Protein phosphatase 2A regulatory subunit,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B3P9_LEIMU

TriTrypDb:

LmxM.32.0670

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	8
GO:0008287	protein serine/threonine phosphatase complex	4	8
GO:0032991	protein-containing complex	1	8
GO:1902494	catalytic complex	2	8
GO:1903293	phosphatase complex	3	8
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B3P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3P9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	8
GO:0019888	protein phosphatase regulator activity	4	8
GO:0030234	enzyme regulator activity	2	8
GO:0098772	molecular function regulator activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.377
CLV_NRD_NRD_1	209	211	PF00675	0.566
CLV_NRD_NRD_1	267	269	PF00675	0.580
CLV_NRD_NRD_1	404	406	PF00675	0.468
CLV_NRD_NRD_1	45	47	PF00675	0.720
CLV_NRD_NRD_1	704	706	PF00675	0.612
CLV_NRD_NRD_1	723	725	PF00675	0.279
CLV_NRD_NRD_1	798	800	PF00675	0.456
CLV_PCSK_KEX2_1	2	4	PF00082	0.377
CLV_PCSK_KEX2_1	208	210	PF00082	0.572
CLV_PCSK_KEX2_1	266	268	PF00082	0.583
CLV_PCSK_KEX2_1	404	406	PF00082	0.468
CLV_PCSK_KEX2_1	424	426	PF00082	0.375
CLV_PCSK_KEX2_1	45	47	PF00082	0.720
CLV_PCSK_KEX2_1	704	706	PF00082	0.582
CLV_PCSK_KEX2_1	723	725	PF00082	0.279
CLV_PCSK_KEX2_1	798	800	PF00082	0.471
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.572
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.583
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.579
CLV_PCSK_SKI1_1	12	16	PF00082	0.307
CLV_PCSK_SKI1_1	405	409	PF00082	0.498
CLV_PCSK_SKI1_1	724	728	PF00082	0.464
DEG_APCC_DBOX_1	403	411	PF00400	0.690
DEG_APCC_DBOX_1	47	55	PF00400	0.254
DEG_APCC_DBOX_1	731	739	PF00400	0.610
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DEG_SPOP_SBC_1	257	261	PF00917	0.774
DEG_SPOP_SBC_1	293	297	PF00917	0.729
DEG_SPOP_SBC_1	432	436	PF00917	0.620
DOC_CDC14_PxL_1	14	22	PF14671	0.210
DOC_CKS1_1	29	34	PF01111	0.446
DOC_CKS1_1	700	705	PF01111	0.782
DOC_CYCLIN_RxL_1	402	409	PF00134	0.687
DOC_CYCLIN_yClb5_NLxxxL_5	80	87	PF00134	0.758
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.210
DOC_MAPK_DCC_7	45	54	PF00069	0.407
DOC_MAPK_gen_1	2	9	PF00069	0.407
DOC_MAPK_gen_1	404	410	PF00069	0.740
DOC_MAPK_gen_1	45	54	PF00069	0.462
DOC_MAPK_gen_1	499	509	PF00069	0.557
DOC_MAPK_MEF2A_6	45	54	PF00069	0.407
DOC_MAPK_MEF2A_6	678	685	PF00069	0.538
DOC_PP2B_LxvP_1	148	151	PF13499	0.767
DOC_PP2B_LxvP_1	15	18	PF13499	0.307
DOC_PP4_FxxP_1	315	318	PF00568	0.669
DOC_PP4_FxxP_1	645	648	PF00568	0.618
DOC_USP7_MATH_1	178	182	PF00917	0.750
DOC_USP7_MATH_1	228	232	PF00917	0.777
DOC_USP7_MATH_1	236	240	PF00917	0.742
