LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3Q7_LEIMU
TriTrypDb:
LmxM.32.0750
Length:
770

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B3Q7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Q7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 118 120 PF00675 0.473
CLV_NRD_NRD_1 19 21 PF00675 0.357
CLV_NRD_NRD_1 238 240 PF00675 0.682
CLV_NRD_NRD_1 679 681 PF00675 0.603
CLV_NRD_NRD_1 683 685 PF00675 0.630
CLV_NRD_NRD_1 705 707 PF00675 0.520
CLV_PCSK_FUR_1 233 237 PF00082 0.706
CLV_PCSK_FUR_1 673 677 PF00082 0.450
CLV_PCSK_FUR_1 680 684 PF00082 0.558
CLV_PCSK_KEX2_1 118 120 PF00082 0.473
CLV_PCSK_KEX2_1 19 21 PF00082 0.357
CLV_PCSK_KEX2_1 235 237 PF00082 0.691
CLV_PCSK_KEX2_1 238 240 PF00082 0.696
CLV_PCSK_KEX2_1 675 677 PF00082 0.561
CLV_PCSK_KEX2_1 679 681 PF00082 0.607
CLV_PCSK_KEX2_1 682 684 PF00082 0.635
CLV_PCSK_KEX2_1 705 707 PF00082 0.520
CLV_PCSK_PC1ET2_1 675 677 PF00082 0.539
CLV_PCSK_PC7_1 233 239 PF00082 0.661
CLV_PCSK_PC7_1 679 685 PF00082 0.607
CLV_PCSK_SKI1_1 201 205 PF00082 0.574
CLV_PCSK_SKI1_1 376 380 PF00082 0.401
CLV_PCSK_SKI1_1 411 415 PF00082 0.448
CLV_PCSK_SKI1_1 457 461 PF00082 0.518
CLV_PCSK_SKI1_1 604 608 PF00082 0.495
CLV_PCSK_SKI1_1 757 761 PF00082 0.554
DEG_APCC_DBOX_1 236 244 PF00400 0.500
DEG_APCC_DBOX_1 375 383 PF00400 0.368
DEG_APCC_DBOX_1 410 418 PF00400 0.438
DEG_APCC_DBOX_1 603 611 PF00400 0.453
DEG_Nend_Nbox_1 1 3 PF02207 0.504
DEG_SCF_FBW7_1 41 48 PF00400 0.468
DEG_SPOP_SBC_1 562 566 PF00917 0.527
DOC_CKS1_1 713 718 PF01111 0.583
DOC_CYCLIN_RxL_1 373 381 PF00134 0.403
DOC_CYCLIN_yCln2_LP_2 416 419 PF00134 0.423
DOC_MAPK_DCC_7 308 316 PF00069 0.466
DOC_MAPK_gen_1 457 465 PF00069 0.407
DOC_MAPK_gen_1 705 713 PF00069 0.548
DOC_MAPK_gen_1 756 764 PF00069 0.510
DOC_MAPK_MEF2A_6 274 281 PF00069 0.757
DOC_MAPK_MEF2A_6 477 486 PF00069 0.452
DOC_MAPK_MEF2A_6 756 764 PF00069 0.560
DOC_MAPK_NFAT4_5 757 765 PF00069 0.503
DOC_PP1_RVXF_1 358 365 PF00149 0.409
DOC_PP1_RVXF_1 475 482 PF00149 0.469
DOC_PP1_RVXF_1 61 67 PF00149 0.536
DOC_PP2B_LxvP_1 416 419 PF13499 0.423
DOC_USP7_MATH_1 167 171 PF00917 0.650
DOC_USP7_MATH_1 212 216 PF00917 0.580
DOC_USP7_MATH_1 241 245 PF00917 0.720
DOC_USP7_MATH_1 257 261 PF00917 0.700
