Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3U5_LEIMU

TriTrypDb:

LmxM.32.1110

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.517
CLV_C14_Caspase3-7	432	436	PF00656	0.633
CLV_C14_Caspase3-7	678	682	PF00656	0.762
CLV_NRD_NRD_1	161	163	PF00675	0.634
CLV_NRD_NRD_1	20	22	PF00675	0.609
CLV_NRD_NRD_1	519	521	PF00675	0.458
CLV_NRD_NRD_1	578	580	PF00675	0.563
CLV_NRD_NRD_1	86	88	PF00675	0.566
CLV_PCSK_KEX2_1	161	163	PF00082	0.634
CLV_PCSK_KEX2_1	340	342	PF00082	0.744
CLV_PCSK_KEX2_1	462	464	PF00082	0.499
CLV_PCSK_KEX2_1	519	521	PF00082	0.552
CLV_PCSK_KEX2_1	578	580	PF00082	0.563
CLV_PCSK_KEX2_1	585	587	PF00082	0.549
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.733
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.516
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.584
CLV_PCSK_SKI1_1	224	228	PF00082	0.669
CLV_PCSK_SKI1_1	248	252	PF00082	0.648
CLV_PCSK_SKI1_1	268	272	PF00082	0.613
CLV_PCSK_SKI1_1	341	345	PF00082	0.735
CLV_PCSK_SKI1_1	488	492	PF00082	0.516
CLV_PCSK_SKI1_1	610	614	PF00082	0.503
DEG_APCC_DBOX_1	169	177	PF00400	0.474
DEG_Nend_UBRbox_4	1	3	PF02207	0.493
DEG_SPOP_SBC_1	643	647	PF00917	0.503
DEG_SPOP_SBC_1	723	727	PF00917	0.714
DOC_CKS1_1	133	138	PF01111	0.596
DOC_CKS1_1	713	718	PF01111	0.690
DOC_CYCLIN_RxL_1	482	495	PF00134	0.543
DOC_CYCLIN_RxL_1	500	511	PF00134	0.511
DOC_MAPK_gen_1	266	274	PF00069	0.602
DOC_MAPK_RevD_3	74	88	PF00069	0.582
DOC_PP4_FxxP_1	69	72	PF00568	0.588
DOC_USP7_MATH_1	108	112	PF00917	0.610
DOC_USP7_MATH_1	114	118	PF00917	0.645
DOC_USP7_MATH_1	120	124	PF00917	0.638
DOC_USP7_MATH_1	153	157	PF00917	0.691
DOC_USP7_MATH_1	255	259	PF00917	0.616
DOC_USP7_MATH_1	397	401	PF00917	0.695
DOC_USP7_MATH_1	60	64	PF00917	0.599
DOC_USP7_MATH_1	650	654	PF00917	0.665
DOC_USP7_MATH_1	658	662	PF00917	0.624
DOC_USP7_MATH_1	704	708	PF00917	0.659
DOC_USP7_MATH_1	724	728	PF00917	0.613
DOC_USP7_MATH_1	743	747	PF00917	0.510
DOC_USP7_MATH_1	748	752	PF00917	0.741
DOC_USP7_MATH_1	79	83	PF00917	0.525
DOC_WW_Pin1_4	132	137	PF00397	0.725
DOC_WW_Pin1_4	154	159	PF00397	0.691
DOC_WW_Pin1_4	198	203	PF00397	0.637
DOC_WW_Pin1_4	258	263	PF00397	0.541
DOC_WW_Pin1_4	356	361	PF00397	0.765
DOC_WW_Pin1_4	629	634	PF00397	0.682
DOC_WW_Pin1_4	712	717	PF00397	0.686
DOC_WW_Pin1_4	731	736	PF00397	0.796
LIG_14-3-3_CanoR_1	276	286	PF00244	0.460
LIG_14-3-3_CanoR_1	321	330	PF00244	0.699
LIG_14-3-3_CanoR_1	341	346	PF00244	0.634
LIG_14-3-3_CanoR_1	404	408	PF00244	0.635
