EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3P6_LEIMU

TriTrypDb:

LmxM.32.0640

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3P6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.502
CLV_NRD_NRD_1	17	19	PF00675	0.678
CLV_NRD_NRD_1	59	61	PF00675	0.478
CLV_PCSK_KEX2_1	152	154	PF00082	0.502
CLV_PCSK_KEX2_1	17	19	PF00082	0.664
CLV_PCSK_KEX2_1	59	61	PF00082	0.495
CLV_PCSK_PC7_1	55	61	PF00082	0.632
CLV_PCSK_SKI1_1	59	63	PF00082	0.533
DEG_APCC_DBOX_1	151	159	PF00400	0.531
DEG_SPOP_SBC_1	88	92	PF00917	0.509
DOC_CYCLIN_RxL_1	119	129	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.707
DOC_MAPK_DCC_7	199	209	PF00069	0.524
DOC_MAPK_gen_1	152	160	PF00069	0.476
DOC_PP2B_LxvP_1	104	107	PF13499	0.497
DOC_USP7_MATH_1	100	104	PF00917	0.430
DOC_USP7_MATH_1	183	187	PF00917	0.574
DOC_USP7_MATH_1	76	80	PF00917	0.597
DOC_USP7_MATH_1	88	92	PF00917	0.669
DOC_WW_Pin1_4	96	101	PF00397	0.688
LIG_14-3-3_CanoR_1	17	26	PF00244	0.741
LIG_14-3-3_CanoR_1	194	200	PF00244	0.531
LIG_14-3-3_CanoR_1	93	98	PF00244	0.689
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	145	149	PF00533	0.518
LIG_FHA_1	106	112	PF00498	0.518
LIG_FHA_1	145	151	PF00498	0.540
LIG_FHA_1	163	169	PF00498	0.450
LIG_FHA_1	18	24	PF00498	0.536
LIG_LIR_Gen_1	253	262	PF02991	0.540
LIG_LIR_Gen_1	271	277	PF02991	0.410
LIG_LIR_Nem_3	109	115	PF02991	0.569
LIG_LIR_Nem_3	271	275	PF02991	0.412
LIG_SH2_STAT5	119	122	PF00017	0.389
LIG_SH2_STAT5	230	233	PF00017	0.423
LIG_SH2_STAT5	49	52	PF00017	0.615
LIG_SH3_3	94	100	PF00018	0.740
LIG_SUMO_SIM_anti_2	135	143	PF11976	0.522
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.551
LIG_SUMO_SIM_par_1	135	143	PF11976	0.491
LIG_TRAF2_1	248	251	PF00917	0.425
MOD_CK1_1	105	111	PF00069	0.600
MOD_CK1_1	2	8	PF00069	0.721
MOD_CK1_1	91	97	PF00069	0.724
MOD_CK2_1	132	138	PF00069	0.467
MOD_CK2_1	245	251	PF00069	0.491
MOD_Cter_Amidation	15	18	PF01082	0.732
MOD_GlcNHglycan	185	188	PF01048	0.633
MOD_GlcNHglycan	195	198	PF01048	0.574
MOD_GlcNHglycan	55	58	PF01048	0.600
MOD_GlcNHglycan	93	96	PF01048	0.593
MOD_GSK3_1	18	25	PF00069	0.651
MOD_GSK3_1	2	9	PF00069	0.708
MOD_GSK3_1	78	85	PF00069	0.621
MOD_GSK3_1	87	94	PF00069	0.580
MOD_GSK3_1	96	103	PF00069	0.488
MOD_N-GLC_1	126	131	PF02516	0.393
MOD_N-GLC_1	77	82	PF02516	0.625
MOD_NEK2_1	1	6	PF00069	0.743
MOD_NEK2_1	126	131	PF00069	0.436
MOD_NEK2_1	164	169	PF00069	0.486
MOD_NEK2_1	77	82	PF00069	0.579
MOD_PIKK_1	4	10	PF00454	0.533
MOD_PK_1	93	99	PF00069	0.739
MOD_PKA_1	17	23	PF00069	0.674
MOD_PKA_2	16	22	PF00069	0.672
MOD_PKA_2	193	199	PF00069	0.510
MOD_Plk_1	212	218	PF00069	0.472
MOD_Plk_1	77	83	PF00069	0.569
MOD_Plk_4	132	138	PF00069	0.451
MOD_Plk_4	212	218	PF00069	0.443
MOD_Plk_4	78	84	PF00069	0.583
MOD_ProDKin_1	96	102	PF00069	0.688
TRG_DiLeu_BaEn_1	212	217	PF01217	0.554
TRG_DiLeu_BaEn_4	212	218	PF01217	0.560
TRG_ENDOCYTIC_2	230	233	PF00928	0.436
TRG_ENDOCYTIC_2	269	272	PF00928	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I197	Leptomonas seymouri	48%	98%
A0A1X0P299	Trypanosomatidae	34%	100%
A0A3R7M928	Trypanosoma rangeli	36%	100%
D0A4S7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
V5DGA0	Trypanosoma cruzi	38%	100%