Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3S0_LEIMU

TriTrypDb:

LmxM.32.0880

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B3S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.745
CLV_NRD_NRD_1	121	123	PF00675	0.395
CLV_NRD_NRD_1	214	216	PF00675	0.716
CLV_NRD_NRD_1	256	258	PF00675	0.534
CLV_NRD_NRD_1	46	48	PF00675	0.451
CLV_NRD_NRD_1	76	78	PF00675	0.435
CLV_NRD_NRD_1	79	81	PF00675	0.465
CLV_NRD_NRD_1	94	96	PF00675	0.370
CLV_PCSK_FUR_1	77	81	PF00082	0.301
CLV_PCSK_FUR_1	92	96	PF00082	0.446
CLV_PCSK_KEX2_1	121	123	PF00082	0.393
CLV_PCSK_KEX2_1	214	216	PF00082	0.716
CLV_PCSK_KEX2_1	256	258	PF00082	0.604
CLV_PCSK_KEX2_1	45	47	PF00082	0.474
CLV_PCSK_KEX2_1	76	78	PF00082	0.485
CLV_PCSK_KEX2_1	79	81	PF00082	0.465
CLV_PCSK_KEX2_1	94	96	PF00082	0.439
CLV_PCSK_SKI1_1	196	200	PF00082	0.532
CLV_PCSK_SKI1_1	79	83	PF00082	0.459
CLV_PCSK_SKI1_1	94	98	PF00082	0.326
DEG_APCC_DBOX_1	213	221	PF00400	0.523
DEG_SCF_FBW7_1	1	8	PF00400	0.393
DEG_SPOP_SBC_1	153	157	PF00917	0.630
DEG_SPOP_SBC_1	285	289	PF00917	0.710
DOC_CDC14_PxL_1	244	252	PF14671	0.452
DOC_CYCLIN_RxL_1	193	203	PF00134	0.627
DOC_CYCLIN_RxL_1	44	54	PF00134	0.619
DOC_CYCLIN_RxL_1	74	87	PF00134	0.716
DOC_MAPK_gen_1	214	220	PF00069	0.526
DOC_MAPK_gen_1	45	51	PF00069	0.582
DOC_MAPK_gen_1	76	84	PF00069	0.714
DOC_USP7_MATH_1	286	290	PF00917	0.763
DOC_WW_Pin1_4	1	6	PF00397	0.555
DOC_WW_Pin1_4	104	109	PF00397	0.729
DOC_WW_Pin1_4	281	286	PF00397	0.609
LIG_14-3-3_CanoR_1	215	221	PF00244	0.389
LIG_14-3-3_CanoR_1	256	261	PF00244	0.688
LIG_14-3-3_CanoR_1	94	99	PF00244	0.647
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_eIF4E_1	12	18	PF01652	0.380
LIG_eIF4E_1	330	336	PF01652	0.530
LIG_FHA_1	155	161	PF00498	0.604
LIG_FHA_1	190	196	PF00498	0.656
LIG_FHA_1	2	8	PF00498	0.539
LIG_FHA_1	22	28	PF00498	0.277
LIG_FHA_1	36	42	PF00498	0.560
LIG_FHA_1	66	72	PF00498	0.742
LIG_FHA_2	6	12	PF00498	0.411
LIG_GBD_Chelix_1	327	335	PF00786	0.452
LIG_LIR_Gen_1	227	238	PF02991	0.539
LIG_LIR_Gen_1	333	340	PF02991	0.454
LIG_LIR_Nem_3	227	233	PF02991	0.546
LIG_LIR_Nem_3	24	29	PF02991	0.530
LIG_LIR_Nem_3	333	337	PF02991	0.316
LIG_PCNA_APIM_2	194	200	PF02747	0.483
LIG_SH2_GRB2like	12	15	PF00017	0.489
LIG_SH2_SRC	12	15	PF00017	0.336
LIG_SH2_SRC	246	249	PF00017	0.452
LIG_SH2_SRC	334	337	PF00017	0.530
LIG_SH2_SRC	72	75	PF00017	0.657
LIG_SH2_STAP1	168	172	PF00017	0.678
LIG_SH2_STAP1	29	33	PF00017	0.530
LIG_SH2_STAP1	98	102	PF00017	0.759
LIG_SH2_STAT5	12	15	PF00017	0.489
LIG_SH2_STAT5	197	200	PF00017	0.530
LIG_SH2_STAT5	230	233	PF00017	0.442
LIG_SH2_STAT5	246	249	PF00017	0.369
LIG_SH2_STAT5	330	333	PF00017	0.530
LIG_SH2_STAT5	334	337	PF00017	0.464
LIG_SH3_3	102	108	PF00018	0.724
LIG_SH3_3	170	176	PF00018	0.576
LIG_SH3_3	232	238	PF00018	0.435
LIG_SH3_3	248	254	PF00018	0.390
LIG_SUMO_SIM_anti_2	154	164	PF11976	0.607
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.393
LIG_TYR_ITIM	228	233	PF00017	0.505
MOD_CK1_1	114	120	PF00069	0.665
MOD_CK1_1	158	164	PF00069	0.773
MOD_CK2_1	220	226	PF00069	0.448
MOD_CK2_1	276	282	PF00069	0.721
MOD_CK2_1	5	11	PF00069	0.418
MOD_Cter_Amidation	119	122	PF01082	0.394
MOD_DYRK1A_RPxSP_1	104	108	PF00069	0.727
MOD_GlcNHglycan	181	184	PF01048	0.462
MOD_GlcNHglycan	202	205	PF01048	0.375
MOD_GlcNHglycan	288	291	PF01048	0.535
MOD_GlcNHglycan	298	301	PF01048	0.600
MOD_GSK3_1	1	8	PF00069	0.448
MOD_GSK3_1	151	158	PF00069	0.784
MOD_GSK3_1	167	174	PF00069	0.602
MOD_GSK3_1	216	223	PF00069	0.436
MOD_GSK3_1	256	263	PF00069	0.692
MOD_GSK3_1	276	283	PF00069	0.717
MOD_GSK3_1	294	301	PF00069	0.778
MOD_GSK3_1	94	101	PF00069	0.610
MOD_N-GLC_1	189	194	PF02516	0.456
MOD_NEK2_1	151	156	PF00069	0.809
MOD_NEK2_1	179	184	PF00069	0.693
MOD_NEK2_1	224	229	PF00069	0.463
MOD_NEK2_1	260	265	PF00069	0.759
MOD_NEK2_1	280	285	PF00069	0.583
MOD_NEK2_2	29	34	PF00069	0.530
MOD_PKA_1	256	262	PF00069	0.737
MOD_PKA_1	94	100	PF00069	0.536
MOD_PKA_2	120	126	PF00069	0.802
MOD_PKA_2	256	262	PF00069	0.750
MOD_PKA_2	94	100	PF00069	0.648
MOD_PKB_1	92	100	PF00069	0.533
MOD_Plk_1	189	195	PF00069	0.572
MOD_Plk_1	35	41	PF00069	0.720
MOD_Plk_1	98	104	PF00069	0.697
MOD_Plk_4	114	120	PF00069	0.691
MOD_Plk_4	158	164	PF00069	0.608
MOD_Plk_4	190	196	PF00069	0.662
MOD_Plk_4	22	28	PF00069	0.530
MOD_Plk_4	256	262	PF00069	0.750
MOD_Plk_4	29	35	PF00069	0.414
MOD_Plk_4	321	327	PF00069	0.530
MOD_Plk_4	330	336	PF00069	0.381
MOD_ProDKin_1	1	7	PF00069	0.551
MOD_ProDKin_1	104	110	PF00069	0.731
MOD_ProDKin_1	281	287	PF00069	0.610
MOD_SUMO_rev_2	57	65	PF00179	0.584
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.530
TRG_ENDOCYTIC_2	230	233	PF00928	0.482
TRG_ENDOCYTIC_2	334	337	PF00928	0.530
TRG_ER_diArg_1	121	124	PF00400	0.595
TRG_ER_diArg_1	44	47	PF00400	0.600
TRG_ER_diArg_1	76	79	PF00400	0.684
TRG_ER_diArg_1	82	85	PF00400	0.683
TRG_ER_diArg_1	92	95	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6H6	Leishmania donovani	82%	100%
A4HLE2	Leishmania braziliensis	60%	99%
A4I8V1	Leishmania infantum	82%	100%
Q4Q4A4	Leishmania major	80%	100%