Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3R9_LEIMU

TriTrypDb:

LmxM.32.0870

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3R9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.597
CLV_C14_Caspase3-7	366	370	PF00656	0.699
CLV_MEL_PAP_1	259	265	PF00089	0.612
CLV_NRD_NRD_1	19	21	PF00675	0.518
CLV_NRD_NRD_1	281	283	PF00675	0.595
CLV_NRD_NRD_1	332	334	PF00675	0.753
CLV_NRD_NRD_1	40	42	PF00675	0.530
CLV_NRD_NRD_1	433	435	PF00675	0.487
CLV_NRD_NRD_1	474	476	PF00675	0.480
CLV_PCSK_KEX2_1	119	121	PF00082	0.727
CLV_PCSK_KEX2_1	261	263	PF00082	0.587
CLV_PCSK_KEX2_1	281	283	PF00082	0.335
CLV_PCSK_KEX2_1	39	41	PF00082	0.528
CLV_PCSK_KEX2_1	474	476	PF00082	0.480
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.727
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.621
CLV_PCSK_SKI1_1	206	210	PF00082	0.492
CLV_PCSK_SKI1_1	21	25	PF00082	0.440
CLV_PCSK_SKI1_1	255	259	PF00082	0.592
CLV_PCSK_SKI1_1	319	323	PF00082	0.650
CLV_PCSK_SKI1_1	334	338	PF00082	0.691
CLV_PCSK_SKI1_1	346	350	PF00082	0.655
CLV_PCSK_SKI1_1	47	51	PF00082	0.568
CLV_PCSK_SKI1_1	59	63	PF00082	0.518
CLV_PCSK_SKI1_1	9	13	PF00082	0.710
DEG_APCC_DBOX_1	205	213	PF00400	0.492
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SPOP_SBC_1	157	161	PF00917	0.633
DOC_CKS1_1	97	102	PF01111	0.767
DOC_CYCLIN_RxL_1	203	210	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.447
DOC_MAPK_gen_1	434	442	PF00069	0.447
DOC_MAPK_MEF2A_6	226	234	PF00069	0.558
DOC_MAPK_RevD_3	440	454	PF00069	0.447
DOC_PP1_RVXF_1	477	484	PF00149	0.584
DOC_PP2B_LxvP_1	220	223	PF13499	0.446
DOC_PP4_FxxP_1	337	340	PF00568	0.695
DOC_PP4_FxxP_1	398	401	PF00568	0.589
DOC_USP7_MATH_1	105	109	PF00917	0.577
DOC_USP7_MATH_1	11	15	PF00917	0.720
DOC_USP7_MATH_1	183	187	PF00917	0.773
DOC_USP7_MATH_1	284	288	PF00917	0.564
DOC_USP7_MATH_1	342	346	PF00917	0.688
DOC_USP7_MATH_1	406	410	PF00917	0.685
DOC_USP7_MATH_1	88	92	PF00917	0.742
DOC_USP7_MATH_1	98	102	PF00917	0.762
DOC_USP7_UBL2_3	322	326	PF12436	0.702
DOC_USP7_UBL2_3	56	60	PF12436	0.752
DOC_WW_Pin1_4	125	130	PF00397	0.817
DOC_WW_Pin1_4	164	169	PF00397	0.618
DOC_WW_Pin1_4	79	84	PF00397	0.804
DOC_WW_Pin1_4	93	98	PF00397	0.590
LIG_14-3-3_CanoR_1	120	129	PF00244	0.689
LIG_14-3-3_CanoR_1	281	290	PF00244	0.426
LIG_Actin_WH2_2	266	283	PF00022	0.546
LIG_APCC_ABBA_1	232	237	PF00400	0.592
LIG_APCC_ABBAyCdc20_2	479	485	PF00400	0.478
LIG_EH_1	2	6	PF12763	0.623
LIG_FHA_1	167	173	PF00498	0.797
LIG_FHA_1	445	451	PF00498	0.456
LIG_FHA_2	153	159	PF00498	0.799
LIG_FHA_2	213	219	PF00498	0.614
LIG_FHA_2	265	271	PF00498	0.621
LIG_FHA_2	313	319	PF00498	0.576
LIG_FHA_2	369	375	PF00498	0.701
LIG_HCF-1_HBM_1	384	387	PF13415	0.474
LIG_LIR_Apic_2	390	396	PF02991	0.665
LIG_LIR_Apic_2	424	430	PF02991	0.564
LIG_LIR_Gen_1	2	12	PF02991	0.646
LIG_LIR_Nem_3	2	8	PF02991	0.604
LIG_LIR_Nem_3	358	364	PF02991	0.783
LIG_MYND_3	429	433	PF01753	0.492
LIG_PTAP_UEV_1	75	80	PF05743	0.513
LIG_Rb_pABgroove_1	437	445	PF01858	0.584
LIG_SH2_CRK	245	249	PF00017	0.453
LIG_SH2_CRK	393	397	PF00017	0.766
LIG_SH2_CRK	443	447	PF00017	0.478
LIG_SH2_GRB2like	484	487	PF00017	0.477
LIG_SH2_NCK_1	443	447	PF00017	0.580
