LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3N6_LEIMU
TriTrypDb:
LmxM.32.0565
Length:
144

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B3N6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3N6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.665
CLV_NRD_NRD_1 86 88 PF00675 0.449
CLV_NRD_NRD_1 93 95 PF00675 0.437
CLV_PCSK_FUR_1 91 95 PF00082 0.503
CLV_PCSK_KEX2_1 93 95 PF00082 0.433
CLV_PCSK_SKI1_1 87 91 PF00082 0.508
DOC_MAPK_gen_1 113 122 PF00069 0.581
DOC_USP7_MATH_1 128 132 PF00917 0.732
DOC_USP7_MATH_1 31 35 PF00917 0.623
DOC_WW_Pin1_4 123 128 PF00397 0.699
DOC_WW_Pin1_4 133 138 PF00397 0.446
DOC_WW_Pin1_4 139 144 PF00397 0.522
LIG_FHA_2 54 60 PF00498 0.421
LIG_FHA_2 8 14 PF00498 0.576
LIG_LIR_Gen_1 4 12 PF02991 0.627
LIG_LIR_Nem_3 4 8 PF02991 0.641
LIG_LIR_Nem_3 47 52 PF02991 0.431
LIG_PCNA_PIPBox_1 95 104 PF02747 0.515
LIG_PDZ_Class_1 139 144 PF00595 0.557
LIG_SH2_NCK_1 27 31 PF00017 0.481
LIG_SH2_STAT5 27 30 PF00017 0.452
LIG_SH2_STAT5 48 51 PF00017 0.453
LIG_SH2_STAT5 74 77 PF00017 0.317
LIG_TRAF2_1 30 33 PF00917 0.576
MOD_CDC14_SPxK_1 136 139 PF00782 0.451
MOD_CDK_SPxK_1 133 139 PF00069 0.452
MOD_CK1_1 123 129 PF00069 0.518
MOD_CK2_1 7 13 PF00069 0.595
MOD_CMANNOS 51 54 PF00535 0.516
MOD_GlcNHglycan 122 125 PF01048 0.682
MOD_GSK3_1 135 142 PF00069 0.482
MOD_NEK2_1 52 57 PF00069 0.482
MOD_ProDKin_1 123 129 PF00069 0.701
MOD_ProDKin_1 133 139 PF00069 0.447
MOD_SUMO_rev_2 12 21 PF00179 0.598
TRG_ER_diArg_1 112 115 PF00400 0.547
TRG_ER_diArg_1 90 93 PF00400 0.541
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6M0 Leptomonas seymouri 63% 100%
A0A1X0P0N5 Trypanosomatidae 60% 100%
A0A3Q8IJY7 Leishmania donovani 91% 100%
A0A422N525 Trypanosoma rangeli 56% 100%
A4HL94 Leishmania braziliensis 75% 100%
A4I8S0 Leishmania infantum 91% 100%
D0A4R2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
Q4Q4F1 Leishmania major 89% 100%
V5BBJ7 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS