Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3R6_LEIMU

TriTrypDb:

LmxM.32.0840

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.585
CLV_C14_Caspase3-7	61	65	PF00656	0.599
CLV_NRD_NRD_1	112	114	PF00675	0.732
CLV_NRD_NRD_1	23	25	PF00675	0.695
CLV_NRD_NRD_1	281	283	PF00675	0.633
CLV_NRD_NRD_1	314	316	PF00675	0.562
CLV_NRD_NRD_1	526	528	PF00675	0.594
CLV_NRD_NRD_1	599	601	PF00675	0.665
CLV_NRD_NRD_1	664	666	PF00675	0.562
CLV_NRD_NRD_1	704	706	PF00675	0.683
CLV_NRD_NRD_1	73	75	PF00675	0.757
CLV_PCSK_FUR_1	110	114	PF00082	0.759
CLV_PCSK_FUR_1	278	282	PF00082	0.636
CLV_PCSK_FUR_1	702	706	PF00082	0.763
CLV_PCSK_KEX2_1	112	114	PF00082	0.732
CLV_PCSK_KEX2_1	23	25	PF00082	0.695
CLV_PCSK_KEX2_1	278	280	PF00082	0.617
CLV_PCSK_KEX2_1	281	283	PF00082	0.661
CLV_PCSK_KEX2_1	526	528	PF00082	0.526
CLV_PCSK_KEX2_1	599	601	PF00082	0.665
CLV_PCSK_KEX2_1	664	666	PF00082	0.569
CLV_PCSK_KEX2_1	704	706	PF00082	0.729
CLV_PCSK_KEX2_1	73	75	PF00082	0.757
CLV_PCSK_SKI1_1	315	319	PF00082	0.498
CLV_PCSK_SKI1_1	392	396	PF00082	0.526
CLV_PCSK_SKI1_1	460	464	PF00082	0.427
CLV_PCSK_SKI1_1	534	538	PF00082	0.609
CLV_PCSK_SKI1_1	600	604	PF00082	0.653
CLV_PCSK_SKI1_1	78	82	PF00082	0.743
CLV_PCSK_SKI1_1	8	12	PF00082	0.717
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DEG_SCF_FBW7_1	552	557	PF00400	0.704
DEG_SCF_TRCP1_1	615	620	PF00400	0.577
DOC_AGCK_PIF_2	484	489	PF00069	0.568
DOC_ANK_TNKS_1	59	66	PF00023	0.504
DOC_CKS1_1	132	137	PF01111	0.679
DOC_CKS1_1	27	32	PF01111	0.711
DOC_CKS1_1	51	56	PF01111	0.711
DOC_CYCLIN_RxL_1	309	320	PF00134	0.676
DOC_CYCLIN_RxL_1	454	467	PF00134	0.519
DOC_CYCLIN_RxL_1	596	605	PF00134	0.690
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.601
DOC_MAPK_gen_1	236	246	PF00069	0.665
DOC_MAPK_gen_1	492	501	PF00069	0.456
DOC_MAPK_gen_1	680	688	PF00069	0.619
DOC_MAPK_MEF2A_6	495	503	PF00069	0.424
DOC_PP1_RVXF_1	6	12	PF00149	0.671
DOC_PP2B_LxvP_1	297	300	PF13499	0.701
DOC_PP2B_LxvP_1	368	371	PF13499	0.499
DOC_PP2B_LxvP_1	86	89	PF13499	0.734
DOC_PP4_FxxP_1	11	14	PF00568	0.714
DOC_USP7_MATH_1	119	123	PF00917	0.726
DOC_USP7_MATH_1	154	158	PF00917	0.634
DOC_USP7_MATH_1	207	211	PF00917	0.534
DOC_USP7_MATH_1	254	258	PF00917	0.739
DOC_USP7_MATH_1	335	339	PF00917	0.567
DOC_USP7_MATH_1	379	383	PF00917	0.519
DOC_USP7_MATH_1	554	558	PF00917	0.705
DOC_USP7_MATH_1	651	655	PF00917	0.592
DOC_USP7_MATH_1	89	93	PF00917	0.732
DOC_WW_Pin1_4	131	136	PF00397	0.540
DOC_WW_Pin1_4	14	19	PF00397	0.664
DOC_WW_Pin1_4	26	31	PF00397	0.722
DOC_WW_Pin1_4	455	460	PF00397	0.422
DOC_WW_Pin1_4	47	52	PF00397	0.764
DOC_WW_Pin1_4	550	555	PF00397	0.702
LIG_14-3-3_CanoR_1	227	232	PF00244	0.592
LIG_14-3-3_CanoR_1	28	34	PF00244	0.672
LIG_14-3-3_CanoR_1	309	313	PF00244	0.566
LIG_14-3-3_CanoR_1	336	344	PF00244	0.296
LIG_14-3-3_CanoR_1	4	11	PF00244	0.662
