Zf-Tim10_DDP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3S1_LEIMU

TriTrypDb:

LmxM.32.0890

Length:

114

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.570
DEG_SCF_FBW7_2	6	13	PF00400	0.544
DOC_CKS1_1	7	12	PF01111	0.550
DOC_PP4_MxPP_1	1	4	PF00568	0.566
DOC_WW_Pin1_4	6	11	PF00397	0.587
LIG_14-3-3_CanoR_1	26	33	PF00244	0.509
LIG_APCC_ABBA_1	8	13	PF00400	0.529
LIG_BRCT_BRCA1_1	34	38	PF00533	0.423
LIG_FHA_1	35	41	PF00498	0.508
LIG_FHA_1	44	50	PF00498	0.477
LIG_FHA_2	7	13	PF00498	0.476
LIG_FHA_2	86	92	PF00498	0.549
LIG_LIR_Gen_1	16	27	PF02991	0.413
LIG_LIR_Gen_1	48	58	PF02991	0.463
LIG_LIR_Gen_1	78	89	PF02991	0.535
LIG_LIR_Nem_3	16	22	PF02991	0.456
LIG_LIR_Nem_3	78	84	PF02991	0.533
LIG_Pex14_1	81	85	PF04695	0.400
LIG_SH2_CRK	19	23	PF00017	0.494
LIG_SH2_GRB2like	21	24	PF00017	0.559
LIG_SH2_SRC	21	24	PF00017	0.486
LIG_SH2_STAP1	11	15	PF00017	0.563
LIG_SH2_STAT3	62	65	PF00017	0.558
LIG_SH2_STAT5	21	24	PF00017	0.559
LIG_SH2_STAT5	50	53	PF00017	0.486
LIG_SH3_3	1	7	PF00018	0.545
LIG_TRAF2_1	10	13	PF00917	0.578
MOD_CK2_1	6	12	PF00069	0.487
MOD_CK2_1	85	91	PF00069	0.537
MOD_GlcNHglycan	28	31	PF01048	0.423
MOD_GlcNHglycan	77	80	PF01048	0.527
MOD_GlcNHglycan	94	97	PF01048	0.611
MOD_GSK3_1	48	55	PF00069	0.464
MOD_GSK3_1	85	92	PF00069	0.529
MOD_N-GLC_1	13	18	PF02516	0.550
MOD_N-GLC_1	33	38	PF02516	0.415
MOD_N-GLC_1	75	80	PF02516	0.523
MOD_N-GLC_1	85	90	PF02516	0.540
MOD_N-GLC_1	92	97	PF02516	0.555
MOD_NEK2_1	32	37	PF00069	0.435
MOD_NEK2_1	52	57	PF00069	0.466
MOD_NEK2_1	85	90	PF00069	0.540
MOD_PIKK_1	43	49	PF00454	0.471
MOD_PKA_2	53	59	PF00069	0.469
MOD_Plk_1	33	39	PF00069	0.512
MOD_Plk_1	85	91	PF00069	0.542
MOD_Plk_1	92	98	PF00069	0.464
MOD_Plk_4	48	54	PF00069	0.464
MOD_ProDKin_1	6	12	PF00069	0.582
MOD_SUMO_rev_2	67	74	PF00179	0.417
TRG_DiLeu_BaEn_1	48	53	PF01217	0.501
TRG_ENDOCYTIC_2	19	22	PF00928	0.495
TRG_ENDOCYTIC_2	50	53	PF00928	0.486
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I217	Leptomonas seymouri	69%	100%
A0A0S4JGU8	Bodo saltans	58%	98%
A0A1X0P0S4	Trypanosomatidae	60%	100%
A0A3Q8IDN3	Leishmania donovani	97%	100%
A0A422P2N7	Trypanosoma rangeli	60%	100%
A4HLE3	Leishmania braziliensis	91%	100%
A4I8V2	Leishmania infantum	97%	100%
D0A4U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
Q4Q4A3	Leishmania major	97%	100%