Putative 2,4-dienoyl-coa reductase fadh1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase fadh1, putative

Species:

Leishmania mexicana

UniProt:

E9B3R5_LEIMU

TriTrypDb:

LmxM.32.0830

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3R5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	6
GO:0010181	FMN binding	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	6
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	6
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.484
CLV_C14_Caspase3-7	559	563	PF00656	0.376
CLV_NRD_NRD_1	294	296	PF00675	0.302
CLV_NRD_NRD_1	521	523	PF00675	0.287
CLV_NRD_NRD_1	567	569	PF00675	0.325
CLV_PCSK_KEX2_1	294	296	PF00082	0.284
CLV_PCSK_KEX2_1	435	437	PF00082	0.353
CLV_PCSK_KEX2_1	521	523	PF00082	0.287
CLV_PCSK_KEX2_1	567	569	PF00082	0.207
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.353
CLV_PCSK_PC7_1	290	296	PF00082	0.275
CLV_PCSK_SKI1_1	216	220	PF00082	0.275
CLV_PCSK_SKI1_1	330	334	PF00082	0.221
CLV_PCSK_SKI1_1	384	388	PF00082	0.472
CLV_PCSK_SKI1_1	605	609	PF00082	0.288
CLV_PCSK_SKI1_1	613	617	PF00082	0.243
CLV_PCSK_SKI1_1	693	697	PF00082	0.458
CLV_PCSK_SKI1_1	96	100	PF00082	0.247
DEG_APCC_DBOX_1	205	213	PF00400	0.421
DEG_APCC_DBOX_1	227	235	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_SPOP_SBC_1	542	546	PF00917	0.374
DEG_SPOP_SBC_1	584	588	PF00917	0.237
DOC_ANK_TNKS_1	521	528	PF00023	0.353
DOC_CKS1_1	606	611	PF01111	0.285
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.334
DOC_MAPK_DCC_7	295	305	PF00069	0.441
DOC_MAPK_gen_1	204	211	PF00069	0.421
DOC_MAPK_gen_1	294	302	PF00069	0.465
DOC_MAPK_gen_1	455	462	PF00069	0.273
DOC_MAPK_gen_1	59	68	PF00069	0.439
DOC_MAPK_gen_1	667	676	PF00069	0.384
DOC_MAPK_gen_1	712	720	PF00069	0.448
DOC_MAPK_HePTP_8	137	149	PF00069	0.346
DOC_MAPK_MEF2A_6	140	149	PF00069	0.452
DOC_MAPK_MEF2A_6	294	302	PF00069	0.426
DOC_MAPK_MEF2A_6	455	464	PF00069	0.403
DOC_MAPK_MEF2A_6	6	15	PF00069	0.282
DOC_PP1_RVXF_1	202	208	PF00149	0.463
DOC_PP2B_LxvP_1	387	390	PF13499	0.398
DOC_PP2B_PxIxI_1	300	306	PF00149	0.504
DOC_USP7_MATH_1	130	134	PF00917	0.441
DOC_USP7_MATH_1	236	240	PF00917	0.424
DOC_USP7_MATH_1	37	41	PF00917	0.512
DOC_USP7_MATH_1	403	407	PF00917	0.392
DOC_USP7_MATH_1	412	416	PF00917	0.398
DOC_USP7_MATH_1	542	546	PF00917	0.157
DOC_USP7_MATH_1	584	588	PF00917	0.312
DOC_USP7_MATH_1	590	594	PF00917	0.453
DOC_USP7_MATH_1	675	679	PF00917	0.314
DOC_USP7_UBL2_3	2	6	PF12436	0.441
DOC_USP7_UBL2_3	569	573	PF12436	0.367
DOC_USP7_UBL2_3	689	693	PF12436	0.273
DOC_USP7_UBL2_3	713	717	PF12436	0.453
DOC_WW_Pin1_4	117	122	PF00397	0.429
DOC_WW_Pin1_4	126	131	PF00397	0.466
DOC_WW_Pin1_4	30	35	PF00397	0.504
DOC_WW_Pin1_4	538	543	PF00397	0.322
DOC_WW_Pin1_4	594	599	PF00397	0.408
DOC_WW_Pin1_4	605	610	PF00397	0.194
DOC_WW_Pin1_4	693	698	PF00397	0.528
DOC_WW_Pin1_4	70	75	PF00397	0.438
LIG_14-3-3_CanoR_1	228	232	PF00244	0.423
LIG_14-3-3_CanoR_1	279	285	PF00244	0.448
LIG_14-3-3_CanoR_1	330	336	PF00244	0.438
LIG_14-3-3_CanoR_1	467	471	PF00244	0.466
LIG_14-3-3_CanoR_1	645	650	PF00244	0.418
LIG_Actin_WH2_2	198	215	PF00022	0.463
LIG_BIR_III_4	217	221	PF00653	0.475
LIG_Clathr_ClatBox_1	662	666	PF01394	0.285
LIG_CtBP_PxDLS_1	10	14	PF00389	0.438
LIG_CtBP_PxDLS_1	142	146	PF00389	0.504
LIG_FHA_1	136	142	PF00498	0.502
LIG_FHA_1	284	290	PF00498	0.509
LIG_FHA_1	449	455	PF00498	0.326
LIG_FHA_1	459	465	PF00498	0.339
LIG_FHA_1	508	514	PF00498	0.451
LIG_FHA_1	631	637	PF00498	0.270
LIG_FHA_1	658	664	PF00498	0.285
LIG_FHA_1	671	677	PF00498	0.381
LIG_FHA_1	681	687	PF00498	0.389
LIG_FHA_1	694	700	PF00498	0.481
LIG_FHA_1	709	715	PF00498	0.551
LIG_FHA_1	97	103	PF00498	0.447
LIG_FHA_2	151	157	PF00498	0.432
LIG_FHA_2	238	244	PF00498	0.438
LIG_FHA_2	27	33	PF00498	0.438
LIG_FHA_2	408	414	PF00498	0.293
LIG_FHA_2	417	423	PF00498	0.222
LIG_FHA_2	467	473	PF00498	0.306
LIG_FHA_2	483	489	PF00498	0.344
LIG_FHA_2	554	560	PF00498	0.427
LIG_IBAR_NPY_1	47	49	PF08397	0.504
LIG_LIR_Gen_1	12	23	PF02991	0.463
LIG_LIR_Gen_1	155	164	PF02991	0.504
LIG_LIR_Nem_3	12	18	PF02991	0.463
LIG_LIR_Nem_3	155	160	PF02991	0.467
LIG_LIR_Nem_3	501	506	PF02991	0.296
LIG_LIR_Nem_3	653	657	PF02991	0.282
LIG_LRP6_Inhibitor_1	641	647	PF00058	0.152
LIG_LYPXL_yS_3	503	506	PF13949	0.285
LIG_OCRL_FandH_1	184	196	PF00620	0.441
LIG_PDZ_Class_2	725	730	PF00595	0.305
LIG_Pex14_2	223	227	PF04695	0.438
LIG_Pex14_2	566	570	PF04695	0.258
LIG_PTB_Apo_2	685	692	PF02174	0.396
LIG_SH2_CRK	4	8	PF00017	0.376
LIG_SH2_CRK	49	53	PF00017	0.504
LIG_SH2_SRC	478	481	PF00017	0.317
LIG_SH2_STAP1	4	8	PF00017	0.319
LIG_SH2_STAP1	478	482	PF00017	0.317
LIG_SH2_STAP1	49	53	PF00017	0.504
LIG_SH2_STAP1	509	513	PF00017	0.285
LIG_SH2_STAT5	180	183	PF00017	0.421
LIG_SH2_STAT5	282	285	PF00017	0.489
LIG_SH2_STAT5	337	340	PF00017	0.504
LIG_SH2_STAT5	509	512	PF00017	0.258
LIG_SH2_STAT5	555	558	PF00017	0.451
LIG_SH2_STAT5	664	667	PF00017	0.317
LIG_SH3_3	603	609	PF00018	0.334
LIG_SH3_3	76	82	PF00018	0.480
LIG_SH3_3	83	89	PF00018	0.450
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.421
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.424
LIG_SUMO_SIM_par_1	671	678	PF11976	0.334
LIG_TRAF2_1	469	472	PF00917	0.285
LIG_TRAF2_1	578	581	PF00917	0.227
LIG_UBA3_1	496	502	PF00899	0.353
LIG_WW_1	609	612	PF00397	0.152
MOD_CK1_1	133	139	PF00069	0.325
MOD_CK1_1	26	32	PF00069	0.282
MOD_CK1_1	466	472	PF00069	0.290
MOD_CK1_1	541	547	PF00069	0.374
MOD_CK2_1	237	243	PF00069	0.283
MOD_CK2_1	26	32	PF00069	0.282
MOD_CK2_1	416	422	PF00069	0.258
MOD_CK2_1	466	472	PF00069	0.285
MOD_CK2_1	482	488	PF00069	0.318
MOD_CK2_1	505	511	PF00069	0.440
MOD_CK2_1	553	559	PF00069	0.427
MOD_CK2_1	684	690	PF00069	0.334
MOD_Cter_Amidation	519	522	PF01082	0.299
MOD_GlcNHglycan	115	118	PF01048	0.338
MOD_GlcNHglycan	253	256	PF01048	0.354
MOD_GlcNHglycan	260	263	PF01048	0.179
MOD_GlcNHglycan	343	346	PF01048	0.377
MOD_GlcNHglycan	39	42	PF01048	0.358
MOD_GlcNHglycan	405	408	PF01048	0.322
MOD_GlcNHglycan	492	495	PF01048	0.349
MOD_GlcNHglycan	550	553	PF01048	0.401
MOD_GlcNHglycan	573	576	PF01048	0.334
MOD_GlcNHglycan	590	593	PF01048	0.409
MOD_GlcNHglycan	74	77	PF01048	0.273
MOD_GSK3_1	113	120	PF00069	0.347
MOD_GSK3_1	126	133	PF00069	0.244
MOD_GSK3_1	187	194	PF00069	0.380
MOD_GSK3_1	26	33	PF00069	0.374
MOD_GSK3_1	265	272	PF00069	0.292
MOD_GSK3_1	403	410	PF00069	0.381
MOD_GSK3_1	412	419	PF00069	0.407
MOD_GSK3_1	537	544	PF00069	0.328
MOD_GSK3_1	584	591	PF00069	0.432
MOD_GSK3_1	66	73	PF00069	0.282
MOD_GSK3_1	680	687	PF00069	0.374
MOD_GSK3_1	693	700	PF00069	0.490
MOD_N-GLC_1	423	428	PF02516	0.242
MOD_N-GLC_1	458	463	PF02516	0.369
MOD_N-GLC_1	708	713	PF02516	0.465
MOD_N-GLC_2	351	353	PF02516	0.281
MOD_N-GLC_2	594	596	PF02516	0.285
MOD_NEK2_1	113	118	PF00069	0.356
MOD_NEK2_1	227	232	PF00069	0.282
MOD_NEK2_1	618	623	PF00069	0.329
MOD_NEK2_1	629	634	PF00069	0.293
MOD_NEK2_1	657	662	PF00069	0.285
MOD_NEK2_1	66	71	PF00069	0.282
MOD_NEK2_2	450	455	PF00069	0.380
MOD_NEK2_2	458	463	PF00069	0.353
MOD_PIKK_1	130	136	PF00454	0.323
MOD_PIKK_1	237	243	PF00454	0.317
MOD_PKA_2	187	193	PF00069	0.363
MOD_PKA_2	227	233	PF00069	0.258
MOD_PKA_2	466	472	PF00069	0.373
MOD_Plk_1	143	149	PF00069	0.342
MOD_Plk_1	423	429	PF00069	0.256
MOD_Plk_1	458	464	PF00069	0.354
MOD_Plk_1	613	619	PF00069	0.317
MOD_Plk_1	670	676	PF00069	0.334
MOD_Plk_4	227	233	PF00069	0.282
MOD_Plk_4	416	422	PF00069	0.258
MOD_Plk_4	613	619	PF00069	0.289
MOD_Plk_4	675	681	PF00069	0.290
MOD_ProDKin_1	117	123	PF00069	0.269
MOD_ProDKin_1	126	132	PF00069	0.321
MOD_ProDKin_1	30	36	PF00069	0.374
MOD_ProDKin_1	538	544	PF00069	0.322
MOD_ProDKin_1	594	600	PF00069	0.408
MOD_ProDKin_1	605	611	PF00069	0.194
MOD_ProDKin_1	693	699	PF00069	0.522
MOD_ProDKin_1	70	76	PF00069	0.282
MOD_SUMO_rev_2	580	584	PF00179	0.321
TRG_DiLeu_BaEn_3	104	110	PF01217	0.204
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.365
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.374
TRG_ENDOCYTIC_2	4	7	PF00928	0.341
TRG_ENDOCYTIC_2	478	481	PF00928	0.317
TRG_ENDOCYTIC_2	49	52	PF00928	0.374
TRG_ENDOCYTIC_2	503	506	PF00928	0.262
TRG_ENDOCYTIC_2	555	558	PF00928	0.451
TRG_ENDOCYTIC_2	612	615	PF00928	0.334
TRG_ENDOCYTIC_2	654	657	PF00928	0.258
TRG_ER_diArg_1	18	21	PF00400	0.282
TRG_ER_diArg_1	204	207	PF00400	0.258
TRG_ER_diArg_1	293	295	PF00400	0.346
TRG_ER_diArg_1	521	523	PF00400	0.287
TRG_ER_diArg_1	566	568	PF00400	0.152

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	72%	100%
A0A0N0P5L6	Leptomonas seymouri	32%	100%
A0A0S4JCH5	Bodo saltans	29%	100%
A0A0S4JST7	Bodo saltans	46%	100%
A0A1X0NKW1	Trypanosomatidae	29%	100%
A0A1X0NU55	Trypanosomatidae	53%	100%
A0A3S5H5T4	Leishmania donovani	31%	100%
A0A3S7X6G9	Leishmania donovani	95%	100%
A4H4Q6	Leishmania braziliensis	31%	100%
A4HLD7	Leishmania braziliensis	85%	100%
A4HSY5	Leishmania infantum	31%	100%
A4I8U6	Leishmania infantum	94%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	32%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	30%	100%
O87278	Rhizobium meliloti (strain 1021)	31%	100%
P16099	Methylophilus methylotrophus	27%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	30%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	29%	100%
P32382	Thermoanaerobacter brockii	34%	100%
P42593	Escherichia coli (strain K12)	44%	100%
Q48303	Hyphomicrobium sp. (strain x)	26%	99%
Q4Q4A9	Leishmania major	93%	100%
Q4QIY4	Leishmania major	32%	100%
V5AR23	Trypanosoma cruzi	52%	100%
V5BNI9	Trypanosoma cruzi	31%	100%