Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3T9_LEIMU

TriTrypDb:

LmxM.32.1050

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3T9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.344
CLV_NRD_NRD_1	233	235	PF00675	0.433
CLV_NRD_NRD_1	263	265	PF00675	0.474
CLV_NRD_NRD_1	379	381	PF00675	0.549
CLV_NRD_NRD_1	74	76	PF00675	0.531
CLV_NRD_NRD_1	77	79	PF00675	0.605
CLV_NRD_NRD_1	84	86	PF00675	0.575
CLV_PCSK_FUR_1	263	267	PF00082	0.354
CLV_PCSK_FUR_1	377	381	PF00082	0.498
CLV_PCSK_FUR_1	75	79	PF00082	0.508
CLV_PCSK_KEX2_1	233	235	PF00082	0.456
CLV_PCSK_KEX2_1	263	265	PF00082	0.383
CLV_PCSK_KEX2_1	267	269	PF00082	0.253
CLV_PCSK_KEX2_1	379	381	PF00082	0.331
CLV_PCSK_KEX2_1	74	76	PF00082	0.575
CLV_PCSK_KEX2_1	77	79	PF00082	0.538
CLV_PCSK_KEX2_1	84	86	PF00082	0.531
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.324
CLV_PCSK_PC7_1	263	269	PF00082	0.323
CLV_PCSK_SKI1_1	237	241	PF00082	0.545
CLV_PCSK_SKI1_1	268	272	PF00082	0.362
CLV_PCSK_SKI1_1	276	280	PF00082	0.375
CLV_PCSK_SKI1_1	30	34	PF00082	0.422
CLV_PCSK_SKI1_1	77	81	PF00082	0.559
DEG_APCC_DBOX_1	267	275	PF00400	0.233
DOC_CYCLIN_RxL_1	263	275	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.373
DOC_MAPK_gen_1	263	271	PF00069	0.464
DOC_MAPK_gen_1	64	72	PF00069	0.565
DOC_MAPK_gen_1	84	90	PF00069	0.544
DOC_MAPK_MEF2A_6	15	23	PF00069	0.528
DOC_WW_Pin1_4	166	171	PF00397	0.450
LIG_14-3-3_CanoR_1	107	116	PF00244	0.728
LIG_14-3-3_CanoR_1	153	160	PF00244	0.454
LIG_14-3-3_CanoR_1	276	286	PF00244	0.355
LIG_14-3-3_CanoR_1	294	299	PF00244	0.324
LIG_14-3-3_CanoR_1	94	103	PF00244	0.585
LIG_Actin_WH2_2	63	79	PF00022	0.564
LIG_CaM_IQ_9	119	134	PF13499	0.407
LIG_Clathr_ClatBox_1	298	302	PF01394	0.366
LIG_FHA_1	153	159	PF00498	0.428
LIG_FHA_1	227	233	PF00498	0.503
LIG_FHA_1	369	375	PF00498	0.401
LIG_FHA_1	400	406	PF00498	0.514
LIG_FHA_1	52	58	PF00498	0.575
LIG_FHA_2	108	114	PF00498	0.691
LIG_FHA_2	333	339	PF00498	0.492
LIG_FHA_2	35	41	PF00498	0.410
LIG_GBD_Chelix_1	72	80	PF00786	0.613
LIG_LIR_Gen_1	280	288	PF02991	0.376
LIG_LIR_Gen_1	302	312	PF02991	0.401
LIG_LIR_Gen_1	412	422	PF02991	0.286
LIG_LIR_Nem_3	302	308	PF02991	0.393
LIG_LIR_Nem_3	412	417	PF02991	0.348
LIG_LIR_Nem_3	419	425	PF02991	0.400
LIG_Pex14_2	325	329	PF04695	0.473
LIG_Rb_pABgroove_1	416	424	PF01858	0.391
LIG_SH2_CRK	181	185	PF00017	0.569
LIG_SH2_NCK_1	211	215	PF00017	0.477
LIG_SH2_STAT5	36	39	PF00017	0.400
LIG_SH2_STAT5	414	417	PF00017	0.382
LIG_SH2_STAT5	425	428	PF00017	0.425
LIG_SH2_STAT5	58	61	PF00017	0.604
LIG_SH3_3	18	24	PF00018	0.406
LIG_SH3_3	298	304	PF00018	0.421
