Dnaj chaperone-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dnaj chaperone-like protein

Species:

Leishmania mexicana

UniProt:

E9B3S2_LEIMU

TriTrypDb:

LmxM.32.0900

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B3S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.361
CLV_NRD_NRD_1	191	193	PF00675	0.343
CLV_NRD_NRD_1	225	227	PF00675	0.525
CLV_NRD_NRD_1	24	26	PF00675	0.455
CLV_NRD_NRD_1	345	347	PF00675	0.665
CLV_PCSK_FUR_1	189	193	PF00082	0.336
CLV_PCSK_KEX2_1	191	193	PF00082	0.343
CLV_PCSK_KEX2_1	20	22	PF00082	0.453
CLV_PCSK_KEX2_1	225	227	PF00082	0.525
CLV_PCSK_KEX2_1	24	26	PF00082	0.449
CLV_PCSK_KEX2_1	345	347	PF00082	0.665
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.453
CLV_PCSK_SKI1_1	12	16	PF00082	0.533
CLV_PCSK_SKI1_1	225	229	PF00082	0.544
CLV_PCSK_SKI1_1	25	29	PF00082	0.422
CLV_PCSK_SKI1_1	294	298	PF00082	0.534
DEG_APCC_DBOX_1	293	301	PF00400	0.334
DEG_SCF_FBW7_1	549	556	PF00400	0.607
DOC_AGCK_PIF_1	208	213	PF00069	0.205
DOC_CDC14_PxL_1	138	146	PF14671	0.304
DOC_MAPK_gen_1	20	28	PF00069	0.269
DOC_MAPK_MEF2A_6	460	469	PF00069	0.325
DOC_MAPK_NFAT4_5	460	468	PF00069	0.325
DOC_PP1_RVXF_1	241	247	PF00149	0.308
DOC_USP7_MATH_1	340	344	PF00917	0.559
DOC_USP7_MATH_1	381	385	PF00917	0.476
DOC_WW_Pin1_4	12	17	PF00397	0.284
DOC_WW_Pin1_4	127	132	PF00397	0.511
DOC_WW_Pin1_4	151	156	PF00397	0.503
DOC_WW_Pin1_4	344	349	PF00397	0.463
DOC_WW_Pin1_4	549	554	PF00397	0.705
DOC_WW_Pin1_4	564	569	PF00397	0.690
LIG_14-3-3_CanoR_1	121	126	PF00244	0.550
LIG_14-3-3_CanoR_1	189	198	PF00244	0.569
LIG_APCC_ABBA_1	471	476	PF00400	0.205
LIG_BRCT_BRCA1_1	129	133	PF00533	0.469
LIG_CtBP_PxDLS_1	155	159	PF00389	0.285
LIG_EH1_1	465	473	PF00400	0.205
LIG_FHA_1	172	178	PF00498	0.304
LIG_FHA_1	191	197	PF00498	0.561
LIG_FHA_1	286	292	PF00498	0.304
LIG_FHA_1	420	426	PF00498	0.359
LIG_FHA_1	434	440	PF00498	0.364
LIG_FHA_1	473	479	PF00498	0.270
LIG_FHA_1	86	92	PF00498	0.366
LIG_FHA_1	98	104	PF00498	0.304
LIG_FHA_2	4	10	PF00498	0.198
LIG_FHA_2	46	52	PF00498	0.269
LIG_FHA_2	501	507	PF00498	0.706
LIG_FHA_2	565	571	PF00498	0.701
LIG_GBD_Chelix_1	423	431	PF00786	0.336
LIG_IBAR_NPY_1	406	408	PF08397	0.454
LIG_LIR_Gen_1	122	133	PF02991	0.521
LIG_LIR_Gen_1	209	218	PF02991	0.304
LIG_LIR_Gen_1	3	10	PF02991	0.269
LIG_LIR_Nem_3	122	128	PF02991	0.526
LIG_LIR_Nem_3	209	214	PF02991	0.304
LIG_LIR_Nem_3	272	278	PF02991	0.308
LIG_LIR_Nem_3	3	8	PF02991	0.269
LIG_LIR_Nem_3	451	455	PF02991	0.469
LIG_LIR_Nem_3	48	53	PF02991	0.269
LIG_LIR_Nem_3	60	65	PF02991	0.268
LIG_NRBOX	160	166	PF00104	0.344
LIG_NRBOX	427	433	PF00104	0.325
LIG_Pex14_2	111	115	PF04695	0.477
LIG_Pex14_2	129	133	PF04695	0.395
LIG_SH2_CRK	23	27	PF00017	0.269
LIG_SH2_CRK	241	245	PF00017	0.316
LIG_SH2_CRK	452	456	PF00017	0.469
LIG_SH2_GRB2like	446	449	PF00017	0.587
LIG_SH2_NCK_1	241	245	PF00017	0.316
LIG_SH2_PTP2	125	128	PF00017	0.502
LIG_SH2_STAT3	408	411	PF00017	0.447
LIG_SH2_STAT5	125	128	PF00017	0.558
LIG_SH2_STAT5	195	198	PF00017	0.584
LIG_SH2_STAT5	206	209	PF00017	0.265
LIG_SH2_STAT5	241	244	PF00017	0.302
LIG_SH2_STAT5	275	278	PF00017	0.304
LIG_SH2_STAT5	303	306	PF00017	0.379
LIG_SH2_STAT5	336	339	PF00017	0.437
LIG_SH2_STAT5	5	8	PF00017	0.197
LIG_SH3_1	520	526	PF00018	0.660
LIG_SH3_3	125	131	PF00018	0.513
LIG_SH3_3	172	178	PF00018	0.205
LIG_SH3_3	520	526	PF00018	0.716
