V-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3N7_LEIMU

TriTrypDb:

LmxM.32.0570

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0034708	methyltransferase complex	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0043527	tRNA methyltransferase complex	5	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9B3N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3N7

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	10
GO:0036265	RNA (guanine-N7)-methylation	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006400	tRNA modification	6	1
GO:0030488	tRNA methylation	5	1
GO:0106004	tRNA (guanine-N7)-methylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.473
CLV_MEL_PAP_1	369	375	PF00089	0.440
CLV_NRD_NRD_1	120	122	PF00675	0.716
CLV_NRD_NRD_1	236	238	PF00675	0.386
CLV_NRD_NRD_1	536	538	PF00675	0.662
CLV_PCSK_FUR_1	533	537	PF00082	0.688
CLV_PCSK_KEX2_1	120	122	PF00082	0.718
CLV_PCSK_KEX2_1	154	156	PF00082	0.416
CLV_PCSK_KEX2_1	236	238	PF00082	0.386
CLV_PCSK_KEX2_1	441	443	PF00082	0.457
CLV_PCSK_KEX2_1	535	537	PF00082	0.670
CLV_PCSK_KEX2_1	569	571	PF00082	0.559
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.416
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.457
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.559
CLV_PCSK_SKI1_1	154	158	PF00082	0.432
CLV_PCSK_SKI1_1	197	201	PF00082	0.524
CLV_PCSK_SKI1_1	236	240	PF00082	0.386
CLV_PCSK_SKI1_1	384	388	PF00082	0.435
DOC_CDC14_PxL_1	5	13	PF14671	0.531
DOC_CYCLIN_RxL_1	230	242	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.613
DOC_MAPK_gen_1	441	448	PF00069	0.395
DOC_PP1_RVXF_1	178	184	PF00149	0.503
DOC_PP1_RVXF_1	55	62	PF00149	0.425
DOC_PP2B_LxvP_1	214	217	PF13499	0.484
DOC_PP2B_LxvP_1	305	308	PF13499	0.659
DOC_PP2B_LxvP_1	62	65	PF13499	0.448
DOC_PP4_FxxP_1	373	376	PF00568	0.535
DOC_PP4_FxxP_1	397	400	PF00568	0.471
DOC_USP7_MATH_1	160	164	PF00917	0.343
DOC_USP7_MATH_1	247	251	PF00917	0.404
DOC_USP7_MATH_1	413	417	PF00917	0.611
DOC_USP7_MATH_1	44	48	PF00917	0.566
DOC_USP7_UBL2_3	565	569	PF12436	0.809
DOC_WW_Pin1_4	181	186	PF00397	0.502
DOC_WW_Pin1_4	346	351	PF00397	0.404
DOC_WW_Pin1_4	38	43	PF00397	0.666
LIG_14-3-3_CanoR_1	155	160	PF00244	0.459
LIG_14-3-3_CanoR_1	178	184	PF00244	0.464
LIG_14-3-3_CanoR_1	265	269	PF00244	0.546
LIG_14-3-3_CanoR_1	419	423	PF00244	0.518
LIG_14-3-3_CanoR_1	512	519	PF00244	0.532
LIG_AP2alpha_1	169	173	PF02296	0.358
LIG_BIR_III_2	423	427	PF00653	0.573
LIG_BRCT_BRCA1_1	393	397	PF00533	0.507
LIG_FHA_1	109	115	PF00498	0.778
LIG_FHA_1	151	157	PF00498	0.448
LIG_FHA_1	186	192	PF00498	0.530
LIG_FHA_1	198	204	PF00498	0.303
