOD_CK2_1	623	629	PF00069	0.561
MOD_CK2_1	636	642	PF00069	0.553
MOD_GlcNHglycan	169	172	PF01048	0.567
MOD_GlcNHglycan	288	291	PF01048	0.268
MOD_GlcNHglycan	35	38	PF01048	0.452
MOD_GlcNHglycan	373	376	PF01048	0.418
MOD_GlcNHglycan	456	459	PF01048	0.524
MOD_GlcNHglycan	471	474	PF01048	0.578
MOD_GlcNHglycan	616	620	PF01048	0.546
MOD_GlcNHglycan	63	66	PF01048	0.523
MOD_GlcNHglycan	71	76	PF01048	0.511
MOD_GSK3_1	201	208	PF00069	0.714
MOD_GSK3_1	243	250	PF00069	0.592
MOD_GSK3_1	334	341	PF00069	0.452
MOD_GSK3_1	357	364	PF00069	0.492
MOD_GSK3_1	447	454	PF00069	0.768
MOD_GSK3_1	458	465	PF00069	0.797
MOD_GSK3_1	485	492	PF00069	0.753
MOD_GSK3_1	503	510	PF00069	0.723
MOD_GSK3_1	55	62	PF00069	0.684
MOD_GSK3_1	595	602	PF00069	0.637
MOD_GSK3_1	604	611	PF00069	0.751
MOD_GSK3_1	615	622	PF00069	0.616
MOD_GSK3_1	84	91	PF00069	0.662
MOD_N-GLC_1	117	122	PF02516	0.518
MOD_N-GLC_1	129	134	PF02516	0.355
MOD_N-GLC_1	469	474	PF02516	0.582
MOD_N-GLC_1	599	604	PF02516	0.346
MOD_N-GLC_2	125	127	PF02516	0.330
MOD_NEK2_1	12	17	PF00069	0.441
MOD_NEK2_1	147	152	PF00069	0.742
MOD_NEK2_1	181	186	PF00069	0.780
MOD_NEK2_1	259	264	PF00069	0.550
MOD_NEK2_1	33	38	PF00069	0.401
MOD_NEK2_1	355	360	PF00069	0.502
MOD_NEK2_1	41	46	PF00069	0.526
MOD_NEK2_1	577	582	PF00069	0.658
MOD_NEK2_2	553	558	PF00069	0.579
MOD_NEK2_2	78	83	PF00069	0.699
MOD_OFUCOSY	390	395	PF10250	0.334
MOD_PIKK_1	170	176	PF00454	0.742
MOD_PIKK_1	181	187	PF00454	0.773
MOD_PIKK_1	494	500	PF00454	0.789
MOD_PK_1	104	110	PF00069	0.753
MOD_PKA_1	507	513	PF00069	0.742
MOD_PKA_2	139	145	PF00069	0.770
MOD_PKA_2	147	153	PF00069	0.739
MOD_PKA_2	458	464	PF00069	0.657
MOD_PKA_2	507	513	PF00069	0.741
MOD_Plk_1	232	238	PF00069	0.705
MOD_Plk_1	442	448	PF00069	0.761
MOD_Plk_1	615	621	PF00069	0.715
MOD_Plk_2-3	589	595	PF00069	0.619
MOD_Plk_2-3	636	642	PF00069	0.619
MOD_Plk_4	227	233	PF00069	0.737
MOD_Plk_4	292	298	PF00069	0.516
MOD_Plk_4	52	58	PF00069	0.693
MOD_Plk_4	545	551	PF00069	0.621
MOD_Plk_4	578	584	PF00069	0.686
MOD_Plk_4	85	91	PF00069	0.639
MOD_ProDKin_1	129	135	PF00069	0.710
MOD_ProDKin_1	623	629	PF00069	0.555
MOD_SUMO_for_1	420	423	PF00179	0.712
MOD_SUMO_rev_2	237	246	PF00179	0.707
MOD_SUMO_rev_2	309	315	PF00179	0.580
MOD_SUMO_rev_2	451	457	PF00179	0.760
MOD_SUMO_rev_2	460	465	PF00179	0.751
MOD_SUMO_rev_2	99	106	PF00179	0.726
TRG_DiLeu_BaEn_1	589	594	PF01217	0.643
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.636
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.614
TRG_ENDOCYTIC_2	105	108	PF00928	0.703
TRG_ENDOCYTIC_2	126	129	PF00928	0.701
TRG_ENDOCYTIC_2	196	199	PF00928	0.653
TRG_ENDOCYTIC_2	255	258	PF00928	0.563
TRG_ENDOCYTIC_2	4	7	PF00928	0.420
TRG_NES_CRM1_1	136	149	PF08389	0.775
TRG_NES_CRM1_1	367	381	PF08389	0.629
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V2	Leptomonas seymouri	59%	98%
A0A0S4JAD3	Bodo saltans	30%	100%
A0A0S4JHU3	Bodo saltans	33%	100%
A0A1X0NTT2	Trypanosomatidae	28%	97%
A0A1X0P9I4	Trypanosomatidae	29%	81%
A0A3S7X6K2	Leishmania donovani	91%	100%
A0A422NUH1	Trypanosoma rangeli	30%	97%
A0A422P3P3	Trypanosoma rangeli	33%	100%
A4HLH5	Leishmania braziliensis	72%	97%
A4I8Y5	Leishmania infantum	91%	100%
C9ZQW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
D0A1W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
Q4Q470	Leishmania major	90%	100%
V5DQN5	Trypanosoma cruzi	33%	100%