DOC_USP7_MATH_1 40 44 PF00917 0.655
DOC_USP7_MATH_1 45 49 PF00917 0.611
DOC_USP7_MATH_1 494 498 PF00917 0.639
DOC_USP7_MATH_1 504 508 PF00917 0.695
DOC_USP7_MATH_1 530 534 PF00917 0.641
DOC_USP7_MATH_1 536 540 PF00917 0.613
DOC_USP7_MATH_1 592 596 PF00917 0.477
DOC_USP7_MATH_1 731 735 PF00917 0.645
DOC_USP7_MATH_1 752 756 PF00917 0.588
DOC_USP7_UBL2_3 514 518 PF12436 0.669
DOC_WW_Pin1_4 226 231 PF00397 0.629
DOC_WW_Pin1_4 307 312 PF00397 0.473
DOC_WW_Pin1_4 41 46 PF00397 0.569
DOC_WW_Pin1_4 588 593 PF00397 0.376
DOC_WW_Pin1_4 595 600 PF00397 0.372
DOC_WW_Pin1_4 619 624 PF00397 0.468
DOC_WW_Pin1_4 694 699 PF00397 0.642
DOC_WW_Pin1_4 712 717 PF00397 0.478
LIG_14-3-3_CanoR_1 10 15 PF00244 0.496
LIG_14-3-3_CanoR_1 213 217 PF00244 0.597
LIG_14-3-3_CanoR_1 51 57 PF00244 0.632
LIG_14-3-3_CanoR_1 582 590 PF00244 0.361
LIG_BIR_III_2 719 723 PF00653 0.607
LIG_BIR_III_4 472 476 PF00653 0.521
LIG_BRCT_BRCA1_1 264 268 PF00533 0.673
LIG_BRCT_BRCA1_1 352 356 PF00533 0.458
LIG_DLG_GKlike_1 10 17 PF00625 0.367
LIG_FHA_1 10 16 PF00498 0.414
LIG_FHA_1 179 185 PF00498 0.681
LIG_FHA_1 485 491 PF00498 0.717
LIG_FHA_1 52 58 PF00498 0.509
LIG_FHA_1 583 589 PF00498 0.393
LIG_FHA_1 619 625 PF00498 0.389
LIG_FHA_1 662 668 PF00498 0.502
LIG_FHA_2 170 176 PF00498 0.655
LIG_FHA_2 333 339 PF00498 0.520
LIG_FHA_2 572 578 PF00498 0.476
LIG_FHA_2 731 737 PF00498 0.451
LIG_Integrin_RGD_1 684 686 PF01839 0.622
LIG_LIR_Apic_2 625 631 PF02991 0.414
LIG_LIR_Gen_1 312 322 PF02991 0.481
LIG_LIR_Gen_1 9 17 PF02991 0.432
LIG_LIR_Nem_3 312 318 PF02991 0.469
LIG_LIR_Nem_3 9 14 PF02991 0.430
LIG_MAD2 615 623 PF02301 0.460
LIG_NRBOX 90 96 PF00104 0.443
LIG_PDZ_Class_2 765 770 PF00595 0.494
LIG_PTB_Apo_2 578 585 PF02174 0.317
LIG_PTB_Phospho_1 578 584 PF10480 0.322
LIG_REV1ctd_RIR_1 765 770 PF16727 0.588
LIG_SH2_CRK 425 429 PF00017 0.327
LIG_SH2_NCK_1 123 127 PF00017 0.499
LIG_SH2_NCK_1 590 594 PF00017 0.412
LIG_SH2_STAP1 425 429 PF00017 0.456
LIG_SH2_STAP1 584 588 PF00017 0.409
LIG_SH2_STAP1 83 87 PF00017 0.576
LIG_SH2_STAT3 455 458 PF00017 0.473
LIG_SH2_STAT5 23 26 PF00017 0.475
LIG_SH2_STAT5 343 346 PF00017 0.428
LIG_SH2_STAT5 374 377 PF00017 0.360
LIG_SH2_STAT5 455 458 PF00017 0.473
LIG_SH2_STAT5 584 587 PF00017 0.433