LIG_14-3-3_CanoR_1	512	520	PF00244	0.535
LIG_14-3-3_CanoR_1	547	553	PF00244	0.788
LIG_14-3-3_CanoR_1	564	571	PF00244	0.500
LIG_14-3-3_CanoR_1	656	666	PF00244	0.451
LIG_BRCT_BRCA1_1	138	142	PF00533	0.673
LIG_eIF4E_1	312	318	PF01652	0.616
LIG_eIF4E_1	497	503	PF01652	0.471
LIG_FAT_LD_1	246	254	PF03623	0.480
LIG_FHA_1	437	443	PF00498	0.526
LIG_FHA_1	530	536	PF00498	0.578
LIG_FHA_1	537	543	PF00498	0.498
LIG_FHA_2	261	267	PF00498	0.793
LIG_FHA_2	268	274	PF00498	0.562
LIG_FHA_2	289	295	PF00498	0.709
LIG_FHA_2	328	334	PF00498	0.468
LIG_FHA_2	511	517	PF00498	0.609
LIG_FHA_2	551	557	PF00498	0.689
LIG_FHA_2	578	584	PF00498	0.535
LIG_GSK3_LRP6_1	14	19	PF00069	0.463
LIG_LIR_Gen_1	201	211	PF02991	0.571
LIG_LIR_Gen_1	500	511	PF02991	0.461
LIG_LIR_Nem_3	131	136	PF02991	0.723
LIG_LIR_Nem_3	139	143	PF02991	0.709
LIG_LIR_Nem_3	201	206	PF02991	0.587
LIG_LIR_Nem_3	414	418	PF02991	0.606
LIG_LIR_Nem_3	500	506	PF02991	0.413
LIG_LYPXL_yS_3	452	455	PF13949	0.539
LIG_NRBOX	340	346	PF00104	0.445
LIG_PCNA_PIPBox_1	387	396	PF02747	0.402
LIG_PTB_Apo_2	211	218	PF02174	0.642
LIG_PTB_Phospho_1	211	217	PF10480	0.646
LIG_RPA_C_Fungi	660	672	PF08784	0.708
LIG_SH2_CRK	325	329	PF00017	0.511
LIG_SH2_STAP1	364	368	PF00017	0.448
LIG_SH2_STAP1	489	493	PF00017	0.554
LIG_SH2_STAT3	102	105	PF00017	0.746
LIG_SH2_STAT5	102	105	PF00017	0.763
LIG_SH2_STAT5	352	355	PF00017	0.488
LIG_SH2_STAT5	359	362	PF00017	0.409
LIG_SH2_STAT5	430	433	PF00017	0.371
LIG_SH3_1	24	30	PF00018	0.712
LIG_SH3_1	447	453	PF00018	0.572
LIG_SH3_2	18	23	PF14604	0.696
LIG_SH3_3	12	18	PF00018	0.637
LIG_SH3_3	24	30	PF00018	0.553
LIG_SH3_3	302	308	PF00018	0.638
LIG_SH3_3	397	403	PF00018	0.401
LIG_SH3_3	447	453	PF00018	0.462
LIG_SH3_3	462	468	PF00018	0.409
LIG_SH3_3	48	54	PF00018	0.777
LIG_SH3_3	76	82	PF00018	0.671
LIG_TRAF2_1	263	266	PF00917	0.790
LIG_TRAF2_1	270	273	PF00917	0.699
LIG_TRAF2_1	300	303	PF00917	0.673
LIG_TRAF2_1	580	583	PF00917	0.707
LIG_TYR_ITIM	323	328	PF00017	0.578
LIG_WRC_WIRS_1	412	417	PF05994	0.618
MOD_CDK_SPK_2	26	31	PF00069	0.633
MOD_CDK_SPK_2	455	460	PF00069	0.412
MOD_CDK_SPK_2	47	52	PF00069	0.617
MOD_CDK_SPxxK_3	131	138	PF00069	0.652
MOD_CK1_1	131	137	PF00069	0.665
MOD_CK1_1	382	388	PF00069	0.487
MOD_CK1_1	426	432	PF00069	0.515
MOD_CK1_1	50	56	PF00069	0.715
MOD_CK1_1	577	583	PF00069	0.665
MOD_CK1_1	654	660	PF00069	0.727
MOD_CK2_1	120	126	PF00069	0.497
MOD_CK2_1	172	178	PF00069	0.525
MOD_CK2_1	260	266	PF00069	0.720
MOD_CK2_1	267	273	PF00069	0.727
MOD_CK2_1	288	294	PF00069	0.711
MOD_CK2_1	327	333	PF00069	0.477
MOD_CK2_1	510	516	PF00069	0.614
MOD_CK2_1	577	583	PF00069	0.501
MOD_GlcNHglycan	209	212	PF01048	0.554
MOD_GlcNHglycan	256	259	PF01048	0.741
MOD_GlcNHglycan	415	418	PF01048	0.443
MOD_GlcNHglycan	615	618	PF01048	0.663
MOD_GlcNHglycan	624	627	PF01048	0.708
MOD_GlcNHglycan	659	662	PF01048	0.697
