LeishMANIAdb
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Putative CYC2-like cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CYC2-like cyclin
Gene product:
G1 cyclin CycE4, putative
Species:
Leishmania mexicana
UniProt:
E9B3R0_LEIMU
TriTrypDb:
LmxM.32.0770
Length:
891

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B3R0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3R0

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 6
GO:0001932 regulation of protein phosphorylation 7 6
GO:0019220 regulation of phosphate metabolic process 6 6
GO:0019222 regulation of metabolic process 3 6
GO:0031323 regulation of cellular metabolic process 4 6
GO:0031399 regulation of protein modification process 6 6
GO:0042325 regulation of phosphorylation 7 6
GO:0043549 regulation of kinase activity 5 6
GO:0045859 regulation of protein kinase activity 6 6
GO:0050789 regulation of biological process 2 6
GO:0050790 regulation of catalytic activity 3 6
GO:0050794 regulation of cellular process 3 6
GO:0051171 regulation of nitrogen compound metabolic process 4 6
GO:0051174 regulation of phosphorus metabolic process 5 6
GO:0051246 regulation of protein metabolic process 5 6
GO:0051338 regulation of transferase activity 4 6
GO:0051726 regulation of cell cycle 4 6
GO:0060255 regulation of macromolecule metabolic process 4 6
GO:0065007 biological regulation 1 6
GO:0065009 regulation of molecular function 2 6
GO:0071900 regulation of protein serine/threonine kinase activity 7 6
GO:0080090 regulation of primary metabolic process 4 6
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 6
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0019899 enzyme binding 3 6
GO:0019900 kinase binding 4 6
GO:0019901 protein kinase binding 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 12 16 PF00656 0.577
CLV_C14_Caspase3-7 449 453 PF00656 0.769
CLV_NRD_NRD_1 304 306 PF00675 0.636
CLV_NRD_NRD_1 474 476 PF00675 0.807
CLV_NRD_NRD_1 496 498 PF00675 0.746
CLV_NRD_NRD_1 574 576 PF00675 0.710
CLV_NRD_NRD_1 60 62 PF00675 0.638
CLV_NRD_NRD_1 720 722 PF00675 0.621
CLV_NRD_NRD_1 766 768 PF00675 0.824
CLV_PCSK_KEX2_1 304 306 PF00082 0.636
CLV_PCSK_KEX2_1 474 476 PF00082 0.807
CLV_PCSK_KEX2_1 495 497 PF00082 0.740
CLV_PCSK_KEX2_1 60 62 PF00082 0.638
CLV_PCSK_KEX2_1 607 609 PF00082 0.671
CLV_PCSK_KEX2_1 620 622 PF00082 0.758
CLV_PCSK_KEX2_1 766 768 PF00082 0.824
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.740
CLV_PCSK_PC1ET2_1 607 609 PF00082 0.671
CLV_PCSK_PC1ET2_1 620 622 PF00082 0.758
CLV_PCSK_SKI1_1 300 304 PF00082 0.374
CLV_PCSK_SKI1_1 474 478 PF00082 0.684
CLV_PCSK_SKI1_1 496 500 PF00082 0.748
CLV_PCSK_SKI1_1 540 544 PF00082 0.817
CLV_PCSK_SKI1_1 608 612 PF00082 0.615
CLV_PCSK_SKI1_1 632 636 PF00082 0.736
DEG_APCC_DBOX_1 270 278 PF00400 0.502
DEG_APCC_DBOX_1 642 650 PF00400 0.772
DEG_COP1_1 179 189 PF00400 0.475
DEG_SCF_FBW7_1 307 313 PF00400 0.667
DEG_SPOP_SBC_1 780 784 PF00917 0.703
DEG_SPOP_SBC_1 788 792 PF00917 0.736
DOC_CKS1_1 307 312 PF01111 0.662
DOC_CKS1_1 425 430 PF01111 0.569
DOC_CKS1_1 758 763 PF01111 0.732
DOC_CYCLIN_RxL_1 490 500 PF00134 0.736
DOC_MAPK_DCC_7 474 483 PF00069 0.794
DOC_MAPK_HePTP_8 471 483 PF00069 0.796
DOC_MAPK_MEF2A_6 199 206 PF00069 0.502
DOC_MAPK_MEF2A_6 474 483 PF00069 0.794
DOC_PP2B_LxvP_1 153 156 PF13499 0.750
DOC_PP2B_LxvP_1 18 21 PF13499 0.775
DOC_PP2B_LxvP_1 489 492 PF13499 0.762
DOC_PP2B_LxvP_1 528 531 PF13499 0.825
DOC_PP2B_LxvP_1 661 664 PF13499 0.833
DOC_PP4_FxxP_1 123 126 PF00568 0.789
DOC_PP4_FxxP_1 477 480 PF00568 0.787
DOC_PP4_FxxP_1 92 95 PF00568 0.663
DOC_USP7_MATH_1 126 130 PF00917 0.683
DOC_USP7_MATH_1 259 263 PF00917 0.576
DOC_USP7_MATH_1 29 33 PF00917 0.721
DOC_USP7_MATH_1 328 332 PF00917 0.723
DOC_USP7_MATH_1 392 396 PF00917 0.683
DOC_USP7_MATH_1 403 407 PF00917 0.723
DOC_USP7_MATH_1 437 441 PF00917 0.767
DOC_USP7_MATH_1 482 486 PF00917 0.563
DOC_USP7_MATH_1 595 599 PF00917 0.630
DOC_USP7_MATH_1 612 616 PF00917 0.736
DOC_USP7_MATH_1 675 679 PF00917 0.657
DOC_USP7_MATH_1 694 698 PF00917 0.727
DOC_USP7_MATH_1 733 737 PF00917 0.770
DOC_USP7_MATH_1 780 784 PF00917 0.769
DOC_USP7_MATH_1 788 792 PF00917 0.709
DOC_USP7_MATH_1 95 99 PF00917 0.828
DOC_WW_Pin1_4 113 118 PF00397 0.721
DOC_WW_Pin1_4 148 153 PF00397 0.812
DOC_WW_Pin1_4 306 311 PF00397 0.684
DOC_WW_Pin1_4 356 361 PF00397 0.822
DOC_WW_Pin1_4 424 429 PF00397 0.568
DOC_WW_Pin1_4 507 512 PF00397 0.781
DOC_WW_Pin1_4 520 525 PF00397 0.654
DOC_WW_Pin1_4 744 749 PF00397 0.681
DOC_WW_Pin1_4 757 762 PF00397 0.713
DOC_WW_Pin1_4 765 770 PF00397 0.730
DOC_WW_Pin1_4 771 776 PF00397 0.674
DOC_WW_Pin1_4 884 889 PF00397 0.771
DOC_WW_Pin1_4 91 96 PF00397 0.716
DOC_WW_Pin1_4 98 103 PF00397 0.766
LIG_14-3-3_CanoR_1 148 152 PF00244 0.758
LIG_14-3-3_CanoR_1 233 241 PF00244 0.447
LIG_14-3-3_CanoR_1 391 401 PF00244 0.609
LIG_14-3-3_CanoR_1 4 10 PF00244 0.739
LIG_14-3-3_CanoR_1 438 447 PF00244 0.780
LIG_14-3-3_CanoR_1 496 502 PF00244 0.854
LIG_14-3-3_CanoR_1 689 693 PF00244 0.726
LIG_14-3-3_CanoR_1 737 746 PF00244 0.678
LIG_14-3-3_CanoR_1 881 891 PF00244 0.782
LIG_14-3-3_CanoR_1 96 100 PF00244 0.792
LIG_Actin_WH2_2 272 289 PF00022 0.502
LIG_BIR_III_4 847 851 PF00653 0.573
LIG_BRCT_BRCA1_1 119 123 PF00533 0.726
LIG_BRCT_BRCA1_1 161 165 PF00533 0.580
LIG_BRCT_BRCA1_1 537 541 PF00533 0.751
LIG_BRCT_BRCA1_2 537 543 PF00533 0.753
LIG_Clathr_ClatBox_1 279 283 PF01394 0.502
LIG_Clathr_ClatBox_1 295 299 PF01394 0.351
LIG_deltaCOP1_diTrp_1 292 297 PF00928 0.570
LIG_EVH1_1 710 714 PF00568 0.791
LIG_FHA_1 122 128 PF00498 0.751
LIG_FHA_1 234 240 PF00498 0.564
LIG_FHA_1 311 317 PF00498 0.630
LIG_FHA_1 320 326 PF00498 0.626
LIG_FHA_1 357 363 PF00498 0.817
LIG_FHA_1 425 431 PF00498 0.774
LIG_FHA_1 458 464 PF00498 0.580
LIG_FHA_1 636 642 PF00498 0.742
LIG_FHA_1 678 684 PF00498 0.761
LIG_FHA_1 788 794 PF00498 0.748
LIG_FHA_2 268 274 PF00498 0.545
LIG_FHA_2 338 344 PF00498 0.774
LIG_FXI_DFP_1 279 283 PF00024 0.502
LIG_LIR_Apic_2 120 126 PF02991 0.724
LIG_LIR_Apic_2 89 95 PF02991 0.658
LIG_LIR_Gen_1 221 229 PF02991 0.502
LIG_LIR_Gen_1 273 284 PF02991 0.502
LIG_LIR_Gen_1 41 51 PF02991 0.627
LIG_LIR_Gen_1 426 437 PF02991 0.567
LIG_LIR_Gen_1 559 570 PF02991 0.583
LIG_LIR_Nem_3 221 226 PF02991 0.502
LIG_LIR_Nem_3 273 279 PF02991 0.502
LIG_LIR_Nem_3 281 285 PF02991 0.388
LIG_LIR_Nem_3 41 46 PF02991 0.649
LIG_LIR_Nem_3 426 432 PF02991 0.575
LIG_LIR_Nem_3 452 458 PF02991 0.779
LIG_LIR_Nem_3 559 565 PF02991 0.589
LIG_LIR_Nem_3 709 713 PF02991 0.797
LIG_LIR_Nem_3 827 833 PF02991 0.722
LIG_LIR_Nem_3 835 841 PF02991 0.619
LIG_LIR_Nem_3 849 855 PF02991 0.633
LIG_MLH1_MIPbox_1 161 165 PF16413 0.580
LIG_REV1ctd_RIR_1 539 549 PF16727 0.815
LIG_SH2_CRK 7 11 PF00017 0.715
LIG_SH2_GRB2like 703 706 PF00017 0.618
LIG_SH2_GRB2like 841 844 PF00017 0.538
LIG_SH2_NCK_1 7 11 PF00017 0.715
LIG_SH2_SRC 246 249 PF00017 0.502
LIG_SH2_SRC 811 814 PF00017 0.811
LIG_SH2_STAP1 47 51 PF00017 0.566
LIG_SH2_STAP1 789 793 PF00017 0.811
LIG_SH2_STAP1 852 856 PF00017 0.762
LIG_SH2_STAT5 211 214 PF00017 0.502
LIG_SH2_STAT5 278 281 PF00017 0.502
LIG_SH2_STAT5 314 317 PF00017 0.700
LIG_SH2_STAT5 703 706 PF00017 0.618
LIG_SH2_STAT5 789 792 PF00017 0.754
LIG_SH2_STAT5 838 841 PF00017 0.685
LIG_SH2_STAT5 876 879 PF00017 0.774
LIG_SH3_2 524 529 PF14604 0.685
LIG_SH3_2 748 753 PF14604 0.638
LIG_SH3_3 115 121 PF00018 0.775
LIG_SH3_3 149 155 PF00018 0.807
LIG_SH3_3 441 447 PF00018 0.666
LIG_SH3_3 476 482 PF00018 0.788
LIG_SH3_3 485 491 PF00018 0.620
LIG_SH3_3 505 511 PF00018 0.598
LIG_SH3_3 521 527 PF00018 0.605
LIG_SH3_3 645 651 PF00018 0.775
LIG_SH3_3 708 714 PF00018 0.798
LIG_SH3_3 745 751 PF00018 0.797
LIG_SH3_3 755 761 PF00018 0.657
LIG_SH3_3 96 102 PF00018 0.577
LIG_TRAF2_1 174 177 PF00917 0.751
LIG_TRAF2_1 50 53 PF00917 0.579
LIG_TYR_ITIM 560 565 PF00017 0.589
LIG_UBA3_1 295 300 PF00899 0.360
LIG_WW_1 700 703 PF00397 0.599
LIG_WW_2 479 482 PF00397 0.784
LIG_WW_3 435 439 PF00397 0.707
LIG_WW_3 699 703 PF00397 0.817
MOD_CDC14_SPxK_1 526 529 PF00782 0.826
MOD_CDC14_SPxK_1 750 753 PF00782 0.597
MOD_CDK_SPK_2 117 122 PF00069 0.715
MOD_CDK_SPK_2 91 96 PF00069 0.681
MOD_CDK_SPxK_1 523 529 PF00069 0.818
MOD_CDK_SPxK_1 747 753 PF00069 0.602
MOD_CDK_SPxxK_3 765 772 PF00069 0.756
MOD_CK1_1 113 119 PF00069 0.751
MOD_CK1_1 157 163 PF00069 0.774
MOD_CK1_1 267 273 PF00069 0.506
MOD_CK1_1 319 325 PF00069 0.789
MOD_CK1_1 331 337 PF00069 0.661
MOD_CK1_1 377 383 PF00069 0.773
MOD_CK1_1 424 430 PF00069 0.613
MOD_CK1_1 439 445 PF00069 0.751
MOD_CK1_1 459 465 PF00069 0.544
MOD_CK1_1 510 516 PF00069 0.835
MOD_CK1_1 523 529 PF00069 0.661
MOD_CK1_1 544 550 PF00069 0.815
MOD_CK1_1 578 584 PF00069 0.769
MOD_CK1_1 591 597 PF00069 0.632
MOD_CK1_1 679 685 PF00069 0.818
MOD_CK1_1 706 712 PF00069 0.659
MOD_CK1_1 736 742 PF00069 0.662
MOD_CK1_1 747 753 PF00069 0.597
MOD_CK1_1 781 787 PF00069 0.810
MOD_CK1_1 88 94 PF00069 0.686
MOD_CK1_1 98 104 PF00069 0.712
MOD_CK2_1 267 273 PF00069 0.502
MOD_CK2_1 286 292 PF00069 0.321
MOD_CK2_1 337 343 PF00069 0.749
MOD_CK2_1 735 741 PF00069 0.623
MOD_CK2_1 814 820 PF00069 0.799
MOD_CMANNOS 294 297 PF00535 0.558
MOD_Cter_Amidation 573 576 PF01082 0.590
MOD_GlcNHglycan 165 168 PF01048 0.716
MOD_GlcNHglycan 261 264 PF01048 0.545
MOD_GlcNHglycan 31 34 PF01048 0.776
MOD_GlcNHglycan 322 325 PF01048 0.724
MOD_GlcNHglycan 379 382 PF01048 0.676
MOD_GlcNHglycan 405 408 PF01048 0.653
MOD_GlcNHglycan 439 442 PF01048 0.844
MOD_GlcNHglycan 484 487 PF01048 0.518
MOD_GlcNHglycan 556 559 PF01048 0.760
MOD_GlcNHglycan 592 596 PF01048 0.741
MOD_GlcNHglycan 598 601 PF01048 0.747
MOD_GlcNHglycan 608 611 PF01048 0.629
MOD_GlcNHglycan 651 654 PF01048 0.747
MOD_GlcNHglycan 670 673 PF01048 0.630
MOD_GlcNHglycan 683 686 PF01048 0.778
MOD_GlcNHglycan 696 699 PF01048 0.651
MOD_GlcNHglycan 705 708 PF01048 0.735
MOD_GlcNHglycan 795 798 PF01048 0.651
MOD_GSK3_1 106 113 PF00069 0.723
MOD_GSK3_1 117 124 PF00069 0.595
MOD_GSK3_1 159 166 PF00069 0.646
MOD_GSK3_1 21 28 PF00069 0.616
MOD_GSK3_1 218 225 PF00069 0.521
MOD_GSK3_1 306 313 PF00069 0.719
MOD_GSK3_1 315 322 PF00069 0.691
MOD_GSK3_1 327 334 PF00069 0.655
MOD_GSK3_1 356 363 PF00069 0.834
MOD_GSK3_1 370 377 PF00069 0.643
MOD_GSK3_1 392 399 PF00069 0.649
MOD_GSK3_1 403 410 PF00069 0.666
MOD_GSK3_1 417 424 PF00069 0.604
MOD_GSK3_1 436 443 PF00069 0.622
MOD_GSK3_1 446 453 PF00069 0.678
MOD_GSK3_1 5 12 PF00069 0.757
MOD_GSK3_1 584 591 PF00069 0.767
MOD_GSK3_1 608 615 PF00069 0.615
MOD_GSK3_1 675 682 PF00069 0.800
MOD_GSK3_1 733 740 PF00069 0.817
MOD_GSK3_1 779 786 PF00069 0.777
MOD_GSK3_1 789 796 PF00069 0.672
MOD_GSK3_1 84 91 PF00069 0.719
MOD_GSK3_1 94 101 PF00069 0.706
MOD_LATS_1 134 140 PF00433 0.791
MOD_N-GLC_1 146 151 PF02516 0.716
MOD_N-GLC_1 160 165 PF02516 0.588
MOD_N-GLC_2 255 257 PF02516 0.502
MOD_N-GLC_2 56 58 PF02516 0.387
MOD_NEK2_1 127 132 PF00069 0.746
