Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3P2_LEIMU

TriTrypDb:

LmxM.32.0605

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.453
CLV_NRD_NRD_1	215	217	PF00675	0.374
CLV_NRD_NRD_1	29	31	PF00675	0.520
CLV_PCSK_KEX2_1	193	195	PF00082	0.604
CLV_PCSK_KEX2_1	215	217	PF00082	0.404
CLV_PCSK_KEX2_1	29	31	PF00082	0.542
CLV_PCSK_KEX2_1	62	64	PF00082	0.536
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.443
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.375
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.536
CLV_PCSK_SKI1_1	254	258	PF00082	0.358
CLV_PCSK_SKI1_1	29	33	PF00082	0.409
DEG_COP1_1	354	364	PF00400	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DOC_CYCLIN_RxL_1	140	151	PF00134	0.479
DOC_CYCLIN_RxL_1	27	37	PF00134	0.420
DOC_CYCLIN_RxL_1	91	102	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.462
DOC_MAPK_gen_1	193	202	PF00069	0.409
DOC_PP1_RVXF_1	418	425	PF00149	0.477
DOC_PP2B_LxvP_1	340	343	PF13499	0.462
DOC_USP7_MATH_1	189	193	PF00917	0.344
DOC_USP7_MATH_1	353	357	PF00917	0.630
DOC_USP7_MATH_1	398	402	PF00917	0.473
DOC_USP7_UBL2_3	193	197	PF12436	0.528
DOC_WW_Pin1_4	246	251	PF00397	0.471
DOC_WW_Pin1_4	34	39	PF00397	0.530
LIG_14-3-3_CanoR_1	176	180	PF00244	0.477
LIG_14-3-3_CanoR_1	294	303	PF00244	0.461
LIG_14-3-3_CanoR_1	373	379	PF00244	0.374
LIG_14-3-3_CanoR_1	412	422	PF00244	0.388
LIG_Actin_WH2_2	114	129	PF00022	0.342
LIG_BIR_III_2	137	141	PF00653	0.436
LIG_EH1_1	220	228	PF00400	0.449
LIG_eIF4E_1	221	227	PF01652	0.443
LIG_FHA_1	123	129	PF00498	0.379
LIG_FHA_1	356	362	PF00498	0.509
LIG_FHA_1	56	62	PF00498	0.455
LIG_FHA_1	73	79	PF00498	0.236
LIG_FHA_2	302	308	PF00498	0.537
LIG_FHA_2	367	373	PF00498	0.346
LIG_GBD_Chelix_1	104	112	PF00786	0.459
LIG_LIR_Gen_1	130	139	PF02991	0.526
LIG_LIR_Nem_3	130	134	PF02991	0.540
LIG_LIR_Nem_3	177	182	PF02991	0.437
LIG_Pex14_1	64	68	PF04695	0.344
LIG_PTB_Apo_2	164	171	PF02174	0.575
LIG_SH2_CRK	233	237	PF00017	0.355
LIG_SH2_STAP1	219	223	PF00017	0.370
LIG_SH2_STAP1	338	342	PF00017	0.405
LIG_SH2_STAT5	179	182	PF00017	0.455
LIG_SH3_3	340	346	PF00018	0.257
LIG_SUMO_SIM_par_1	37	42	PF11976	0.427
LIG_TRAF2_1	172	175	PF00917	0.412
LIG_UBA3_1	95	100	PF00899	0.412
LIG_WRC_WIRS_1	276	281	PF05994	0.401
MOD_CK1_1	148	154	PF00069	0.648
MOD_CK1_1	278	284	PF00069	0.279
MOD_CK1_1	299	305	PF00069	0.498
MOD_CK1_1	347	353	PF00069	0.571
MOD_CK1_1	355	361	PF00069	0.623
MOD_CK1_1	414	420	PF00069	0.431
MOD_CK1_1	8	14	PF00069	0.648
MOD_CK2_1	151	157	PF00069	0.582
MOD_CK2_1	379	385	PF00069	0.500
