Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3U7_LEIMU

TriTrypDb:

LmxM.32.1130

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.268
CLV_NRD_NRD_1	558	560	PF00675	0.472
CLV_NRD_NRD_1	583	585	PF00675	0.501
CLV_PCSK_FUR_1	567	571	PF00082	0.523
CLV_PCSK_KEX2_1	2	4	PF00082	0.731
CLV_PCSK_KEX2_1	558	560	PF00082	0.456
CLV_PCSK_KEX2_1	569	571	PF00082	0.455
CLV_PCSK_KEX2_1	583	585	PF00082	0.488
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.544
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.513
CLV_PCSK_PC7_1	565	571	PF00082	0.414
CLV_PCSK_SKI1_1	171	175	PF00082	0.606
CLV_PCSK_SKI1_1	272	276	PF00082	0.640
CLV_PCSK_SKI1_1	569	573	PF00082	0.486
CLV_PCSK_SKI1_1	88	92	PF00082	0.650
CLV_Separin_Metazoa	593	597	PF03568	0.762
DEG_Nend_UBRbox_1	1	4	PF02207	0.648
DEG_SCF_FBW7_2	587	593	PF00400	0.750
DEG_SPOP_SBC_1	520	524	PF00917	0.340
DOC_CKS1_1	587	592	PF01111	0.804
DOC_CYCLIN_RxL_1	467	478	PF00134	0.391
DOC_MAPK_gen_1	295	304	PF00069	0.237
DOC_MAPK_HePTP_8	140	152	PF00069	0.227
DOC_MAPK_MEF2A_6	134	142	PF00069	0.345
DOC_MAPK_MEF2A_6	143	152	PF00069	0.335
DOC_MAPK_MEF2A_6	509	517	PF00069	0.244
DOC_PP1_RVXF_1	205	212	PF00149	0.342
DOC_PP1_RVXF_1	468	475	PF00149	0.399
DOC_PP4_FxxP_1	213	216	PF00568	0.349
DOC_USP7_MATH_1	163	167	PF00917	0.393
DOC_USP7_MATH_1	196	200	PF00917	0.230
DOC_USP7_MATH_1	217	221	PF00917	0.418
DOC_USP7_MATH_1	25	29	PF00917	0.570
DOC_USP7_MATH_1	468	472	PF00917	0.354
DOC_USP7_MATH_1	519	523	PF00917	0.443
DOC_USP7_MATH_1	588	592	PF00917	0.665
DOC_USP7_MATH_1	599	603	PF00917	0.644
DOC_USP7_MATH_1	629	633	PF00917	0.734
DOC_USP7_MATH_1	666	670	PF00917	0.789
DOC_USP7_UBL2_3	569	573	PF12436	0.678
DOC_WW_Pin1_4	177	182	PF00397	0.336
DOC_WW_Pin1_4	393	398	PF00397	0.353
DOC_WW_Pin1_4	475	480	PF00397	0.325
DOC_WW_Pin1_4	481	486	PF00397	0.415
DOC_WW_Pin1_4	586	591	PF00397	0.789
DOC_WW_Pin1_4	595	600	PF00397	0.773
DOC_WW_Pin1_4	602	607	PF00397	0.709
DOC_WW_Pin1_4	656	661	PF00397	0.799
LIG_14-3-3_CanoR_1	149	153	PF00244	0.229
LIG_14-3-3_CanoR_1	3	8	PF00244	0.686
LIG_14-3-3_CanoR_1	340	344	PF00244	0.341
LIG_14-3-3_CanoR_1	366	376	PF00244	0.432
LIG_14-3-3_CanoR_1	656	660	PF00244	0.763
LIG_14-3-3_CanoR_1	78	86	PF00244	0.398
LIG_Actin_WH2_2	135	151	PF00022	0.349
LIG_Actin_WH2_2	498	516	PF00022	0.325
LIG_APCC_ABBA_1	492	497	PF00400	0.383
LIG_BIR_III_4	122	126	PF00653	0.414
LIG_BRCT_BRCA1_1	198	202	PF00533	0.321
LIG_BRCT_BRCA1_1	470	474	PF00533	0.391
LIG_FHA_1	145	151	PF00498	0.360
