POT family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

POT family protein

Gene product:

POT family, putative

Species:

Leishmania mexicana

UniProt:

E9B3Q3_LEIMU

TriTrypDb:

LmxM.32.0710

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Q3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0022857	transmembrane transporter activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	330	332	PF00675	0.237
CLV_NRD_NRD_1	535	537	PF00675	0.441
CLV_PCSK_KEX2_1	325	327	PF00082	0.217
CLV_PCSK_KEX2_1	330	332	PF00082	0.233
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.171
CLV_PCSK_PC7_1	326	332	PF00082	0.171
CLV_PCSK_SKI1_1	114	118	PF00082	0.525
CLV_PCSK_SKI1_1	148	152	PF00082	0.352
CLV_PCSK_SKI1_1	232	236	PF00082	0.257
CLV_PCSK_SKI1_1	312	316	PF00082	0.262
CLV_PCSK_SKI1_1	424	428	PF00082	0.177
DEG_APCC_DBOX_1	147	155	PF00400	0.568
DEG_MDM2_SWIB_1	472	480	PF02201	0.341
DEG_Nend_UBRbox_4	1	3	PF02207	0.619
DOC_AGCK_PIF_1	30	35	PF00069	0.393
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.288
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.276
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.231
DOC_MAPK_gen_1	421	431	PF00069	0.525
DOC_MAPK_gen_1	572	580	PF00069	0.525
DOC_MAPK_MEF2A_6	312	320	PF00069	0.464
DOC_MAPK_MEF2A_6	424	431	PF00069	0.300
DOC_MAPK_NFAT4_5	424	432	PF00069	0.335
DOC_PP2B_LxvP_1	427	430	PF13499	0.319
DOC_PP2B_LxvP_1	450	453	PF13499	0.284
DOC_PP2B_LxvP_1	454	457	PF13499	0.284
DOC_PP2B_LxvP_1	479	482	PF13499	0.371
DOC_PP2B_LxvP_1	5	8	PF13499	0.601
DOC_PP2B_LxvP_1	543	546	PF13499	0.276
DOC_PP4_FxxP_1	255	258	PF00568	0.300
DOC_USP7_MATH_1	165	169	PF00917	0.726
DOC_USP7_MATH_1	200	204	PF00917	0.674
DOC_USP7_MATH_1	286	290	PF00917	0.228
DOC_USP7_MATH_1	380	384	PF00917	0.535
DOC_USP7_MATH_1	407	411	PF00917	0.379
DOC_WW_Pin1_4	208	213	PF00397	0.678
DOC_WW_Pin1_4	389	394	PF00397	0.407
DOC_WW_Pin1_4	593	598	PF00397	0.256
DOC_WW_Pin1_4	95	100	PF00397	0.513
LIG_14-3-3_CanoR_1	317	321	PF00244	0.572
LIG_14-3-3_CanoR_1	417	421	PF00244	0.594
LIG_14-3-3_CanoR_1	536	545	PF00244	0.264
LIG_Actin_WH2_2	245	263	PF00022	0.177
LIG_Actin_WH2_2	25	43	PF00022	0.281
LIG_BIR_III_2	209	213	PF00653	0.570
LIG_BIR_III_4	405	409	PF00653	0.516
LIG_BRCT_BRCA1_1	235	239	PF00533	0.442
LIG_BRCT_BRCA1_1	288	292	PF00533	0.177
LIG_BRCT_BRCA1_1	618	622	PF00533	0.372
LIG_Clathr_ClatBox_1	14	18	PF01394	0.474
LIG_CSL_BTD_1	5	8	PF09270	0.446
LIG_eIF4E_1	279	285	PF01652	0.284
LIG_eIF4E_1	86	92	PF01652	0.379
LIG_FHA_1	133	139	PF00498	0.473
LIG_FHA_1	178	184	PF00498	0.646
LIG_FHA_1	217	223	PF00498	0.606
