Diacylglycerol_acyltransferase_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B3T3_LEIMU

TriTrypDb:

LmxM.32.1000

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B3T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3T3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.713
CLV_C14_Caspase3-7	716	720	PF00656	0.664
CLV_NRD_NRD_1	1015	1017	PF00675	0.335
CLV_NRD_NRD_1	153	155	PF00675	0.389
CLV_NRD_NRD_1	287	289	PF00675	0.522
CLV_NRD_NRD_1	295	297	PF00675	0.542
CLV_NRD_NRD_1	350	352	PF00675	0.453
CLV_NRD_NRD_1	500	502	PF00675	0.488
CLV_NRD_NRD_1	531	533	PF00675	0.467
CLV_NRD_NRD_1	594	596	PF00675	0.526
CLV_NRD_NRD_1	655	657	PF00675	0.261
CLV_NRD_NRD_1	825	827	PF00675	0.536
CLV_PCSK_FUR_1	293	297	PF00082	0.452
CLV_PCSK_FUR_1	823	827	PF00082	0.534
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.335
CLV_PCSK_KEX2_1	133	135	PF00082	0.431
CLV_PCSK_KEX2_1	137	139	PF00082	0.406
CLV_PCSK_KEX2_1	153	155	PF00082	0.312
CLV_PCSK_KEX2_1	164	166	PF00082	0.433
CLV_PCSK_KEX2_1	287	289	PF00082	0.473
CLV_PCSK_KEX2_1	295	297	PF00082	0.559
CLV_PCSK_KEX2_1	350	352	PF00082	0.453
CLV_PCSK_KEX2_1	499	501	PF00082	0.463
CLV_PCSK_KEX2_1	508	510	PF00082	0.384
CLV_PCSK_KEX2_1	531	533	PF00082	0.467
CLV_PCSK_KEX2_1	570	572	PF00082	0.349
CLV_PCSK_KEX2_1	654	656	PF00082	0.261
CLV_PCSK_KEX2_1	825	827	PF00082	0.497
CLV_PCSK_KEX2_1	854	856	PF00082	0.519
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.431
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.406
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.402
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.348
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.349
CLV_PCSK_PC1ET2_1	854	856	PF00082	0.519
CLV_PCSK_PC7_1	291	297	PF00082	0.486
CLV_PCSK_PC7_1	650	656	PF00082	0.261
CLV_PCSK_SKI1_1	287	291	PF00082	0.491
CLV_PCSK_SKI1_1	382	386	PF00082	0.480
CLV_PCSK_SKI1_1	47	51	PF00082	0.314
CLV_PCSK_SKI1_1	477	481	PF00082	0.330
CLV_PCSK_SKI1_1	532	536	PF00082	0.443
CLV_PCSK_SKI1_1	570	574	PF00082	0.350
CLV_PCSK_SKI1_1	650	654	PF00082	0.261
CLV_PCSK_SKI1_1	657	661	PF00082	0.261
CLV_PCSK_SKI1_1	691	695	PF00082	0.434
CLV_PCSK_SKI1_1	72	76	PF00082	0.622
CLV_PCSK_SKI1_1	825	829	PF00082	0.550
CLV_Separin_Metazoa	985	989	PF03568	0.657
DEG_COP1_1	220	229	PF00400	0.665
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DOC_CKS1_1	22	27	PF01111	0.665
DOC_CKS1_1	298	303	PF01111	0.645
DOC_CKS1_1	489	494	PF01111	0.671
DOC_CKS1_1	588	593	PF01111	0.613
DOC_CYCLIN_RxL_1	568	578	PF00134	0.562
DOC_CYCLIN_RxL_1	821	831	PF00134	0.699
DOC_CYCLIN_yClb3_PxF_3	587	593	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.582
DOC_MAPK_DCC_7	67	75	PF00069	0.323