DOC_USP7_MATH_1	24	28	PF00917	0.278
DOC_USP7_MATH_1	287	291	PF00917	0.773
DOC_USP7_MATH_1	293	297	PF00917	0.773
DOC_USP7_MATH_1	321	325	PF00917	0.714
DOC_USP7_MATH_1	353	357	PF00917	0.772
DOC_USP7_MATH_1	374	378	PF00917	0.621
DOC_USP7_MATH_1	432	436	PF00917	0.778
DOC_USP7_MATH_1	583	587	PF00917	0.581
DOC_USP7_MATH_1	59	63	PF00917	0.312
DOC_USP7_MATH_1	64	68	PF00917	0.312
DOC_USP7_MATH_1	70	74	PF00917	0.589
DOC_USP7_MATH_1	717	721	PF00917	0.701
DOC_USP7_MATH_1	828	832	PF00917	0.376
DOC_USP7_UBL2_3	521	525	PF12436	0.692
DOC_WW_Pin1_4	105	110	PF00397	0.749
DOC_WW_Pin1_4	146	151	PF00397	0.763
DOC_WW_Pin1_4	187	192	PF00397	0.792
DOC_WW_Pin1_4	258	263	PF00397	0.784
DOC_WW_Pin1_4	268	273	PF00397	0.776
DOC_WW_Pin1_4	28	33	PF00397	0.432
DOC_WW_Pin1_4	435	440	PF00397	0.781
DOC_WW_Pin1_4	472	477	PF00397	0.585
DOC_WW_Pin1_4	591	596	PF00397	0.678
DOC_WW_Pin1_4	666	671	PF00397	0.582
DOC_WW_Pin1_4	699	704	PF00397	0.759
LIG_14-3-3_CanoR_1	110	120	PF00244	0.748
LIG_14-3-3_CanoR_1	133	142	PF00244	0.817
LIG_14-3-3_CanoR_1	182	192	PF00244	0.719
LIG_14-3-3_CanoR_1	2	8	PF00244	0.419
LIG_14-3-3_CanoR_1	256	262	PF00244	0.784
LIG_14-3-3_CanoR_1	288	292	PF00244	0.656
LIG_14-3-3_CanoR_1	329	339	PF00244	0.778
LIG_14-3-3_CanoR_1	404	408	PF00244	0.682
LIG_14-3-3_CanoR_1	441	449	PF00244	0.723
LIG_14-3-3_CanoR_1	535	540	PF00244	0.627
LIG_14-3-3_CanoR_1	632	636	PF00244	0.664
LIG_14-3-3_CanoR_1	72	81	PF00244	0.782
LIG_14-3-3_CanoR_1	798	803	PF00244	0.673
LIG_14-3-3_CanoR_1	811	818	PF00244	0.737
LIG_14-3-3_CanoR_1	821	825	PF00244	0.582
LIG_14-3-3_CanoR_1	827	833	PF00244	0.483
LIG_14-3-3_CanoR_1	90	95	PF00244	0.778
LIG_14-3-3_CanoR_1	97	104	PF00244	0.792
LIG_BRCT_BRCA1_1	433	437	PF00533	0.831
LIG_BRCT_BRCA1_1	563	567	PF00533	0.592
LIG_EH_1	513	517	PF12763	0.740
LIG_eIF4E_1	739	745	PF01652	0.623
LIG_EVH1_1	29	33	PF00568	0.394
LIG_FHA_1	143	149	PF00498	0.824
LIG_FHA_1	213	219	PF00498	0.680
LIG_FHA_1	301	307	PF00498	0.655
LIG_FHA_1	386	392	PF00498	0.620
LIG_FHA_1	441	447	PF00498	0.739
LIG_FHA_1	488	494	PF00498	0.609
LIG_FHA_1	522	528	PF00498	0.695
LIG_FHA_1	534	540	PF00498	0.666
LIG_FHA_1	572	578	PF00498	0.542
LIG_FHA_1	587	593	PF00498	0.591
LIG_FHA_1	658	664	PF00498	0.612
LIG_FHA_1	767	773	PF00498	0.543
LIG_FHA_1	783	789	PF00498	0.611
LIG_FHA_2	214	220	PF00498	0.767
LIG_FHA_2	404	410	PF00498	0.689
LIG_FHA_2	567	573	PF00498	0.566
LIG_FHA_2	583	589	PF00498	0.512
LIG_FHA_2	773	779	PF00498	0.709
LIG_FHA_2	91	97	PF00498	0.634
LIG_LIR_Gen_1	613	620	PF02991	0.563
LIG_LIR_Gen_1	653	663	PF02991	0.630
LIG_LIR_Gen_1	679	688	PF02991	0.564
LIG_LIR_Gen_1	785	794	PF02991	0.659
LIG_LIR_Nem_3	451	456	PF02991	0.679
LIG_LIR_Nem_3	613	618	PF02991	0.569
LIG_LIR_Nem_3	653	659	PF02991	0.648
LIG_LIR_Nem_3	679	683	PF02991	0.559
LIG_LIR_Nem_3	785	789	PF02991	0.615
LIG_LIR_Nem_3	850	854	PF02991	0.392
LIG_LYPXL_SIV_4	461	469	PF13949	0.634
LIG_PCNA_PIPBox_1	7	16	PF02747	0.229
LIG_Pex14_1	578	582	PF04695	0.609
LIG_Pex14_2	315	319	PF04695	0.657
LIG_Pex14_2	748	752	PF04695	0.544
LIG_PTB_Apo_2	762	769	PF02174	0.604
LIG_PTB_Phospho_1	762	768	PF10480	0.605
LIG_Rb_LxCxE_1	572	591	PF01857	0.567
LIG_SH2_CRK	203	207	PF00017	0.624
LIG_SH2_CRK	851	855	PF00017	0.407
LIG_SH2_NCK_1	203	207	PF00017	0.679
LIG_SH2_PTP2	462	465	PF00017	0.623
LIG_SH2_SRC	462	465	PF00017	0.623
LIG_SH2_SRC	596	599	PF00017	0.710
LIG_SH2_STAP1	453	457	PF00017	0.614
LIG_SH2_STAP1	563	567	PF00017	0.681
LIG_SH2_STAP1	768	772	PF00017	0.604
LIG_SH2_STAT3	456	459	PF00017	0.663
LIG_SH2_STAT3	563	566	PF00017	0.695
LIG_SH2_STAT5	313	316	PF00017	0.621
LIG_SH2_STAT5	371	374	PF00017	0.623
LIG_SH2_STAT5	456	459	PF00017	0.614
LIG_SH2_STAT5	462	465	PF00017	0.563
LIG_SH2_STAT5	492	495	PF00017	0.596
LIG_SH2_STAT5	674	677	PF00017	0.575
LIG_SH2_STAT5	768	771	PF00017	0.548
LIG_SH3_1	608	614	PF00018	0.585
LIG_SH3_1	697	703	PF00018	0.780
LIG_SH3_2	700	705	PF14604	0.787
LIG_SH3_3	27	33	PF00018	0.394
LIG_SH3_3	446	452	PF00018	0.672
LIG_SH3_3	608	614	PF00018	0.585
LIG_SH3_3	697	703	PF00018	0.743
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.831
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.697
LIG_SUMO_SIM_anti_2	406	412	PF11976	0.741
LIG_SUMO_SIM_par_1	302	308	PF11976	0.642
LIG_SUMO_SIM_par_1	56	62	PF11976	0.250
LIG_TRAF2_1	649	652	PF00917	0.674
LIG_TRAF2_1	93	96	PF00917	0.775
LIG_TYR_ITIM	849	854	PF00017	0.365
LIG_WRC_WIRS_1	783	788	PF05994	0.625
LIG_WW_3	647	651	PF00397	0.711
MOD_CDC14_SPxK_1	438	441	PF00782	0.760
MOD_CDK_SPK_2	105	110	PF00069	0.749
MOD_CDK_SPK_2	699	704	PF00069	0.784
MOD_CDK_SPxK_1	435	441	PF00069	0.765
MOD_CDK_SPxK_1	699	705	PF00069	0.785
MOD_CDK_SPxxK_3	187	194	PF00069	0.823
MOD_CDK_SPxxK_3	666	673	PF00069	0.568
MOD_CK1_1	121	127	PF00069	0.682
MOD_CK1_1	137	143	PF00069	0.823
MOD_CK1_1	186	192	PF00069	0.716
MOD_CK1_1	204	210	PF00069	0.834
MOD_CK1_1	248	254	PF00069	0.813
MOD_CK1_1	261	267	PF00069	0.646
MOD_CK1_1	273	279	PF00069	0.841
MOD_CK1_1	297	303	PF00069	0.687
MOD_CK1_1	305	311	PF00069	0.600
MOD_CK1_1	324	330	PF00069	0.596
MOD_CK1_1	332	338	PF00069	0.758
MOD_CK1_1	373	379	PF00069	0.625
MOD_CK1_1	427	433	PF00069	0.818
MOD_CK1_1	435	441	PF00069	0.729
MOD_CK1_1	487	493	PF00069	0.634
MOD_CK1_1	533	539	PF00069	0.680
MOD_CK1_1	586	592	PF00069	0.582
MOD_CK1_1	622	628	PF00069	0.602
MOD_CK1_1	657	663	PF00069	0.602
MOD_CK1_1	776	782	PF00069	0.641