MOD_CK2_1	398	404	PF00069	0.400
MOD_GlcNHglycan	101	104	PF01048	0.430
MOD_GlcNHglycan	183	186	PF01048	0.406
MOD_GlcNHglycan	331	334	PF01048	0.529
MOD_GSK3_1	1	8	PF00069	0.578
MOD_GSK3_1	141	148	PF00069	0.603
MOD_GSK3_1	248	255	PF00069	0.368
MOD_GSK3_1	260	267	PF00069	0.374
MOD_GSK3_1	275	282	PF00069	0.290
MOD_GSK3_1	295	302	PF00069	0.392
MOD_GSK3_1	347	354	PF00069	0.473
MOD_GSK3_1	360	367	PF00069	0.459
MOD_GSK3_1	373	380	PF00069	0.383
MOD_GSK3_1	414	421	PF00069	0.597
MOD_N-GLC_1	148	153	PF02516	0.685
MOD_N-GLC_1	158	163	PF02516	0.476
MOD_N-GLC_2	264	266	PF02516	0.236
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	10	15	PF00069	0.580
MOD_NEK2_1	145	150	PF00069	0.654
MOD_NEK2_1	252	257	PF00069	0.323
MOD_NEK2_1	279	284	PF00069	0.552
MOD_NEK2_1	288	293	PF00069	0.384
MOD_NEK2_1	351	356	PF00069	0.551
MOD_NEK2_1	364	369	PF00069	0.472
MOD_NEK2_1	374	379	PF00069	0.417
MOD_NEK2_1	411	416	PF00069	0.430
MOD_NEK2_1	49	54	PF00069	0.473
MOD_NEK2_2	122	127	PF00069	0.431
MOD_PIKK_1	237	243	PF00454	0.301
MOD_PIKK_1	377	383	PF00454	0.519
MOD_PIKK_1	41	47	PF00454	0.408
MOD_PIKK_1	49	55	PF00454	0.457
MOD_PK_1	310	316	PF00069	0.330
MOD_PK_1	63	69	PF00069	0.485
MOD_PKA_2	175	181	PF00069	0.434
MOD_PKA_2	411	417	PF00069	0.411
MOD_Plk_1	141	147	PF00069	0.525
MOD_Plk_1	148	154	PF00069	0.727
MOD_Plk_1	174	180	PF00069	0.474
MOD_Plk_1	237	243	PF00069	0.337
MOD_Plk_1	264	270	PF00069	0.484
MOD_Plk_1	299	305	PF00069	0.423
MOD_Plk_4	148	154	PF00069	0.592
MOD_Plk_4	248	254	PF00069	0.413
MOD_Plk_4	310	316	PF00069	0.353
MOD_Plk_4	360	366	PF00069	0.526
MOD_Plk_4	374	380	PF00069	0.263
MOD_Plk_4	389	395	PF00069	0.418
MOD_Plk_4	414	420	PF00069	0.394
MOD_Plk_4	63	69	PF00069	0.433
MOD_ProDKin_1	246	252	PF00069	0.463
MOD_ProDKin_1	34	40	PF00069	0.525
MOD_SUMO_rev_2	192	199	PF00179	0.498
MOD_SUMO_rev_2	337	343	PF00179	0.445
TRG_DiLeu_BaEn_1	317	322	PF01217	0.507
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.356
TRG_ENDOCYTIC_2	179	182	PF00928	0.455
TRG_ENDOCYTIC_2	233	236	PF00928	0.452
TRG_ER_diArg_1	28	30	PF00400	0.527
TRG_NLS_MonoExtC_3	214	220	PF00514	0.276
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R7	Leptomonas seymouri	55%	99%
A0A1X0P0P1	Trypanosomatidae	29%	98%
A0A3Q8IHM8	Leishmania donovani	91%	100%
A0A3S5IQQ0	Trypanosoma rangeli	27%	100%
A4HLA0	Leishmania braziliensis	79%	100%
A4I8S6	Leishmania infantum	91%	100%
D0A4S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
Q4Q4E5	Leishmania major	91%	100%
V5BFC5	Trypanosoma cruzi	27%	98%