LIG_FHA_1	178	184	PF00498	0.391
LIG_FHA_1	216	222	PF00498	0.394
LIG_FHA_1	223	229	PF00498	0.401
LIG_FHA_1	260	266	PF00498	0.382
LIG_FHA_1	269	275	PF00498	0.381
LIG_FHA_1	400	406	PF00498	0.435
LIG_FHA_1	531	537	PF00498	0.553
LIG_FHA_1	607	613	PF00498	0.797
LIG_FHA_1	80	86	PF00498	0.424
LIG_FHA_1	96	102	PF00498	0.291
LIG_FHA_2	106	112	PF00498	0.400
LIG_FHA_2	154	160	PF00498	0.314
LIG_FHA_2	494	500	PF00498	0.380
LIG_FHA_2	64	70	PF00498	0.397
LIG_LIR_Apic_2	212	216	PF02991	0.380
LIG_LIR_Apic_2	475	479	PF02991	0.342
LIG_LIR_Gen_1	199	206	PF02991	0.295
LIG_LIR_Gen_1	224	232	PF02991	0.220
LIG_LIR_Gen_1	324	334	PF02991	0.446
LIG_LIR_Gen_1	427	437	PF02991	0.344
LIG_LIR_Gen_1	487	495	PF02991	0.357
LIG_LIR_Gen_1	59	68	PF02991	0.377
LIG_LIR_Gen_1	631	642	PF02991	0.743
LIG_LIR_Nem_3	144	148	PF02991	0.372
LIG_LIR_Nem_3	199	203	PF02991	0.232
LIG_LIR_Nem_3	324	330	PF02991	0.414
LIG_LIR_Nem_3	427	433	PF02991	0.324
LIG_LIR_Nem_3	440	446	PF02991	0.328
LIG_LIR_Nem_3	471	476	PF02991	0.327
LIG_LIR_Nem_3	487	492	PF02991	0.359
LIG_LIR_Nem_3	493	498	PF02991	0.376
LIG_LIR_Nem_3	59	64	PF02991	0.402
LIG_LIR_Nem_3	631	637	PF02991	0.742
LIG_LIR_Nem_3	71	76	PF02991	0.426
LIG_MYND_1	250	254	PF01753	0.354
LIG_Pex3_1	13	24	PF04882	0.629
LIG_PTB_Apo_2	454	461	PF02174	0.368
LIG_PTB_Phospho_1	454	460	PF10480	0.370
LIG_SH2_CRK	476	480	PF00017	0.366
LIG_SH2_CRK	545	549	PF00017	0.447
LIG_SH2_CRK	61	65	PF00017	0.451
LIG_SH2_CRK	634	638	PF00017	0.811
LIG_SH2_NCK_1	495	499	PF00017	0.479
LIG_SH2_NCK_1	634	638	PF00017	0.803
LIG_SH2_PTP2	489	492	PF00017	0.377
LIG_SH2_SRC	489	492	PF00017	0.374
LIG_SH2_STAP1	361	365	PF00017	0.427
LIG_SH2_STAT5	117	120	PF00017	0.378
LIG_SH2_STAT5	346	349	PF00017	0.376
LIG_SH2_STAT5	444	447	PF00017	0.295
LIG_SH2_STAT5	460	463	PF00017	0.364
LIG_SH2_STAT5	489	492	PF00017	0.369
LIG_SH2_STAT5	495	498	PF00017	0.427
LIG_SH3_3	113	119	PF00018	0.220
LIG_SH3_3	244	250	PF00018	0.427
LIG_SH3_3	403	409	PF00018	0.460
LIG_SH3_3	584	590	PF00018	0.805
LIG_SH3_3	658	664	PF00018	0.793
LIG_SH3_3	8	14	PF00018	0.367
LIG_SH3_5	485	489	PF00018	0.389
LIG_SUMO_SIM_anti_2	218	225	PF11976	0.264
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.305
LIG_SUMO_SIM_par_1	102	108	PF11976	0.381
LIG_SUMO_SIM_par_1	17	23	PF11976	0.477
LIG_SUMO_SIM_par_1	224	231	PF11976	0.408
LIG_SUMO_SIM_par_1	478	484	PF11976	0.299
LIG_TYR_ITIM	543	548	PF00017	0.480
LIG_UBA3_1	228	235	PF00899	0.291
LIG_WRC_WIRS_1	197	202	PF05994	0.349
LIG_WRC_WIRS_1	21	26	PF05994	0.602
