Mitochondrial escape protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3R8_LEIMU

TriTrypDb:

LmxM.32.0860

Length:

416

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 12
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3R8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.300
CLV_NRD_NRD_1	367	369	PF00675	0.719
CLV_NRD_NRD_1	55	57	PF00675	0.347
CLV_NRD_NRD_1	8	10	PF00675	0.425
CLV_PCSK_KEX2_1	200	202	PF00082	0.300
CLV_PCSK_KEX2_1	389	391	PF00082	0.631
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.659
CLV_PCSK_SKI1_1	150	154	PF00082	0.271
CLV_PCSK_SKI1_1	2	6	PF00082	0.489
CLV_PCSK_SKI1_1	200	204	PF00082	0.289
CLV_PCSK_SKI1_1	378	382	PF00082	0.545
CLV_PCSK_SKI1_1	59	63	PF00082	0.328
DEG_Nend_UBRbox_1	1	4	PF02207	0.562
DEG_SPOP_SBC_1	94	98	PF00917	0.423
DOC_CYCLIN_RxL_1	21	29	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.528
DOC_MAPK_gen_1	315	323	PF00069	0.513
DOC_MAPK_MEF2A_6	188	196	PF00069	0.528
DOC_MAPK_MEF2A_6	316	325	PF00069	0.446
DOC_PP1_RVXF_1	157	163	PF00149	0.528
DOC_PP2B_LxvP_1	19	22	PF13499	0.576
DOC_PP2B_LxvP_1	276	279	PF13499	0.486
DOC_PP2B_LxvP_1	82	85	PF13499	0.528
DOC_PP4_FxxP_1	129	132	PF00568	0.375
DOC_USP7_MATH_1	101	105	PF00917	0.592
DOC_USP7_MATH_1	110	114	PF00917	0.573
DOC_USP7_MATH_1	137	141	PF00917	0.528
DOC_USP7_MATH_1	216	220	PF00917	0.519
DOC_USP7_MATH_1	281	285	PF00917	0.480
DOC_USP7_MATH_1	319	323	PF00917	0.246
DOC_USP7_MATH_1	384	388	PF00917	0.388
DOC_USP7_MATH_1	401	405	PF00917	0.457
DOC_USP7_MATH_1	95	99	PF00917	0.537
DOC_USP7_UBL2_3	385	389	PF12436	0.324
DOC_WW_Pin1_4	103	108	PF00397	0.477
DOC_WW_Pin1_4	112	117	PF00397	0.417
DOC_WW_Pin1_4	12	17	PF00397	0.626
DOC_WW_Pin1_4	202	207	PF00397	0.489
DOC_WW_Pin1_4	214	219	PF00397	0.534
DOC_WW_Pin1_4	35	40	PF00397	0.490
LIG_14-3-3_CanoR_1	59	64	PF00244	0.492
LIG_14-3-3_CanoR_1	9	19	PF00244	0.638
LIG_Actin_WH2_2	185	202	PF00022	0.528
LIG_AP2alpha_1	125	129	PF02296	0.375
LIG_APCC_ABBA_1	358	363	PF00400	0.429
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.423
LIG_APCC_ABBAyCdc20_2	351	357	PF00400	0.289
LIG_BRCT_BRCA1_1	321	325	PF00533	0.246
LIG_BRCT_BRCA1_1	387	391	PF00533	0.316
LIG_deltaCOP1_diTrp_1	267	275	PF00928	0.480
LIG_EVH1_1	19	23	PF00568	0.541
LIG_FHA_1	147	153	PF00498	0.476
LIG_FHA_1	235	241	PF00498	0.528
LIG_FHA_1	3	9	PF00498	0.740
LIG_FHA_1	316	322	PF00498	0.416
LIG_FHA_1	89	95	PF00498	0.594
LIG_FHA_2	300	306	PF00498	0.528
LIG_FHA_2	48	54	PF00498	0.500
LIG_LIR_Apic_2	127	132	PF02991	0.375
LIG_LIR_Apic_2	167	172	PF02991	0.528
LIG_LIR_Gen_1	135	146	PF02991	0.482
LIG_LIR_Gen_1	219	229	PF02991	0.423
LIG_LIR_Gen_1	274	282	PF02991	0.544
LIG_LIR_Gen_1	322	333	PF02991	0.356
LIG_LIR_Gen_1	66	71	PF02991	0.461
LIG_LIR_Gen_1	78	85	PF02991	0.461
LIG_LIR_Nem_3	135	141	PF02991	0.482
LIG_LIR_Nem_3	267	272	PF02991	0.485
LIG_LIR_Nem_3	274	278	PF02991	0.490
LIG_LIR_Nem_3	322	328	PF02991	0.356
LIG_LIR_Nem_3	340	346	PF02991	0.326
LIG_LIR_Nem_3	349	353	PF02991	0.334
LIG_LIR_Nem_3	66	70	PF02991	0.461
LIG_LIR_Nem_3	78	82	PF02991	0.461
LIG_MYND_1	17	21	PF01753	0.558
LIG_NRBOX	330	336	PF00104	0.394
LIG_Pex14_2	125	129	PF04695	0.375
LIG_SH2_STAT5	347	350	PF00017	0.379
LIG_SH2_STAT5	353	356	PF00017	0.387
LIG_SH2_STAT5	49	52	PF00017	0.468