MOD_CK1_1	820	826	PF00069	0.665
MOD_CK2_1	151	157	PF00069	0.765
MOD_CK2_1	166	172	PF00069	0.770
MOD_CK2_1	243	249	PF00069	0.636
MOD_CK2_1	505	511	PF00069	0.670
MOD_CK2_1	582	588	PF00069	0.620
MOD_CK2_1	591	597	PF00069	0.684
MOD_CK2_1	90	96	PF00069	0.776
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.711
MOD_GlcNHglycan	120	123	PF01048	0.438
MOD_GlcNHglycan	129	132	PF01048	0.558
MOD_GlcNHglycan	136	139	PF01048	0.595
MOD_GlcNHglycan	195	198	PF01048	0.568
MOD_GlcNHglycan	22	25	PF01048	0.229
MOD_GlcNHglycan	238	241	PF01048	0.534
MOD_GlcNHglycan	244	248	PF01048	0.604
MOD_GlcNHglycan	272	275	PF01048	0.628
MOD_GlcNHglycan	281	284	PF01048	0.547
MOD_GlcNHglycan	296	299	PF01048	0.447
MOD_GlcNHglycan	323	326	PF01048	0.473
MOD_GlcNHglycan	342	345	PF01048	0.615
MOD_GlcNHglycan	355	358	PF01048	0.619
MOD_GlcNHglycan	372	375	PF01048	0.280
MOD_GlcNHglycan	413	416	PF01048	0.563
MOD_GlcNHglycan	427	430	PF01048	0.449
MOD_GlcNHglycan	486	489	PF01048	0.517
MOD_GlcNHglycan	511	514	PF01048	0.421
MOD_GlcNHglycan	621	624	PF01048	0.404
MOD_GlcNHglycan	670	673	PF01048	0.429
MOD_GlcNHglycan	74	77	PF01048	0.518
MOD_GlcNHglycan	775	778	PF01048	0.486
MOD_GlcNHglycan	802	805	PF01048	0.432
MOD_GlcNHglycan	832	835	PF01048	0.397
MOD_GSK3_1	133	140	PF00069	0.835
MOD_GSK3_1	142	149	PF00069	0.787
MOD_GSK3_1	152	159	PF00069	0.787
MOD_GSK3_1	178	185	PF00069	0.745
MOD_GSK3_1	20	27	PF00069	0.241
MOD_GSK3_1	245	252	PF00069	0.807
MOD_GSK3_1	257	264	PF00069	0.643
MOD_GSK3_1	273	280	PF00069	0.707
MOD_GSK3_1	287	294	PF00069	0.702
MOD_GSK3_1	321	328	PF00069	0.690
MOD_GSK3_1	335	342	PF00069	0.786
MOD_GSK3_1	355	362	PF00069	0.777
MOD_GSK3_1	366	373	PF00069	0.609
MOD_GSK3_1	37	44	PF00069	0.469
MOD_GSK3_1	424	431	PF00069	0.773
MOD_GSK3_1	433	440	PF00069	0.743
MOD_GSK3_1	468	475	PF00069	0.646
MOD_GSK3_1	484	491	PF00069	0.603
MOD_GSK3_1	505	512	PF00069	0.643
MOD_GSK3_1	530	537	PF00069	0.698
MOD_GSK3_1	582	589	PF00069	0.580
MOD_GSK3_1	618	625	PF00069	0.557
MOD_GSK3_1	734	741	PF00069	0.624
MOD_GSK3_1	772	779	PF00069	0.655
MOD_GSK3_1	788	795	PF00069	0.639
MOD_GSK3_1	85	92	PF00069	0.776
MOD_LATS_1	35	41	PF00433	0.431
MOD_N-GLC_1	657	662	PF02516	0.423
MOD_N-GLC_1	763	768	PF02516	0.408
MOD_NEK2_1	134	139	PF00069	0.816
MOD_NEK2_1	142	147	PF00069	0.768
MOD_NEK2_1	20	25	PF00069	0.354
MOD_NEK2_1	291	296	PF00069	0.735
MOD_NEK2_1	299	304	PF00069	0.606
MOD_NEK2_1	323	328	PF00069	0.699
MOD_NEK2_1	339	344	PF00069	0.735
MOD_NEK2_1	360	365	PF00069	0.649
MOD_NEK2_1	530	535	PF00069	0.706
MOD_NEK2_1	618	623	PF00069	0.558
MOD_NEK2_1	752	757	PF00069	0.607
MOD_NEK2_1	763	768	PF00069	0.521
MOD_NEK2_1	797	802	PF00069	0.641
MOD_NEK2_1	83	88	PF00069	0.732