DOC_MAPK_DCC_7	837	847	PF00069	0.723
DOC_MAPK_FxFP_2	181	184	PF00069	0.649
DOC_MAPK_gen_1	161	171	PF00069	0.645
DOC_MAPK_gen_1	481	490	PF00069	0.593
DOC_MAPK_gen_1	528	538	PF00069	0.612
DOC_MAPK_gen_1	654	664	PF00069	0.461
DOC_MAPK_gen_1	837	847	PF00069	0.723
DOC_MAPK_HePTP_8	652	664	PF00069	0.461
DOC_MAPK_MEF2A_6	395	402	PF00069	0.621
DOC_MAPK_MEF2A_6	531	538	PF00069	0.596
DOC_MAPK_MEF2A_6	655	664	PF00069	0.461
DOC_MAPK_MEF2A_6	67	75	PF00069	0.323
DOC_MAPK_NFAT4_5	657	665	PF00069	0.461
DOC_MAPK_RevD_3	488	501	PF00069	0.565
DOC_PP1_RVXF_1	140	147	PF00149	0.584
DOC_PP1_RVXF_1	45	51	PF00149	0.461
DOC_PP1_RVXF_1	593	600	PF00149	0.606
DOC_PP1_RVXF_1	70	77	PF00149	0.421
DOC_PP1_RVXF_1	955	962	PF00149	0.517
DOC_PP2B_LxvP_1	54	57	PF13499	0.348
DOC_PP2B_LxvP_1	936	939	PF13499	0.639
DOC_PP2B_PxIxI_1	397	403	PF00149	0.626
DOC_PP4_FxxP_1	181	184	PF00568	0.649
DOC_PP4_FxxP_1	547	550	PF00568	0.556
DOC_PP4_FxxP_1	799	802	PF00568	0.632
DOC_PP4_FxxP_1	961	964	PF00568	0.519
DOC_PP4_FxxP_1	98	101	PF00568	0.380
DOC_USP7_MATH_1	195	199	PF00917	0.683
DOC_USP7_MATH_1	236	240	PF00917	0.829
DOC_USP7_MATH_1	26	30	PF00917	0.654
DOC_USP7_MATH_1	321	325	PF00917	0.835
DOC_USP7_MATH_1	889	893	PF00917	0.632
DOC_USP7_UBL2_3	133	137	PF12436	0.664
DOC_USP7_UBL2_3	898	902	PF12436	0.708
DOC_WW_Pin1_4	21	26	PF00397	0.665
DOC_WW_Pin1_4	225	230	PF00397	0.677
DOC_WW_Pin1_4	242	247	PF00397	0.776
DOC_WW_Pin1_4	250	255	PF00397	0.710
DOC_WW_Pin1_4	294	299	PF00397	0.735
DOC_WW_Pin1_4	439	444	PF00397	0.733
DOC_WW_Pin1_4	488	493	PF00397	0.672
DOC_WW_Pin1_4	587	592	PF00397	0.710
DOC_WW_Pin1_4	691	696	PF00397	0.735
DOC_WW_Pin1_4	732	737	PF00397	0.697
DOC_WW_Pin1_4	778	783	PF00397	0.667
DOC_WW_Pin1_4	784	789	PF00397	0.669
DOC_WW_Pin1_4	798	803	PF00397	0.730
DOC_WW_Pin1_4	838	843	PF00397	0.692
DOC_WW_Pin1_4	909	914	PF00397	0.660
LIG_14-3-3_CanoR_1	165	170	PF00244	0.602
LIG_14-3-3_CanoR_1	322	327	PF00244	0.653
LIG_14-3-3_CanoR_1	416	422	PF00244	0.732
LIG_14-3-3_CanoR_1	685	695	PF00244	0.720
LIG_14-3-3_CanoR_1	79	89	PF00244	0.364
LIG_14-3-3_CanoR_1	969	974	PF00244	0.567
LIG_Actin_WH2_2	991	1006	PF00022	0.502
LIG_AP2alpha_1	930	934	PF02296	0.633
LIG_AP2alpha_2	472	474	PF02296	0.577
LIG_APCC_ABBA_1	480	485	PF00400	0.518
LIG_BRCT_BRCA1_1	324	328	PF00533	0.663
LIG_CtBP_PxDLS_1	246	250	PF00389	0.632
LIG_EH_1	214	218	PF12763	0.661
LIG_eIF4E_1	166	172	PF01652	0.598
LIG_eIF4E_1	175	181	PF01652	0.627
LIG_FHA_1	221	227	PF00498	0.702
LIG_FHA_1	424	430	PF00498	0.651
LIG_FHA_1	443	449	PF00498	0.621
LIG_FHA_1	51	57	PF00498	0.348
LIG_FHA_1	931	937	PF00498	0.604
LIG_FHA_2	375	381	PF00498	0.625
LIG_FHA_2	450	456	PF00498	0.715