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.325
LIG_SUMO_SIM_anti_2	212	220	PF11976	0.205
LIG_SUMO_SIM_anti_2	487	493	PF11976	0.205
LIG_SUMO_SIM_par_1	148	154	PF11976	0.205
LIG_SUMO_SIM_par_1	212	220	PF11976	0.261
LIG_SUMO_SIM_par_1	226	232	PF11976	0.321
LIG_SUMO_SIM_par_1	421	426	PF11976	0.205
LIG_SUMO_SIM_par_1	453	459	PF11976	0.308
LIG_SUMO_SIM_par_1	487	493	PF11976	0.205
LIG_SUMO_SIM_par_1	6	11	PF11976	0.251
LIG_SUMO_SIM_par_1	91	98	PF11976	0.292
LIG_TRAF2_1	503	506	PF00917	0.639
LIG_TYR_ITIM	273	278	PF00017	0.325
LIG_UBA3_1	227	231	PF00899	0.398
LIG_WRC_WIRS_1	112	117	PF05994	0.325
LIG_WRC_WIRS_1	210	215	PF05994	0.205
LIG_WRC_WIRS_1	82	87	PF05994	0.540
MOD_CDK_SPK_2	564	569	PF00069	0.649
MOD_CDK_SPxxK_3	564	571	PF00069	0.628
MOD_CK1_1	154	160	PF00069	0.486
MOD_CK1_1	209	215	PF00069	0.278
MOD_CK1_1	302	308	PF00069	0.471
MOD_CK1_1	532	538	PF00069	0.523
MOD_CK2_1	3	9	PF00069	0.219
MOD_CK2_1	45	51	PF00069	0.304
MOD_CK2_1	500	506	PF00069	0.673
MOD_CK2_1	557	563	PF00069	0.646
MOD_CK2_1	564	570	PF00069	0.578
MOD_CMANNOS	198	201	PF00535	0.381
MOD_GlcNHglycan	158	161	PF01048	0.205
MOD_GlcNHglycan	498	501	PF01048	0.604
MOD_GlcNHglycan	531	534	PF01048	0.540
MOD_GlcNHglycan	549	552	PF01048	0.655
MOD_GSK3_1	156	163	PF00069	0.205
MOD_GSK3_1	216	223	PF00069	0.355
MOD_GSK3_1	298	305	PF00069	0.416
MOD_GSK3_1	340	347	PF00069	0.613
MOD_GSK3_1	419	426	PF00069	0.265
MOD_GSK3_1	496	503	PF00069	0.572
MOD_GSK3_1	549	556	PF00069	0.650
MOD_GSK3_1	572	579	PF00069	0.592
MOD_GSK3_1	81	88	PF00069	0.499
MOD_LATS_1	119	125	PF00433	0.300
MOD_N-GLC_1	239	244	PF02516	0.394
MOD_N-GLC_1	359	364	PF02516	0.588
MOD_N-GLC_1	448	453	PF02516	0.350
MOD_NEK2_1	111	116	PF00069	0.284
MOD_NEK2_1	156	161	PF00069	0.358
MOD_NEK2_1	285	290	PF00069	0.369
MOD_NEK2_1	299	304	PF00069	0.352
MOD_NEK2_1	419	424	PF00069	0.384
MOD_NEK2_1	432	437	PF00069	0.339
MOD_NEK2_1	456	461	PF00069	0.437
MOD_NEK2_1	85	90	PF00069	0.496
MOD_NEK2_2	206	211	PF00069	0.325
MOD_PKA_2	190	196	PF00069	0.397
MOD_PKA_2	576	582	PF00069	0.684
MOD_Plk_1	239	245	PF00069	0.424
MOD_Plk_1	573	579	PF00069	0.689
MOD_Plk_2-3	3	9	PF00069	0.205
MOD_Plk_4	111	117	PF00069	0.287
MOD_Plk_4	160	166	PF00069	0.369
MOD_Plk_4	171	177	PF00069	0.254
MOD_Plk_4	285	291	PF00069	0.304
MOD_Plk_4	299	305	PF00069	0.426
MOD_Plk_4	3	9	PF00069	0.205
MOD_Plk_4	419	425	PF00069	0.371
MOD_Plk_4	484	490	PF00069	0.234
MOD_ProDKin_1	12	18	PF00069	0.325
MOD_ProDKin_1	127	133	PF00069	0.363
MOD_ProDKin_1	151	157	PF00069	0.501
MOD_ProDKin_1	344	350	PF00069	0.573
MOD_ProDKin_1	549	555	PF00069	0.638
MOD_ProDKin_1	564	570	PF00069	0.612
MOD_SUMO_rev_2	224	233	PF00179	0.432
MOD_SUMO_rev_2	504	509	PF00179	0.594
TRG_ENDOCYTIC_2	125	128	PF00928	0.369
TRG_ENDOCYTIC_2	23	26	PF00928	0.304
TRG_ENDOCYTIC_2	241	244	PF00928	0.370
TRG_ENDOCYTIC_2	275	278	PF00928	0.304
TRG_ENDOCYTIC_2	452	455	PF00928	0.304
TRG_ENDOCYTIC_2	5	8	PF00928	0.304
TRG_ENDOCYTIC_2	50	53	PF00928	0.304
TRG_ER_diArg_1	189	192	PF00400	0.392
TRG_ER_diArg_1	225	227	PF00400	0.385
TRG_ER_diArg_1	23	25	PF00400	0.284
TRG_ER_diArg_1	344	346	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P4	Leptomonas seymouri	50%	100%
A0A3S7X6M9	Leishmania donovani	87%	100%
A4HLE4	Leishmania braziliensis	64%	100%
A4I8V3	Leishmania infantum	87%	100%
Q4Q4A2	Leishmania major	85%	100%