Putative pumilio protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3U9_LEIMU

TriTrypDb:

LmxM.32.1150

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U9

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.493
CLV_C14_Caspase3-7	697	701	PF00656	0.649
CLV_C14_Caspase3-7	712	716	PF00656	0.374
CLV_NRD_NRD_1	154	156	PF00675	0.731
CLV_NRD_NRD_1	337	339	PF00675	0.723
CLV_NRD_NRD_1	789	791	PF00675	0.502
CLV_NRD_NRD_1	94	96	PF00675	0.453
CLV_PCSK_KEX2_1	337	339	PF00082	0.723
CLV_PCSK_KEX2_1	675	677	PF00082	0.490
CLV_PCSK_KEX2_1	789	791	PF00082	0.502
CLV_PCSK_KEX2_1	94	96	PF00082	0.453
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.490
CLV_PCSK_PC7_1	333	339	PF00082	0.749
CLV_PCSK_SKI1_1	704	708	PF00082	0.620
CLV_PCSK_SKI1_1	711	715	PF00082	0.463
CLV_PCSK_SKI1_1	769	773	PF00082	0.461
CLV_PCSK_SKI1_1	791	795	PF00082	0.563
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DEG_SPOP_SBC_1	803	807	PF00917	0.695
DOC_ANK_TNKS_1	20	27	PF00023	0.735
DOC_ANK_TNKS_1	695	702	PF00023	0.697
DOC_CKS1_1	129	134	PF01111	0.730
DOC_CKS1_1	209	214	PF01111	0.618
DOC_MAPK_DCC_7	112	122	PF00069	0.632
DOC_MAPK_gen_1	711	720	PF00069	0.587
DOC_MAPK_gen_1	786	794	PF00069	0.551
DOC_MAPK_MEF2A_6	466	474	PF00069	0.425
DOC_PP2B_LxvP_1	223	226	PF13499	0.727
DOC_PP4_FxxP_1	444	447	PF00568	0.399
DOC_PP4_FxxP_1	66	69	PF00568	0.733
DOC_USP7_MATH_1	116	120	PF00917	0.671
DOC_USP7_MATH_1	138	142	PF00917	0.841
DOC_USP7_MATH_1	210	214	PF00917	0.749
DOC_USP7_MATH_1	224	228	PF00917	0.601
DOC_USP7_MATH_1	69	73	PF00917	0.771
DOC_USP7_MATH_1	694	698	PF00917	0.728
DOC_USP7_MATH_2	132	138	PF00917	0.712
DOC_USP7_UBL2_3	156	160	PF12436	0.726
DOC_USP7_UBL2_3	462	466	PF12436	0.425
DOC_USP7_UBL2_3	610	614	PF12436	0.340
DOC_WW_Pin1_4	128	133	PF00397	0.728
DOC_WW_Pin1_4	190	195	PF00397	0.601
DOC_WW_Pin1_4	202	207	PF00397	0.605
DOC_WW_Pin1_4	208	213	PF00397	0.594
DOC_WW_Pin1_4	429	434	PF00397	0.469
DOC_WW_Pin1_4	443	448	PF00397	0.335
DOC_WW_Pin1_4	466	471	PF00397	0.430
DOC_WW_Pin1_4	57	62	PF00397	0.723
DOC_WW_Pin1_4	644	649	PF00397	0.433
DOC_WW_Pin1_4	72	77	PF00397	0.652
LIG_14-3-3_CanoR_1	359	367	PF00244	0.689
LIG_14-3-3_CanoR_1	676	684	PF00244	0.549
LIG_14-3-3_CanoR_1	775	780	PF00244	0.531