LIG_FHA_1	35	41	PF00498	0.371
LIG_FHA_1	363	369	PF00498	0.462
LIG_FHA_1	417	423	PF00498	0.510
LIG_FHA_1	466	472	PF00498	0.337
LIG_FHA_1	85	91	PF00498	0.340
LIG_FHA_1	96	102	PF00498	0.421
LIG_FHA_2	154	160	PF00498	0.653
LIG_FHA_2	215	221	PF00498	0.615
LIG_FHA_2	558	564	PF00498	0.442
LIG_FXI_DFP_1	102	106	PF00024	0.482
LIG_LIR_Apic_2	254	258	PF02991	0.305
LIG_LIR_Gen_1	34	40	PF02991	0.297
LIG_LIR_Gen_1	397	407	PF02991	0.371
LIG_LIR_Gen_1	458	469	PF02991	0.242
LIG_LIR_Gen_1	539	549	PF02991	0.274
LIG_LIR_Gen_1	9	20	PF02991	0.487
LIG_LIR_Nem_3	277	283	PF02991	0.242
LIG_LIR_Nem_3	289	295	PF02991	0.276
LIG_LIR_Nem_3	34	38	PF02991	0.317
LIG_LIR_Nem_3	349	353	PF02991	0.458
LIG_LIR_Nem_3	397	402	PF02991	0.371
LIG_LIR_Nem_3	458	464	PF02991	0.242
LIG_LIR_Nem_3	506	512	PF02991	0.300
LIG_LIR_Nem_3	588	593	PF02991	0.329
LIG_LIR_Nem_3	619	625	PF02991	0.270
LIG_LIR_Nem_3	9	15	PF02991	0.514
LIG_Pex14_2	292	296	PF04695	0.301
LIG_Pex14_2	472	476	PF04695	0.385
LIG_PTB_Apo_2	49	56	PF02174	0.276
LIG_PTB_Phospho_1	49	55	PF10480	0.276
LIG_SH2_CRK	281	285	PF00017	0.335
LIG_SH2_CRK	35	39	PF00017	0.335
LIG_SH2_NCK_1	26	30	PF00017	0.393
LIG_SH2_PTP2	55	58	PF00017	0.393
LIG_SH2_STAP1	241	245	PF00017	0.429
LIG_SH2_STAP1	26	30	PF00017	0.393
LIG_SH2_STAP1	86	90	PF00017	0.331
LIG_SH2_STAT3	547	550	PF00017	0.276
LIG_SH2_STAT5	102	105	PF00017	0.422
LIG_SH2_STAT5	35	38	PF00017	0.276
LIG_SH2_STAT5	529	532	PF00017	0.278
LIG_SH2_STAT5	547	550	PF00017	0.186
LIG_SH2_STAT5	55	58	PF00017	0.155
LIG_SH2_STAT5	623	626	PF00017	0.327
LIG_SH2_STAT5	86	89	PF00017	0.393
LIG_SH3_3	591	597	PF00018	0.315
LIG_SH3_3	70	76	PF00018	0.559
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.393
LIG_SUMO_SIM_par_1	36	42	PF11976	0.430
LIG_SUMO_SIM_par_1	451	459	PF11976	0.218
LIG_TRFH_1	55	59	PF08558	0.300
LIG_TRFH_1	593	597	PF08558	0.297
LIG_TYR_ITIM	23	28	PF00017	0.365
LIG_TYR_ITIM	53	58	PF00017	0.365
LIG_WRC_WIRS_1	252	257	PF05994	0.305
LIG_WRC_WIRS_1	608	613	PF05994	0.341
MOD_CDK_SPxxK_3	593	600	PF00069	0.256
MOD_CK1_1	168	174	PF00069	0.595
MOD_CK1_1	31	37	PF00069	0.393
MOD_CK1_1	362	368	PF00069	0.486
MOD_CK1_1	383	389	PF00069	0.563
MOD_CK1_1	392	398	PF00069	0.478
MOD_CK1_1	516	522	PF00069	0.218
MOD_CK1_1	585	591	PF00069	0.276
MOD_CK1_1	610	616	PF00069	0.297
MOD_CK2_1	153	159	PF00069	0.615
MOD_CK2_1	176	182	PF00069	0.531
MOD_CK2_1	221	227	PF00069	0.668
MOD_CK2_1	452	458	PF00069	0.280
MOD_CK2_1	557	563	PF00069	0.276
MOD_GlcNHglycan	124	127	PF01048	0.306
MOD_GlcNHglycan	166	170	PF01048	0.398
MOD_GlcNHglycan	332	335	PF01048	0.299
