Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3T8_LEIMU

TriTrypDb:

LmxM.32.1040

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.666
CLV_C14_Caspase3-7	425	429	PF00656	0.378
CLV_NRD_NRD_1	153	155	PF00675	0.551
CLV_NRD_NRD_1	218	220	PF00675	0.499
CLV_NRD_NRD_1	45	47	PF00675	0.496
CLV_NRD_NRD_1	84	86	PF00675	0.523
CLV_PCSK_FUR_1	82	86	PF00082	0.450
CLV_PCSK_KEX2_1	152	154	PF00082	0.550
CLV_PCSK_KEX2_1	45	47	PF00082	0.505
CLV_PCSK_KEX2_1	81	83	PF00082	0.494
CLV_PCSK_KEX2_1	84	86	PF00082	0.521
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.626
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.493
CLV_PCSK_SKI1_1	78	82	PF00082	0.403
CLV_Separin_Metazoa	60	64	PF03568	0.442
DEG_APCC_DBOX_1	260	268	PF00400	0.603
DEG_APCC_DBOX_1	70	78	PF00400	0.241
DEG_Nend_UBRbox_2	1	3	PF02207	0.665
DEG_SCF_FBW7_1	235	240	PF00400	0.449
DOC_CKS1_1	309	314	PF01111	0.535
DOC_MAPK_gen_1	152	160	PF00069	0.609
DOC_MAPK_gen_1	193	202	PF00069	0.414
DOC_MAPK_gen_1	219	227	PF00069	0.449
DOC_MAPK_gen_1	389	397	PF00069	0.428
DOC_MAPK_JIP1_4	154	160	PF00069	0.638
DOC_MAPK_MEF2A_6	324	331	PF00069	0.599
DOC_PP2B_LxvP_1	213	216	PF13499	0.417
DOC_PP4_FxxP_1	306	309	PF00568	0.563
DOC_PP4_FxxP_1	36	39	PF00568	0.597
DOC_USP7_MATH_1	103	107	PF00917	0.671
DOC_USP7_MATH_1	136	140	PF00917	0.766
DOC_USP7_MATH_1	195	199	PF00917	0.544
DOC_USP7_MATH_1	297	301	PF00917	0.661
DOC_USP7_MATH_1	393	397	PF00917	0.653
DOC_WW_Pin1_4	233	238	PF00397	0.481
DOC_WW_Pin1_4	308	313	PF00397	0.543
LIG_14-3-3_CanoR_1	114	120	PF00244	0.615
LIG_14-3-3_CanoR_1	161	165	PF00244	0.493
LIG_14-3-3_CanoR_1	223	228	PF00244	0.279
LIG_14-3-3_CanoR_1	255	259	PF00244	0.597
LIG_14-3-3_CanoR_1	392	398	PF00244	0.592
LIG_14-3-3_CanoR_1	50	59	PF00244	0.439
LIG_Actin_WH2_2	62	80	PF00022	0.462
LIG_BIR_III_4	291	295	PF00653	0.438
LIG_BIR_III_4	365	369	PF00653	0.625
LIG_BRCT_BRCA1_1	161	165	PF00533	0.456
LIG_FHA_1	105	111	PF00498	0.516
LIG_FHA_1	128	134	PF00498	0.646
LIG_FHA_1	175	181	PF00498	0.510
LIG_FHA_1	234	240	PF00498	0.454
LIG_FHA_1	27	33	PF00498	0.564
LIG_FHA_1	314	320	PF00498	0.429
LIG_FHA_1	374	380	PF00498	0.609
LIG_FHA_2	122	128	PF00498	0.725
LIG_FHA_2	238	244	PF00498	0.459
LIG_FHA_2	270	276	PF00498	0.600
LIG_FHA_2	337	343	PF00498	0.435
LIG_FHA_2	372	378	PF00498	0.552
LIG_FHA_2	440	446	PF00498	0.567
LIG_FXI_DFP_1	33	37	PF00024	0.641
LIG_LIR_Apic_2	35	39	PF02991	0.482
LIG_LIR_Gen_1	58	67	PF02991	0.434
LIG_LIR_Gen_1	70	80	PF02991	0.286
LIG_LIR_Nem_3	162	168	PF02991	0.553
LIG_LIR_Nem_3	332	337	PF02991	0.381
LIG_LIR_Nem_3	58	62	PF02991	0.439
LIG_LIR_Nem_3	70	76	PF02991	0.286
LIG_MYND_1	305	309	PF01753	0.526
LIG_PCNA_PIPBox_1	245	254	PF02747	0.532
LIG_PDZ_Class_3	445	450	PF00595	0.604
LIG_Pex14_2	306	310	PF04695	0.570
LIG_SH2_SRC	273	276	PF00017	0.608
LIG_SH2_SRC	9	12	PF00017	0.667