LIG_SH2_SRC	443	446	PF00017	0.583
LIG_SH2_SRC	484	487	PF00017	0.477
LIG_SH2_STAP1	245	249	PF00017	0.453
LIG_SH2_STAT5	252	255	PF00017	0.487
LIG_SH2_STAT5	361	364	PF00017	0.686
LIG_SH3_3	375	381	PF00018	0.788
LIG_SH3_3	73	79	PF00018	0.629
LIG_SH3_3	94	100	PF00018	0.780
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.465
LIG_TRAF2_1	108	111	PF00917	0.819
LIG_TRAF2_1	189	192	PF00917	0.586
LIG_TRAF2_1	35	38	PF00917	0.636
MOD_CDK_SPxxK_3	79	86	PF00069	0.717
MOD_CK1_1	101	107	PF00069	0.790
MOD_CK1_1	164	170	PF00069	0.718
MOD_CK1_1	264	270	PF00069	0.620
MOD_CK1_1	285	291	PF00069	0.573
MOD_CK1_1	312	318	PF00069	0.765
MOD_CK1_1	91	97	PF00069	0.745
MOD_CK2_1	105	111	PF00069	0.782
MOD_CK2_1	120	126	PF00069	0.659
MOD_CK2_1	152	158	PF00069	0.800
MOD_CK2_1	193	199	PF00069	0.593
MOD_CK2_1	264	270	PF00069	0.686
MOD_CK2_1	32	38	PF00069	0.640
MOD_CK2_1	464	470	PF00069	0.607
MOD_Cter_Amidation	259	262	PF01082	0.594
MOD_GlcNHglycan	100	103	PF01048	0.758
MOD_GlcNHglycan	178	182	PF01048	0.647
MOD_GlcNHglycan	284	287	PF01048	0.660
MOD_GlcNHglycan	311	314	PF01048	0.740
MOD_GlcNHglycan	337	340	PF01048	0.692
MOD_GlcNHglycan	415	419	PF01048	0.717
MOD_GlcNHglycan	69	73	PF01048	0.614
MOD_GlcNHglycan	76	79	PF01048	0.542
MOD_GlcNHglycan	90	93	PF01048	0.796
MOD_GSK3_1	101	108	PF00069	0.802
MOD_GSK3_1	152	159	PF00069	0.681
MOD_GSK3_1	233	240	PF00069	0.422
MOD_GSK3_1	282	289	PF00069	0.592
MOD_GSK3_1	305	312	PF00069	0.771
MOD_GSK3_1	402	409	PF00069	0.708
MOD_GSK3_1	74	81	PF00069	0.763
MOD_GSK3_1	84	91	PF00069	0.673
MOD_N-GLC_1	402	407	PF02516	0.662
MOD_N-GLC_1	88	93	PF02516	0.546
MOD_NEK2_1	251	256	PF00069	0.503
MOD_PIKK_1	161	167	PF00454	0.799
MOD_PIKK_1	22	28	PF00454	0.613
MOD_PIKK_1	453	459	PF00454	0.495
MOD_PK_1	435	441	PF00069	0.467
MOD_PKA_1	261	267	PF00069	0.626
MOD_PKA_1	453	459	PF00069	0.495
MOD_PKA_1	59	65	PF00069	0.572
MOD_PKA_2	261	267	PF00069	0.582
MOD_Plk_1	157	163	PF00069	0.710
MOD_Plk_1	193	199	PF00069	0.624
MOD_Plk_1	275	281	PF00069	0.564
MOD_Plk_1	368	374	PF00069	0.697
MOD_Plk_1	423	429	PF00069	0.590
MOD_Plk_4	243	249	PF00069	0.407
MOD_Plk_4	264	270	PF00069	0.708
MOD_Plk_4	275	281	PF00069	0.518
MOD_Plk_4	435	441	PF00069	0.467
MOD_ProDKin_1	125	131	PF00069	0.819
MOD_ProDKin_1	164	170	PF00069	0.619
MOD_ProDKin_1	79	85	PF00069	0.809
MOD_ProDKin_1	93	99	PF00069	0.589
MOD_SUMO_for_1	321	324	PF00179	0.735
MOD_SUMO_for_1	362	365	PF00179	0.681
MOD_SUMO_for_1	412	415	PF00179	0.723
MOD_SUMO_rev_2	288	298	PF00179	0.643
MOD_SUMO_rev_2	428	437	PF00179	0.455
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.608
TRG_ENDOCYTIC_2	245	248	PF00928	0.397
TRG_ENDOCYTIC_2	443	446	PF00928	0.481
TRG_ER_diArg_1	280	282	PF00400	0.598
TRG_ER_diArg_1	39	41	PF00400	0.629
TRG_ER_diArg_1	473	475	PF00400	0.482
TRG_NLS_Bipartite_1	40	62	PF00514	0.678
TRG_NLS_MonoExtC_3	118	124	PF00514	0.826
TRG_NLS_MonoExtN_4	56	62	PF00514	0.748
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA2	Leptomonas seymouri	46%	100%
A0A3Q8ITX1	Leishmania donovani	91%	100%
A4HLE1	Leishmania braziliensis	75%	99%
A4I8V0	Leishmania infantum	91%	100%
Q4Q4A5	Leishmania major	89%	100%