LIG_14-3-3_CanoR_1	94	102	PF00244	0.479
LIG_BRCT_BRCA1_1	194	198	PF00533	0.671
LIG_BRCT_BRCA1_1	377	381	PF00533	0.715
LIG_CSL_BTD_1	691	694	PF09270	0.686
LIG_CtBP_PxDLS_1	447	451	PF00389	0.365
LIG_eIF4E_1	458	464	PF01652	0.340
LIG_FHA_1	467	473	PF00498	0.425
LIG_FHA_1	679	685	PF00498	0.723
LIG_FHA_2	125	131	PF00498	0.727
LIG_FHA_2	272	278	PF00498	0.719
LIG_FHA_2	662	668	PF00498	0.373
LIG_FHA_2	700	706	PF00498	0.685
LIG_FHA_2	73	79	PF00498	0.474
LIG_IBAR_NPY_1	179	181	PF08397	0.634
LIG_IBAR_NPY_1	300	302	PF08397	0.661
LIG_LIR_Apic_2	442	447	PF02991	0.395
LIG_LIR_Apic_2	64	69	PF02991	0.733
LIG_LIR_Apic_2	768	773	PF02991	0.442
LIG_LIR_Apic_2	776	782	PF02991	0.412
LIG_LIR_Gen_1	124	132	PF02991	0.710
LIG_LIR_Gen_1	437	448	PF02991	0.365
LIG_LIR_Gen_1	579	589	PF02991	0.341
LIG_LIR_Gen_1	616	627	PF02991	0.415
LIG_LIR_Gen_1	758	767	PF02991	0.340
LIG_LIR_Gen_1	78	83	PF02991	0.485
LIG_LIR_Nem_3	130	136	PF02991	0.764
LIG_LIR_Nem_3	196	202	PF02991	0.603
LIG_LIR_Nem_3	437	443	PF02991	0.372
LIG_LIR_Nem_3	452	458	PF02991	0.363
LIG_LIR_Nem_3	579	585	PF02991	0.341
LIG_LIR_Nem_3	595	600	PF02991	0.340
LIG_LIR_Nem_3	616	622	PF02991	0.415
LIG_LIR_Nem_3	64	70	PF02991	0.666
LIG_LIR_Nem_3	740	746	PF02991	0.507
LIG_LIR_Nem_3	758	763	PF02991	0.226
LIG_LIR_Nem_3	78	82	PF02991	0.447
LIG_LIR_Nem_3	98	103	PF02991	0.324
LIG_LYPXL_S_1	66	70	PF13949	0.677
LIG_LYPXL_yS_3	67	70	PF13949	0.672
LIG_MYND_3	117	121	PF01753	0.600
LIG_NRBOX	459	465	PF00104	0.340
LIG_NRP_CendR_1	841	842	PF00754	0.666
LIG_PCNA_yPIPBox_3	457	466	PF02747	0.346
LIG_PCNA_yPIPBox_3	594	606	PF02747	0.345
LIG_Pex14_2	440	444	PF04695	0.340
LIG_SH2_CRK	317	321	PF00017	0.770
LIG_SH2_CRK	50	54	PF00017	0.740
LIG_SH2_CRK	619	623	PF00017	0.469
LIG_SH2_CRK	779	783	PF00017	0.436
LIG_SH2_GRB2like	50	53	PF00017	0.597
LIG_SH2_GRB2like	743	746	PF00017	0.455
LIG_SH2_NCK_1	317	321	PF00017	0.719
LIG_SH2_NCK_1	50	54	PF00017	0.699
LIG_SH2_PTP2	770	773	PF00017	0.553
LIG_SH2_SRC	218	221	PF00017	0.631
LIG_SH2_STAP1	410	414	PF00017	0.400
LIG_SH2_STAP1	50	54	PF00017	0.610
LIG_SH2_STAP1	743	747	PF00017	0.455
LIG_SH2_STAT3	2	5	PF00017	0.705
LIG_SH2_STAT3	260	263	PF00017	0.630
LIG_SH2_STAT3	458	461	PF00017	0.340
LIG_SH2_STAT3	600	603	PF00017	0.340
LIG_SH2_STAT3	746	749	PF00017	0.340
LIG_SH2_STAT5	261	264	PF00017	0.623
LIG_SH2_STAT5	458	461	PF00017	0.367
LIG_SH2_STAT5	600	603	PF00017	0.340
LIG_SH2_STAT5	628	631	PF00017	0.425
LIG_SH2_STAT5	746	749	PF00017	0.340
LIG_SH2_STAT5	770	773	PF00017	0.416
LIG_SH2_STAT5	777	780	PF00017	0.441
LIG_SH3_3	105	111	PF00018	0.657
LIG_SH3_3	790	796	PF00018	0.485
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.409
LIG_SUMO_SIM_anti_2	445	453	PF11976	0.282
LIG_SUMO_SIM_anti_2	667	673	PF11976	0.507
LIG_SUMO_SIM_par_1	445	453	PF11976	0.365
LIG_SUMO_SIM_par_1	482	487	PF11976	0.367
LIG_TRAF2_1	575	578	PF00917	0.340
LIG_UBA3_1	511	516	PF00899	0.400
LIG_UBA3_1	581	587	PF00899	0.400
MOD_CDK_SPxxK_3	644	651	PF00069	0.455
MOD_CK1_1	184	190	PF00069	0.692
MOD_CK1_1	193	199	PF00069	0.555
MOD_CK1_1	248	254	PF00069	0.667
MOD_CK1_1	3	9	PF00069	0.651
MOD_CK1_1	369	375	PF00069	0.675
MOD_CK1_1	432	438	PF00069	0.425
MOD_CK1_1	548	554	PF00069	0.429
MOD_CK1_1	72	78	PF00069	0.526
MOD_CK1_1	807	813	PF00069	0.771
MOD_CK2_1	124	130	PF00069	0.727
MOD_CK2_1	443	449	PF00069	0.481
MOD_CK2_1	610	616	PF00069	0.373
MOD_CK2_1	699	705	PF00069	0.696
MOD_CK2_1	828	834	PF00069	0.754
MOD_Cter_Amidation	153	156	PF01082	0.736
MOD_GlcNHglycan	13	16	PF01048	0.675
MOD_GlcNHglycan	134	139	PF01048	0.720
MOD_GlcNHglycan	150	153	PF01048	0.849
MOD_GlcNHglycan	227	230	PF01048	0.684
MOD_GlcNHglycan	247	250	PF01048	0.630
MOD_GlcNHglycan	30	33	PF01048	0.679
MOD_GlcNHglycan	342	345	PF01048	0.743
MOD_GlcNHglycan	362	365	PF01048	0.737
MOD_GlcNHglycan	371	374	PF01048	0.743
MOD_GlcNHglycan	42	45	PF01048	0.794
MOD_GlcNHglycan	425	428	PF01048	0.384
MOD_GlcNHglycan	547	550	PF01048	0.443
MOD_GSK3_1	124	131	PF00069	0.809
MOD_GSK3_1	134	141	PF00069	0.719
MOD_GSK3_1	144	151	PF00069	0.514
MOD_GSK3_1	186	193	PF00069	0.768
MOD_GSK3_1	283	290	PF00069	0.735
MOD_GSK3_1	315	322	PF00069	0.776
MOD_GSK3_1	371	378	PF00069	0.716
MOD_GSK3_1	423	430	PF00069	0.480
MOD_GSK3_1	466	473	PF00069	0.516
MOD_GSK3_1	57	64	PF00069	0.685
MOD_GSK3_1	610	617	PF00069	0.373
MOD_GSK3_1	674	681	PF00069	0.578
MOD_GSK3_1	68	75	PF00069	0.423
MOD_GSK3_1	688	695	PF00069	0.745
MOD_GSK3_1	802	809	PF00069	0.762
MOD_N-GLC_1	340	345	PF02516	0.740
MOD_NEK2_1	271	276	PF00069	0.654
MOD_NEK2_1	315	320	PF00069	0.769
MOD_NEK2_1	423	428	PF00069	0.425
MOD_NEK2_1	545	550	PF00069	0.404
MOD_NEK2_1	627	632	PF00069	0.459
MOD_NEK2_1	674	679	PF00069	0.554
MOD_NEK2_1	82	87	PF00069	0.594
MOD_NEK2_2	699	704	PF00069	0.670
MOD_PIKK_1	169	175	PF00454	0.724
MOD_PIKK_1	193	199	PF00454	0.605
MOD_PIKK_1	254	260	PF00454	0.672
MOD_PIKK_1	283	289	PF00454	0.804
MOD_PIKK_1	315	321	PF00454	0.721
MOD_PIKK_1	397	403	PF00454	0.562
MOD_PIKK_1	93	99	PF00454	0.518
MOD_PK_1	614	620	PF00069	0.478
MOD_PKA_1	675	681	PF00069	0.492
MOD_PKA_2	17	23	PF00069	0.667
MOD_PKA_2	230	236	PF00069	0.687
MOD_PKA_2	245	251	PF00069	0.738
MOD_PKA_2	675	681	PF00069	0.511
MOD_PKA_2	785	791	PF00069	0.553
MOD_PKA_2	93	99	PF00069	0.470
MOD_Plk_1	134	140	PF00069	0.766
MOD_Plk_1	3	9	PF00069	0.596
MOD_Plk_1	484	490	PF00069	0.455
MOD_Plk_1	577	583	PF00069	0.455
MOD_Plk_4	181	187	PF00069	0.828
MOD_Plk_4	577	583	PF00069	0.457
MOD_Plk_4	614	620	PF00069	0.478
MOD_Plk_4	62	68	PF00069	0.684
MOD_Plk_4	730	736	PF00069	0.392
MOD_ProDKin_1	128	134	PF00069	0.729
MOD_ProDKin_1	190	196	PF00069	0.599
MOD_ProDKin_1	202	208	PF00069	0.602
MOD_ProDKin_1	429	435	PF00069	0.469
MOD_ProDKin_1	443	449	PF00069	0.341
MOD_ProDKin_1	466	472	PF00069	0.430
MOD_ProDKin_1	57	63	PF00069	0.722
MOD_ProDKin_1	644	650	PF00069	0.433
MOD_ProDKin_1	72	78	PF00069	0.650
MOD_SUMO_for_1	609	612	PF00179	0.365
MOD_SUMO_rev_2	161	169	PF00179	0.631
MOD_SUMO_rev_2	393	400	PF00179	0.552
MOD_SUMO_rev_2	611	615	PF00179	0.346
MOD_SUMO_rev_2	708	716	PF00179	0.643
TRG_DiLeu_BaEn_2	418	424	PF01217	0.340
TRG_DiLeu_BaEn_2	755	761	PF01217	0.425
TRG_ENDOCYTIC_2	302	305	PF00928	0.724
TRG_ENDOCYTIC_2	50	53	PF00928	0.698
TRG_ENDOCYTIC_2	619	622	PF00928	0.469
TRG_ENDOCYTIC_2	67	70	PF00928	0.660
TRG_ER_diArg_1	337	339	PF00400	0.727
TRG_ER_diArg_1	93	95	PF00400	0.451
TRG_NES_CRM1_1	477	489	PF08389	0.425
TRG_NES_CRM1_1	579	595	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2G5	Trypanosomatidae	48%	92%
A0A3Q8IET5	Leishmania donovani	96%	100%
A0A3R7N6T6	Trypanosoma rangeli	50%	100%
A4HLH0	Leishmania braziliensis	88%	99%
A4I8Y0	Leishmania infantum	96%	100%
D0A4X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q475	Leishmania major	96%	100%
V5BZN6	Trypanosoma cruzi	49%	100%