LIG_FHA_2	489	495	PF00498	0.668
LIG_FHA_2	577	583	PF00498	0.636
LIG_FHA_2	673	679	PF00498	0.461
LIG_FHA_2	692	698	PF00498	0.693
LIG_HP1_1	71	75	PF01393	0.322
LIG_Integrin_RGD_1	758	760	PF01839	0.443
LIG_LIR_Apic_2	544	550	PF02991	0.557
LIG_LIR_Apic_2	797	802	PF02991	0.635
LIG_LIR_Gen_1	231	240	PF02991	0.673
LIG_LIR_Gen_1	992	1003	PF02991	0.499
LIG_LIR_Nem_3	1000	1005	PF02991	0.511
LIG_LIR_Nem_3	231	237	PF02991	0.678
LIG_LIR_Nem_3	472	478	PF02991	0.571
LIG_LIR_Nem_3	544	548	PF02991	0.575
LIG_LIR_Nem_3	554	559	PF02991	0.616
LIG_LIR_Nem_3	992	998	PF02991	0.495
LIG_MYND_1	802	806	PF01753	0.716
LIG_NRBOX	626	632	PF00104	0.575
LIG_PDZ_Class_3	1016	1021	PF00595	0.528
LIG_Pex14_1	116	120	PF04695	0.283
LIG_Pex14_1	163	167	PF04695	0.598
LIG_Pex14_2	474	478	PF04695	0.684
LIG_Pex14_2	930	934	PF04695	0.594
LIG_PROFILIN_1	338	344	PF00235	0.627
LIG_PTB_Apo_2	212	219	PF02174	0.634
LIG_REV1ctd_RIR_1	472	481	PF16727	0.573
LIG_SH2_CRK	175	179	PF00017	0.621
LIG_SH2_CRK	63	67	PF00017	0.513
LIG_SH2_NCK_1	971	975	PF00017	0.584
LIG_SH2_PTP2	548	551	PF00017	0.563
LIG_SH2_SRC	122	125	PF00017	0.474
LIG_SH2_SRC	618	621	PF00017	0.639
LIG_SH2_STAP1	117	121	PF00017	0.300
LIG_SH2_STAP1	618	622	PF00017	0.635
LIG_SH2_STAT3	1005	1008	PF00017	0.562
LIG_SH2_STAT3	681	684	PF00017	0.461
LIG_SH2_STAT5	1009	1012	PF00017	0.536
LIG_SH2_STAT5	122	125	PF00017	0.469
LIG_SH2_STAT5	155	158	PF00017	0.604
LIG_SH2_STAT5	166	169	PF00017	0.692
LIG_SH2_STAT5	354	357	PF00017	0.526
LIG_SH2_STAT5	469	472	PF00017	0.538
LIG_SH2_STAT5	548	551	PF00017	0.563
LIG_SH2_STAT5	63	66	PF00017	0.540
LIG_SH2_STAT5	674	677	PF00017	0.461
LIG_SH2_STAT5	681	684	PF00017	0.461
LIG_SH2_STAT5	960	963	PF00017	0.512
LIG_SH2_STAT5	971	974	PF00017	0.578
LIG_SH2_STAT5	977	980	PF00017	0.590
LIG_SH2_STAT5	994	997	PF00017	0.428
LIG_SH3_1	295	301	PF00018	0.647
LIG_SH3_2	298	303	PF14604	0.645
LIG_SH3_2	340	345	PF14604	0.685
LIG_SH3_2	591	596	PF14604	0.610
LIG_SH3_3	223	229	PF00018	0.737
LIG_SH3_3	295	301	PF00018	0.711
LIG_SH3_3	332	338	PF00018	0.708
LIG_SH3_3	340	346	PF00018	0.712
LIG_SH3_3	388	394	PF00018	0.606
LIG_SH3_3	467	473	PF00018	0.546
LIG_SH3_3	476	482	PF00018	0.524
LIG_SH3_3	486	492	PF00018	0.658
LIG_SH3_3	585	591	PF00018	0.710
LIG_SH3_3	65	71	PF00018	0.320
LIG_SH3_3	783	789	PF00018	0.730
LIG_SH3_3	952	958	PF00018	0.526
LIG_SH3_CIN85_PxpxPR_1	732	737	PF14604	0.642
LIG_SUMO_SIM_par_1	444	449	PF11976	0.624
LIG_SUMO_SIM_par_1	52	58	PF11976	0.348
LIG_TRAF2_1	738	741	PF00917	0.744
LIG_TRAF2_1	989	992	PF00917	0.500
LIG_TRFH_1	478	482	PF08558	0.318
LIG_TRFH_1	961	965	PF08558	0.389
LIG_WRC_WIRS_1	56	61	PF05994	0.352
LIG_WRC_WIRS_1	673	678	PF05994	0.293
MOD_CDK_SPK_2	732	737	PF00069	0.547
