YEATS_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

YEATS family, putative

Species:

Leishmania mexicana

UniProt:

E9B3U2_LEIMU

TriTrypDb:

LmxM.32.1080

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0000123	histone acetyltransferase complex	4	1
GO:0005654	nucleoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0035267	NuA4 histone acetyltransferase complex	7	1
GO:0043189	H4/H2A histone acetyltransferase complex	6	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1902562	H4 histone acetyltransferase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9B3U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051252	regulation of RNA metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:2001141	regulation of RNA biosynthetic process	6	11
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.788
CLV_NRD_NRD_1	166	168	PF00675	0.296
CLV_NRD_NRD_1	170	172	PF00675	0.296
CLV_NRD_NRD_1	211	213	PF00675	0.709
CLV_NRD_NRD_1	266	268	PF00675	0.796
CLV_NRD_NRD_1	55	57	PF00675	0.778
CLV_NRD_NRD_1	67	69	PF00675	0.714
CLV_PCSK_KEX2_1	166	168	PF00082	0.297
CLV_PCSK_KEX2_1	170	172	PF00082	0.297
CLV_PCSK_KEX2_1	211	213	PF00082	0.640
CLV_PCSK_KEX2_1	266	268	PF00082	0.750
CLV_PCSK_KEX2_1	402	404	PF00082	0.560
CLV_PCSK_KEX2_1	54	56	PF00082	0.784
CLV_PCSK_KEX2_1	67	69	PF00082	0.715
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.566
CLV_PCSK_PC7_1	166	172	PF00082	0.353
CLV_PCSK_SKI1_1	166	170	PF00082	0.285
CLV_PCSK_SKI1_1	211	215	PF00082	0.717
CLV_PCSK_SKI1_1	306	310	PF00082	0.608
CLV_PCSK_SKI1_1	321	325	PF00082	0.542
CLV_PCSK_SKI1_1	437	441	PF00082	0.596
DOC_ANK_TNKS_1	111	118	PF00023	0.522
DOC_CKS1_1	119	124	PF01111	0.809
DOC_CKS1_1	345	350	PF01111	0.498
DOC_CKS1_1	363	368	PF01111	0.700
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.664
DOC_MAPK_JIP1_4	249	255	PF00069	0.748
DOC_PP1_RVXF_1	150	157	PF00149	0.487
DOC_PP2B_LxvP_1	196	199	PF13499	0.562
DOC_PP2B_LxvP_1	214	217	PF13499	0.714
DOC_PP4_FxxP_1	14	17	PF00568	0.678
DOC_PP4_FxxP_1	156	159	PF00568	0.471
DOC_PP4_FxxP_1	162	165	PF00568	0.496
DOC_USP7_MATH_1	123	127	PF00917	0.835
DOC_USP7_MATH_1	19	23	PF00917	0.684
DOC_USP7_MATH_1	219	223	PF00917	0.698
DOC_USP7_MATH_1	387	391	PF00917	0.592
DOC_USP7_MATH_1	48	52	PF00917	0.779
DOC_USP7_UBL2_3	440	444	PF12436	0.622
DOC_WW_Pin1_4	118	123	PF00397	0.783
DOC_WW_Pin1_4	140	145	PF00397	0.595
DOC_WW_Pin1_4	223	228	PF00397	0.743
DOC_WW_Pin1_4	31	36	PF00397	0.701
DOC_WW_Pin1_4	344	349	PF00397	0.638
DOC_WW_Pin1_4	362	367	PF00397	0.697
DOC_WW_Pin1_4	46	51	PF00397	0.676
