PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9B3T5_LEIMU

TriTrypDb:

LmxM.32.1020

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3T5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.762
CLV_C14_Caspase3-7	905	909	PF00656	0.663
CLV_NRD_NRD_1	11	13	PF00675	0.609
CLV_NRD_NRD_1	145	147	PF00675	0.833
CLV_NRD_NRD_1	289	291	PF00675	0.683
CLV_NRD_NRD_1	311	313	PF00675	0.769
CLV_NRD_NRD_1	57	59	PF00675	0.846
CLV_NRD_NRD_1	610	612	PF00675	0.631
CLV_NRD_NRD_1	807	809	PF00675	0.433
CLV_NRD_NRD_1	860	862	PF00675	0.530
CLV_NRD_NRD_1	99	101	PF00675	0.825
CLV_PCSK_FUR_1	97	101	PF00082	0.749
CLV_PCSK_KEX2_1	11	13	PF00082	0.734
CLV_PCSK_KEX2_1	145	147	PF00082	0.837
CLV_PCSK_KEX2_1	289	291	PF00082	0.683
CLV_PCSK_KEX2_1	311	313	PF00082	0.847
CLV_PCSK_KEX2_1	57	59	PF00082	0.846
CLV_PCSK_KEX2_1	610	612	PF00082	0.631
CLV_PCSK_KEX2_1	806	808	PF00082	0.433
CLV_PCSK_KEX2_1	97	99	PF00082	0.826
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.631
CLV_PCSK_PC7_1	94	100	PF00082	0.742
CLV_PCSK_SKI1_1	265	269	PF00082	0.747
CLV_PCSK_SKI1_1	808	812	PF00082	0.530
CLV_PCSK_SKI1_1	825	829	PF00082	0.249
CLV_PCSK_SKI1_1	850	854	PF00082	0.530
CLV_PCSK_SKI1_1	861	865	PF00082	0.530
CLV_PCSK_SKI1_1	910	914	PF00082	0.489
DEG_APCC_DBOX_1	806	814	PF00400	0.316
DEG_COP1_1	887	895	PF00400	0.578
DEG_SCF_FBW7_1	509	514	PF00400	0.511
DEG_SPOP_SBC_1	234	238	PF00917	0.542
DEG_SPOP_SBC_1	25	29	PF00917	0.729
DEG_SPOP_SBC_1	294	298	PF00917	0.539
DEG_SPOP_SBC_1	578	582	PF00917	0.720
DOC_CKS1_1	223	228	PF01111	0.542
DOC_CKS1_1	397	402	PF01111	0.518
DOC_CKS1_1	895	900	PF01111	0.629
DOC_CYCLIN_RxL_1	857	866	PF00134	0.530
DOC_MAPK_gen_1	164	174	PF00069	0.742
DOC_MAPK_gen_1	838	845	PF00069	0.530
DOC_MAPK_gen_1	847	856	PF00069	0.381
DOC_MAPK_gen_1	865	873	PF00069	0.530
DOC_MAPK_MEF2A_6	195	203	PF00069	0.531
DOC_MAPK_MEF2A_6	599	607	PF00069	0.549
DOC_MAPK_MEF2A_6	65	74	PF00069	0.743
DOC_MAPK_MEF2A_6	838	845	PF00069	0.530
DOC_MAPK_MEF2A_6	847	856	PF00069	0.381
DOC_MAPK_NFAT4_5	838	846	PF00069	0.530
DOC_PP2B_LxvP_1	461	464	PF13499	0.679
DOC_SPAK_OSR1_1	594	598	PF12202	0.674
DOC_USP7_MATH_1	214	218	PF00917	0.777
DOC_USP7_MATH_1	25	29	PF00917	0.776
DOC_USP7_MATH_1	326	330	PF00917	0.576
DOC_USP7_MATH_1	39	43	PF00917	0.818
DOC_USP7_MATH_1	435	439	PF00917	0.809
DOC_USP7_MATH_1	546	550	PF00917	0.582
DOC_USP7_MATH_1	570	574	PF00917	0.725
DOC_USP7_MATH_1	578	582	PF00917	0.824
DOC_USP7_MATH_1	628	632	PF00917	0.655
DOC_USP7_MATH_1	775	779	PF00917	0.579
DOC_USP7_MATH_1	788	792	PF00917	0.545
DOC_USP7_MATH_1	893	897	PF00917	0.790
DOC_USP7_MATH_2	157	163	PF00917	0.544
DOC_USP7_UBL2_3	584	588	PF12436	0.815
DOC_WW_Pin1_4	124	129	PF00397	0.819
DOC_WW_Pin1_4	14	19	PF00397	0.732
DOC_WW_Pin1_4	222	227	PF00397	0.702
DOC_WW_Pin1_4	229	234	PF00397	0.807
DOC_WW_Pin1_4	295	300	PF00397	0.742
DOC_WW_Pin1_4	315	320	PF00397	0.483
DOC_WW_Pin1_4	396	401	PF00397	0.565
DOC_WW_Pin1_4	447	452	PF00397	0.568
DOC_WW_Pin1_4	507	512	PF00397	0.788
DOC_WW_Pin1_4	808	813	PF00397	0.369
DOC_WW_Pin1_4	891	896	PF00397	0.599
LIG_14-3-3_CanoR_1	171	181	PF00244	0.815
LIG_14-3-3_CanoR_1	243	249	PF00244	0.544
LIG_14-3-3_CanoR_1	571	578	PF00244	0.785
LIG_14-3-3_CanoR_1	65	73	PF00244	0.756
LIG_14-3-3_CanoR_1	97	105	PF00244	0.823
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_4	908	912	PF00653	0.596
LIG_BRCT_BRCA1_1	161	165	PF00533	0.722
LIG_BRCT_BRCA1_1	887	891	PF00533	0.735
LIG_CtBP_PxDLS_1	254	258	PF00389	0.743
LIG_EVH1_1	461	465	PF00568	0.698
LIG_FHA_1	174	180	PF00498	0.662
LIG_FHA_1	213	219	PF00498	0.657
LIG_FHA_1	222	228	PF00498	0.717
LIG_FHA_1	250	256	PF00498	0.617
LIG_FHA_1	491	497	PF00498	0.737
LIG_FHA_1	840	846	PF00498	0.445
LIG_FHA_2	127	133	PF00498	0.826
LIG_FHA_2	189	195	PF00498	0.817
LIG_FHA_2	428	434	PF00498	0.747
LIG_FHA_2	721	727	PF00498	0.634
LIG_FHA_2	797	803	PF00498	0.238
LIG_FHA_2	826	832	PF00498	0.530
LIG_FHA_2	903	909	PF00498	0.811
LIG_HP1_1	70	74	PF01393	0.741
LIG_IBAR_NPY_1	69	71	PF08397	0.817
LIG_Integrin_RGD_1	34	36	PF01839	0.683
LIG_Integrin_RGD_1	906	908	PF01839	0.729
LIG_LIR_Apic_2	329	335	PF02991	0.787
LIG_LIR_Gen_1	288	299	PF02991	0.644
LIG_LIR_Gen_1	428	439	PF02991	0.799
LIG_LIR_Gen_1	476	483	PF02991	0.756
LIG_LIR_Gen_1	887	895	PF02991	0.752
LIG_LIR_Nem_3	288	294	PF02991	0.657
LIG_LIR_Nem_3	428	434	PF02991	0.805
LIG_LIR_Nem_3	476	480	PF02991	0.748
LIG_LIR_Nem_3	715	719	PF02991	0.598
LIG_LIR_Nem_3	887	892	PF02991	0.725
LIG_LYPXL_yS_3	384	387	PF13949	0.806
LIG_PCNA_yPIPBox_3	664	674	PF02747	0.582
LIG_PDZ_Class_3	911	916	PF00595	0.785
LIG_SH2_CRK	407	411	PF00017	0.826
LIG_SH2_CRK	436	440	PF00017	0.586
LIG_SH2_CRK	458	462	PF00017	0.793
LIG_SH2_CRK	469	473	PF00017	0.629
LIG_SH2_GRB2like	105	108	PF00017	0.815
LIG_SH2_NCK_1	407	411	PF00017	0.748
LIG_SH2_NCK_1	431	435	PF00017	0.593
LIG_SH2_NCK_1	436	440	PF00017	0.576
LIG_SH2_PTP2	291	294	PF00017	0.658
LIG_SH2_PTP2	71	74	PF00017	0.820
LIG_SH2_SRC	291	294	PF00017	0.658
LIG_SH2_SRC	332	335	PF00017	0.840
LIG_SH2_SRC	374	377	PF00017	0.831
LIG_SH2_SRC	407	410	PF00017	0.680
LIG_SH2_SRC	431	434	PF00017	0.536
LIG_SH2_STAP1	431	435	PF00017	0.531
LIG_SH2_STAP1	618	622	PF00017	0.537
LIG_SH2_STAT3	355	358	PF00017	0.814
LIG_SH2_STAT3	362	365	PF00017	0.755
LIG_SH2_STAT3	393	396	PF00017	0.832
LIG_SH2_STAT5	291	294	PF00017	0.658
LIG_SH2_STAT5	374	377	PF00017	0.831
LIG_SH2_STAT5	460	463	PF00017	0.785
LIG_SH2_STAT5	709	712	PF00017	0.597
LIG_SH2_STAT5	71	74	PF00017	0.820
LIG_SH2_STAT5	757	760	PF00017	0.530
LIG_SH2_STAT5	844	847	PF00017	0.530
LIG_SH3_1	406	412	PF00018	0.745
LIG_SH3_3	155	161	PF00018	0.806
LIG_SH3_3	289	295	PF00018	0.554
LIG_SH3_3	316	322	PF00018	0.739
LIG_SH3_3	382	388	PF00018	0.626
LIG_SH3_3	406	412	PF00018	0.823
LIG_SH3_3	459	465	PF00018	0.726
LIG_SH3_3	539	545	PF00018	0.753
LIG_SH3_3	76	82	PF00018	0.728
LIG_SH3_3	842	848	PF00018	0.384
LIG_SH3_3	887	893	PF00018	0.741
LIG_SH3_4	746	753	PF00018	0.602
LIG_SUMO_SIM_anti_2	826	831	PF11976	0.530
LIG_SUMO_SIM_par_1	180	186	PF11976	0.528
LIG_SUMO_SIM_par_1	819	824	PF11976	0.444
LIG_TRAF2_1	623	626	PF00917	0.650
LIG_TRAF2_1	787	790	PF00917	0.416
LIG_TRAF2_1	814	817	PF00917	0.530
LIG_TYR_ITIM	434	439	PF00017	0.597
LIG_WRC_WIRS_1	474	479	PF05994	0.745
LIG_WRC_WIRS_1	864	869	PF05994	0.384
MOD_CDK_SPxK_1	396	402	PF00069	0.522
MOD_CDK_SPxxK_3	14	21	PF00069	0.635
MOD_CK1_1	101	107	PF00069	0.742
MOD_CK1_1	120	126	PF00069	0.519
MOD_CK1_1	183	189	PF00069	0.622
MOD_CK1_1	217	223	PF00069	0.766
MOD_CK1_1	261	267	PF00069	0.804
MOD_CK1_1	269	275	PF00069	0.768
MOD_CK1_1	297	303	PF00069	0.776
MOD_CK1_1	414	420	PF00069	0.625
MOD_CK1_1	42	48	PF00069	0.812
MOD_CK1_1	450	456	PF00069	0.603
MOD_CK1_1	53	59	PF00069	0.592
MOD_CK1_1	547	553	PF00069	0.745
MOD_CK1_1	565	571	PF00069	0.617
MOD_CK1_1	580	586	PF00069	0.586
MOD_CK1_1	712	718	PF00069	0.612
MOD_CK1_1	77	83	PF00069	0.563
MOD_CK1_1	846	852	PF00069	0.530
MOD_CK1_1	894	900	PF00069	0.786
MOD_CK2_1	190	196	PF00069	0.736
MOD_CK2_1	244	250	PF00069	0.727
MOD_CK2_1	269	275	PF00069	0.845
MOD_CK2_1	427	433	PF00069	0.746
MOD_CK2_1	720	726	PF00069	0.522
MOD_CK2_1	77	83	PF00069	0.729
MOD_CK2_1	811	817	PF00069	0.530
MOD_CK2_1	84	90	PF00069	0.787
MOD_Cter_Amidation	9	12	PF01082	0.548
MOD_GlcNHglycan	140	143	PF01048	0.821
MOD_GlcNHglycan	18	21	PF01048	0.783
MOD_GlcNHglycan	212	215	PF01048	0.679
MOD_GlcNHglycan	238	241	PF01048	0.800
MOD_GlcNHglycan	268	271	PF01048	0.780
MOD_GlcNHglycan	28	31	PF01048	0.569
MOD_GlcNHglycan	481	484	PF01048	0.800
MOD_GlcNHglycan	488	491	PF01048	0.767
MOD_GlcNHglycan	537	540	PF01048	0.671
MOD_GlcNHglycan	564	567	PF01048	0.793
MOD_GlcNHglycan	572	575	PF01048	0.701
MOD_GlcNHglycan	789	793	PF01048	0.709
MOD_GlcNHglycan	794	797	PF01048	0.482
MOD_GlcNHglycan	813	816	PF01048	0.207
MOD_GSK3_1	117	124	PF00069	0.748
MOD_GSK3_1	170	177	PF00069	0.785
MOD_GSK3_1	182	189	PF00069	0.625
MOD_GSK3_1	210	217	PF00069	0.677
MOD_GSK3_1	218	225	PF00069	0.714
MOD_GSK3_1	229	236	PF00069	0.634
MOD_GSK3_1	249	256	PF00069	0.590
MOD_GSK3_1	257	264	PF00069	0.679
MOD_GSK3_1	265	272	PF00069	0.698
MOD_GSK3_1	276	283	PF00069	0.610
MOD_GSK3_1	293	300	PF00069	0.542
MOD_GSK3_1	40	47	PF00069	0.812
MOD_GSK3_1	475	482	PF00069	0.677
MOD_GSK3_1	486	493	PF00069	0.803
MOD_GSK3_1	507	514	PF00069	0.567
MOD_GSK3_1	52	59	PF00069	0.612
MOD_GSK3_1	546	553	PF00069	0.677
MOD_GSK3_1	556	563	PF00069	0.728
MOD_GSK3_1	565	572	PF00069	0.641
MOD_GSK3_1	576	583	PF00069	0.554
MOD_GSK3_1	771	778	PF00069	0.586
MOD_GSK3_1	788	795	PF00069	0.528
MOD_GSK3_1	821	828	PF00069	0.530
MOD_GSK3_1	839	846	PF00069	0.216
MOD_GSK3_1	84	91	PF00069	0.735
MOD_GSK3_1	99	106	PF00069	0.819
MOD_N-GLC_1	106	111	PF02516	0.739
MOD_N-GLC_1	118	123	PF02516	0.602
MOD_N-GLC_1	218	223	PF02516	0.686
MOD_N-GLC_1	243	248	PF02516	0.691
MOD_N-GLC_1	261	266	PF02516	0.599
MOD_N-GLC_1	414	419	PF02516	0.632
MOD_N-GLC_1	490	495	PF02516	0.661
MOD_N-GLC_1	63	68	PF02516	0.732
MOD_N-GLC_1	808	813	PF02516	0.369
MOD_NEK2_1	1	6	PF00069	0.791
MOD_NEK2_1	118	123	PF00069	0.635
MOD_NEK2_1	133	138	PF00069	0.842
MOD_NEK2_1	172	177	PF00069	0.833
MOD_NEK2_1	218	223	PF00069	0.834
MOD_NEK2_1	257	262	PF00069	0.770
MOD_NEK2_1	266	271	PF00069	0.744
MOD_NEK2_1	44	49	PF00069	0.561
MOD_NEK2_1	63	68	PF00069	0.727
MOD_NEK2_1	84	89	PF00069	0.702
MOD_NEK2_1	843	848	PF00069	0.369
MOD_NEK2_1	863	868	PF00069	0.530
MOD_NEK2_2	326	331	PF00069	0.641
MOD_NEK2_2	709	714	PF00069	0.606
