Geranylgeranyl transferase type-2 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein prenyltransferase alpha subunit repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B3T6_LEIMU

TriTrypDb:

LmxM.32.1030

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005968	Rab-protein geranylgeranyltransferase complex	4	11
GO:0032991	protein-containing complex	1	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3T6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0018344	protein geranylgeranylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0004661	protein geranylgeranyltransferase activity	4	11
GO:0004663	Rab geranylgeranyltransferase activity	5	11
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.336
CLV_C14_Caspase3-7	362	366	PF00656	0.298
CLV_C14_Caspase3-7	91	95	PF00656	0.503
CLV_NRD_NRD_1	174	176	PF00675	0.330
CLV_NRD_NRD_1	198	200	PF00675	0.244
CLV_NRD_NRD_1	343	345	PF00675	0.454
CLV_NRD_NRD_1	456	458	PF00675	0.458
CLV_NRD_NRD_1	473	475	PF00675	0.486
CLV_NRD_NRD_1	68	70	PF00675	0.314
CLV_PCSK_KEX2_1	198	200	PF00082	0.234
CLV_PCSK_KEX2_1	424	426	PF00082	0.529
CLV_PCSK_KEX2_1	455	457	PF00082	0.468
CLV_PCSK_KEX2_1	473	475	PF00082	0.445
CLV_PCSK_KEX2_1	68	70	PF00082	0.313
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.309
CLV_PCSK_SKI1_1	117	121	PF00082	0.252
CLV_PCSK_SKI1_1	199	203	PF00082	0.259
CLV_PCSK_SKI1_1	305	309	PF00082	0.363
CLV_PCSK_SKI1_1	32	36	PF00082	0.414
CLV_PCSK_SKI1_1	425	429	PF00082	0.497
CLV_PCSK_SKI1_1	69	73	PF00082	0.318
CLV_PCSK_SKI1_1	9	13	PF00082	0.588
CLV_Separin_Metazoa	341	345	PF03568	0.206
DEG_APCC_DBOX_1	68	76	PF00400	0.335
DEG_SCF_FBW7_1	98	103	PF00400	0.329
DEG_SPOP_SBC_1	231	235	PF00917	0.579
DOC_PP2B_LxvP_1	56	59	PF13499	0.496
DOC_PP4_FxxP_1	241	244	PF00568	0.368
DOC_PP4_FxxP_1	334	337	PF00568	0.428
DOC_USP7_MATH_1	221	225	PF00917	0.665
DOC_USP7_MATH_1	231	235	PF00917	0.723
DOC_USP7_MATH_1	273	277	PF00917	0.401
DOC_USP7_MATH_1	47	51	PF00917	0.224
DOC_USP7_MATH_1	82	86	PF00917	0.591
DOC_USP7_UBL2_3	113	117	PF12436	0.492
DOC_USP7_UBL2_3	5	9	PF12436	0.629
DOC_WW_Pin1_4	10	15	PF00397	0.591
DOC_WW_Pin1_4	217	222	PF00397	0.664
DOC_WW_Pin1_4	233	238	PF00397	0.655
DOC_WW_Pin1_4	240	245	PF00397	0.434
DOC_WW_Pin1_4	96	101	PF00397	0.681
LIG_14-3-3_CanoR_1	418	424	PF00244	0.435
LIG_14-3-3_CanoR_1	425	431	PF00244	0.351
LIG_Actin_WH2_1	305	322	PF00022	0.269
LIG_APCC_ABBAyCdc20_2	320	326	PF00400	0.406
LIG_APCC_ABBAyCdc20_2	473	479	PF00400	0.469
LIG_BRCT_BRCA1_1	330	334	PF00533	0.426
LIG_Clathr_ClatBox_1	184	188	PF01394	0.431
LIG_EVH1_2	237	241	PF00568	0.397
LIG_FHA_1	164	170	PF00498	0.488
LIG_FHA_1	245	251	PF00498	0.311
LIG_FHA_1	49	55	PF00498	0.460
LIG_FHA_1	97	103	PF00498	0.434
LIG_FHA_2	377	383	PF00498	0.529
LIG_FHA_2	89	95	PF00498	0.503
LIG_LIR_Apic_2	331	337	PF02991	0.323
LIG_LIR_Gen_1	166	174	PF02991	0.463
LIG_LIR_Nem_3	166	170	PF02991	0.471
LIG_LIR_Nem_3	259	264	PF02991	0.429
LIG_LIR_Nem_3	60	65	PF02991	0.313
LIG_NRBOX	169	175	PF00104	0.447
LIG_OCRL_FandH_1	128	140	PF00620	0.512
LIG_OCRL_FandH_1	458	470	PF00620	0.444
LIG_PCNA_yPIPBox_3	17	31	PF02747	0.439
LIG_Pex14_2	334	338	PF04695	0.427
LIG_RPA_C_Fungi	63	75	PF08784	0.208
LIG_SH2_CRK	31	35	PF00017	0.347
LIG_SH2_STAP1	477	481	PF00017	0.438
LIG_SH2_STAT5	252	255	PF00017	0.363
LIG_SH2_STAT5	324	327	PF00017	0.342
LIG_SH2_STAT5	388	391	PF00017	0.372
LIG_SH2_STAT5	461	464	PF00017	0.457
LIG_SH2_STAT5	62	65	PF00017	0.387
LIG_SH3_3	215	221	PF00018	0.573
