Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B3Q5_LEIMU

TriTrypDb:

LmxM.32.0730

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B3Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Q5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.710
CLV_C14_Caspase3-7	441	445	PF00656	0.558
CLV_NRD_NRD_1	348	350	PF00675	0.479
CLV_PCSK_KEX2_1	348	350	PF00082	0.603
CLV_PCSK_SKI1_1	124	128	PF00082	0.448
DEG_COP1_1	24	33	PF00400	0.691
DEG_SPOP_SBC_1	56	60	PF00917	0.671
DOC_CKS1_1	125	130	PF01111	0.436
DOC_CYCLIN_RxL_1	82	92	PF00134	0.585
DOC_MAPK_gen_1	82	90	PF00069	0.562
DOC_MAPK_RevD_3	334	349	PF00069	0.495
DOC_PP4_FxxP_1	111	114	PF00568	0.444
DOC_USP7_MATH_1	114	118	PF00917	0.493
DOC_USP7_MATH_1	21	25	PF00917	0.700
DOC_USP7_MATH_1	323	327	PF00917	0.623
DOC_USP7_MATH_1	328	332	PF00917	0.558
DOC_USP7_MATH_1	41	45	PF00917	0.643
DOC_USP7_MATH_1	438	442	PF00917	0.476
DOC_USP7_MATH_1	461	465	PF00917	0.620
DOC_USP7_MATH_1	57	61	PF00917	0.640
DOC_WW_Pin1_4	124	129	PF00397	0.444
DOC_WW_Pin1_4	156	161	PF00397	0.419
DOC_WW_Pin1_4	19	24	PF00397	0.708
DOC_WW_Pin1_4	292	297	PF00397	0.526
DOC_WW_Pin1_4	58	63	PF00397	0.769
LIG_14-3-3_CanoR_1	348	356	PF00244	0.491
LIG_14-3-3_CanoR_1	76	85	PF00244	0.395
LIG_Actin_WH2_2	22	40	PF00022	0.665
LIG_AP2alpha_2	305	307	PF02296	0.734
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	219	223	PF00533	0.509
LIG_FHA_1	110	116	PF00498	0.517
LIG_FHA_1	121	127	PF00498	0.377
LIG_FHA_1	212	218	PF00498	0.496
LIG_FHA_1	239	245	PF00498	0.543
LIG_FHA_1	358	364	PF00498	0.538
LIG_FHA_1	374	380	PF00498	0.451
LIG_FHA_1	50	56	PF00498	0.728
LIG_LIR_Apic_2	110	114	PF02991	0.436
LIG_LIR_Gen_1	483	493	PF02991	0.454
LIG_LIR_Nem_3	483	488	PF02991	0.449
LIG_PDZ_Class_3	503	508	PF00595	0.638
LIG_PTAP_UEV_1	355	360	PF05743	0.409
LIG_SH2_CRK	172	176	PF00017	0.543
LIG_SH2_NCK_1	9	13	PF00017	0.633
LIG_SH2_SRC	412	415	PF00017	0.598
LIG_SH2_SRC	9	12	PF00017	0.610
LIG_SH2_STAP1	485	489	PF00017	0.559
LIG_SH2_STAT5	150	153	PF00017	0.399
LIG_SH2_STAT5	172	175	PF00017	0.403
LIG_SH2_STAT5	410	413	PF00017	0.509
LIG_SH3_2	296	301	PF14604	0.750
LIG_SH3_3	122	128	PF00018	0.478
LIG_SH3_3	17	23	PF00018	0.649
LIG_SH3_3	293	299	PF00018	0.704
LIG_SH3_3	353	359	PF00018	0.438
LIG_SH3_3	488	494	PF00018	0.665
LIG_SUMO_SIM_par_1	138	143	PF11976	0.385
LIG_TYR_ITIM	170	175	PF00017	0.544
LIG_UBA3_1	180	187	PF00899	0.488