LIG_SH2_STAP1	221	225	PF00017	0.511
LIG_SH2_STAP1	315	319	PF00017	0.454
LIG_SH2_STAP1	9	13	PF00017	0.666
LIG_SH2_STAT5	315	318	PF00017	0.456
LIG_SH2_STAT5	334	337	PF00017	0.272
LIG_SH2_STAT5	73	76	PF00017	0.412
LIG_SH3_3	107	113	PF00018	0.645
LIG_SH3_3	117	123	PF00018	0.725
LIG_SH3_3	306	312	PF00018	0.624
LIG_SUMO_SIM_par_1	236	244	PF11976	0.502
LIG_TRAF2_1	231	234	PF00917	0.500
LIG_TRAF2_1	281	284	PF00917	0.785
LIG_UBA3_1	213	220	PF00899	0.568
LIG_UBA3_1	76	81	PF00899	0.431
MOD_CK1_1	104	110	PF00069	0.686
MOD_CK1_1	163	169	PF00069	0.514
MOD_CK1_1	254	260	PF00069	0.530
MOD_CK1_1	285	291	PF00069	0.663
MOD_CK1_1	396	402	PF00069	0.567
MOD_CK2_1	121	127	PF00069	0.695
MOD_CK2_1	237	243	PF00069	0.442
MOD_CK2_1	269	275	PF00069	0.701
MOD_CK2_1	371	377	PF00069	0.600
MOD_CK2_1	405	411	PF00069	0.599
MOD_CK2_1	90	96	PF00069	0.444
MOD_GlcNHglycan	102	106	PF01048	0.606
MOD_GlcNHglycan	137	141	PF01048	0.671
MOD_GlcNHglycan	165	168	PF01048	0.462
MOD_GlcNHglycan	23	26	PF01048	0.576
MOD_GlcNHglycan	299	302	PF01048	0.699
MOD_GSK3_1	101	108	PF00069	0.601
MOD_GSK3_1	159	166	PF00069	0.666
MOD_GSK3_1	233	240	PF00069	0.500
MOD_GSK3_1	282	289	PF00069	0.665
MOD_N-GLC_1	98	103	PF02516	0.547
MOD_NEK2_1	159	164	PF00069	0.474
MOD_NEK2_1	348	353	PF00069	0.551
MOD_NEK2_1	90	95	PF00069	0.610
MOD_NEK2_2	26	31	PF00069	0.628
MOD_NEK2_2	393	398	PF00069	0.561
MOD_PIKK_1	201	207	PF00454	0.431
MOD_PIKK_1	50	56	PF00454	0.515
MOD_PKA_2	115	121	PF00069	0.623
MOD_PKA_2	160	166	PF00069	0.546
MOD_PKA_2	195	201	PF00069	0.588
MOD_PKA_2	254	260	PF00069	0.481
MOD_Plk_1	282	288	PF00069	0.517
MOD_Plk_2-3	405	411	PF00069	0.696
MOD_Plk_4	129	135	PF00069	0.477
MOD_Plk_4	160	166	PF00069	0.500
MOD_Plk_4	237	243	PF00069	0.479
MOD_ProDKin_1	233	239	PF00069	0.481
MOD_ProDKin_1	308	314	PF00069	0.544
MOD_SUMO_for_1	175	178	PF00179	0.404
MOD_SUMO_for_1	388	391	PF00179	0.430
MOD_SUMO_rev_2	17	24	PF00179	0.500
MOD_SUMO_rev_2	178	184	PF00179	0.591
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.563
TRG_DiLeu_LyEn_5	234	239	PF01217	0.453
TRG_ENDOCYTIC_2	59	62	PF00928	0.428
TRG_ENDOCYTIC_2	73	76	PF00928	0.272
TRG_ER_diArg_1	113	116	PF00400	0.624
TRG_ER_diArg_1	153	155	PF00400	0.553
TRG_ER_diArg_1	337	340	PF00400	0.370
TRG_ER_diArg_1	82	85	PF00400	0.476
TRG_NES_CRM1_1	318	333	PF08389	0.504
TRG_NLS_MonoExtC_3	80	85	PF00514	0.495
TRG_NLS_MonoExtN_4	151	156	PF00514	0.598
TRG_NLS_MonoExtN_4	78	85	PF00514	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG4	Leptomonas seymouri	59%	100%
A0A1X0P2F5	Trypanosomatidae	28%	100%
A0A3R7P2X0	Trypanosoma rangeli	32%	100%
A0A3S7X6N5	Leishmania donovani	92%	100%
A4HLF8	Leishmania braziliensis	80%	100%
A4I8W9	Leishmania infantum	92%	100%
D0A4W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
Q4Q486	Leishmania major	91%	100%
V5AZU2	Trypanosoma cruzi	33%	100%