LIG_SH3_3	8	14	PF00018	0.604
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.367
LIG_SUMO_SIM_par_1	33	38	PF11976	0.402
LIG_SUMO_SIM_par_1	54	60	PF11976	0.491
LIG_TRAF2_1	20	23	PF00917	0.380
LIG_TRAF2_1	243	246	PF00917	0.556
LIG_UBA3_1	135	144	PF00899	0.390
LIG_UBA3_1	169	176	PF00899	0.452
MOD_CDK_SPxxK_3	10	17	PF00069	0.573
MOD_CK1_1	232	238	PF00069	0.627
MOD_CK1_1	259	265	PF00069	0.264
MOD_CK1_1	401	407	PF00069	0.503
MOD_CK1_1	419	425	PF00069	0.287
MOD_CK1_1	84	90	PF00069	0.609
MOD_CK2_1	240	246	PF00069	0.441
MOD_CK2_1	273	279	PF00069	0.445
MOD_CK2_1	289	295	PF00069	0.364
MOD_CK2_1	376	382	PF00069	0.487
MOD_CK2_1	84	90	PF00069	0.559
MOD_GlcNHglycan	221	224	PF01048	0.596
MOD_GlcNHglycan	264	267	PF01048	0.269
MOD_GlcNHglycan	275	278	PF01048	0.326
MOD_GlcNHglycan	292	295	PF01048	0.319
MOD_GlcNHglycan	329	333	PF01048	0.269
MOD_GlcNHglycan	411	414	PF01048	0.551
MOD_GlcNHglycan	419	422	PF01048	0.411
MOD_GlcNHglycan	439	442	PF01048	0.287
MOD_GlcNHglycan	83	87	PF01048	0.652
MOD_GSK3_1	159	166	PF00069	0.647
MOD_GSK3_1	217	224	PF00069	0.703
MOD_GSK3_1	226	233	PF00069	0.729
MOD_GSK3_1	240	247	PF00069	0.529
MOD_GSK3_1	401	408	PF00069	0.565
MOD_GSK3_1	433	440	PF00069	0.485
MOD_GSK3_1	464	471	PF00069	0.440
MOD_GSK3_1	60	67	PF00069	0.470
MOD_GSK3_1	82	89	PF00069	0.643
MOD_GSK3_1	96	103	PF00069	0.500
MOD_N-GLC_1	159	164	PF02516	0.668
MOD_N-GLC_1	259	264	PF02516	0.282
MOD_NEK2_1	169	174	PF00069	0.378
MOD_NEK2_1	250	255	PF00069	0.284
MOD_NEK2_1	30	35	PF00069	0.392
MOD_NEK2_1	359	364	PF00069	0.469
MOD_NEK2_1	437	442	PF00069	0.346
MOD_PIKK_1	226	232	PF00454	0.519
MOD_PIKK_1	398	404	PF00454	0.430
MOD_PKA_2	417	423	PF00069	0.449
MOD_PKA_2	464	470	PF00069	0.225
MOD_Plk_1	262	268	PF00069	0.253
MOD_Plk_1	328	334	PF00069	0.309
MOD_Plk_1	359	365	PF00069	0.372
MOD_Plk_4	169	175	PF00069	0.428
MOD_Plk_4	30	36	PF00069	0.365
MOD_Plk_4	359	365	PF00069	0.453
MOD_Plk_4	401	407	PF00069	0.382
MOD_Plk_4	433	439	PF00069	0.416
MOD_Plk_4	60	66	PF00069	0.361
MOD_ProDKin_1	10	16	PF00069	0.584
MOD_ProDKin_1	217	223	PF00069	0.669
MOD_ProDKin_1	233	239	PF00069	0.643
MOD_ProDKin_1	240	246	PF00069	0.425
MOD_ProDKin_1	96	102	PF00069	0.666
MOD_SUMO_for_1	143	146	PF00179	0.421
MOD_SUMO_for_1	441	444	PF00179	0.423
MOD_SUMO_rev_2	13	19	PF00179	0.470
TRG_DiLeu_BaEn_2	313	319	PF01217	0.413
TRG_DiLeu_BaEn_4	245	251	PF01217	0.330
TRG_ENDOCYTIC_2	126	129	PF00928	0.274
TRG_ENDOCYTIC_2	167	170	PF00928	0.407
TRG_ENDOCYTIC_2	31	34	PF00928	0.360
TRG_ENDOCYTIC_2	335	338	PF00928	0.284
TRG_ENDOCYTIC_2	388	391	PF00928	0.365
TRG_ENDOCYTIC_2	477	480	PF00928	0.351
TRG_ER_diArg_1	197	199	PF00400	0.287
TRG_ER_diArg_1	455	457	PF00400	0.462
TRG_ER_diArg_1	472	474	PF00400	0.470
TRG_ER_diArg_1	68	70	PF00400	0.335
TRG_NES_CRM1_1	137	149	PF08389	0.357
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W4	Leptomonas seymouri	51%	100%
A0A0S4JI96	Bodo saltans	29%	100%
A0A1X0P0V1	Trypanosomatidae	26%	88%
A0A3S7X6L4	Leishmania donovani	88%	100%
A0A422P2I9	Trypanosoma rangeli	32%	97%
A4HLF6	Leishmania braziliensis	74%	99%
A4I8W7	Leishmania infantum	88%	100%
A5A779	Sus scrofa	26%	86%
D0A4W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
O93829	Candida albicans	24%	100%
Q08602	Rattus norvegicus	26%	86%
Q4Q488	Leishmania major	87%	100%
Q5EA80	Bos taurus	26%	86%
Q5NVK5	Pongo abelii	27%	86%
Q92696	Homo sapiens	27%	86%
Q9FJ32	Arabidopsis thaliana	24%	71%
Q9JHK4	Mus musculus	26%	86%
V5BJU9	Trypanosoma cruzi	35%	100%