MOD_GlcNHglycan	344	347	PF01048	0.231
MOD_GlcNHglycan	368	371	PF01048	0.299
MOD_GlcNHglycan	387	390	PF01048	0.330
MOD_GlcNHglycan	490	493	PF01048	0.288
MOD_GlcNHglycan	538	541	PF01048	0.485
MOD_GlcNHglycan	553	556	PF01048	0.155
MOD_GlcNHglycan	585	588	PF01048	0.282
MOD_GlcNHglycan	65	68	PF01048	0.307
MOD_GlcNHglycan	95	98	PF01048	0.393
MOD_GSK3_1	214	221	PF00069	0.665
MOD_GSK3_1	269	276	PF00069	0.237
MOD_GSK3_1	362	369	PF00069	0.454
MOD_GSK3_1	379	386	PF00069	0.471
MOD_GSK3_1	391	398	PF00069	0.484
MOD_GSK3_1	607	614	PF00069	0.189
MOD_N-GLC_1	395	400	PF02516	0.273
MOD_NEK2_1	122	127	PF00069	0.258
MOD_NEK2_1	251	256	PF00069	0.305
MOD_NEK2_1	39	44	PF00069	0.290
MOD_NEK2_1	503	508	PF00069	0.276
MOD_NEK2_1	513	518	PF00069	0.276
MOD_NEK2_1	573	578	PF00069	0.504
MOD_NEK2_1	607	612	PF00069	0.288
MOD_NEK2_1	616	621	PF00069	0.246
MOD_NEK2_1	63	68	PF00069	0.375
MOD_NEK2_1	93	98	PF00069	0.311
MOD_NEK2_2	127	132	PF00069	0.393
MOD_NEK2_2	416	421	PF00069	0.525
MOD_PIKK_1	611	617	PF00454	0.177
MOD_PK_1	357	363	PF00069	0.457
MOD_PKA_1	330	336	PF00069	0.371
MOD_PKA_1	536	542	PF00069	0.241
MOD_PKA_2	316	322	PF00069	0.569
MOD_PKA_2	330	336	PF00069	0.479
MOD_PKA_2	416	422	PF00069	0.525
MOD_Plk_1	395	401	PF00069	0.427
MOD_Plk_4	153	159	PF00069	0.641
MOD_Plk_4	251	257	PF00069	0.218
MOD_Plk_4	316	322	PF00069	0.483
MOD_Plk_4	34	40	PF00069	0.306
MOD_Plk_4	407	413	PF00069	0.470
MOD_Plk_4	465	471	PF00069	0.301
MOD_Plk_4	503	509	PF00069	0.344
MOD_Plk_4	557	563	PF00069	0.276
MOD_Plk_4	573	579	PF00069	0.442
MOD_Plk_4	616	622	PF00069	0.286
MOD_Plk_4	7	13	PF00069	0.628
MOD_Plk_4	86	92	PF00069	0.344
MOD_ProDKin_1	208	214	PF00069	0.678
MOD_ProDKin_1	389	395	PF00069	0.407
MOD_ProDKin_1	593	599	PF00069	0.256
MOD_ProDKin_1	95	101	PF00069	0.515
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.276
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.253
TRG_ENDOCYTIC_2	102	105	PF00928	0.342
TRG_ENDOCYTIC_2	128	131	PF00928	0.276
TRG_ENDOCYTIC_2	25	28	PF00928	0.360
TRG_ENDOCYTIC_2	280	283	PF00928	0.276
TRG_ENDOCYTIC_2	298	301	PF00928	0.276
TRG_ENDOCYTIC_2	35	38	PF00928	0.300
TRG_ENDOCYTIC_2	432	435	PF00928	0.276
TRG_ENDOCYTIC_2	55	58	PF00928	0.155
TRG_ER_diArg_1	329	331	PF00400	0.515
TRG_ER_diArg_1	75	78	PF00400	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C4	Leptomonas seymouri	58%	96%
A0A1X0P0R8	Trypanosomatidae	39%	95%
A0A3S7X6J4	Leishmania donovani	89%	100%
A0A422P2J5	Trypanosoma rangeli	38%	99%
A4HLB1	Leishmania braziliensis	76%	100%
A4I8T7	Leishmania infantum	89%	100%
Q4Q4D4	Leishmania major	87%	100%
V5BPE7	Trypanosoma cruzi	40%	100%