IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3U8_LEIMU

TriTrypDb:

LmxM.32.1140

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B3U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.388
CLV_C14_Caspase3-7	296	300	PF00656	0.363
CLV_NRD_NRD_1	358	360	PF00675	0.600
CLV_NRD_NRD_1	392	394	PF00675	0.464
CLV_NRD_NRD_1	421	423	PF00675	0.497
CLV_PCSK_KEX2_1	358	360	PF00082	0.600
CLV_PCSK_SKI1_1	208	212	PF00082	0.454
CLV_PCSK_SKI1_1	56	60	PF00082	0.582
DEG_SPOP_SBC_1	238	242	PF00917	0.262
DOC_MAPK_DCC_7	82	90	PF00069	0.297
DOC_MAPK_RevD_3	379	394	PF00069	0.353
DOC_PP4_MxPP_1	320	323	PF00568	0.356
DOC_SPAK_OSR1_1	200	204	PF12202	0.406
DOC_USP7_MATH_1	238	242	PF00917	0.368
DOC_USP7_MATH_1	243	247	PF00917	0.375
DOC_USP7_MATH_1	274	278	PF00917	0.448
DOC_USP7_MATH_1	302	306	PF00917	0.351
DOC_USP7_MATH_1	344	348	PF00917	0.462
DOC_USP7_MATH_1	417	421	PF00917	0.728
DOC_USP7_MATH_1	76	80	PF00917	0.418
DOC_USP7_UBL2_3	204	208	PF12436	0.356
DOC_WW_Pin1_4	279	284	PF00397	0.333
DOC_WW_Pin1_4	298	303	PF00397	0.479
DOC_WW_Pin1_4	318	323	PF00397	0.350
LIG_14-3-3_CanoR_1	359	369	PF00244	0.349
LIG_Actin_WH2_2	31	49	PF00022	0.253
LIG_Actin_WH2_2	377	395	PF00022	0.353
LIG_BRCT_BRCA1_1	144	148	PF00533	0.341
LIG_BRCT_BRCA1_1	154	158	PF00533	0.356
LIG_deltaCOP1_diTrp_1	134	142	PF00928	0.356
LIG_FHA_1	17	23	PF00498	0.420
LIG_FHA_1	172	178	PF00498	0.363
LIG_FHA_1	184	190	PF00498	0.382
LIG_FHA_1	205	211	PF00498	0.339
LIG_FHA_1	240	246	PF00498	0.310
LIG_FHA_1	286	292	PF00498	0.409
LIG_FHA_1	87	93	PF00498	0.418
LIG_FHA_2	204	210	PF00498	0.335
LIG_FHA_2	294	300	PF00498	0.384
LIG_FHA_2	49	55	PF00498	0.418
LIG_FHA_2	57	63	PF00498	0.352
LIG_FHA_2	94	100	PF00498	0.348
LIG_HCF-1_HBM_1	261	264	PF13415	0.358
LIG_LIR_Gen_1	261	271	PF02991	0.340
LIG_LIR_Gen_1	363	374	PF02991	0.305
LIG_LIR_Gen_1	388	395	PF02991	0.340
LIG_LIR_Nem_3	155	161	PF02991	0.338
LIG_LIR_Nem_3	261	267	PF02991	0.343
LIG_LIR_Nem_3	305	309	PF02991	0.330
LIG_LIR_Nem_3	363	369	PF02991	0.322
LIG_LIR_Nem_3	388	392	PF02991	0.231
LIG_PCNA_APIM_2	198	204	PF02747	0.404
LIG_PCNA_yPIPBox_3	311	320	PF02747	0.413
LIG_Pex14_2	376	380	PF04695	0.413
LIG_SH2_CRK	10	14	PF00017	0.360
LIG_SH2_CRK	154	158	PF00017	0.324
LIG_SH2_CRK	199	203	PF00017	0.324
LIG_SH2_NCK_1	10	14	PF00017	0.386
LIG_SH2_PTP2	366	369	PF00017	0.353
LIG_SH2_STAP1	154	158	PF00017	0.324
LIG_SH2_STAT5	325	328	PF00017	0.335
LIG_SH2_STAT5	366	369	PF00017	0.413
LIG_SH3_3	1	7	PF00018	0.460
LIG_SH3_3	220	226	PF00018	0.334
LIG_SUMO_SIM_anti_2	209	217	PF11976	0.251
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.368
LIG_SUMO_SIM_par_1	176	181	PF11976	0.365
LIG_SUMO_SIM_par_1	209	217	PF11976	0.349
LIG_SUMO_SIM_par_1	88	94	PF11976	0.399
LIG_TRAF2_1	52	55	PF00917	0.375
LIG_WW_1	322	325	PF00397	0.369
LIG_WW_2	225	228	PF00397	0.349
LIG_WW_3	321	325	PF00397	0.361
MOD_CAAXbox	429	432	PF01239	0.687
MOD_CDC14_SPxK_1	321	324	PF00782	0.439
MOD_CDK_SPxK_1	318	324	PF00069	0.437
MOD_CK1_1	113	119	PF00069	0.418
MOD_CK1_1	171	177	PF00069	0.484
MOD_CK1_1	282	288	PF00069	0.279
MOD_CK1_1	348	354	PF00069	0.496
MOD_CK1_1	410	416	PF00069	0.674
MOD_CK2_1	344	350	PF00069	0.467
MOD_CK2_1	48	54	PF00069	0.414
MOD_CK2_1	93	99	PF00069	0.338
MOD_Cter_Amidation	356	359	PF01082	0.611
MOD_GlcNHglycan	122	125	PF01048	0.686
MOD_GlcNHglycan	144	147	PF01048	0.567
MOD_GlcNHglycan	245	248	PF01048	0.598
MOD_GlcNHglycan	252	255	PF01048	0.638
MOD_GlcNHglycan	276	279	PF01048	0.569
MOD_GlcNHglycan	332	335	PF01048	0.609
MOD_GlcNHglycan	362	365	PF01048	0.695
MOD_GlcNHglycan	79	82	PF01048	0.648
MOD_GSK3_1	113	120	PF00069	0.385
MOD_GSK3_1	126	133	PF00069	0.386
MOD_GSK3_1	140	147	PF00069	0.346
MOD_GSK3_1	176	183	PF00069	0.381
MOD_GSK3_1	239	246	PF00069	0.341
MOD_GSK3_1	248	255	PF00069	0.410
MOD_GSK3_1	281	288	PF00069	0.348
MOD_GSK3_1	289	296	PF00069	0.477
MOD_GSK3_1	298	305	PF00069	0.398
MOD_GSK3_1	338	345	PF00069	0.411
MOD_GSK3_1	67	74	PF00069	0.357
MOD_N-GLC_2	427	429	PF02516	0.392
MOD_NEK2_1	178	183	PF00069	0.365
MOD_NEK2_1	185	190	PF00069	0.325
MOD_NEK2_1	212	217	PF00069	0.339
MOD_NEK2_1	250	255	PF00069	0.300
MOD_NEK2_1	407	412	PF00069	0.674
MOD_NEK2_1	64	69	PF00069	0.383
MOD_NEK2_1	77	82	PF00069	0.366
MOD_PIKK_1	168	174	PF00454	0.336
MOD_PIKK_1	93	99	PF00454	0.377
MOD_Plk_1	93	99	PF00069	0.334
MOD_Plk_4	152	158	PF00069	0.334
MOD_Plk_4	185	191	PF00069	0.406
MOD_Plk_4	28	34	PF00069	0.260
MOD_Plk_4	367	373	PF00069	0.356
MOD_Plk_4	385	391	PF00069	0.249
MOD_Plk_4	86	92	PF00069	0.318
MOD_Plk_4	99	105	PF00069	0.319
MOD_ProDKin_1	279	285	PF00069	0.336
MOD_ProDKin_1	298	304	PF00069	0.475
MOD_ProDKin_1	318	324	PF00069	0.351
MOD_SUMO_for_1	33	36	PF00179	0.375
MOD_SUMO_rev_2	420	425	PF00179	0.695
MOD_SUMO_rev_2	50	58	PF00179	0.385
TRG_ENDOCYTIC_2	154	157	PF00928	0.327
TRG_ENDOCYTIC_2	199	202	PF00928	0.324
TRG_ENDOCYTIC_2	264	267	PF00928	0.336
TRG_ENDOCYTIC_2	306	309	PF00928	0.322
TRG_ENDOCYTIC_2	366	369	PF00928	0.371
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J7	Leptomonas seymouri	54%	89%
A0A3S7X6Q5	Leishmania donovani	89%	100%
A4HLG8	Leishmania braziliensis	78%	100%
A4HLG9	Leishmania braziliensis	71%	100%
A4I8X9	Leishmania infantum	89%	100%
Q4Q476	Leishmania major	88%	100%