LIG_WRC_WIRS_1	210	215	PF05994	0.386
LIG_WRC_WIRS_1	223	228	PF05994	0.347
MOD_CK1_1	105	111	PF00069	0.316
MOD_CK1_1	141	147	PF00069	0.381
MOD_CK1_1	151	157	PF00069	0.330
MOD_CK1_1	192	198	PF00069	0.376
MOD_CK1_1	224	230	PF00069	0.357
MOD_CK1_1	260	266	PF00069	0.343
MOD_CK1_1	380	386	PF00069	0.512
MOD_CK1_1	396	402	PF00069	0.427
MOD_CK1_1	423	429	PF00069	0.380
MOD_CK1_1	438	444	PF00069	0.394
MOD_CK1_1	453	459	PF00069	0.219
MOD_CK1_1	493	499	PF00069	0.444
MOD_CK1_1	602	608	PF00069	0.762
MOD_CK1_1	655	661	PF00069	0.809
MOD_CK1_1	80	86	PF00069	0.408
MOD_CK1_1	95	101	PF00069	0.346
MOD_CK2_1	356	362	PF00069	0.428
MOD_CK2_1	446	452	PF00069	0.382
MOD_CK2_1	493	499	PF00069	0.378
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.770
MOD_GlcNHglycan	127	130	PF01048	0.639
MOD_GlcNHglycan	135	138	PF01048	0.595
MOD_GlcNHglycan	185	188	PF01048	0.642
MOD_GlcNHglycan	193	197	PF01048	0.544
MOD_GlcNHglycan	203	206	PF01048	0.427
MOD_GlcNHglycan	27	30	PF01048	0.647
MOD_GlcNHglycan	280	283	PF01048	0.617
MOD_GlcNHglycan	318	322	PF01048	0.714
MOD_GlcNHglycan	379	382	PF01048	0.700
MOD_GlcNHglycan	388	391	PF01048	0.650
MOD_GlcNHglycan	422	425	PF01048	0.560
MOD_GlcNHglycan	437	440	PF01048	0.563
MOD_GlcNHglycan	502	505	PF01048	0.634
MOD_GlcNHglycan	523	526	PF01048	0.743
MOD_GlcNHglycan	590	593	PF01048	0.523
MOD_GlcNHglycan	616	619	PF01048	0.467
MOD_GlcNHglycan	631	634	PF01048	0.602
MOD_GlcNHglycan	88	91	PF01048	0.628
MOD_GSK3_1	100	107	PF00069	0.311
MOD_GSK3_1	144	151	PF00069	0.408
MOD_GSK3_1	153	160	PF00069	0.360
MOD_GSK3_1	175	182	PF00069	0.417
MOD_GSK3_1	192	199	PF00069	0.321
MOD_GSK3_1	211	218	PF00069	0.312
MOD_GSK3_1	224	231	PF00069	0.298
MOD_GSK3_1	268	275	PF00069	0.455
MOD_GSK3_1	285	292	PF00069	0.384
MOD_GSK3_1	313	320	PF00069	0.508
MOD_GSK3_1	328	335	PF00069	0.361
MOD_GSK3_1	380	387	PF00069	0.504
MOD_GSK3_1	416	423	PF00069	0.378
MOD_GSK3_1	438	445	PF00069	0.376
MOD_GSK3_1	446	453	PF00069	0.368
MOD_GSK3_1	468	475	PF00069	0.325
MOD_GSK3_1	521	528	PF00069	0.507
MOD_GSK3_1	595	602	PF00069	0.732
MOD_GSK3_1	629	636	PF00069	0.745
MOD_GSK3_1	652	659	PF00069	0.789
MOD_GSK3_1	76	83	PF00069	0.410
MOD_GSK3_1	92	99	PF00069	0.337
MOD_N-GLC_1	289	294	PF02516	0.628
MOD_N-GLC_1	424	429	PF02516	0.535
MOD_N-GLC_1	456	461	PF02516	0.582
MOD_N-GLC_1	629	634	PF02516	0.534
MOD_N-GLC_1	80	85	PF02516	0.599
MOD_N-GLC_1	96	101	PF02516	0.446
MOD_NEK2_1	102	107	PF00069	0.313
MOD_NEK2_1	148	153	PF00069	0.304
MOD_NEK2_1	164	169	PF00069	0.300