MOD_NEK2_1	830	835	PF00069	0.405
MOD_NEK2_1	847	852	PF00069	0.306
MOD_NEK2_2	600	605	PF00069	0.631
MOD_PIKK_1	111	117	PF00454	0.780
MOD_PIKK_1	297	303	PF00454	0.722
MOD_PIKK_1	332	338	PF00454	0.750
MOD_PIKK_1	366	372	PF00454	0.675
MOD_PIKK_1	374	380	PF00454	0.632
MOD_PK_1	505	511	PF00069	0.637
MOD_PKA_1	267	273	PF00069	0.634
MOD_PKA_1	424	430	PF00069	0.780
MOD_PKA_1	798	804	PF00069	0.671
MOD_PKA_2	132	138	PF00069	0.822
MOD_PKA_2	193	199	PF00069	0.817
MOD_PKA_2	267	273	PF00069	0.689
MOD_PKA_2	287	293	PF00069	0.701
MOD_PKA_2	328	334	PF00069	0.828
MOD_PKA_2	403	409	PF00069	0.664
MOD_PKA_2	424	430	PF00069	0.744
MOD_PKA_2	440	446	PF00069	0.701
MOD_PKA_2	509	515	PF00069	0.674
MOD_PKA_2	534	540	PF00069	0.632
MOD_PKA_2	600	606	PF00069	0.695
MOD_PKA_2	631	637	PF00069	0.654
MOD_PKA_2	797	803	PF00069	0.663
MOD_PKA_2	810	816	PF00069	0.602
MOD_PKA_2	820	826	PF00069	0.571
MOD_PKA_2	89	95	PF00069	0.783
MOD_PKA_2	96	102	PF00069	0.778
MOD_Plk_1	156	162	PF00069	0.780
MOD_Plk_1	571	577	PF00069	0.541
MOD_Plk_1	583	589	PF00069	0.578
MOD_Plk_1	717	723	PF00069	0.710
MOD_Plk_1	763	769	PF00069	0.606
MOD_Plk_2-3	96	102	PF00069	0.771
MOD_Plk_4	213	219	PF00069	0.702
MOD_Plk_4	24	30	PF00069	0.494
MOD_Plk_4	250	256	PF00069	0.612
MOD_Plk_4	3	9	PF00069	0.446
MOD_Plk_4	488	494	PF00069	0.571
MOD_Plk_4	53	59	PF00069	0.319
MOD_Plk_4	571	577	PF00069	0.580
MOD_Plk_4	717	723	PF00069	0.711
MOD_Plk_4	734	740	PF00069	0.513
MOD_Plk_4	763	769	PF00069	0.568
MOD_Plk_4	820	826	PF00069	0.610
MOD_ProDKin_1	105	111	PF00069	0.749
MOD_ProDKin_1	146	152	PF00069	0.765
MOD_ProDKin_1	187	193	PF00069	0.790
MOD_ProDKin_1	258	264	PF00069	0.785
MOD_ProDKin_1	268	274	PF00069	0.775
MOD_ProDKin_1	28	34	PF00069	0.437
MOD_ProDKin_1	435	441	PF00069	0.780
MOD_ProDKin_1	472	478	PF00069	0.581
MOD_ProDKin_1	591	597	PF00069	0.684
MOD_ProDKin_1	666	672	PF00069	0.585
MOD_ProDKin_1	699	705	PF00069	0.760
MOD_SUMO_for_1	789	792	PF00179	0.658
MOD_SUMO_rev_2	40	44	PF00179	0.480
TRG_ENDOCYTIC_2	462	465	PF00928	0.585
TRG_ENDOCYTIC_2	504	507	PF00928	0.592
TRG_ENDOCYTIC_2	851	854	PF00928	0.372
TRG_ER_diArg_1	1	3	PF00400	0.593
TRG_ER_diArg_1	394	397	PF00400	0.621
TRG_ER_diArg_1	403	405	PF00400	0.652
TRG_ER_diArg_1	45	48	PF00400	0.532
TRG_ER_diArg_1	703	705	PF00400	0.778
TRG_ER_diArg_1	722	724	PF00400	0.497
TRG_ER_diArg_1	797	799	PF00400	0.684
TRG_ER_FFAT_2	369	377	PF00635	0.622
TRG_NLS_MonoExtN_4	206	212	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP1	Leptomonas seymouri	63%	100%
A0A3S7X6D7	Leishmania donovani	90%	99%
A4HLA7	Leishmania braziliensis	79%	100%
A4I8T3	Leishmania infantum	90%	93%
Q4Q4D8	Leishmania major	90%	100%
V5BFC1	Trypanosoma cruzi	38%	100%