Nkap_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-induced vulval development antagonist, putative

Species:

Leishmania mexicana

UniProt:

E9B3N8_LEIMU

TriTrypDb:

LmxM.32.0580

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3N8

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	8
GO:0005488	binding	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.656
CLV_NRD_NRD_1	141	143	PF00675	0.804
CLV_NRD_NRD_1	192	194	PF00675	0.825
CLV_NRD_NRD_1	206	208	PF00675	0.818
CLV_NRD_NRD_1	302	304	PF00675	0.376
CLV_NRD_NRD_1	32	34	PF00675	0.555
CLV_NRD_NRD_1	354	356	PF00675	0.387
CLV_NRD_NRD_1	38	40	PF00675	0.642
CLV_PCSK_FUR_1	30	34	PF00082	0.671
CLV_PCSK_KEX2_1	192	194	PF00082	0.825
CLV_PCSK_KEX2_1	208	210	PF00082	0.817
CLV_PCSK_KEX2_1	298	300	PF00082	0.376
CLV_PCSK_KEX2_1	30	32	PF00082	0.553
CLV_PCSK_KEX2_1	302	304	PF00082	0.376
CLV_PCSK_KEX2_1	37	39	PF00082	0.611
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.817
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.376
CLV_PCSK_PC7_1	33	39	PF00082	0.590
CLV_Separin_Metazoa	139	143	PF03568	0.820
DEG_Nend_UBRbox_2	1	3	PF02207	0.674
DOC_MAPK_MEF2A_6	361	370	PF00069	0.501
DOC_PP1_RVXF_1	206	213	PF00149	0.741
DOC_USP7_MATH_1	101	105	PF00917	0.608
DOC_USP7_MATH_1	112	116	PF00917	0.693
DOC_USP7_MATH_1	134	138	PF00917	0.784
DOC_USP7_MATH_1	253	257	PF00917	0.739
DOC_USP7_MATH_1	259	263	PF00917	0.769
DOC_USP7_MATH_1	87	91	PF00917	0.622
DOC_USP7_MATH_2	47	53	PF00917	0.516
DOC_USP7_UBL2_3	166	170	PF12436	0.650
DOC_WW_Pin1_4	102	107	PF00397	0.522
DOC_WW_Pin1_4	124	129	PF00397	0.807
DOC_WW_Pin1_4	43	48	PF00397	0.691
LIG_14-3-3_CanoR_1	59	67	PF00244	0.516
LIG_CaM_IQ_9	347	363	PF13499	0.430
LIG_FHA_1	151	157	PF00498	0.731
LIG_FHA_1	159	165	PF00498	0.610
LIG_FHA_2	106	112	PF00498	0.697
LIG_FHA_2	287	293	PF00498	0.693
LIG_FHA_2	307	313	PF00498	0.171
LIG_FHA_2	91	97	PF00498	0.627
LIG_LIR_Nem_3	24	29	PF02991	0.627
LIG_Pex14_1	22	26	PF04695	0.622
LIG_Pex14_2	293	297	PF04695	0.376
LIG_SH2_STAT3	14	17	PF00017	0.594
LIG_SH2_STAT5	321	324	PF00017	0.352
LIG_SH2_STAT5	334	337	PF00017	0.376
LIG_SH2_STAT5	76	79	PF00017	0.514
LIG_SH3_1	193	199	PF00018	0.610
LIG_SH3_3	127	133	PF00018	0.773
LIG_SH3_3	154	160	PF00018	0.682
LIG_SH3_3	184	190	PF00018	0.629
LIG_SH3_3	193	199	PF00018	0.716
LIG_SUMO_SIM_par_1	180	188	PF11976	0.497
LIG_TRAF2_1	309	312	PF00917	0.501
LIG_TRAF2_1	47	50	PF00917	0.690
LIG_WW_3	139	143	PF00397	0.820
MOD_CK1_1	105	111	PF00069	0.639
MOD_CK1_1	115	121	PF00069	0.765
MOD_CK1_1	286	292	PF00069	0.568
MOD_CK1_1	328	334	PF00069	0.430
MOD_CK1_1	52	58	PF00069	0.723
MOD_CK1_1	90	96	PF00069	0.730
MOD_CK2_1	107	113	PF00069	0.665
MOD_CK2_1	142	148	PF00069	0.801
MOD_CK2_1	286	292	PF00069	0.616
MOD_CK2_1	306	312	PF00069	0.171
MOD_CK2_1	43	49	PF00069	0.762
MOD_CK2_1	57	63	PF00069	0.589
MOD_Cter_Amidation	205	208	PF01082	0.818
MOD_GlcNHglycan	117	120	PF01048	0.678
MOD_GlcNHglycan	122	125	PF01048	0.713
MOD_GlcNHglycan	136	139	PF01048	0.706
MOD_GlcNHglycan	161	164	PF01048	0.607
MOD_GlcNHglycan	261	265	PF01048	0.793
MOD_GlcNHglycan	323	326	PF01048	0.376
MOD_GlcNHglycan	49	54	PF01048	0.730
MOD_GlcNHglycan	77	80	PF01048	0.517
MOD_GlcNHglycan	89	92	PF01048	0.621
MOD_GSK3_1	101	108	PF00069	0.756
MOD_GSK3_1	111	118	PF00069	0.613
MOD_GSK3_1	120	127	PF00069	0.479
MOD_GSK3_1	321	328	PF00069	0.430
MOD_GSK3_1	373	380	PF00069	0.454
MOD_GSK3_1	45	52	PF00069	0.708
MOD_GSK3_1	55	62	PF00069	0.604
MOD_NEK2_1	21	26	PF00069	0.557
MOD_NEK2_1	323	328	PF00069	0.376
MOD_NEK2_1	373	378	PF00069	0.430
MOD_NEK2_1	81	86	PF00069	0.557
MOD_PIKK_1	198	204	PF00454	0.786
MOD_PIKK_1	283	289	PF00454	0.577
MOD_PIKK_1	292	298	PF00454	0.376
MOD_PIKK_1	57	63	PF00454	0.742
MOD_PKA_1	142	148	PF00069	0.753
MOD_Plk_1	112	118	PF00069	0.523
MOD_Plk_1	239	245	PF00069	0.732
MOD_Plk_4	239	245	PF00069	0.612
MOD_ProDKin_1	102	108	PF00069	0.523
MOD_ProDKin_1	124	130	PF00069	0.810
MOD_ProDKin_1	43	49	PF00069	0.689
TRG_DiLeu_BaEn_2	238	244	PF01217	0.510
TRG_DiLeu_BaEn_2	368	374	PF01217	0.424
TRG_ER_diArg_1	207	210	PF00400	0.818
TRG_ER_diArg_1	225	228	PF00400	0.539
TRG_ER_diArg_1	29	32	PF00400	0.552
TRG_ER_diArg_1	301	303	PF00400	0.376
TRG_ER_diArg_1	37	39	PF00400	0.601
TRG_ER_diLys_1	377	380	PF00400	0.596
TRG_NLS_Bipartite_1	192	211	PF00514	0.813
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC1	Leptomonas seymouri	51%	91%
A0A3S7X6H7	Leishmania donovani	88%	100%
A0A422N868	Trypanosoma rangeli	33%	100%
A4HL96	Leishmania braziliensis	77%	99%
A4I8S2	Leishmania infantum	88%	100%
Q4Q4E9	Leishmania major	89%	100%