Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3P5_LEIMU

TriTrypDb:

LmxM.32.0630

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.725
CLV_C14_Caspase3-7	126	130	PF00656	0.631
CLV_C14_Caspase3-7	217	221	PF00656	0.454
CLV_C14_Caspase3-7	40	44	PF00656	0.368
CLV_C14_Caspase3-7	440	444	PF00656	0.658
CLV_MEL_PAP_1	212	218	PF00089	0.454
CLV_NRD_NRD_1	178	180	PF00675	0.581
CLV_NRD_NRD_1	205	207	PF00675	0.660
CLV_NRD_NRD_1	229	231	PF00675	0.704
CLV_NRD_NRD_1	289	291	PF00675	0.589
CLV_PCSK_FUR_1	176	180	PF00082	0.576
CLV_PCSK_FUR_1	362	366	PF00082	0.497
CLV_PCSK_KEX2_1	176	178	PF00082	0.572
CLV_PCSK_KEX2_1	205	207	PF00082	0.665
CLV_PCSK_KEX2_1	229	231	PF00082	0.704
CLV_PCSK_KEX2_1	288	290	PF00082	0.588
CLV_PCSK_KEX2_1	364	366	PF00082	0.596
CLV_PCSK_KEX2_1	46	48	PF00082	0.630
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.596
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.572
CLV_PCSK_PC7_1	285	291	PF00082	0.523
CLV_PCSK_SKI1_1	132	136	PF00082	0.377
CLV_PCSK_SKI1_1	179	183	PF00082	0.614
CLV_PCSK_SKI1_1	230	234	PF00082	0.551
CLV_PCSK_SKI1_1	239	243	PF00082	0.432
CLV_PCSK_SKI1_1	25	29	PF00082	0.600
CLV_PCSK_SKI1_1	294	298	PF00082	0.665
CLV_PCSK_SKI1_1	327	331	PF00082	0.537
CLV_PCSK_SKI1_1	408	412	PF00082	0.422
CLV_PCSK_SKI1_1	47	51	PF00082	0.652
DEG_APCC_DBOX_1	131	139	PF00400	0.359
DEG_APCC_DBOX_1	178	186	PF00400	0.637
DEG_APCC_DBOX_1	403	411	PF00400	0.485
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_ANK_TNKS_1	116	123	PF00023	0.593
DOC_CKS1_1	358	363	PF01111	0.538
DOC_CYCLIN_RxL_1	128	139	PF00134	0.293
DOC_CYCLIN_RxL_1	176	184	PF00134	0.462
DOC_CYCLIN_RxL_1	288	299	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.635
DOC_MAPK_gen_1	205	213	PF00069	0.694
DOC_MAPK_gen_1	288	298	PF00069	0.544
DOC_MAPK_gen_1	479	489	PF00069	0.409
DOC_MAPK_MEF2A_6	479	487	PF00069	0.496
DOC_PP2B_LxvP_1	211	214	PF13499	0.698
DOC_USP7_MATH_1	195	199	PF00917	0.531
DOC_USP7_MATH_1	214	218	PF00917	0.455
DOC_USP7_MATH_1	265	269	PF00917	0.460
DOC_USP7_MATH_1	382	386	PF00917	0.595
DOC_USP7_MATH_1	425	429	PF00917	0.761
DOC_USP7_MATH_1	441	445	PF00917	0.357
DOC_USP7_MATH_1	478	482	PF00917	0.466
DOC_USP7_MATH_1	85	89	PF00917	0.555
DOC_USP7_MATH_1	98	102	PF00917	0.534
DOC_USP7_UBL2_3	482	486	PF12436	0.427
DOC_WW_Pin1_4	308	313	PF00397	0.753
DOC_WW_Pin1_4	357	362	PF00397	0.554
DOC_WW_Pin1_4	463	468	PF00397	0.478
DOC_WW_Pin1_4	472	477	PF00397	0.397
DOC_WW_Pin1_4	91	96	PF00397	0.784
LIG_14-3-3_CanoR_1	206	212	PF00244	0.665
LIG_14-3-3_CanoR_1	215	223	PF00244	0.581
LIG_APCC_ABBA_1	336	341	PF00400	0.527
LIG_BRCT_BRCA1_1	267	271	PF00533	0.470
LIG_BRCT_BRCA1_1	275	279	PF00533	0.541
LIG_eIF4E_1	463	469	PF01652	0.365
LIG_FHA_1	1	7	PF00498	0.491
LIG_FHA_1	151	157	PF00498	0.559
LIG_FHA_1	164	170	PF00498	0.524
LIG_FHA_1	208	214	PF00498	0.734
LIG_FHA_1	293	299	PF00498	0.592
LIG_FHA_1	358	364	PF00498	0.492
LIG_FHA_1	450	456	PF00498	0.386
LIG_FHA_1	478	484	PF00498	0.457
LIG_FHA_1	57	63	PF00498	0.594
LIG_FHA_2	124	130	PF00498	0.532
LIG_FHA_2	149	155	PF00498	0.634
LIG_FHA_2	240	246	PF00498	0.547
LIG_FHA_2	28	34	PF00498	0.632
LIG_FHA_2	438	444	PF00498	0.675
LIG_FHA_2	6	12	PF00498	0.562
LIG_LIR_Apic_2	471	476	PF02991	0.533
LIG_LIR_Nem_3	103	108	PF02991	0.746