LIG_FHA_1	209	215	PF00498	0.405
LIG_FHA_1	253	259	PF00498	0.491
LIG_FHA_1	336	342	PF00498	0.543
LIG_FHA_1	434	440	PF00498	0.477
LIG_FHA_1	508	514	PF00498	0.533
LIG_FHA_1	573	579	PF00498	0.489
LIG_FHA_2	159	165	PF00498	0.477
LIG_FHA_2	418	424	PF00498	0.460
LIG_FHA_2	506	512	PF00498	0.681
LIG_LIR_Apic_2	141	145	PF02991	0.586
LIG_LIR_Apic_2	371	376	PF02991	0.527
LIG_LIR_Apic_2	394	400	PF02991	0.476
LIG_LIR_Gen_1	337	347	PF02991	0.452
LIG_LIR_Gen_1	447	456	PF02991	0.524
LIG_LIR_Gen_1	524	532	PF02991	0.673
LIG_LIR_Gen_1	76	85	PF02991	0.489
LIG_LIR_Nem_3	171	176	PF02991	0.383
LIG_LIR_Nem_3	337	342	PF02991	0.449
LIG_LIR_Nem_3	355	360	PF02991	0.573
LIG_LIR_Nem_3	395	401	PF02991	0.360
LIG_LIR_Nem_3	447	451	PF02991	0.488
LIG_LIR_Nem_3	524	530	PF02991	0.663
LIG_LIR_Nem_3	76	82	PF02991	0.486
LIG_MYND_3	483	487	PF01753	0.536
LIG_Pex14_1	143	147	PF04695	0.586
LIG_Pex14_2	169	173	PF04695	0.358
LIG_SH2_CRK	402	406	PF00017	0.589
LIG_SH2_GRB2like	402	405	PF00017	0.496
LIG_SH2_NCK_1	402	406	PF00017	0.522
LIG_SH2_NCK_1	527	531	PF00017	0.550
LIG_SH2_SRC	147	150	PF00017	0.572
LIG_SH2_SRC	402	405	PF00017	0.517
LIG_SH2_STAP1	287	291	PF00017	0.626
LIG_SH2_STAP1	309	313	PF00017	0.465
LIG_SH2_STAT5	213	216	PF00017	0.327
LIG_SH2_STAT5	256	259	PF00017	0.506
LIG_SH2_STAT5	280	283	PF00017	0.572
LIG_SH2_STAT5	312	315	PF00017	0.345
LIG_SH3_3	344	350	PF00018	0.527
LIG_SH3_3	373	379	PF00018	0.403
LIG_SH3_3	451	457	PF00018	0.498
LIG_SH3_3	478	484	PF00018	0.563
LIG_SH3_3	526	532	PF00018	0.613
LIG_SH3_3	62	68	PF00018	0.528
LIG_SH3_4	144	151	PF00018	0.554
LIG_SUMO_SIM_par_1	186	192	PF11976	0.567
LIG_TRAF2_1	226	229	PF00917	0.653
LIG_TRAF2_1	499	502	PF00917	0.730
LIG_WRC_WIRS_1	342	347	PF05994	0.546
MOD_CK1_1	12	18	PF00069	0.395
MOD_CK1_1	158	164	PF00069	0.520
MOD_CK1_1	207	213	PF00069	0.395
MOD_CK1_1	267	273	PF00069	0.416
MOD_CK1_1	331	337	PF00069	0.325
MOD_CK1_1	418	424	PF00069	0.532
MOD_CK1_1	548	554	PF00069	0.747
MOD_CK2_1	158	164	PF00069	0.520
MOD_CK2_1	276	282	PF00069	0.470
MOD_CK2_1	331	337	PF00069	0.532
MOD_CK2_1	511	517	PF00069	0.557
MOD_Cter_Amidation	567	570	PF01082	0.731
MOD_DYRK1A_RPxSP_1	346	350	PF00069	0.317
MOD_GlcNHglycan	228	233	PF01048	0.557
MOD_GlcNHglycan	269	272	PF01048	0.525
MOD_GlcNHglycan	415	418	PF01048	0.588
MOD_GlcNHglycan	550	553	PF01048	0.790
MOD_GlcNHglycan	560	563	PF01048	0.653
MOD_GlcNHglycan	72	75	PF01048	0.389
MOD_GSK3_1	150	157	PF00069	0.437
MOD_GSK3_1	179	186	PF00069	0.494
MOD_GSK3_1	193	200	PF00069	0.273
MOD_GSK3_1	204	211	PF00069	0.377
MOD_GSK3_1	224	231	PF00069	0.330
MOD_GSK3_1	3	10	PF00069	0.611
