Coiled-coil domain-containing protein 40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil domain-containing protein 40 homolog

Species:

Leishmania mexicana

UniProt:

E9B3P0_LEIMU

TriTrypDb:

LmxM.32.0590

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3P0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0001578	microtubule bundle formation	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.531
CLV_C14_Caspase3-7	294	298	PF00656	0.393
CLV_NRD_NRD_1	157	159	PF00675	0.440
CLV_NRD_NRD_1	246	248	PF00675	0.405
CLV_NRD_NRD_1	251	253	PF00675	0.403
CLV_NRD_NRD_1	31	33	PF00675	0.507
CLV_NRD_NRD_1	334	336	PF00675	0.612
CLV_NRD_NRD_1	37	39	PF00675	0.464
CLV_NRD_NRD_1	391	393	PF00675	0.529
CLV_NRD_NRD_1	456	458	PF00675	0.436
CLV_NRD_NRD_1	462	464	PF00675	0.451
CLV_NRD_NRD_1	611	613	PF00675	0.253
CLV_NRD_NRD_1	652	654	PF00675	0.390
CLV_NRD_NRD_1	754	756	PF00675	0.573
CLV_NRD_NRD_1	847	849	PF00675	0.439
CLV_PCSK_KEX2_1	157	159	PF00082	0.440
CLV_PCSK_KEX2_1	186	188	PF00082	0.449
CLV_PCSK_KEX2_1	210	212	PF00082	0.554
CLV_PCSK_KEX2_1	246	248	PF00082	0.405
CLV_PCSK_KEX2_1	31	33	PF00082	0.544
CLV_PCSK_KEX2_1	455	457	PF00082	0.444
CLV_PCSK_KEX2_1	582	584	PF00082	0.285
CLV_PCSK_KEX2_1	611	613	PF00082	0.251
CLV_PCSK_KEX2_1	617	619	PF00082	0.251
CLV_PCSK_KEX2_1	749	751	PF00082	0.454
CLV_PCSK_KEX2_1	754	756	PF00082	0.459
CLV_PCSK_KEX2_1	809	811	PF00082	0.523
CLV_PCSK_KEX2_1	847	849	PF00082	0.422
CLV_PCSK_KEX2_1	89	91	PF00082	0.314
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.449
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.554
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.287
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.255
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.454
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.508
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.314
CLV_PCSK_PC7_1	206	212	PF00082	0.555
CLV_PCSK_PC7_1	750	756	PF00082	0.463
CLV_PCSK_SKI1_1	358	362	PF00082	0.566
CLV_PCSK_SKI1_1	385	389	PF00082	0.543
CLV_PCSK_SKI1_1	392	396	PF00082	0.464
CLV_PCSK_SKI1_1	679	683	PF00082	0.611
CLV_PCSK_SKI1_1	741	745	PF00082	0.507
CLV_PCSK_SKI1_1	758	762	PF00082	0.396
DEG_APCC_DBOX_1	175	183	PF00400	0.263
DEG_APCC_DBOX_1	237	245	PF00400	0.522
DEG_APCC_DBOX_1	37	45	PF00400	0.479
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DOC_MAPK_gen_1	172	181	PF00069	0.514
DOC_MAPK_gen_1	60	69	PF00069	0.433
DOC_MAPK_gen_1	616	623	PF00069	0.384
DOC_MAPK_gen_1	676	683	PF00069	0.468
DOC_MAPK_gen_1	713	721	PF00069	0.541
DOC_MAPK_gen_1	847	853	PF00069	0.410
DOC_MAPK_MEF2A_6	176	184	PF00069	0.512
DOC_MAPK_MEF2A_6	573	581	PF00069	0.266
DOC_PP1_RVXF_1	644	651	PF00149	0.389
DOC_PP1_RVXF_1	677	684	PF00149	0.616
DOC_USP7_MATH_1	110	114	PF00917	0.544
DOC_USP7_MATH_1	291	295	PF00917	0.553
DOC_USP7_MATH_1	4	8	PF00917	0.689
DOC_USP7_MATH_1	594	598	PF00917	0.278
DOC_USP7_MATH_1	833	837	PF00917	0.549
DOC_USP7_MATH_1	849	853	PF00917	0.345
DOC_USP7_MATH_1	9	13	PF00917	0.638