LIG_LIR_Nem_3	139	145	PF02991	0.420
LIG_LIR_Nem_3	245	249	PF02991	0.487
LIG_LIR_Nem_3	268	274	PF02991	0.459
LIG_LYPXL_S_1	156	160	PF13949	0.649
LIG_LYPXL_yS_3	105	108	PF13949	0.786
LIG_LYPXL_yS_3	157	160	PF13949	0.633
LIG_PDZ_Class_2	485	490	PF00595	0.548
LIG_SH2_CRK	473	477	PF00017	0.566
LIG_SH2_STAP1	346	350	PF00017	0.293
LIG_SH2_STAT5	251	254	PF00017	0.400
LIG_SH2_STAT5	274	277	PF00017	0.477
LIG_SH2_STAT5	456	459	PF00017	0.427
LIG_SH3_1	177	183	PF00018	0.461
LIG_SH3_3	177	183	PF00018	0.614
LIG_SH3_3	307	313	PF00018	0.726
LIG_SH3_3	92	98	PF00018	0.741
LIG_SUMO_SIM_par_1	294	299	PF11976	0.599
MOD_CDK_SPK_2	357	362	PF00069	0.518
MOD_CDK_SPK_2	91	96	PF00069	0.733
MOD_CDK_SPxxK_3	357	364	PF00069	0.545
MOD_CDK_SPxxK_3	463	470	PF00069	0.482
MOD_CDK_SPxxK_3	472	479	PF00069	0.389
MOD_CK1_1	101	107	PF00069	0.750
MOD_CK1_1	148	154	PF00069	0.529
MOD_CK1_1	308	314	PF00069	0.724
MOD_CK1_1	421	427	PF00069	0.446
MOD_CK1_1	449	455	PF00069	0.364
MOD_CK1_1	94	100	PF00069	0.734
MOD_CK2_1	148	154	PF00069	0.578
MOD_CK2_1	195	201	PF00069	0.450
MOD_CK2_1	239	245	PF00069	0.566
MOD_CK2_1	27	33	PF00069	0.576
MOD_CK2_1	85	91	PF00069	0.769
MOD_GlcNHglycan	113	116	PF01048	0.731
MOD_GlcNHglycan	197	200	PF01048	0.566
MOD_GlcNHglycan	306	310	PF01048	0.710
MOD_GlcNHglycan	420	423	PF01048	0.672
MOD_GlcNHglycan	427	430	PF01048	0.708
MOD_GlcNHglycan	87	90	PF01048	0.651
MOD_GSK3_1	104	111	PF00069	0.590
MOD_GSK3_1	214	221	PF00069	0.523
MOD_GSK3_1	327	334	PF00069	0.547
MOD_GSK3_1	41	48	PF00069	0.518
MOD_GSK3_1	421	428	PF00069	0.637
MOD_GSK3_1	437	444	PF00069	0.524
MOD_GSK3_1	65	72	PF00069	0.543
MOD_GSK3_1	94	101	PF00069	0.778
MOD_N-GLC_1	85	90	PF02516	0.737
MOD_NEK2_1	186	191	PF00069	0.496
MOD_NEK2_1	27	32	PF00069	0.536
MOD_NEK2_1	305	310	PF00069	0.654
MOD_NEK2_1	389	394	PF00069	0.572
MOD_NEK2_1	448	453	PF00069	0.321
MOD_NEK2_1	77	82	PF00069	0.514
MOD_PIKK_1	108	114	PF00454	0.760
MOD_PK_1	32	38	PF00069	0.572
MOD_PKA_2	214	220	PF00069	0.630
MOD_PKA_2	382	388	PF00069	0.588
MOD_PKA_2	441	447	PF00069	0.527
MOD_PKA_2	478	484	PF00069	0.464
MOD_PKB_1	237	245	PF00069	0.499
MOD_Plk_1	32	38	PF00069	0.650
MOD_Plk_4	104	110	PF00069	0.748
MOD_Plk_4	164	170	PF00069	0.460
MOD_Plk_4	207	213	PF00069	0.661
MOD_Plk_4	218	224	PF00069	0.637
MOD_ProDKin_1	308	314	PF00069	0.752
MOD_ProDKin_1	357	363	PF00069	0.544
MOD_ProDKin_1	463	469	PF00069	0.478
MOD_ProDKin_1	472	478	PF00069	0.396
MOD_ProDKin_1	91	97	PF00069	0.784
TRG_DiLeu_BaEn_2	22	28	PF01217	0.616
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.670
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.554
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.561
TRG_ENDOCYTIC_2	105	108	PF00928	0.744
TRG_ENDOCYTIC_2	157	160	PF00928	0.563
TRG_ENDOCYTIC_2	251	254	PF00928	0.533
TRG_ER_diArg_1	176	179	PF00400	0.580
TRG_ER_diArg_1	287	290	PF00400	0.565
TRG_NES_CRM1_1	405	418	PF08389	0.560
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL5	Leptomonas seymouri	37%	100%
A0A1X0P1W2	Trypanosomatidae	24%	100%
A0A3Q8IHD2	Leishmania donovani	87%	100%
A0A3R7K4P6	Trypanosoma rangeli	24%	100%
A4HLA3	Leishmania braziliensis	75%	100%
A4I8S9	Leishmania infantum	87%	100%
Q4Q4E2	Leishmania major	87%	100%
V5BJY6	Trypanosoma cruzi	23%	100%