LIG_14-3-3_CanoR_1	467	472	PF00244	0.624
LIG_14-3-3_CanoR_1	482	488	PF00244	0.486
LIG_14-3-3_CanoR_1	508	517	PF00244	0.448
LIG_14-3-3_CanoR_1	538	543	PF00244	0.452
LIG_14-3-3_CanoR_1	579	588	PF00244	0.549
LIG_14-3-3_CanoR_1	628	633	PF00244	0.706
LIG_14-3-3_CanoR_1	663	671	PF00244	0.792
LIG_14-3-3_CanoR_1	747	753	PF00244	0.696
LIG_14-3-3_CanoR_1	94	98	PF00244	0.580
LIG_14-3-3_CterR_2	756	760	PF00244	0.689
LIG_APCC_ABBA_1	471	476	PF00400	0.616
LIG_Clathr_ClatBox_1	39	43	PF01394	0.538
LIG_deltaCOP1_diTrp_1	256	265	PF00928	0.614
LIG_eIF4E_1	34	40	PF01652	0.541
LIG_EVH1_1	69	73	PF00568	0.595
LIG_FHA_1	15	21	PF00498	0.547
LIG_FHA_1	155	161	PF00498	0.553
LIG_FHA_1	195	201	PF00498	0.659
LIG_FHA_1	325	331	PF00498	0.761
LIG_FHA_1	334	340	PF00498	0.752
LIG_FHA_1	372	378	PF00498	0.738
LIG_FHA_1	468	474	PF00498	0.655
LIG_FHA_1	51	57	PF00498	0.559
LIG_FHA_1	562	568	PF00498	0.542
LIG_FHA_2	110	116	PF00498	0.716
LIG_FHA_2	133	139	PF00498	0.806
LIG_FHA_2	356	362	PF00498	0.807
LIG_FHA_2	387	393	PF00498	0.747
LIG_FHA_2	404	410	PF00498	0.517
LIG_FHA_2	484	490	PF00498	0.607
LIG_FHA_2	507	513	PF00498	0.473
LIG_FHA_2	539	545	PF00498	0.500
LIG_FHA_2	617	623	PF00498	0.663
LIG_FHA_2	678	684	PF00498	0.746
LIG_FHA_2	732	738	PF00498	0.761
LIG_Integrin_RGD_1	433	435	PF01839	0.559
LIG_LIR_Apic_2	256	262	PF02991	0.542
LIG_LIR_Gen_1	236	247	PF02991	0.638
LIG_LIR_Gen_1	269	279	PF02991	0.555
LIG_LIR_Gen_1	499	507	PF02991	0.446
LIG_LIR_Gen_1	511	518	PF02991	0.451
LIG_LIR_Nem_3	236	242	PF02991	0.649
LIG_LIR_Nem_3	269	274	PF02991	0.471
LIG_LIR_Nem_3	288	292	PF02991	0.553
LIG_LIR_Nem_3	454	459	PF02991	0.533
LIG_LIR_Nem_3	486	490	PF02991	0.526
LIG_LIR_Nem_3	499	504	PF02991	0.414
LIG_LIR_Nem_3	511	517	PF02991	0.450
LIG_NRBOX	35	41	PF00104	0.601
LIG_PCNA_yPIPBox_3	585	594	PF02747	0.547
LIG_Pex14_1	285	289	PF04695	0.460
LIG_Pex14_2	487	491	PF04695	0.494
LIG_SH2_CRK	289	293	PF00017	0.543
LIG_SH2_CRK	501	505	PF00017	0.454
LIG_SH2_CRK	514	518	PF00017	0.445
LIG_SH2_STAP1	30	34	PF00017	0.609
LIG_SH2_STAP1	501	505	PF00017	0.489
LIG_SH2_STAP1	514	518	PF00017	0.481
LIG_SH2_STAP1	542	546	PF00017	0.455
LIG_SH3_1	630	636	PF00018	0.660
LIG_SH3_3	196	202	PF00018	0.669
LIG_SH3_3	292	298	PF00018	0.518
LIG_SH3_3	336	342	PF00018	0.780
LIG_SH3_3	42	48	PF00018	0.609
LIG_SH3_3	630	636	PF00018	0.784
LIG_SH3_3	67	73	PF00018	0.524
LIG_Sin3_3	230	237	PF02671	0.707
LIG_SUMO_SIM_anti_2	168	175	PF11976	0.479
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.621