LIG_14-3-3_CanoR_1	211	217	PF00244	0.745
LIG_14-3-3_CanoR_1	356	364	PF00244	0.714
LIG_14-3-3_CanoR_1	386	392	PF00244	0.641
LIG_14-3-3_CanoR_1	55	63	PF00244	0.726
LIG_14-3-3_CanoR_1	67	76	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_4	28	32	PF00653	0.626
LIG_BRCT_BRCA1_1	371	375	PF00533	0.666
LIG_CSL_BTD_1	237	240	PF09270	0.704
LIG_eIF4E_1	247	253	PF01652	0.740
LIG_FHA_1	229	235	PF00498	0.700
LIG_FHA_1	256	262	PF00498	0.615
LIG_FHA_1	284	290	PF00498	0.626
LIG_FHA_1	38	44	PF00498	0.527
LIG_FHA_1	422	428	PF00498	0.550
LIG_FHA_2	178	184	PF00498	0.471
LIG_FHA_2	332	338	PF00498	0.736
LIG_FHA_2	345	351	PF00498	0.790
LIG_FHA_2	408	414	PF00498	0.531
LIG_FHA_2	427	433	PF00498	0.578
LIG_GSK3_LRP6_1	344	349	PF00069	0.499
LIG_LIR_Apic_2	161	165	PF02991	0.497
LIG_LIR_Apic_2	245	250	PF02991	0.692
LIG_LIR_Apic_2	370	374	PF02991	0.703
LIG_LIR_Gen_1	145	156	PF02991	0.335
LIG_LIR_Gen_1	372	383	PF02991	0.644
LIG_LIR_Nem_3	145	151	PF02991	0.449
LIG_LIR_Nem_3	372	378	PF02991	0.645
LIG_LIR_Nem_3	86	92	PF02991	0.643
LIG_MYND_3	314	318	PF01753	0.673
LIG_Pex14_1	371	375	PF04695	0.553
LIG_Pex14_2	367	371	PF04695	0.681
LIG_SH2_CRK	148	152	PF00017	0.447
LIG_SH2_CRK	247	251	PF00017	0.735
LIG_SH2_CRK	74	78	PF00017	0.519
LIG_SH2_SRC	18	21	PF00017	0.720
LIG_SH2_STAT3	382	385	PF00017	0.665
LIG_SH2_STAT5	74	77	PF00017	0.509
LIG_SH3_2	262	267	PF14604	0.508
LIG_SH3_3	113	119	PF00018	0.796
LIG_SH3_3	131	137	PF00018	0.675
LIG_SH3_3	138	144	PF00018	0.685
LIG_SH3_3	20	26	PF00018	0.633
LIG_SH3_3	224	230	PF00018	0.717
LIG_SH3_3	234	240	PF00018	0.706
LIG_SH3_3	256	262	PF00018	0.682
LIG_SH3_3	342	348	PF00018	0.505
LIG_SH3_3	422	428	PF00018	0.611
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.765
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.561
LIG_SUMO_SIM_anti_2	388	395	PF11976	0.635
LIG_SUMO_SIM_par_1	251	258	PF11976	0.652
LIG_SUMO_SIM_par_1	280	287	PF11976	0.716
LIG_SUMO_SIM_par_1	423	429	PF11976	0.583
LIG_TRAF2_1	415	418	PF00917	0.547
LIG_TYR_ITIM	146	151	PF00017	0.606
LIG_WW_1	217	220	PF00397	0.685
LIG_WW_3	263	267	PF00397	0.509
MOD_CDC14_SPxK_1	34	37	PF00782	0.796
MOD_CDK_SPxK_1	31	37	PF00069	0.795
MOD_CK1_1	126	132	PF00069	0.719
MOD_CK1_1	142	148	PF00069	0.580
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK1_1	254	260	PF00069	0.680
MOD_CK1_1	33	39	PF00069	0.654
MOD_CK1_1	355	361	PF00069	0.662
MOD_CK1_1	362	368	PF00069	0.662
MOD_CK1_1	49	55	PF00069	0.687
MOD_CK2_1	177	183	PF00069	0.471
MOD_CK2_1	346	352	PF00069	0.741
MOD_CK2_1	407	413	PF00069	0.597
MOD_CK2_1	426	432	PF00069	0.531
MOD_GlcNHglycan	1	4	PF01048	0.715
MOD_GlcNHglycan	125	128	PF01048	0.810
MOD_GlcNHglycan	221	224	PF01048	0.784
MOD_GlcNHglycan	59	62	PF01048	0.712
MOD_GSK3_1	100	107	PF00069	0.659
MOD_GSK3_1	121	128	PF00069	0.817
MOD_GSK3_1	219	226	PF00069	0.750
MOD_GSK3_1	251	258	PF00069	0.539
MOD_GSK3_1	326	333	PF00069	0.699
MOD_GSK3_1	33	40	PF00069	0.647
MOD_GSK3_1	351	358	PF00069	0.793
MOD_GSK3_1	408	415	PF00069	0.611
MOD_GSK3_1	46	53	PF00069	0.776
MOD_GSK3_1	57	64	PF00069	0.786
MOD_N-GLC_1	61	66	PF02516	0.759
MOD_NEK2_1	147	152	PF00069	0.532
MOD_NEK2_1	242	247	PF00069	0.582
MOD_NEK2_1	30	35	PF00069	0.774
MOD_NEK2_1	309	314	PF00069	0.596
MOD_NEK2_1	367	372	PF00069	0.713
MOD_PIKK_1	2	8	PF00454	0.724
MOD_PIKK_1	37	43	PF00454	0.631
MOD_PIKK_1	426	432	PF00454	0.584
MOD_PK_1	251	257	PF00069	0.658
MOD_PKA_1	266	272	PF00069	0.770
MOD_PKA_1	67	73	PF00069	0.690
MOD_PKA_2	266	272	PF00069	0.770
MOD_PKA_2	330	336	PF00069	0.478
MOD_PKA_2	355	361	PF00069	0.478
MOD_PKA_2	385	391	PF00069	0.577
MOD_PKA_2	67	73	PF00069	0.578
MOD_PKB_1	54	62	PF00069	0.725
MOD_Plk_1	177	183	PF00069	0.471
MOD_Plk_1	358	364	PF00069	0.658
MOD_Plk_1	412	418	PF00069	0.551
MOD_Plk_1	61	67	PF00069	0.669
MOD_Plk_2-3	177	183	PF00069	0.562
MOD_Plk_4	142	148	PF00069	0.628
MOD_Plk_4	199	205	PF00069	0.562
MOD_Plk_4	359	365	PF00069	0.706
MOD_Plk_4	421	427	PF00069	0.537
MOD_ProDKin_1	118	124	PF00069	0.784
MOD_ProDKin_1	140	146	PF00069	0.592
MOD_ProDKin_1	223	229	PF00069	0.740
MOD_ProDKin_1	31	37	PF00069	0.705
MOD_ProDKin_1	344	350	PF00069	0.641
MOD_ProDKin_1	362	368	PF00069	0.693
MOD_ProDKin_1	46	52	PF00069	0.674
MOD_SUMO_for_1	401	404	PF00179	0.519
TRG_DiLeu_BaEn_1	359	364	PF01217	0.668
TRG_DiLeu_BaEn_4	417	423	PF01217	0.541
TRG_ENDOCYTIC_2	148	151	PF00928	0.442
TRG_ENDOCYTIC_2	74	77	PF00928	0.502
TRG_ENDOCYTIC_2	89	92	PF00928	0.645
TRG_ER_diArg_1	165	167	PF00400	0.492
TRG_ER_diArg_1	169	171	PF00400	0.491
TRG_ER_diArg_1	211	213	PF00400	0.742
TRG_ER_diArg_1	265	267	PF00400	0.636
TRG_ER_diArg_1	54	56	PF00400	0.812
TRG_ER_diArg_1	66	68	PF00400	0.685
TRG_NES_CRM1_1	15	28	PF08389	0.753
TRG_NES_CRM1_1	417	430	PF08389	0.612
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S1	Leptomonas seymouri	47%	93%
A0A1X0P1J8	Trypanosomatidae	26%	91%
A0A3R7LCY2	Trypanosoma rangeli	27%	96%
A0A3S7X6P8	Leishmania donovani	93%	100%
A4HLG2	Leishmania braziliensis	80%	100%
A4I8X3	Leishmania infantum	93%	100%
D0A4W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
Q4Q482	Leishmania major	92%	100%
V5DG54	Trypanosoma cruzi	29%	82%