LIG_UBA3_1	315	321	PF00899	0.602
MOD_CK1_1	146	152	PF00069	0.402
MOD_CK1_1	2	8	PF00069	0.727
MOD_CK1_1	246	252	PF00069	0.514
MOD_CK1_1	326	332	PF00069	0.654
MOD_CK1_1	44	50	PF00069	0.688
MOD_CK1_1	58	64	PF00069	0.704
MOD_CK2_1	2	8	PF00069	0.726
MOD_DYRK1A_RPxSP_1	124	128	PF00069	0.480
MOD_GlcNHglycan	133	136	PF01048	0.503
MOD_GlcNHglycan	165	168	PF01048	0.445
MOD_GlcNHglycan	219	222	PF01048	0.427
MOD_GlcNHglycan	234	237	PF01048	0.524
MOD_GlcNHglycan	262	265	PF01048	0.350
MOD_GlcNHglycan	31	34	PF01048	0.659
MOD_GlcNHglycan	328	331	PF01048	0.657
MOD_GlcNHglycan	339	342	PF01048	0.446
MOD_GlcNHglycan	38	41	PF01048	0.636
MOD_GlcNHglycan	4	7	PF01048	0.758
MOD_GlcNHglycan	452	455	PF01048	0.495
MOD_GlcNHglycan	463	466	PF01048	0.620
MOD_GSK3_1	120	127	PF00069	0.442
MOD_GSK3_1	207	214	PF00069	0.532
MOD_GSK3_1	21	28	PF00069	0.719
MOD_GSK3_1	232	239	PF00069	0.607
MOD_GSK3_1	350	357	PF00069	0.656
MOD_GSK3_1	373	380	PF00069	0.547
MOD_GSK3_1	385	392	PF00069	0.546
MOD_GSK3_1	44	51	PF00069	0.705
MOD_GSK3_1	56	63	PF00069	0.700
MOD_GSK3_1	89	96	PF00069	0.522
MOD_NEK2_1	1	6	PF00069	0.771
MOD_NEK2_1	217	222	PF00069	0.636
MOD_NEK2_1	36	41	PF00069	0.550
MOD_NEK2_1	374	379	PF00069	0.574
MOD_NEK2_1	391	396	PF00069	0.430
MOD_PIKK_1	207	213	PF00454	0.496
MOD_PK_1	224	230	PF00069	0.549
MOD_PKA_1	348	354	PF00069	0.598
MOD_PKA_2	131	137	PF00069	0.495
MOD_PKA_2	163	169	PF00069	0.522
MOD_PKA_2	326	332	PF00069	0.564
MOD_PKA_2	348	354	PF00069	0.656
MOD_PKA_2	399	405	PF00069	0.500
MOD_Plk_1	109	115	PF00069	0.604
MOD_Plk_1	374	380	PF00069	0.572
MOD_Plk_4	146	152	PF00069	0.375
MOD_Plk_4	25	31	PF00069	0.705
MOD_Plk_4	386	392	PF00069	0.446
MOD_Plk_4	418	424	PF00069	0.446
MOD_ProDKin_1	124	130	PF00069	0.453
MOD_ProDKin_1	156	162	PF00069	0.414
MOD_ProDKin_1	19	25	PF00069	0.708
MOD_ProDKin_1	292	298	PF00069	0.529
MOD_ProDKin_1	58	64	PF00069	0.769
TRG_ENDOCYTIC_2	172	175	PF00928	0.397
TRG_ENDOCYTIC_2	485	488	PF00928	0.553
TRG_ER_diArg_1	347	349	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT4	Leptomonas seymouri	61%	100%
A0A1X0P1X3	Trypanosomatidae	46%	92%
A0A3Q8IGG9	Leishmania donovani	89%	99%
A0A422P2K2	Trypanosoma rangeli	48%	100%
A4HLB3	Leishmania braziliensis	82%	100%
A4I8T9	Leishmania infantum	89%	96%
D0A4T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4Q4D2	Leishmania major	90%	100%
V5DG89	Trypanosoma cruzi	45%	100%