LIG_SH3_3	117	123	PF00018	0.498
LIG_SH3_3	127	133	PF00018	0.453
LIG_SH3_3	14	20	PF00018	0.706
LIG_SH3_3	151	157	PF00018	0.486
LIG_SH3_3	275	281	PF00018	0.524
LIG_SH3_3	288	294	PF00018	0.539
LIG_SH3_CIN85_PxpxPR_1	116	121	PF14604	0.423
LIG_Sin3_3	325	332	PF02671	0.253
LIG_SUMO_SIM_anti_2	148	156	PF11976	0.468
LIG_SUMO_SIM_par_1	148	156	PF11976	0.468
LIG_SUMO_SIM_par_1	24	29	PF11976	0.486
LIG_SUMO_SIM_par_1	332	338	PF11976	0.447
LIG_SxIP_EBH_1	24	37	PF03271	0.445
LIG_UBA3_1	408	416	PF00899	0.365
LIG_WRC_WIRS_1	126	131	PF05994	0.375
LIG_WRC_WIRS_1	336	341	PF05994	0.469
LIG_WW_3	21	25	PF00397	0.625
MOD_CDK_SPK_2	116	121	PF00069	0.433
MOD_CDK_SPxxK_3	35	42	PF00069	0.554
MOD_CK1_1	217	223	PF00069	0.548
MOD_CK1_1	301	307	PF00069	0.504
MOD_CK1_1	337	343	PF00069	0.388
MOD_CK1_1	373	379	PF00069	0.457
MOD_CK1_1	90	96	PF00069	0.469
MOD_CK2_1	335	341	PF00069	0.504
MOD_CK2_1	86	92	PF00069	0.412
MOD_GlcNHglycan	101	104	PF01048	0.339
MOD_GlcNHglycan	108	111	PF01048	0.313
MOD_GlcNHglycan	116	119	PF01048	0.271
MOD_GlcNHglycan	12	15	PF01048	0.462
MOD_GlcNHglycan	179	182	PF01048	0.223
MOD_GlcNHglycan	240	243	PF01048	0.281
MOD_GlcNHglycan	283	286	PF01048	0.196
MOD_GlcNHglycan	370	375	PF01048	0.673
MOD_GlcNHglycan	97	100	PF01048	0.342
MOD_GSK3_1	106	113	PF00069	0.420
MOD_GSK3_1	229	236	PF00069	0.591
MOD_GSK3_1	315	322	PF00069	0.521
MOD_GSK3_1	47	54	PF00069	0.485
MOD_GSK3_1	86	93	PF00069	0.530
MOD_GSK3_1	95	102	PF00069	0.568
MOD_N-GLC_1	184	189	PF02516	0.244
MOD_N-GLC_1	299	304	PF02516	0.334
MOD_NEK2_1	125	130	PF00069	0.566
MOD_NEK2_1	238	243	PF00069	0.416
MOD_NEK2_1	26	31	PF00069	0.487
MOD_NEK2_1	314	319	PF00069	0.510
MOD_NEK2_1	334	339	PF00069	0.334
MOD_NEK2_1	51	56	PF00069	0.472
MOD_PKA_1	315	321	PF00069	0.396
MOD_PKA_1	385	391	PF00069	0.408
MOD_PKA_2	146	152	PF00069	0.541
MOD_PKA_2	238	244	PF00069	0.485
MOD_Plk_1	370	376	PF00069	0.400
MOD_Plk_1	51	57	PF00069	0.508
MOD_Plk_4	125	131	PF00069	0.475
MOD_Plk_4	137	143	PF00069	0.439
MOD_Plk_4	26	32	PF00069	0.480
MOD_Plk_4	319	325	PF00069	0.440
MOD_ProDKin_1	103	109	PF00069	0.477
MOD_ProDKin_1	112	118	PF00069	0.417
MOD_ProDKin_1	12	18	PF00069	0.622
MOD_ProDKin_1	202	208	PF00069	0.489
MOD_ProDKin_1	214	220	PF00069	0.534
MOD_ProDKin_1	35	41	PF00069	0.490
TRG_DiLeu_BaEn_4	155	161	PF01217	0.528
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.508
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.433
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.453
TRG_ENDOCYTIC_2	343	346	PF00928	0.385
TRG_ER_diArg_1	199	201	PF00400	0.530
TRG_ER_diArg_1	213	216	PF00400	0.590
TRG_ER_diArg_1	263	266	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P304	Leptomonas seymouri	57%	96%
A0A0N0P958	Leptomonas seymouri	26%	100%
A0A0S4JG88	Bodo saltans	32%	100%
A0A1X0P126	Trypanosomatidae	34%	100%
A0A3Q8IGS5	Leishmania donovani	93%	96%
A0A3S7X466	Leishmania donovani	26%	100%
A4HJ26	Leishmania braziliensis	26%	100%
A4HLE0	Leishmania braziliensis	82%	100%
A4I6E8	Leishmania infantum	26%	100%
A4I8U9	Leishmania infantum	93%	96%
D0A4U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E8NHM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q4A6	Leishmania major	90%	100%
Q4Q6L5	Leishmania major	27%	100%
V5BPD5	Trypanosoma cruzi	35%	100%