MOD_CDK_SPxK_1	297	303	PF00069	0.693
MOD_CDK_SPxxK_3	732	739	PF00069	0.547
MOD_CK1_1	198	204	PF00069	0.739
MOD_CK1_1	220	226	PF00069	0.654
MOD_CK1_1	245	251	PF00069	0.683
MOD_CK1_1	29	35	PF00069	0.539
MOD_CK1_1	324	330	PF00069	0.596
MOD_CK1_1	374	380	PF00069	0.484
MOD_CK1_1	401	407	PF00069	0.661
MOD_CK1_1	410	416	PF00069	0.564
MOD_CK1_1	433	439	PF00069	0.590
MOD_CK1_1	442	448	PF00069	0.597
MOD_CK1_1	565	571	PF00069	0.387
MOD_CK1_1	686	692	PF00069	0.653
MOD_CK1_1	735	741	PF00069	0.691
MOD_CK1_1	765	771	PF00069	0.652
MOD_CK1_1	777	783	PF00069	0.611
MOD_CK1_1	795	801	PF00069	0.764
MOD_CK1_1	858	864	PF00069	0.577
MOD_CK1_1	875	881	PF00069	0.559
MOD_CK1_1	911	917	PF00069	0.581
MOD_CK2_1	326	332	PF00069	0.650
MOD_CK2_1	576	582	PF00069	0.527
MOD_CK2_1	611	617	PF00069	0.579
MOD_CK2_1	672	678	PF00069	0.293
MOD_CK2_1	735	741	PF00069	0.691
MOD_CK2_1	861	867	PF00069	0.652
MOD_CK2_1	876	882	PF00069	0.535
MOD_Cter_Amidation	823	826	PF01082	0.534
MOD_DYRK1A_RPxSP_1	840	844	PF00069	0.651
MOD_GlcNHglycan	197	200	PF01048	0.605
MOD_GlcNHglycan	209	212	PF01048	0.598
MOD_GlcNHglycan	219	222	PF01048	0.620
MOD_GlcNHglycan	265	268	PF01048	0.709
MOD_GlcNHglycan	275	280	PF01048	0.565
MOD_GlcNHglycan	28	31	PF01048	0.578
MOD_GlcNHglycan	32	35	PF01048	0.547
MOD_GlcNHglycan	40	43	PF01048	0.450
MOD_GlcNHglycan	432	435	PF01048	0.611
MOD_GlcNHglycan	439	442	PF01048	0.564
MOD_GlcNHglycan	455	458	PF01048	0.636
MOD_GlcNHglycan	619	623	PF01048	0.529
MOD_GlcNHglycan	643	646	PF01048	0.348
MOD_GlcNHglycan	667	670	PF01048	0.293
MOD_GlcNHglycan	686	689	PF01048	0.580
MOD_GlcNHglycan	721	724	PF01048	0.673
MOD_GlcNHglycan	762	765	PF01048	0.647
MOD_GlcNHglycan	794	797	PF01048	0.625
MOD_GlcNHglycan	857	860	PF01048	0.569
MOD_GSK3_1	195	202	PF00069	0.640
MOD_GSK3_1	21	28	PF00069	0.651
MOD_GSK3_1	225	232	PF00069	0.649
MOD_GSK3_1	250	257	PF00069	0.621
MOD_GSK3_1	299	306	PF00069	0.667
MOD_GSK3_1	322	329	PF00069	0.633
MOD_GSK3_1	417	424	PF00069	0.773
MOD_GSK3_1	433	440	PF00069	0.572
MOD_GSK3_1	449	456	PF00069	0.750
MOD_GSK3_1	672	679	PF00069	0.293
MOD_GSK3_1	683	690	PF00069	0.293
MOD_GSK3_1	699	706	PF00069	0.546
MOD_GSK3_1	713	720	PF00069	0.653
MOD_GSK3_1	773	780	PF00069	0.641
MOD_GSK3_1	794	801	PF00069	0.677
MOD_GSK3_1	872	879	PF00069	0.652
MOD_GSK3_1	908	915	PF00069	0.617
MOD_GSK3_1	930	937	PF00069	0.489
MOD_LATS_1	294	300	PF00433	0.633
MOD_LATS_1	320	326	PF00433	0.616
MOD_N-GLC_1	263	268	PF02516	0.629
MOD_N-GLC_1	374	379	PF02516	0.506
MOD_N-GLC_1	575	580	PF02516	0.510
MOD_N-GLC_1	732	737	PF02516	0.624
MOD_N-GLC_1	773	778	PF02516	0.602
MOD_NEK2_1	217	222	PF00069	0.654
MOD_NEK2_1	421	426	PF00069	0.589