LIG_SH2_STAT5 628 631 PF00017 0.423
LIG_SH2_STAT5 750 753 PF00017 0.472
LIG_SH3_3 107 113 PF00018 0.627
LIG_SH3_3 114 120 PF00018 0.613
LIG_SH3_3 400 406 PF00018 0.438
LIG_SH3_3 412 418 PF00018 0.370
LIG_SH3_3 483 489 PF00018 0.513
LIG_SUMO_SIM_anti_2 389 395 PF11976 0.449
LIG_SUMO_SIM_anti_2 412 418 PF11976 0.377
LIG_SUMO_SIM_anti_2 621 628 PF11976 0.427
LIG_SUMO_SIM_par_1 277 282 PF11976 0.616
LIG_WRPW_2 401 404 PF00400 0.521
MOD_CDK_SPxK_1 595 601 PF00069 0.421
MOD_CDK_SPxxK_3 226 233 PF00069 0.557
MOD_CK1_1 231 237 PF00069 0.602
MOD_CK1_1 242 248 PF00069 0.636
MOD_CK1_1 252 258 PF00069 0.572
MOD_CK1_1 270 276 PF00069 0.722
MOD_CK1_1 497 503 PF00069 0.610
MOD_CK1_1 539 545 PF00069 0.643
MOD_CK1_1 595 601 PF00069 0.456
MOD_CK1_1 661 667 PF00069 0.560
MOD_CK1_1 68 74 PF00069 0.586
MOD_CK1_1 714 720 PF00069 0.664
MOD_CK1_1 755 761 PF00069 0.500
MOD_CK2_1 151 157 PF00069 0.507
MOD_CK2_1 332 338 PF00069 0.529
MOD_CK2_1 571 577 PF00069 0.328
MOD_CK2_1 721 727 PF00069 0.580
MOD_CK2_1 730 736 PF00069 0.630
MOD_Cter_Amidation 17 20 PF01082 0.362
MOD_GlcNHglycan 148 151 PF01048 0.562
MOD_GlcNHglycan 198 201 PF01048 0.621
MOD_GlcNHglycan 230 233 PF01048 0.780
MOD_GlcNHglycan 254 257 PF01048 0.623
MOD_GlcNHglycan 259 262 PF01048 0.665
MOD_GlcNHglycan 323 326 PF01048 0.570
MOD_GlcNHglycan 33 36 PF01048 0.610
MOD_GlcNHglycan 425 428 PF01048 0.419
MOD_GlcNHglycan 448 452 PF01048 0.370
MOD_GlcNHglycan 467 470 PF01048 0.614
MOD_GlcNHglycan 496 499 PF01048 0.634
MOD_GlcNHglycan 534 537 PF01048 0.487
MOD_GlcNHglycan 538 541 PF01048 0.469
MOD_GlcNHglycan 544 547 PF01048 0.472
MOD_GlcNHglycan 58 61 PF01048 0.549
MOD_GlcNHglycan 689 692 PF01048 0.569
MOD_GlcNHglycan 732 736 PF01048 0.773
MOD_GlcNHglycan 91 94 PF01048 0.330
MOD_GSK3_1 139 146 PF00069 0.460
MOD_GSK3_1 222 229 PF00069 0.641
MOD_GSK3_1 252 259 PF00069 0.639
MOD_GSK3_1 40 47 PF00069 0.654
MOD_GSK3_1 52 59 PF00069 0.632
MOD_GSK3_1 532 539 PF00069 0.672
MOD_GSK3_1 558 565 PF00069 0.483
MOD_GSK3_1 571 578 PF00069 0.452
MOD_GSK3_1 588 595 PF00069 0.399
MOD_GSK3_1 64 71 PF00069 0.419
MOD_N-GLC_1 152 157 PF02516 0.507
MOD_N-GLC_1 52 57 PF02516 0.502
MOD_N-GLC_1 619 624 PF02516 0.485
MOD_N-GLC_2 581 583 PF02516 0.357
MOD_NEK2_1 31 36 PF00069 0.676