MOD_NEK2_1 224 229 PF00069 0.502
MOD_NEK2_1 234 239 PF00069 0.376
MOD_NEK2_1 258 263 PF00069 0.502
MOD_NEK2_1 327 332 PF00069 0.675
MOD_NEK2_1 451 456 PF00069 0.824
MOD_NEK2_1 541 546 PF00069 0.817
MOD_NEK2_1 635 640 PF00069 0.736
MOD_NEK2_1 676 681 PF00069 0.648
MOD_NEK2_1 683 688 PF00069 0.619
MOD_NEK2_1 85 90 PF00069 0.687
MOD_PIKK_1 21 27 PF00454 0.712
MOD_PIKK_1 670 676 PF00454 0.839
MOD_PIKK_1 69 75 PF00454 0.712
MOD_PIKK_1 783 789 PF00454 0.831
MOD_PK_1 497 503 PF00069 0.808
MOD_PK_1 529 535 PF00069 0.814
MOD_PKA_1 575 581 PF00069 0.607
MOD_PKA_2 121 127 PF00069 0.686
MOD_PKA_2 147 153 PF00069 0.757
MOD_PKA_2 213 219 PF00069 0.502
MOD_PKA_2 232 238 PF00069 0.262
MOD_PKA_2 25 31 PF00069 0.623
MOD_PKA_2 437 443 PF00069 0.715
MOD_PKA_2 584 590 PF00069 0.745
MOD_PKA_2 688 694 PF00069 0.667
MOD_PKA_2 69 75 PF00069 0.686
MOD_PKA_2 701 707 PF00069 0.736
MOD_PKA_2 736 742 PF00069 0.772
MOD_PKA_2 95 101 PF00069 0.784
MOD_Plk_1 14 20 PF00069 0.589
MOD_Plk_1 160 166 PF00069 0.613
MOD_Plk_1 176 182 PF00069 0.687
MOD_Plk_1 267 273 PF00069 0.502
MOD_Plk_1 370 376 PF00069 0.684
MOD_Plk_1 430 436 PF00069 0.611
MOD_Plk_1 451 457 PF00069 0.562
MOD_Plk_1 656 662 PF00069 0.843
MOD_Plk_2-3 36 42 PF00069 0.679
MOD_Plk_4 160 166 PF00069 0.615
MOD_Plk_4 185 191 PF00069 0.500
MOD_Plk_4 310 316 PF00069 0.682
MOD_Plk_4 440 446 PF00069 0.783
MOD_Plk_4 637 643 PF00069 0.750
MOD_Plk_4 95 101 PF00069 0.570
MOD_ProDKin_1 113 119 PF00069 0.724
MOD_ProDKin_1 148 154 PF00069 0.809
MOD_ProDKin_1 306 312 PF00069 0.688
MOD_ProDKin_1 356 362 PF00069 0.825
MOD_ProDKin_1 424 430 PF00069 0.569
MOD_ProDKin_1 507 513 PF00069 0.778
MOD_ProDKin_1 520 526 PF00069 0.655
MOD_ProDKin_1 744 750 PF00069 0.683
MOD_ProDKin_1 757 763 PF00069 0.714
MOD_ProDKin_1 765 771 PF00069 0.728
MOD_ProDKin_1 884 890 PF00069 0.776
MOD_ProDKin_1 91 97 PF00069 0.732
MOD_ProDKin_1 98 104 PF00069 0.765
MOD_SUMO_rev_2 599 609 PF00179 0.608
TRG_DiLeu_BaEn_4 656 662 PF01217 0.843
TRG_ENDOCYTIC_2 562 565 PF00928 0.632
TRG_ENDOCYTIC_2 710 713 PF00928 0.792
TRG_ER_diArg_1 303 305 PF00400 0.623
TRG_ER_diArg_1 496 498 PF00400 0.801
TRG_ER_diArg_1 60 62 PF00400 0.636
TRG_ER_diArg_1 879 882 PF00400 0.780
TRG_ER_FFAT_2 329 340 PF00635 0.560
TRG_NES_CRM1_1 275 290 PF08389 0.502
TRG_NES_CRM1_1 293 306 PF08389 0.330
TRG_NLS_Bipartite_1 607 623 PF00514 0.599
TRG_NLS_MonoExtN_4 492 499 PF00514 0.738
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.795

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDM6 Leishmania donovani 87% 100%
A4HLB8 Leishmania braziliensis 72% 100%
A4I8U4 Leishmania infantum 87% 100%
Q4Q4C8 Leishmania major 86% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS