TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3Q2_LEIMU

TriTrypDb:

LmxM.32.0700

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3Q2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	4
GO:0051879	Hsp90 protein binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.456
CLV_NRD_NRD_1	162	164	PF00675	0.468
CLV_NRD_NRD_1	190	192	PF00675	0.485
CLV_NRD_NRD_1	32	34	PF00675	0.534
CLV_NRD_NRD_1	83	85	PF00675	0.459
CLV_PCSK_KEX2_1	102	104	PF00082	0.555
CLV_PCSK_KEX2_1	190	192	PF00082	0.485
CLV_PCSK_KEX2_1	32	34	PF00082	0.534
CLV_PCSK_SKI1_1	168	172	PF00082	0.452
CLV_PCSK_SKI1_1	242	246	PF00082	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DEG_SPOP_SBC_1	243	247	PF00917	0.572
DOC_CDC14_PxL_1	277	285	PF14671	0.364
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.355
DOC_MAPK_gen_1	177	185	PF00069	0.400
DOC_MAPK_gen_1	321	331	PF00069	0.418
DOC_MAPK_MEF2A_6	177	185	PF00069	0.394
DOC_MAPK_MEF2A_6	324	332	PF00069	0.472
DOC_MAPK_NFAT4_5	178	186	PF00069	0.411
DOC_PP2B_LxvP_1	278	281	PF13499	0.357
DOC_USP7_MATH_1	10	14	PF00917	0.584
DOC_USP7_MATH_1	133	137	PF00917	0.358
DOC_USP7_MATH_1	152	156	PF00917	0.390
DOC_USP7_MATH_1	235	239	PF00917	0.466
DOC_USP7_MATH_1	243	247	PF00917	0.325
DOC_USP7_MATH_1	66	70	PF00917	0.467
DOC_WW_Pin1_4	249	254	PF00397	0.368
LIG_14-3-3_CanoR_1	228	237	PF00244	0.537
LIG_14-3-3_CanoR_1	242	251	PF00244	0.344
LIG_APCC_ABBA_1	283	288	PF00400	0.376
LIG_APCC_ABBA_1	353	358	PF00400	0.447
LIG_deltaCOP1_diTrp_1	41	49	PF00928	0.504
LIG_eIF4E_1	361	367	PF01652	0.376
LIG_FHA_1	113	119	PF00498	0.392
LIG_FHA_1	374	380	PF00498	0.421
LIG_FHA_2	218	224	PF00498	0.452
LIG_FHA_2	52	58	PF00498	0.503
LIG_LIR_Apic_2	358	364	PF02991	0.386
LIG_LIR_Gen_1	204	213	PF02991	0.426
LIG_LIR_Gen_1	41	50	PF02991	0.500
LIG_LIR_Gen_1	69	80	PF02991	0.486
LIG_LIR_Nem_3	340	346	PF02991	0.398
LIG_LIR_Nem_3	349	353	PF02991	0.393
LIG_LIR_Nem_3	69	75	PF02991	0.500
LIG_MYND_1	364	368	PF01753	0.378
LIG_Rb_pABgroove_1	280	288	PF01858	0.330
LIG_REV1ctd_RIR_1	329	337	PF16727	0.463
LIG_RPA_C_Fungi	130	142	PF08784	0.368
LIG_SH2_CRK	265	269	PF00017	0.543
LIG_SH2_GRB2like	132	135	PF00017	0.368
LIG_SH2_NCK_1	344	348	PF00017	0.272
LIG_SH2_NCK_1	361	365	PF00017	0.485
LIG_SH2_NCK_1	72	76	PF00017	0.496
LIG_SH2_SRC	72	75	PF00017	0.529
LIG_SH2_STAP1	114	118	PF00017	0.484
LIG_SH2_STAT5	114	117	PF00017	0.383
LIG_SH2_STAT5	271	274	PF00017	0.486
LIG_SH3_3	189	195	PF00018	0.587
LIG_TRAF2_1	13	16	PF00917	0.572
LIG_TRAF2_1	220	223	PF00917	0.587
LIG_TRAF2_1	98	101	PF00917	0.586
LIG_TYR_ITIM	341	346	PF00017	0.336
LIG_TYR_ITIM	70	75	PF00017	0.504
LIG_UBA3_1	366	375	PF00899	0.384
MOD_CDK_SPK_2	249	254	PF00069	0.466
MOD_CK2_1	10	16	PF00069	0.496
MOD_CK2_1	110	116	PF00069	0.487
MOD_CK2_1	203	209	PF00069	0.382
MOD_CK2_1	217	223	PF00069	0.446
MOD_Cter_Amidation	188	191	PF01082	0.518
MOD_GlcNHglycan	246	249	PF01048	0.463
MOD_GSK3_1	122	129	PF00069	0.570
MOD_N-GLC_1	133	138	PF02516	0.365
MOD_N-GLC_1	51	56	PF02516	0.511
MOD_NEK2_1	127	132	PF00069	0.472
MOD_PIKK_1	229	235	PF00454	0.642
MOD_Plk_1	133	139	PF00069	0.357
MOD_Plk_1	357	363	PF00069	0.411
MOD_Plk_2-3	51	57	PF00069	0.465
MOD_Plk_4	127	133	PF00069	0.481
MOD_Plk_4	66	72	PF00069	0.581
MOD_ProDKin_1	249	255	PF00069	0.371
MOD_SUMO_rev_2	204	213	PF00179	0.495
TRG_DiLeu_BaEn_1	362	367	PF01217	0.522
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.455
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.486
TRG_ENDOCYTIC_2	343	346	PF00928	0.352
TRG_ENDOCYTIC_2	72	75	PF00928	0.504
TRG_ER_diArg_1	190	192	PF00400	0.538
TRG_ER_diArg_1	319	322	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R4	Leptomonas seymouri	80%	100%
A0A1X0P0Q3	Trypanosomatidae	61%	100%
A0A3S7X6F2	Leishmania donovani	95%	100%
A0A422P2K3	Trypanosoma rangeli	59%	100%
A1Z6M6	Drosophila melanogaster	30%	98%
A4HLB0	Leishmania braziliensis	87%	100%
A4I8T6	Leishmania infantum	95%	100%
D0A4T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	90%
O13754	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O95801	Homo sapiens	28%	100%
P33313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q4Q4D5	Leishmania major	94%	100%
Q54M20	Dictyostelium discoideum	25%	98%
Q5EA11	Bos taurus	29%	100%
Q8R3H9	Mus musculus	26%	100%