Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3V3_LEIMU

TriTrypDb:

LmxM.32.1190

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.468
CLV_C14_Caspase3-7	823	827	PF00656	0.640
CLV_NRD_NRD_1	136	138	PF00675	0.524
CLV_NRD_NRD_1	246	248	PF00675	0.433
CLV_NRD_NRD_1	286	288	PF00675	0.509
CLV_NRD_NRD_1	325	327	PF00675	0.618
CLV_NRD_NRD_1	39	41	PF00675	0.594
CLV_NRD_NRD_1	440	442	PF00675	0.615
CLV_NRD_NRD_1	462	464	PF00675	0.560
CLV_NRD_NRD_1	481	483	PF00675	0.587
CLV_NRD_NRD_1	487	489	PF00675	0.599
CLV_NRD_NRD_1	583	585	PF00675	0.576
CLV_NRD_NRD_1	63	65	PF00675	0.605
CLV_NRD_NRD_1	638	640	PF00675	0.667
CLV_NRD_NRD_1	763	765	PF00675	0.522
CLV_PCSK_FUR_1	284	288	PF00082	0.526
CLV_PCSK_KEX2_1	136	138	PF00082	0.524
CLV_PCSK_KEX2_1	246	248	PF00082	0.433
CLV_PCSK_KEX2_1	286	288	PF00082	0.509
CLV_PCSK_KEX2_1	325	327	PF00082	0.607
CLV_PCSK_KEX2_1	39	41	PF00082	0.594
CLV_PCSK_KEX2_1	440	442	PF00082	0.592
CLV_PCSK_KEX2_1	462	464	PF00082	0.560
CLV_PCSK_KEX2_1	481	483	PF00082	0.587
CLV_PCSK_KEX2_1	487	489	PF00082	0.599
CLV_PCSK_KEX2_1	583	585	PF00082	0.576
CLV_PCSK_KEX2_1	63	65	PF00082	0.605
CLV_PCSK_KEX2_1	638	640	PF00082	0.667
CLV_PCSK_KEX2_1	763	765	PF00082	0.522
CLV_PCSK_SKI1_1	136	140	PF00082	0.593
CLV_PCSK_SKI1_1	219	223	PF00082	0.570
CLV_PCSK_SKI1_1	39	43	PF00082	0.593
CLV_PCSK_SKI1_1	481	485	PF00082	0.718
CLV_PCSK_SKI1_1	63	67	PF00082	0.525
CLV_PCSK_SKI1_1	832	836	PF00082	0.454
CLV_Separin_Metazoa	666	670	PF03568	0.455
DEG_APCC_DBOX_1	135	143	PF00400	0.598
DEG_APCC_DBOX_1	38	46	PF00400	0.588
DEG_APCC_DBOX_1	62	70	PF00400	0.594
DEG_APCC_DBOX_1	8	16	PF00400	0.537
DEG_SCF_FBW7_1	843	848	PF00400	0.529
DOC_CKS1_1	520	525	PF01111	0.638
DOC_CYCLIN_RxL_1	133	141	PF00134	0.442
DOC_CYCLIN_RxL_1	61	71	PF00134	0.615
DOC_CYCLIN_RxL_1	829	836	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	721	727	PF00134	0.434
DOC_MAPK_gen_1	111	120	PF00069	0.511
DOC_MAPK_gen_1	14	23	PF00069	0.615
DOC_MAPK_gen_1	192	200	PF00069	0.569
DOC_MAPK_gen_1	39	47	PF00069	0.590
DOC_MAPK_gen_1	52	61	PF00069	0.446
DOC_MAPK_gen_1	63	69	PF00069	0.435
DOC_MAPK_gen_1	791	800	PF00069	0.493
DOC_MAPK_MEF2A_6	194	202	PF00069	0.548
DOC_MAPK_MEF2A_6	39	47	PF00069	0.536
DOC_MAPK_RevD_3	25	40	PF00069	0.598
DOC_PP1_RVXF_1	584	590	PF00149	0.531
DOC_PP1_RVXF_1	737	743	PF00149	0.528
DOC_PP2B_LxvP_1	30	33	PF13499	0.603
DOC_PP2B_LxvP_1	308	311	PF13499	0.443
DOC_PP2B_LxvP_1	43	46	PF13499	0.439
DOC_PP2B_LxvP_1	483	486	PF13499	0.479
DOC_PP2B_LxvP_1	569	572	PF13499	0.675
DOC_PP2B_LxvP_1	721	724	PF13499	0.536
DOC_PP4_FxxP_1	341	344	PF00568	0.387
DOC_USP7_MATH_1	193	197	PF00917	0.572
DOC_USP7_MATH_1	25	29	PF00917	0.482
DOC_USP7_MATH_1	260	264	PF00917	0.593
DOC_USP7_MATH_1	267	271	PF00917	0.595
DOC_USP7_MATH_1	332	336	PF00917	0.574
DOC_USP7_MATH_1	525	529	PF00917	0.721
DOC_USP7_MATH_1	683	687	PF00917	0.527
DOC_USP7_MATH_1	752	756	PF00917	0.656
DOC_USP7_MATH_1	839	843	PF00917	0.542
DOC_USP7_MATH_1	852	856	PF00917	0.520
DOC_WW_Pin1_4	175	180	PF00397	0.461
DOC_WW_Pin1_4	270	275	PF00397	0.518
DOC_WW_Pin1_4	397	402	PF00397	0.556
DOC_WW_Pin1_4	405	410	PF00397	0.601
DOC_WW_Pin1_4	508	513	PF00397	0.710
DOC_WW_Pin1_4	519	524	PF00397	0.566
DOC_WW_Pin1_4	536	541	PF00397	0.525
DOC_WW_Pin1_4	557	562	PF00397	0.653
DOC_WW_Pin1_4	657	662	PF00397	0.514
DOC_WW_Pin1_4	687	692	PF00397	0.549
DOC_WW_Pin1_4	723	728	PF00397	0.552
DOC_WW_Pin1_4	804	809	PF00397	0.526
DOC_WW_Pin1_4	841	846	PF00397	0.642
LIG_14-3-3_CanoR_1	114	119	PF00244	0.514
LIG_14-3-3_CanoR_1	192	202	PF00244	0.557
LIG_14-3-3_CanoR_1	256	265	PF00244	0.594
LIG_14-3-3_CanoR_1	331	341	PF00244	0.673
LIG_14-3-3_CanoR_1	402	409	PF00244	0.553
LIG_14-3-3_CanoR_1	516	520	PF00244	0.637
LIG_14-3-3_CanoR_1	586	596	PF00244	0.525
LIG_14-3-3_CanoR_1	638	647	PF00244	0.625
LIG_14-3-3_CanoR_1	715	723	PF00244	0.573
LIG_Actin_WH2_2	23	41	PF00022	0.525
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BIR_III_2	72	76	PF00653	0.558
LIG_BRCT_BRCA1_1	116	120	PF00533	0.648
LIG_BRCT_BRCA1_1	170	174	PF00533	0.596
LIG_BRCT_BRCA1_1	19	23	PF00533	0.411
LIG_BRCT_BRCA1_1	594	598	PF00533	0.549
LIG_CaM_NSCaTE_8	438	445	PF13499	0.573
LIG_DLG_GKlike_1	588	596	PF00625	0.560
LIG_EVH1_1	265	269	PF00568	0.487
LIG_FHA_1	175	181	PF00498	0.603
LIG_FHA_1	197	203	PF00498	0.425
LIG_FHA_1	209	215	PF00498	0.540
LIG_FHA_1	22	28	PF00498	0.525
LIG_FHA_1	225	231	PF00498	0.452
LIG_FHA_1	310	316	PF00498	0.528
LIG_FHA_1	337	343	PF00498	0.646
LIG_FHA_1	402	408	PF00498	0.552
LIG_FHA_1	425	431	PF00498	0.448
LIG_FHA_1	515	521	PF00498	0.606
LIG_FHA_1	548	554	PF00498	0.533
LIG_FHA_1	647	653	PF00498	0.418
LIG_FHA_1	842	848	PF00498	0.588
LIG_FHA_2	347	353	PF00498	0.470
LIG_FHA_2	509	515	PF00498	0.528
LIG_GBD_Chelix_1	102	110	PF00786	0.492
LIG_LIR_Apic_2	339	344	PF02991	0.415
LIG_LIR_Gen_1	20	31	PF02991	0.402
LIG_LIR_Gen_1	605	616	PF02991	0.486
LIG_LIR_Nem_3	20	26	PF02991	0.408
LIG_LIR_Nem_3	466	472	PF02991	0.545
LIG_LIR_Nem_3	605	611	PF02991	0.503
LIG_LIR_Nem_3	71	77	PF02991	0.556
LIG_LIR_Nem_3	719	725	PF02991	0.412
LIG_LIR_Nem_3	780	785	PF02991	0.583
LIG_LYPXL_yS_3	10	13	PF13949	0.590
LIG_MLH1_MIPbox_1	170	174	PF16413	0.542
LIG_NRBOX	134	140	PF00104	0.590
LIG_NRBOX	479	485	PF00104	0.613
LIG_PCNA_yPIPBox_3	471	484	PF02747	0.656
LIG_PDZ_Class_1	863	868	PF00595	0.555
LIG_SH2_NCK_1	104	108	PF00017	0.491
LIG_SH2_SRC	185	188	PF00017	0.354
LIG_SH2_STAP1	232	236	PF00017	0.470
LIG_SH2_STAP1	241	245	PF00017	0.436
LIG_SH2_STAT3	785	788	PF00017	0.600
LIG_SH2_STAT5	185	188	PF00017	0.433
LIG_SH2_STAT5	519	522	PF00017	0.787
LIG_SH2_STAT5	608	611	PF00017	0.465
LIG_SH2_STAT5	722	725	PF00017	0.413
LIG_SH2_STAT5	785	788	PF00017	0.600
LIG_SH3_2	470	475	PF14604	0.615
LIG_SH3_3	145	151	PF00018	0.543
LIG_SH3_3	263	269	PF00018	0.490
LIG_SH3_3	308	314	PF00018	0.486
LIG_SH3_3	431	437	PF00018	0.637
LIG_SH3_3	467	473	PF00018	0.670
LIG_SH3_3	497	503	PF00018	0.527
LIG_SH3_3	5	11	PF00018	0.509
LIG_SH3_3	530	536	PF00018	0.523
LIG_SH3_3	62	68	PF00018	0.537
LIG_SH3_3	652	658	PF00018	0.441
LIG_SH3_3	702	708	PF00018	0.464
LIG_SH3_3	721	727	PF00018	0.345
LIG_SUMO_SIM_par_1	276	282	PF11976	0.410
LIG_SUMO_SIM_par_1	360	368	PF11976	0.447
LIG_SUMO_SIM_par_1	550	556	PF11976	0.536
LIG_SUMO_SIM_par_1	621	626	PF11976	0.573
LIG_SxIP_EBH_1	854	867	PF03271	0.550
LIG_TRAF2_1	130	133	PF00917	0.634
LIG_TRAF2_1	571	574	PF00917	0.668
LIG_TRAF2_1	694	697	PF00917	0.588
LIG_TYR_ITIM	720	725	PF00017	0.409
LIG_TYR_ITIM	8	13	PF00017	0.447
LIG_UBA3_1	371	376	PF00899	0.523
LIG_UBA3_1	737	744	PF00899	0.398
LIG_WRC_WIRS_1	611	616	PF05994	0.444
MOD_CDK_SPK_2	397	402	PF00069	0.541
MOD_CDK_SPK_2	405	410	PF00069	0.601
MOD_CDK_SPK_2	657	662	PF00069	0.527
MOD_CK1_1	149	155	PF00069	0.637
MOD_CK1_1	175	181	PF00069	0.629
MOD_CK1_1	196	202	PF00069	0.482
MOD_CK1_1	270	276	PF00069	0.546
MOD_CK1_1	367	373	PF00069	0.392
MOD_CK1_1	425	431	PF00069	0.622
MOD_CK1_1	508	514	PF00069	0.643
MOD_CK1_1	528	534	PF00069	0.475
MOD_CK1_1	610	616	PF00069	0.446
MOD_CK1_1	755	761	PF00069	0.651
MOD_CK1_1	817	823	PF00069	0.560
MOD_CK1_1	841	847	PF00069	0.585
MOD_CK1_1	89	95	PF00069	0.607
MOD_CK2_1	102	108	PF00069	0.495
MOD_CK2_1	127	133	PF00069	0.720
MOD_CK2_1	508	514	PF00069	0.709
MOD_CK2_1	756	762	PF00069	0.594
MOD_CMANNOS	435	438	PF00535	0.552
MOD_Cter_Amidation	284	287	PF01082	0.543
MOD_GlcNHglycan	123	126	PF01048	0.521
MOD_GlcNHglycan	151	154	PF01048	0.632
MOD_GlcNHglycan	262	265	PF01048	0.677
MOD_GlcNHglycan	269	272	PF01048	0.581
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	385	388	PF01048	0.474
MOD_GlcNHglycan	414	417	PF01048	0.703
MOD_GlcNHglycan	424	427	PF01048	0.554
MOD_GlcNHglycan	507	510	PF01048	0.629
MOD_GlcNHglycan	604	607	PF01048	0.686
MOD_GlcNHglycan	625	628	PF01048	0.509
MOD_GlcNHglycan	731	734	PF01048	0.415
MOD_GlcNHglycan	752	755	PF01048	0.611
MOD_GlcNHglycan	770	773	PF01048	0.695
MOD_GlcNHglycan	802	805	PF01048	0.699
MOD_GlcNHglycan	816	819	PF01048	0.520
MOD_GlcNHglycan	822	825	PF01048	0.500
MOD_GlcNHglycan	847	850	PF01048	0.648
MOD_GlcNHglycan	89	92	PF01048	0.570
MOD_GSK3_1	114	121	PF00069	0.583
MOD_GSK3_1	149	156	PF00069	0.598
MOD_GSK3_1	168	175	PF00069	0.571
MOD_GSK3_1	17	24	PF00069	0.486
MOD_GSK3_1	204	211	PF00069	0.587
MOD_GSK3_1	255	262	PF00069	0.554
MOD_GSK3_1	332	339	PF00069	0.474
MOD_GSK3_1	363	370	PF00069	0.342
MOD_GSK3_1	397	404	PF00069	0.539
MOD_GSK3_1	425	432	PF00069	0.547
MOD_GSK3_1	514	521	PF00069	0.528
MOD_GSK3_1	536	543	PF00069	0.685
MOD_GSK3_1	547	554	PF00069	0.636
MOD_GSK3_1	588	595	PF00069	0.558
MOD_GSK3_1	683	690	PF00069	0.518
MOD_GSK3_1	752	759	PF00069	0.546
MOD_GSK3_1	796	803	PF00069	0.701
MOD_GSK3_1	82	89	PF00069	0.639
MOD_GSK3_1	841	848	PF00069	0.612
MOD_GSK3_1	852	859	PF00069	0.432
MOD_N-GLC_1	417	422	PF02516	0.561
MOD_N-GLC_1	86	91	PF02516	0.613
MOD_NEK2_1	1	6	PF00069	0.541
MOD_NEK2_1	118	123	PF00069	0.649
MOD_NEK2_1	138	143	PF00069	0.428
MOD_NEK2_1	173	178	PF00069	0.470
MOD_NEK2_1	26	31	PF00069	0.500
MOD_NEK2_1	383	388	PF00069	0.510
MOD_NEK2_1	553	558	PF00069	0.551
MOD_NEK2_1	587	592	PF00069	0.523
MOD_NEK2_1	594	599	PF00069	0.535
MOD_NEK2_1	800	805	PF00069	0.679
MOD_NEK2_1	856	861	PF00069	0.569
MOD_NEK2_1	86	91	PF00069	0.613
MOD_NEK2_2	752	757	PF00069	0.654
MOD_PIKK_1	332	338	PF00454	0.474
MOD_PIKK_1	374	380	PF00454	0.465
MOD_PIKK_1	463	469	PF00454	0.514
MOD_PKA_1	638	644	PF00069	0.646
MOD_PKA_2	193	199	PF00069	0.580
MOD_PKA_2	255	261	PF00069	0.565
MOD_PKA_2	332	338	PF00069	0.635
MOD_PKA_2	346	352	PF00069	0.433
MOD_PKA_2	401	407	PF00069	0.561
MOD_PKA_2	515	521	PF00069	0.595
MOD_PKA_2	587	593	PF00069	0.524
MOD_PKA_2	637	643	PF00069	0.653
MOD_PKA_2	714	720	PF00069	0.520
MOD_PKB_1	586	594	PF00069	0.564
MOD_Plk_1	367	373	PF00069	0.392
MOD_Plk_1	417	423	PF00069	0.559
MOD_Plk_4	138	144	PF00069	0.458
MOD_Plk_4	17	23	PF00069	0.453
MOD_Plk_4	196	202	PF00069	0.540
MOD_Plk_4	337	343	PF00069	0.444
MOD_Plk_4	367	373	PF00069	0.341
MOD_Plk_4	515	521	PF00069	0.606
MOD_Plk_4	525	531	PF00069	0.608
MOD_Plk_4	588	594	PF00069	0.562
MOD_Plk_4	607	613	PF00069	0.469
MOD_Plk_4	756	762	PF00069	0.594
MOD_Plk_4	777	783	PF00069	0.631
MOD_Plk_4	807	813	PF00069	0.595
MOD_Plk_4	856	862	PF00069	0.617
MOD_Plk_4	89	95	PF00069	0.596
MOD_ProDKin_1	175	181	PF00069	0.453
MOD_ProDKin_1	270	276	PF00069	0.502
MOD_ProDKin_1	397	403	PF00069	0.557
MOD_ProDKin_1	405	411	PF00069	0.600
MOD_ProDKin_1	508	514	PF00069	0.709
MOD_ProDKin_1	519	525	PF00069	0.566
MOD_ProDKin_1	536	542	PF00069	0.525
MOD_ProDKin_1	557	563	PF00069	0.651
MOD_ProDKin_1	657	663	PF00069	0.513
MOD_ProDKin_1	687	693	PF00069	0.552
MOD_ProDKin_1	723	729	PF00069	0.548
MOD_ProDKin_1	804	810	PF00069	0.527
MOD_ProDKin_1	841	847	PF00069	0.643
MOD_SUMO_for_1	699	702	PF00179	0.456
TRG_DiLeu_BaEn_4	718	724	PF01217	0.509
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.576
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.498
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.552
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.514
TRG_DiLeu_BaLyEn_6	842	847	PF01217	0.462
TRG_ENDOCYTIC_2	10	13	PF00928	0.590
TRG_ENDOCYTIC_2	608	611	PF00928	0.465
TRG_ENDOCYTIC_2	722	725	PF00928	0.413
TRG_ENDOCYTIC_2	78	81	PF00928	0.415
TRG_ER_diArg_1	13	16	PF00400	0.580
TRG_ER_diArg_1	135	137	PF00400	0.520
TRG_ER_diArg_1	245	247	PF00400	0.400
TRG_ER_diArg_1	283	286	PF00400	0.495
TRG_ER_diArg_1	325	327	PF00400	0.638
TRG_ER_diArg_1	330	333	PF00400	0.633
TRG_ER_diArg_1	38	40	PF00400	0.597
TRG_ER_diArg_1	440	442	PF00400	0.615
TRG_ER_diArg_1	461	463	PF00400	0.562
TRG_ER_diArg_1	480	482	PF00400	0.570
TRG_ER_diArg_1	486	488	PF00400	0.636
TRG_ER_diArg_1	583	586	PF00400	0.535
TRG_ER_diArg_1	63	65	PF00400	0.601
TRG_ER_diArg_1	679	682	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS9	Leptomonas seymouri	36%	93%
A0A3S7X6J9	Leishmania donovani	83%	98%
A4HLH4	Leishmania braziliensis	66%	97%
A4I8Y4	Leishmania infantum	84%	98%
Q4Q471	Leishmania major	83%	100%