MOD_GSK3_1	307	314	PF00069	0.450
MOD_GSK3_1	331	338	PF00069	0.514
MOD_GSK3_1	361	368	PF00069	0.547
MOD_GSK3_1	40	47	PF00069	0.622
MOD_GSK3_1	413	420	PF00069	0.485
MOD_GSK3_1	429	436	PF00069	0.347
MOD_GSK3_1	460	467	PF00069	0.644
MOD_GSK3_1	503	510	PF00069	0.657
MOD_LATS_1	152	158	PF00433	0.420
MOD_N-GLC_1	3	8	PF02516	0.643
MOD_N-GLC_1	301	306	PF02516	0.705
MOD_N-GLC_1	328	333	PF02516	0.527
MOD_N-GLC_1	335	340	PF02516	0.561
MOD_N-GLC_1	548	553	PF02516	0.783
MOD_N-GLC_1	83	88	PF02516	0.534
MOD_N-GLC_1	97	102	PF02516	0.652
MOD_NEK2_1	212	217	PF00069	0.403
MOD_NEK2_1	261	266	PF00069	0.558
MOD_NEK2_1	341	346	PF00069	0.501
MOD_NEK2_1	521	526	PF00069	0.567
MOD_NEK2_2	406	411	PF00069	0.434
MOD_OFUCOSY	235	241	PF10250	0.430
MOD_PKA_1	120	126	PF00069	0.723
MOD_PKA_1	154	160	PF00069	0.407
MOD_PKA_2	120	126	PF00069	0.723
MOD_PKA_2	154	160	PF00069	0.407
MOD_PKA_2	179	185	PF00069	0.485
MOD_PKA_2	247	253	PF00069	0.383
MOD_PKA_2	264	270	PF00069	0.453
MOD_PKA_2	418	424	PF00069	0.515
MOD_PKA_2	511	517	PF00069	0.560
MOD_PKB_1	570	578	PF00069	0.600
MOD_Plk_1	276	282	PF00069	0.540
MOD_Plk_1	287	293	PF00069	0.643
MOD_Plk_1	301	307	PF00069	0.706
MOD_Plk_1	328	334	PF00069	0.441
MOD_Plk_1	335	341	PF00069	0.519
MOD_Plk_1	433	439	PF00069	0.465
MOD_Plk_1	83	89	PF00069	0.533
MOD_Plk_2-3	511	517	PF00069	0.638
MOD_Plk_4	163	169	PF00069	0.352
MOD_Plk_4	197	203	PF00069	0.428
MOD_Plk_4	208	214	PF00069	0.344
MOD_Plk_4	252	258	PF00069	0.497
MOD_Plk_4	307	313	PF00069	0.489
MOD_Plk_4	361	367	PF00069	0.437
MOD_Plk_4	44	50	PF00069	0.553
MOD_Plk_4	444	450	PF00069	0.473
MOD_ProDKin_1	181	187	PF00069	0.511
MOD_ProDKin_1	346	352	PF00069	0.404
MOD_ProDKin_1	38	44	PF00069	0.658
MOD_SUMO_for_1	138	141	PF00179	0.629
MOD_SUMO_rev_2	73	80	PF00179	0.428
TRG_DiLeu_BaEn_1	337	342	PF01217	0.469
TRG_DiLeu_BaEn_2	433	439	PF01217	0.544
TRG_ENDOCYTIC_2	402	405	PF00928	0.502
TRG_ENDOCYTIC_2	527	530	PF00928	0.548
TRG_ER_diArg_1	177	180	PF00400	0.493
TRG_ER_diArg_1	236	238	PF00400	0.386
TRG_ER_diArg_1	345	348	PF00400	0.539
TRG_ER_diArg_1	532	535	PF00400	0.594
TRG_ER_diArg_1	570	573	PF00400	0.607
TRG_NES_CRM1_1	54	66	PF08389	0.543
TRG_NLS_MonoExtC_3	568	574	PF00514	0.749
TRG_NLS_MonoExtN_4	120	125	PF00514	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL73	Leptomonas seymouri	66%	100%
A0A1X0P0S8	Trypanosomatidae	30%	100%
A0A3Q8IGQ7	Leishmania donovani	93%	100%
A0A422N539	Trypanosoma rangeli	33%	100%
A4HL95	Leishmania braziliensis	79%	99%
A4I8S1	Leishmania infantum	94%	100%
D0A4R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q4F0	Leishmania major	93%	100%
V5D2Q1	Trypanosoma cruzi	32%	100%