IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3U8_LEIMU

TriTrypDb:

LmxM.32.1140

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	5
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

E9B3U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.388
CLV_C14_Caspase3-7	296	300	PF00656	0.363
CLV_NRD_NRD_1	358	360	PF00675	0.600
CLV_NRD_NRD_1	392	394	PF00675	0.464
CLV_NRD_NRD_1	421	423	PF00675	0.497
CLV_PCSK_KEX2_1	358	360	PF00082	0.600
CLV_PCSK_SKI1_1	208	212	PF00082	0.454
CLV_PCSK_SKI1_1	56	60	PF00082	0.582
DEG_SPOP_SBC_1	238	242	PF00917	0.262
DOC_MAPK_DCC_7	82	90	PF00069	0.297

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J7	Leptomonas seymouri	54%	89%
A0A3S7X6Q5	Leishmania donovani	89%	100%
A4HLG8	Leishmania braziliensis	78%	100%
A4HLG9	Leishmania braziliensis	71%	100%
A4I8X9	Leishmania infantum	89%	100%
Q4Q476	Leishmania major	88%	100%

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