MOD_NEK2_1	20	25	PF00069	0.473
MOD_NEK2_1	209	214	PF00069	0.289
MOD_NEK2_1	222	227	PF00069	0.349
MOD_NEK2_1	228	233	PF00069	0.311
MOD_NEK2_1	259	264	PF00069	0.425
MOD_NEK2_1	289	294	PF00069	0.455
MOD_NEK2_1	334	339	PF00069	0.370
MOD_NEK2_1	356	361	PF00069	0.319
MOD_NEK2_1	472	477	PF00069	0.369
MOD_NEK2_1	544	549	PF00069	0.428
MOD_NEK2_1	76	81	PF00069	0.439
MOD_NEK2_2	409	414	PF00069	0.311
MOD_PIKK_1	33	39	PF00454	0.454
MOD_PK_1	451	457	PF00069	0.463
MOD_PKA_2	133	139	PF00069	0.369
MOD_PKA_2	148	154	PF00069	0.336
MOD_PKA_2	164	170	PF00069	0.307
MOD_PKA_2	33	39	PF00069	0.366
MOD_PKA_2	339	345	PF00069	0.336
MOD_PKA_2	450	456	PF00069	0.459
MOD_PKA_2	557	563	PF00069	0.664
MOD_PKA_2	655	661	PF00069	0.751
MOD_PKA_2	77	83	PF00069	0.460
MOD_PKA_2	92	98	PF00069	0.432
MOD_Plk_1	192	198	PF00069	0.370
MOD_Plk_1	289	295	PF00069	0.414
MOD_Plk_1	298	304	PF00069	0.387
MOD_Plk_1	424	430	PF00069	0.386
MOD_Plk_1	451	457	PF00069	0.380
MOD_Plk_1	490	496	PF00069	0.404
MOD_Plk_1	498	504	PF00069	0.467
MOD_Plk_1	80	86	PF00069	0.399
MOD_Plk_1	95	101	PF00069	0.275
MOD_Plk_4	148	154	PF00069	0.331
MOD_Plk_4	179	185	PF00069	0.372
MOD_Plk_4	196	202	PF00069	0.287
MOD_Plk_4	217	223	PF00069	0.382
MOD_Plk_4	356	362	PF00069	0.432
MOD_Plk_4	416	422	PF00069	0.391
MOD_Plk_4	456	462	PF00069	0.415
MOD_Plk_4	490	496	PF00069	0.440
MOD_Plk_4	544	550	PF00069	0.371
MOD_Plk_4	96	102	PF00069	0.338
MOD_ProDKin_1	177	183	PF00069	0.329
MOD_ProDKin_1	393	399	PF00069	0.356
MOD_ProDKin_1	475	481	PF00069	0.333
MOD_ProDKin_1	586	592	PF00069	0.791
MOD_ProDKin_1	595	601	PF00069	0.773
MOD_ProDKin_1	602	608	PF00069	0.711
MOD_ProDKin_1	656	662	PF00069	0.798
MOD_SUMO_rev_2	351	356	PF00179	0.446
TRG_DiLeu_BaEn_1	46	51	PF01217	0.388
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.566
TRG_ENDOCYTIC_2	346	349	PF00928	0.431
TRG_ENDOCYTIC_2	489	492	PF00928	0.406
TRG_ENDOCYTIC_2	495	498	PF00928	0.436
TRG_ENDOCYTIC_2	545	548	PF00928	0.447
TRG_ENDOCYTIC_2	61	64	PF00928	0.384
TRG_ENDOCYTIC_2	634	637	PF00928	0.813
TRG_ER_diArg_1	294	297	PF00400	0.408
TRG_ER_diArg_1	364	367	PF00400	0.406
TRG_ER_diArg_1	557	559	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM2	Leptomonas seymouri	49%	100%
A0A0S4J6Q6	Bodo saltans	31%	100%
A0A1X0P168	Trypanosomatidae	33%	100%
A0A3Q8IHQ4	Leishmania donovani	87%	100%
A0A3R7N2S1	Trypanosoma rangeli	33%	100%
A4HLG7	Leishmania braziliensis	61%	95%
A4I8X8	Leishmania infantum	87%	100%
Q4Q477	Leishmania major	84%	100%
V5BJT9	Trypanosoma cruzi	30%	100%