LIG_SUMO_SIM_par_1	37	44	PF11976	0.547
LIG_SUMO_SIM_par_1	76	82	PF11976	0.455
LIG_TRAF2_1	406	409	PF00917	0.692
LIG_TRAF2_1	682	685	PF00917	0.753
LIG_TRAF2_2	652	657	PF00917	0.512
LIG_WRC_WIRS_1	484	489	PF05994	0.543
LIG_WRC_WIRS_1	749	754	PF05994	0.766
MOD_CDK_SPxxK_3	154	161	PF00069	0.535
MOD_CK1_1	134	140	PF00069	0.692
MOD_CK1_1	258	264	PF00069	0.569
MOD_CK1_1	275	281	PF00069	0.324
MOD_CK1_1	324	330	PF00069	0.546
MOD_CK1_1	400	406	PF00069	0.658
MOD_CK1_1	499	505	PF00069	0.455
MOD_CK1_1	726	732	PF00069	0.782
MOD_CK2_1	109	115	PF00069	0.733
MOD_CK2_1	124	130	PF00069	0.507
MOD_CK2_1	3	9	PF00069	0.423
MOD_CK2_1	319	325	PF00069	0.776
MOD_CK2_1	386	392	PF00069	0.761
MOD_CK2_1	403	409	PF00069	0.528
MOD_CK2_1	48	54	PF00069	0.474
MOD_CK2_1	483	489	PF00069	0.589
MOD_CK2_1	506	512	PF00069	0.469
MOD_CK2_1	538	544	PF00069	0.486
MOD_CK2_1	601	607	PF00069	0.458
MOD_CK2_1	616	622	PF00069	0.564
MOD_CK2_1	677	683	PF00069	0.761
MOD_CK2_1	731	737	PF00069	0.735
MOD_GlcNHglycan	112	115	PF01048	0.674
MOD_GlcNHglycan	122	125	PF01048	0.604
MOD_GlcNHglycan	127	130	PF01048	0.547
MOD_GlcNHglycan	191	195	PF01048	0.607
MOD_GlcNHglycan	224	227	PF01048	0.580
MOD_GlcNHglycan	310	313	PF01048	0.517
MOD_GlcNHglycan	351	354	PF01048	0.753
MOD_GlcNHglycan	368	371	PF01048	0.762
MOD_GlcNHglycan	399	402	PF01048	0.751
MOD_GlcNHglycan	50	53	PF01048	0.477
MOD_GlcNHglycan	58	61	PF01048	0.436
MOD_GlcNHglycan	665	668	PF01048	0.732
MOD_GlcNHglycan	704	707	PF01048	0.709
MOD_GlcNHglycan	726	729	PF01048	0.778
MOD_GSK3_1	110	117	PF00069	0.654
MOD_GSK3_1	120	127	PF00069	0.660
MOD_GSK3_1	149	156	PF00069	0.663
MOD_GSK3_1	186	193	PF00069	0.536
MOD_GSK3_1	194	201	PF00069	0.619
MOD_GSK3_1	222	229	PF00069	0.654
MOD_GSK3_1	254	261	PF00069	0.564
MOD_GSK3_1	274	281	PF00069	0.522
MOD_GSK3_1	320	327	PF00069	0.564
MOD_GSK3_1	399	406	PF00069	0.655
MOD_GSK3_1	508	515	PF00069	0.577
MOD_GSK3_1	56	63	PF00069	0.532
MOD_GSK3_1	624	631	PF00069	0.627
MOD_GSK3_1	698	705	PF00069	0.717
MOD_GSK3_1	722	729	PF00069	0.796
MOD_GSK3_1	738	745	PF00069	0.658
MOD_GSK3_1	79	86	PF00069	0.480
MOD_N-GLC_1	154	159	PF02516	0.539
MOD_NEK2_1	3	8	PF00069	0.442
MOD_NEK2_1	308	313	PF00069	0.380
MOD_NEK2_1	330	335	PF00069	0.766
MOD_NEK2_1	365	370	PF00069	0.524
MOD_NEK2_1	513	518	PF00069	0.549
MOD_NEK2_1	531	536	PF00069	0.456
MOD_NEK2_1	573	578	PF00069	0.547
MOD_NEK2_1	616	621	PF00069	0.655
MOD_NEK2_1	624	629	PF00069	0.661
MOD_NEK2_1	742	747	PF00069	0.611
MOD_NEK2_2	469	474	PF00069	0.611
MOD_NEK2_2	658	663	PF00069	0.584
MOD_PIKK_1	333	339	PF00454	0.739
MOD_PIKK_1	378	384	PF00454	0.775
MOD_PIKK_1	506	512	PF00454	0.469
MOD_PIKK_1	580	586	PF00454	0.482
MOD_PIKK_1	601	607	PF00454	0.462
MOD_PIKK_1	650	656	PF00454	0.742
MOD_PKA_2	275	281	PF00069	0.452
MOD_PKA_2	308	314	PF00069	0.474
MOD_PKA_2	320	326	PF00069	0.729
MOD_PKA_2	366	372	PF00069	0.708
MOD_PKA_2	403	409	PF00069	0.627
MOD_PKA_2	476	482	PF00069	0.572
MOD_PKA_2	743	749	PF00069	0.679
MOD_PKA_2	93	99	PF00069	0.575
MOD_Plk_1	114	120	PF00069	0.725
MOD_Plk_1	13	19	PF00069	0.594
MOD_Plk_1	190	196	PF00069	0.697
MOD_Plk_1	235	241	PF00069	0.693
MOD_Plk_1	255	261	PF00069	0.357
MOD_Plk_1	330	336	PF00069	0.765
MOD_Plk_1	378	384	PF00069	0.833
MOD_Plk_1	738	744	PF00069	0.766
MOD_Plk_4	14	20	PF00069	0.522
MOD_Plk_4	176	182	PF00069	0.565
MOD_Plk_4	195	201	PF00069	0.513
MOD_Plk_4	469	475	PF00069	0.641
MOD_Plk_4	496	502	PF00069	0.494
MOD_Plk_4	513	519	PF00069	0.545
MOD_Plk_4	62	68	PF00069	0.523
MOD_Plk_4	79	85	PF00069	0.350
MOD_ProDKin_1	132	138	PF00069	0.726
MOD_ProDKin_1	154	160	PF00069	0.692
MOD_ProDKin_1	198	204	PF00069	0.640
MOD_ProDKin_1	258	264	PF00069	0.535
MOD_ProDKin_1	356	362	PF00069	0.766
MOD_ProDKin_1	629	635	PF00069	0.680
MOD_ProDKin_1	712	718	PF00069	0.687
MOD_ProDKin_1	731	737	PF00069	0.796
MOD_SUMO_rev_2	454	464	PF00179	0.556
MOD_SUMO_rev_2	537	546	PF00179	0.453
TRG_AP2beta_CARGO_1	454	463	PF09066	0.608
TRG_DiLeu_BaEn_1	591	596	PF01217	0.577
TRG_DiLeu_BaEn_1	607	612	PF01217	0.363
TRG_DiLeu_BaEn_4	495	501	PF01217	0.492
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.520
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.736
TRG_DiLeu_LyEn_5	607	612	PF01217	0.506
TRG_ENDOCYTIC_2	289	292	PF00928	0.588
TRG_ENDOCYTIC_2	501	504	PF00928	0.457
TRG_ENDOCYTIC_2	514	517	PF00928	0.443
TRG_ER_diArg_1	160	162	PF00400	0.669
TRG_ER_diArg_1	265	268	PF00400	0.565
TRG_ER_diArg_1	518	520	PF00400	0.549
TRG_ER_diArg_1	668	671	PF00400	0.708
TRG_NES_CRM1_1	172	186	PF08389	0.339
TRG_NLS_MonoExtC_3	386	392	PF00514	0.711
TRG_NLS_MonoExtN_4	384	391	PF00514	0.718
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S9	Leptomonas seymouri	56%	95%
A0A3Q8IDP5	Leishmania donovani	92%	100%
A0A3R7RSB8	Trypanosoma rangeli	36%	100%
A4HLG5	Leishmania braziliensis	81%	99%
A4I8X6	Leishmania infantum	93%	100%
D0A4X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q479	Leishmania major	92%	99%