DOC_USP7_UBL2_3	341	345	PF12436	0.627
DOC_USP7_UBL2_3	354	358	PF12436	0.456
DOC_USP7_UBL2_3	381	385	PF12436	0.530
LIG_14-3-3_CanoR_1	238	242	PF00244	0.506
LIG_14-3-3_CanoR_1	252	258	PF00244	0.431
LIG_14-3-3_CanoR_1	520	528	PF00244	0.394
LIG_14-3-3_CanoR_1	583	588	PF00244	0.465
LIG_14-3-3_CanoR_1	631	641	PF00244	0.433
LIG_APCC_ABBA_1	740	745	PF00400	0.468
LIG_APCC_ABBAyCdc20_2	646	652	PF00400	0.393
LIG_BRCT_BRCA1_1	857	861	PF00533	0.566
LIG_Clathr_ClatBox_1	139	143	PF01394	0.534
LIG_Clathr_ClatBox_1	265	269	PF01394	0.527
LIG_FHA_1	134	140	PF00498	0.423
LIG_FHA_1	521	527	PF00498	0.281
LIG_FHA_2	161	167	PF00498	0.443
LIG_FHA_2	213	219	PF00498	0.481
LIG_FHA_2	404	410	PF00498	0.563
LIG_FHA_2	430	436	PF00498	0.394
LIG_FHA_2	49	55	PF00498	0.546
LIG_FHA_2	529	535	PF00498	0.315
LIG_FHA_2	680	686	PF00498	0.553
LIG_FHA_2	775	781	PF00498	0.463
LIG_LIR_Gen_1	517	526	PF02991	0.251
LIG_LIR_Nem_3	517	521	PF02991	0.367
LIG_LIR_Nem_3	858	864	PF02991	0.457
LIG_MYND_1	862	866	PF01753	0.602
LIG_PCNA_yPIPBox_3	280	293	PF02747	0.545
LIG_PDZ_Class_1	870	875	PF00595	0.493
LIG_Rb_LxCxE_1	666	685	PF01857	0.545
LIG_SH2_CRK	827	831	PF00017	0.558
LIG_SH2_GRB2like	128	131	PF00017	0.426
LIG_SH2_STAP1	475	479	PF00017	0.533
LIG_SH2_STAT3	70	73	PF00017	0.417
LIG_SH2_STAT5	125	128	PF00017	0.486
LIG_SH3_3	22	28	PF00018	0.530
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.258
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.529
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.395
LIG_SUMO_SIM_par_1	178	183	PF11976	0.283
LIG_SUMO_SIM_par_1	264	269	PF11976	0.529
LIG_SUMO_SIM_par_1	299	304	PF11976	0.474
LIG_SUMO_SIM_par_1	849	856	PF11976	0.382
LIG_TRAF2_1	103	106	PF00917	0.577
LIG_TRAF2_1	331	334	PF00917	0.602
LIG_TRAF2_1	387	390	PF00917	0.508
LIG_UBA3_1	179	186	PF00899	0.406
LIG_UBA3_1	556	564	PF00899	0.285
LIG_UBA3_1	698	704	PF00899	0.517
LIG_UBA3_1	742	749	PF00899	0.455
MOD_CK1_1	14	20	PF00069	0.566
MOD_CK1_1	327	333	PF00069	0.566
MOD_CK1_1	375	381	PF00069	0.548
MOD_CK1_1	53	59	PF00069	0.330
MOD_CK2_1	106	112	PF00069	0.584
MOD_CK2_1	165	171	PF00069	0.432
MOD_CK2_1	201	207	PF00069	0.451
MOD_CK2_1	218	224	PF00069	0.410
MOD_CK2_1	279	285	PF00069	0.577
MOD_CK2_1	327	333	PF00069	0.435
MOD_CK2_1	347	353	PF00069	0.403
MOD_CK2_1	403	409	PF00069	0.556
MOD_CK2_1	48	54	PF00069	0.546
MOD_CK2_1	506	512	PF00069	0.482
MOD_CK2_1	528	534	PF00069	0.224
MOD_CK2_1	679	685	PF00069	0.551
MOD_CK2_1	760	766	PF00069	0.469
MOD_CK2_1	774	780	PF00069	0.370
MOD_CK2_1	833	839	PF00069	0.401
MOD_CK2_1	849	855	PF00069	0.297
MOD_Cter_Amidation	845	848	PF01082	0.553
MOD_GlcNHglycan	108	111	PF01048	0.562
MOD_GlcNHglycan	112	115	PF01048	0.558
MOD_GlcNHglycan	194	197	PF01048	0.501
MOD_GlcNHglycan	54	58	PF01048	0.510
MOD_GlcNHglycan	596	599	PF01048	0.278
MOD_GlcNHglycan	745	749	PF01048	0.391
MOD_GlcNHglycan	855	860	PF01048	0.533
MOD_GSK3_1	106	113	PF00069	0.466
MOD_GSK3_1	287	294	PF00069	0.460
MOD_GSK3_1	324	331	PF00069	0.511
MOD_GSK3_1	372	379	PF00069	0.576
MOD_GSK3_1	425	432	PF00069	0.443
MOD_GSK3_1	75	82	PF00069	0.483
MOD_N-GLC_1	192	197	PF02516	0.525
MOD_N-GLC_1	4	9	PF02516	0.623
MOD_N-GLC_1	425	430	PF02516	0.432
MOD_N-GLC_1	558	563	PF02516	0.374
MOD_NEK2_1	135	140	PF00069	0.403
MOD_NEK2_1	180	185	PF00069	0.511
MOD_NEK2_1	324	329	PF00069	0.528
MOD_NEK2_1	429	434	PF00069	0.429
MOD_NEK2_1	493	498	PF00069	0.443
MOD_NEK2_1	630	635	PF00069	0.408
MOD_PIKK_1	201	207	PF00454	0.436
MOD_PIKK_1	279	285	PF00454	0.563
MOD_PIKK_1	403	409	PF00454	0.486
MOD_PIKK_1	586	592	PF00454	0.266
MOD_PIKK_1	686	692	PF00454	0.624
MOD_PIKK_1	720	726	PF00454	0.520
MOD_PIKK_1	774	780	PF00454	0.507
MOD_PKA_2	212	218	PF00069	0.517
MOD_PKA_2	237	243	PF00069	0.503
MOD_PKA_2	251	257	PF00069	0.432
MOD_PKA_2	279	285	PF00069	0.434
MOD_PKA_2	375	381	PF00069	0.479
MOD_PKA_2	544	550	PF00069	0.145
MOD_PKA_2	61	67	PF00069	0.559
MOD_PKA_2	630	636	PF00069	0.438
MOD_PKA_2	658	664	PF00069	0.555
MOD_PKA_2	686	692	PF00069	0.514
MOD_PKB_1	414	422	PF00069	0.436
MOD_Plk_1	324	330	PF00069	0.528
MOD_Plk_1	376	382	PF00069	0.582
MOD_Plk_1	4	10	PF00069	0.742
MOD_Plk_1	425	431	PF00069	0.432
MOD_Plk_1	493	499	PF00069	0.439
MOD_Plk_1	679	685	PF00069	0.551
MOD_Plk_2-3	218	224	PF00069	0.486
MOD_Plk_4	135	141	PF00069	0.423
MOD_Plk_4	237	243	PF00069	0.392
MOD_Plk_4	544	550	PF00069	0.251
MOD_Plk_4	583	589	PF00069	0.394
MOD_Plk_4	849	855	PF00069	0.346
MOD_SUMO_for_1	140	143	PF00179	0.434
MOD_SUMO_for_1	149	152	PF00179	0.374
MOD_SUMO_for_1	380	383	PF00179	0.532
MOD_SUMO_for_1	677	680	PF00179	0.610
MOD_SUMO_for_1	798	801	PF00179	0.512
MOD_SUMO_rev_2	204	212	PF00179	0.504
MOD_SUMO_rev_2	224	233	PF00179	0.318
MOD_SUMO_rev_2	330	338	PF00179	0.473
MOD_SUMO_rev_2	377	387	PF00179	0.529
MOD_SUMO_rev_2	396	406	PF00179	0.312
MOD_SUMO_rev_2	574	584	PF00179	0.307
MOD_SUMO_rev_2	619	627	PF00179	0.392
MOD_SUMO_rev_2	647	655	PF00179	0.366
MOD_SUMO_rev_2	689	698	PF00179	0.551
MOD_SUMO_rev_2	801	811	PF00179	0.471
TRG_DiLeu_BaEn_1	229	234	PF01217	0.405
TRG_DiLeu_BaEn_1	367	372	PF01217	0.633
TRG_DiLeu_BaEn_1	694	699	PF01217	0.497
TRG_DiLeu_BaEn_3	700	706	PF01217	0.519
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.266
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.463
TRG_ENDOCYTIC_2	321	324	PF00928	0.454
TRG_ENDOCYTIC_2	475	478	PF00928	0.505
TRG_ENDOCYTIC_2	827	830	PF00928	0.637
TRG_ER_diArg_1	101	104	PF00400	0.566
TRG_ER_diArg_1	31	33	PF00400	0.593
TRG_ER_diArg_1	414	417	PF00400	0.428
TRG_ER_diArg_1	454	457	PF00400	0.470
TRG_ER_diArg_1	610	612	PF00400	0.266
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I582	Leptomonas seymouri	81%	100%
A0A0S4JM03	Bodo saltans	50%	99%
A0A1X0P1D5	Trypanosomatidae	59%	100%
A0A3R7RFG2	Trypanosoma rangeli	59%	100%
A0A3S7X6D9	Leishmania donovani	96%	100%
A4HL98	Leishmania braziliensis	90%	100%
A4I8S4	Leishmania infantum	96%	100%
D0A4R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4G0X9	Homo sapiens	25%	77%
Q4Q4E7	Leishmania major	96%	100%
Q56A40	Danio rerio	24%	93%
Q8BI79	Mus musculus	25%	73%
V5BJZ2	Trypanosoma cruzi	58%	100%