MOD_NEK2_1 465 470 PF00069 0.457
MOD_NEK2_1 571 576 PF00069 0.323
MOD_NEK2_1 89 94 PF00069 0.379
MOD_PIKK_1 634 640 PF00454 0.547
MOD_PK_1 239 245 PF00069 0.491
MOD_PKA_1 675 681 PF00069 0.582
MOD_PKA_2 196 202 PF00069 0.586
MOD_PKA_2 212 218 PF00069 0.557
MOD_PKA_2 222 228 PF00069 0.630
MOD_PKA_2 494 500 PF00069 0.752
MOD_PKA_2 575 581 PF00069 0.407
MOD_PKA_2 64 70 PF00069 0.616
MOD_PKA_2 675 681 PF00069 0.613
MOD_PKA_2 9 15 PF00069 0.514
MOD_PKB_1 237 245 PF00069 0.634
MOD_Plk_1 178 184 PF00069 0.676
MOD_Plk_1 52 58 PF00069 0.438
MOD_Plk_1 649 655 PF00069 0.482
MOD_Plk_1 744 750 PF00069 0.452
MOD_Plk_4 10 16 PF00069 0.401
MOD_Plk_4 351 357 PF00069 0.382
MOD_Plk_4 388 394 PF00069 0.436
MOD_Plk_4 441 447 PF00069 0.390
MOD_Plk_4 52 58 PF00069 0.691
MOD_Plk_4 755 761 PF00069 0.411
MOD_ProDKin_1 226 232 PF00069 0.630
MOD_ProDKin_1 307 313 PF00069 0.472
MOD_ProDKin_1 41 47 PF00069 0.568
MOD_ProDKin_1 588 594 PF00069 0.379
MOD_ProDKin_1 595 601 PF00069 0.378
MOD_ProDKin_1 619 625 PF00069 0.468
MOD_ProDKin_1 694 700 PF00069 0.640
MOD_ProDKin_1 712 718 PF00069 0.480
MOD_SUMO_for_1 459 462 PF00179 0.462
MOD_SUMO_rev_2 515 520 PF00179 0.616
MOD_SUMO_rev_2 55 64 PF00179 0.547
TRG_DiLeu_BaEn_1 336 341 PF01217 0.516
TRG_DiLeu_BaEn_1 461 466 PF01217 0.436
TRG_DiLeu_BaEn_4 461 467 PF01217 0.432
TRG_DiLeu_LyEn_5 461 466 PF01217 0.370
TRG_ENDOCYTIC_2 343 346 PF00928 0.448
TRG_ENDOCYTIC_2 425 428 PF00928 0.394
TRG_ENDOCYTIC_2 646 649 PF00928 0.437
TRG_ER_diArg_1 109 112 PF00400 0.539
TRG_ER_diArg_1 117 119 PF00400 0.433
TRG_ER_diArg_1 233 236 PF00400 0.667
TRG_ER_diArg_1 237 239 PF00400 0.691
TRG_ER_diArg_1 679 681 PF00400 0.602
TRG_ER_diArg_1 682 684 PF00400 0.629
TRG_ER_diArg_1 704 706 PF00400 0.514
TRG_Pf-PMV_PEXEL_1 376 380 PF00026 0.401
TRG_Pf-PMV_PEXEL_1 457 461 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 98 102 PF00026 0.442

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P467 Leptomonas seymouri 56% 89%
A0A1X0P116 Trypanosomatidae 31% 100%
A0A3Q8IGR5 Leishmania donovani 90% 100%
A4HLB5 Leishmania braziliensis 77% 100%
A4I8U1 Leishmania infantum 90% 100%
D0A4T7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
Q4Q4D0 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS