Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B3U1_LEIMU

TriTrypDb:

LmxM.32.1070

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3U1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.670
CLV_NRD_NRD_1	223	225	PF00675	0.636
CLV_PCSK_KEX2_1	217	219	PF00082	0.670
CLV_PCSK_SKI1_1	122	126	PF00082	0.722
CLV_PCSK_SKI1_1	25	29	PF00082	0.512
DOC_PP1_RVXF_1	120	126	PF00149	0.409
DOC_PP1_RVXF_1	78	85	PF00149	0.638
DOC_PP4_FxxP_1	125	128	PF00568	0.428
DOC_WW_Pin1_4	207	212	PF00397	0.441
LIG_14-3-3_CanoR_1	218	227	PF00244	0.383
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BRCT_BRCA1_1	68	72	PF00533	0.739
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.619
LIG_FHA_2	14	20	PF00498	0.599
LIG_FHA_2	203	209	PF00498	0.535
LIG_FHA_2	33	39	PF00498	0.644
LIG_HCF-1_HBM_1	19	22	PF13415	0.595
LIG_IBAR_NPY_1	30	32	PF08397	0.609
LIG_IBAR_NPY_1	76	78	PF08397	0.654
LIG_LIR_Nem_3	116	121	PF02991	0.431
LIG_LIR_Nem_3	158	163	PF02991	0.524
LIG_LIR_Nem_3	208	212	PF02991	0.340
LIG_PDZ_Class_2	238	243	PF00595	0.575
LIG_Pex14_1	55	59	PF04695	0.660
LIG_REV1ctd_RIR_1	70	76	PF16727	0.640
LIG_SH2_CRK	209	213	PF00017	0.340
LIG_SH2_CRK	61	65	PF00017	0.669
LIG_SH2_NCK_1	209	213	PF00017	0.398
LIG_SH2_STAT5	209	212	PF00017	0.463
LIG_SH2_STAT5	23	26	PF00017	0.644
LIG_SH2_STAT5	32	35	PF00017	0.643
LIG_SH2_STAT5	81	84	PF00017	0.653
LIG_SH3_3	136	142	PF00018	0.498
LIG_SH3_3	208	214	PF00018	0.466
LIG_SH3_4	141	148	PF00018	0.500
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.389
LIG_SUMO_SIM_par_1	109	116	PF11976	0.309
LIG_TRFH_1	22	26	PF08558	0.707
LIG_TRFH_1	61	65	PF08558	0.703
MOD_CK1_1	106	112	PF00069	0.475
MOD_CK1_1	2	8	PF00069	0.691
MOD_CK1_1	230	236	PF00069	0.425
MOD_CK2_1	202	208	PF00069	0.523
MOD_CK2_1	85	91	PF00069	0.643
MOD_GlcNHglycan	234	237	PF01048	0.701
MOD_GlcNHglycan	68	71	PF01048	0.466
MOD_GlcNHglycan	8	11	PF01048	0.526
MOD_GSK3_1	113	120	PF00069	0.288
MOD_GSK3_1	2	9	PF00069	0.749
MOD_GSK3_1	227	234	PF00069	0.532
MOD_GSK3_1	99	106	PF00069	0.532
MOD_NEK2_1	113	118	PF00069	0.396
MOD_NEK2_1	202	207	PF00069	0.455
MOD_NEK2_1	85	90	PF00069	0.629
MOD_NEK2_2	128	133	PF00069	0.429
MOD_PIKK_1	202	208	PF00454	0.446
MOD_PIKK_1	228	234	PF00454	0.412
MOD_PKA_2	2	8	PF00069	0.676
MOD_Plk_1	128	134	PF00069	0.420
MOD_Plk_1	85	91	PF00069	0.631
MOD_Plk_2-3	86	92	PF00069	0.631
MOD_Plk_4	103	109	PF00069	0.321
MOD_Plk_4	13	19	PF00069	0.621
MOD_ProDKin_1	207	213	PF00069	0.440
TRG_ENDOCYTIC_2	160	163	PF00928	0.479
TRG_ENDOCYTIC_2	209	212	PF00928	0.342
TRG_ENDOCYTIC_2	61	64	PF00928	0.672
TRG_ER_diArg_1	216	218	PF00400	0.461
TRG_NES_CRM1_1	173	187	PF08389	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	74%	100%
A0A0S4IVH5	Bodo saltans	55%	100%
A0A0S4IXX7	Bodo saltans	43%	92%
A0A1X0NYZ9	Trypanosomatidae	64%	100%
A0A3Q8IGT4	Leishmania donovani	93%	100%
A0A422MZK8	Trypanosoma rangeli	59%	100%
A4HGE2	Leishmania braziliensis	64%	100%
A4HLG1	Leishmania braziliensis	82%	100%
A4I3H5	Leishmania infantum	63%	100%
A4I8X2	Leishmania infantum	93%	100%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
I1ZAQ0	Leishmania donovani	63%	100%
Q4Q483	Leishmania major	94%	100%
Q4Q8G9	Leishmania major	61%	100%
V5AL49	Trypanosoma cruzi	62%	95%