MOD_GlcNHglycan	98	101	PF01048	0.505
MOD_GSK3_1	120	127	PF00069	0.691
MOD_GSK3_1	173	180	PF00069	0.455
MOD_GSK3_1	29	36	PF00069	0.772
MOD_GSK3_1	378	385	PF00069	0.495
MOD_GSK3_1	422	429	PF00069	0.551
MOD_GSK3_1	46	53	PF00069	0.749
MOD_GSK3_1	550	557	PF00069	0.725
MOD_GSK3_1	574	581	PF00069	0.561
MOD_GSK3_1	613	620	PF00069	0.657
MOD_GSK3_1	651	658	PF00069	0.674
MOD_GSK3_1	96	103	PF00069	0.717
MOD_N-GLC_2	404	406	PF02516	0.385
MOD_NEK2_1	212	217	PF00069	0.603
MOD_NEK2_1	288	293	PF00069	0.715
MOD_NEK2_1	3	8	PF00069	0.634
MOD_NEK2_1	301	306	PF00069	0.685
MOD_NEK2_1	378	383	PF00069	0.519
MOD_NEK2_1	411	416	PF00069	0.613
MOD_NEK2_1	436	441	PF00069	0.416
MOD_NEK2_1	46	51	PF00069	0.559
MOD_NEK2_1	536	541	PF00069	0.642
MOD_NEK2_1	679	684	PF00069	0.616
MOD_PIKK_1	101	107	PF00454	0.621
MOD_PIKK_1	537	543	PF00454	0.559
MOD_PKA_2	154	160	PF00069	0.608
MOD_PKA_2	165	171	PF00069	0.682
MOD_PKA_2	3	9	PF00069	0.619
MOD_PKA_2	308	314	PF00069	0.560
MOD_PKA_2	335	341	PF00069	0.294
MOD_PKA_2	491	497	PF00069	0.502
MOD_PKA_2	574	580	PF00069	0.583
MOD_PKA_2	655	661	PF00069	0.476
MOD_PKB_1	225	233	PF00069	0.586
MOD_PKB_1	527	535	PF00069	0.673
MOD_PKB_1	611	619	PF00069	0.767
MOD_Plk_1	120	126	PF00069	0.637
MOD_Plk_1	301	307	PF00069	0.654
MOD_Plk_2-3	242	248	PF00069	0.466
MOD_Plk_2-3	267	273	PF00069	0.615
MOD_Plk_4	128	134	PF00069	0.732
MOD_Plk_4	212	218	PF00069	0.576
MOD_Plk_4	426	432	PF00069	0.452
MOD_Plk_4	437	443	PF00069	0.356
MOD_ProDKin_1	131	137	PF00069	0.537
MOD_ProDKin_1	14	20	PF00069	0.669
MOD_ProDKin_1	26	32	PF00069	0.722
MOD_ProDKin_1	455	461	PF00069	0.416
MOD_ProDKin_1	47	53	PF00069	0.765
MOD_ProDKin_1	550	556	PF00069	0.704
TRG_DiLeu_BaEn_1	340	345	PF01217	0.444
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.739
TRG_ENDOCYTIC_2	143	146	PF00928	0.665
TRG_ENDOCYTIC_2	213	216	PF00928	0.532
TRG_ENDOCYTIC_2	325	328	PF00928	0.447
TRG_ENDOCYTIC_2	391	394	PF00928	0.510
TRG_ENDOCYTIC_2	430	433	PF00928	0.371
TRG_ENDOCYTIC_2	452	455	PF00928	0.518
TRG_ER_diArg_1	109	112	PF00400	0.727
TRG_ER_diArg_1	278	281	PF00400	0.616
TRG_ER_diArg_1	526	529	PF00400	0.573
TRG_ER_diArg_1	563	566	PF00400	0.634
TRG_ER_diArg_1	598	600	PF00400	0.662
TRG_ER_diArg_1	611	614	PF00400	0.763
TRG_ER_diArg_1	664	666	PF00400	0.569
TRG_ER_diArg_1	683	686	PF00400	0.633
TRG_ER_diArg_1	704	706	PF00400	0.746
TRG_ER_diArg_1	73	75	PF00400	0.757
TRG_NES_CRM1_1	510	522	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E3	Leptomonas seymouri	61%	99%
A0A1X0P130	Trypanosomatidae	50%	100%
A0A3Q8IK12	Leishmania donovani	92%	100%
A0A422P2K6	Trypanosoma rangeli	50%	100%
A4HLD8	Leishmania braziliensis	81%	100%
A4I8U7	Leishmania infantum	92%	100%
D0A4U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q4A8	Leishmania major	92%	100%
V5AZV9	Trypanosoma cruzi	49%	100%