MOD_PIKK_1	107	113	PF00454	0.797
MOD_PIKK_1	146	152	PF00454	0.829
MOD_PIKK_1	281	287	PF00454	0.845
MOD_PIKK_1	425	431	PF00454	0.615
MOD_PIKK_1	481	487	PF00454	0.688
MOD_PIKK_1	496	502	PF00454	0.638
MOD_PIKK_1	560	566	PF00454	0.762
MOD_PK_1	180	186	PF00069	0.528
MOD_PK_1	648	654	PF00069	0.418
MOD_PKA_1	98	104	PF00069	0.828
MOD_PKA_2	170	176	PF00069	0.738
MOD_PKA_2	485	491	PF00069	0.782
MOD_PKA_2	56	62	PF00069	0.840
MOD_PKA_2	570	576	PF00069	0.717
MOD_PKA_2	64	70	PF00069	0.700
MOD_PKA_2	846	852	PF00069	0.530
MOD_PKA_2	98	104	PF00069	0.828
MOD_PKB_1	97	105	PF00069	0.827
MOD_Plk_1	218	224	PF00069	0.720
MOD_Plk_1	243	249	PF00069	0.688
MOD_Plk_1	261	267	PF00069	0.600
MOD_Plk_1	414	420	PF00069	0.633
MOD_Plk_1	825	831	PF00069	0.530
MOD_Plk_1	84	90	PF00069	0.742
MOD_Plk_4	326	332	PF00069	0.743
MOD_Plk_4	414	420	PF00069	0.548
MOD_Plk_4	450	456	PF00069	0.689
MOD_Plk_4	825	831	PF00069	0.530
MOD_Plk_4	84	90	PF00069	0.646
MOD_Plk_4	885	891	PF00069	0.724
MOD_ProDKin_1	124	130	PF00069	0.819
MOD_ProDKin_1	14	20	PF00069	0.731
MOD_ProDKin_1	222	228	PF00069	0.706
MOD_ProDKin_1	229	235	PF00069	0.798
MOD_ProDKin_1	295	301	PF00069	0.745
MOD_ProDKin_1	315	321	PF00069	0.484
MOD_ProDKin_1	396	402	PF00069	0.568
MOD_ProDKin_1	447	453	PF00069	0.567
MOD_ProDKin_1	507	513	PF00069	0.789
MOD_ProDKin_1	808	814	PF00069	0.369
MOD_ProDKin_1	891	897	PF00069	0.604
MOD_SUMO_rev_2	814	821	PF00179	0.433
TRG_DiLeu_BaEn_2	886	892	PF01217	0.733
TRG_DiLeu_BaEn_4	816	822	PF01217	0.530
TRG_ENDOCYTIC_2	291	294	PF00928	0.658
TRG_ENDOCYTIC_2	384	387	PF00928	0.806
TRG_ENDOCYTIC_2	394	397	PF00928	0.669
TRG_ENDOCYTIC_2	431	434	PF00928	0.774
TRG_ENDOCYTIC_2	436	439	PF00928	0.777
TRG_ENDOCYTIC_2	458	461	PF00928	0.798
TRG_ENDOCYTIC_2	469	472	PF00928	0.628
TRG_ENDOCYTIC_2	71	74	PF00928	0.820
TRG_ER_diArg_1	144	146	PF00400	0.835
TRG_ER_diArg_1	206	209	PF00400	0.835
TRG_ER_diArg_1	289	291	PF00400	0.566
TRG_ER_diArg_1	57	60	PF00400	0.768
TRG_ER_diArg_1	665	668	PF00400	0.647
TRG_ER_diArg_1	806	808	PF00400	0.433
TRG_ER_diArg_1	867	870	PF00400	0.530
TRG_ER_diArg_1	96	99	PF00400	0.821
TRG_NES_CRM1_1	642	653	PF08389	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IM55	Leishmania donovani	87%	100%
A4HLF5	Leishmania braziliensis	64%	100%
A4I8W6	Leishmania infantum	86%	96%
Q4Q489	Leishmania major	86%	99%