MOD_NEK2_1	50	55	PF00069	0.348
MOD_NEK2_1	641	646	PF00069	0.293
MOD_NEK2_1	660	665	PF00069	0.293
MOD_NEK2_1	930	935	PF00069	0.487
MOD_NEK2_1	950	955	PF00069	0.279
MOD_NEK2_2	199	204	PF00069	0.505
MOD_PIKK_1	576	582	PF00454	0.625
MOD_PIKK_1	663	669	PF00454	0.293
MOD_PK_1	322	328	PF00069	0.670
MOD_PKA_2	321	327	PF00069	0.581
MOD_PKA_2	660	666	PF00069	0.205
MOD_PKA_2	684	690	PF00069	0.348
MOD_PKA_2	81	87	PF00069	0.517
MOD_PKA_2	917	923	PF00069	0.542
MOD_PKB_1	499	507	PF00069	0.566
MOD_Plk_1	128	134	PF00069	0.522
MOD_Plk_1	562	568	PF00069	0.379
MOD_Plk_1	618	624	PF00069	0.606
MOD_Plk_1	876	882	PF00069	0.662
MOD_Plk_4	700	706	PF00069	0.632
MOD_Plk_4	869	875	PF00069	0.511
MOD_Plk_4	950	956	PF00069	0.390
MOD_ProDKin_1	21	27	PF00069	0.576
MOD_ProDKin_1	225	231	PF00069	0.601
MOD_ProDKin_1	242	248	PF00069	0.737
MOD_ProDKin_1	250	256	PF00069	0.644
MOD_ProDKin_1	294	300	PF00069	0.677
MOD_ProDKin_1	439	445	PF00069	0.678
MOD_ProDKin_1	488	494	PF00069	0.588
MOD_ProDKin_1	587	593	PF00069	0.643
MOD_ProDKin_1	691	697	PF00069	0.676
MOD_ProDKin_1	732	738	PF00069	0.623
MOD_ProDKin_1	778	784	PF00069	0.584
MOD_ProDKin_1	798	804	PF00069	0.671
MOD_ProDKin_1	838	844	PF00069	0.612
MOD_ProDKin_1	909	915	PF00069	0.567
MOD_SUMO_for_1	514	517	PF00179	0.589
MOD_SUMO_for_1	901	904	PF00179	0.638
MOD_SUMO_rev_2	33	40	PF00179	0.549
MOD_SUMO_rev_2	374	384	PF00179	0.499
TRG_DiLeu_BaEn_1	285	290	PF01217	0.603
TRG_DiLeu_BaEn_4	285	291	PF01217	0.609
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.543
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.348
TRG_DiLeu_BaLyEn_6	823	828	PF01217	0.621
TRG_DiLeu_BaLyEn_6	918	923	PF01217	0.401
TRG_DiLeu_LyEn_5	285	290	PF01217	0.593
TRG_ENDOCYTIC_2	117	120	PF00928	0.299
TRG_ENDOCYTIC_2	166	169	PF00928	0.658
TRG_ENDOCYTIC_2	175	178	PF00928	0.517
TRG_ENDOCYTIC_2	471	474	PF00928	0.476
TRG_ENDOCYTIC_2	548	551	PF00928	0.447
TRG_ENDOCYTIC_2	559	562	PF00928	0.504
TRG_ENDOCYTIC_2	63	66	PF00928	0.568
TRG_ENDOCYTIC_2	960	963	PF00928	0.365
TRG_ER_diArg_1	152	154	PF00400	0.471
TRG_ER_diArg_1	287	289	PF00400	0.615
TRG_ER_diArg_1	290	293	PF00400	0.639
TRG_ER_diArg_1	349	351	PF00400	0.588
TRG_ER_diArg_1	498	501	PF00400	0.577
TRG_ER_diArg_1	5	8	PF00400	0.562
TRG_ER_diArg_1	530	532	PF00400	0.522
TRG_ER_diArg_1	536	539	PF00400	0.433
TRG_ER_diArg_1	653	656	PF00400	0.293
TRG_ER_diArg_1	823	826	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	528	533	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	825	830	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P762	Leptomonas seymouri	48%	91%
A0A3S7X6M4	Leishmania donovani	84%	100%
A4I8W4	Leishmania infantum	83%	91%
Q4Q491	Leishmania major	83%	100%