LIG_SH3_3	50	56	PF00018	0.601
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.377
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.504
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.396
LIG_SUMO_SIM_par_1	297	302	PF11976	0.380
LIG_TRAF2_1	289	292	PF00917	0.559
LIG_TRAF2_1	335	338	PF00917	0.528
LIG_TRAF2_1	97	100	PF00917	0.424
LIG_WRC_WIRS_1	326	331	PF05994	0.458
LIG_WW_3	12	16	PF00397	0.524
MOD_CK1_1	34	40	PF00069	0.386
MOD_CK1_1	92	98	PF00069	0.682
MOD_CK2_1	286	292	PF00069	0.470
MOD_CK2_1	332	338	PF00069	0.508
MOD_CK2_1	94	100	PF00069	0.648
MOD_GlcNHglycan	283	286	PF01048	0.473
MOD_GlcNHglycan	397	400	PF01048	0.469
MOD_GSK3_1	272	279	PF00069	0.315
MOD_GSK3_1	357	364	PF00069	0.333
MOD_GSK3_1	395	402	PF00069	0.516
MOD_GSK3_1	421	428	PF00069	0.470
MOD_N-GLC_1	258	263	PF02516	0.677
MOD_N-GLC_1	312	317	PF02516	0.268
MOD_N-GLC_1	46	51	PF02516	0.600
MOD_N-GLC_2	368	370	PF02516	0.501
MOD_NEK2_1	325	330	PF00069	0.461
MOD_NEK2_1	357	362	PF00069	0.390
MOD_NEK2_1	395	400	PF00069	0.401
MOD_NEK2_1	421	426	PF00069	0.440
MOD_NEK2_2	152	157	PF00069	0.412
MOD_NEK2_2	200	205	PF00069	0.508
MOD_NEK2_2	277	282	PF00069	0.389
MOD_PIKK_1	286	292	PF00454	0.256
MOD_PIKK_1	368	374	PF00454	0.455
MOD_PKA_2	131	137	PF00069	0.482
MOD_PKA_2	152	158	PF00069	0.464
MOD_PKA_2	319	325	PF00069	0.355
MOD_PKA_2	332	338	PF00069	0.469
MOD_PKA_2	34	40	PF00069	0.402
MOD_PKA_2	65	71	PF00069	0.554
MOD_Plk_1	257	263	PF00069	0.709
MOD_Plk_1	312	318	PF00069	0.478
MOD_Plk_4	17	23	PF00069	0.506
MOD_Plk_4	294	300	PF00069	0.392
MOD_Plk_4	40	46	PF00069	0.493
MOD_ProDKin_1	166	172	PF00069	0.453
MOD_SUMO_for_1	239	242	PF00179	0.405
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.382
TRG_ENDOCYTIC_2	181	184	PF00928	0.583
TRG_ENDOCYTIC_2	283	286	PF00928	0.374
TRG_ENDOCYTIC_2	414	417	PF00928	0.382
TRG_ER_diArg_1	175	178	PF00400	0.587
TRG_ER_diArg_1	232	234	PF00400	0.432
TRG_ER_diArg_1	262	264	PF00400	0.509
TRG_ER_diArg_1	266	269	PF00400	0.350
TRG_ER_diArg_1	377	380	PF00400	0.489
TRG_ER_diArg_1	74	77	PF00400	0.610
TRG_ER_diArg_1	83	85	PF00400	0.600
TRG_NLS_MonoCore_2	263	268	PF00514	0.339
TRG_NLS_MonoExtC_3	263	268	PF00514	0.339
TRG_NLS_MonoExtN_4	263	270	PF00514	0.310
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H7	Leptomonas seymouri	56%	94%
A0A1X0P162	Trypanosomatidae	50%	100%
A0A3Q8IGI7	Leishmania donovani	85%	100%
A0A422P2L6	Trypanosoma rangeli	47%	100%
A4HLF9	Leishmania braziliensis	75%	100%
A4I8X0	Leishmania infantum	84%	100%
D0A4W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q485	Leishmania major	84%	100%