SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3M9_LEIMU

TriTrypDb:

LmxM.32.0510

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3M9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.537
CLV_NRD_NRD_1	343	345	PF00675	0.641
CLV_NRD_NRD_1	431	433	PF00675	0.649
CLV_NRD_NRD_1	649	651	PF00675	0.612
CLV_NRD_NRD_1	823	825	PF00675	0.433
CLV_PCSK_KEX2_1	431	433	PF00082	0.649
CLV_PCSK_KEX2_1	487	489	PF00082	0.362
CLV_PCSK_KEX2_1	634	636	PF00082	0.604
CLV_PCSK_KEX2_1	648	650	PF00082	0.485
CLV_PCSK_KEX2_1	823	825	PF00082	0.433
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.349
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.589
CLV_PCSK_SKI1_1	141	145	PF00082	0.632
CLV_PCSK_SKI1_1	161	165	PF00082	0.480
CLV_PCSK_SKI1_1	188	192	PF00082	0.478
CLV_PCSK_SKI1_1	218	222	PF00082	0.597
CLV_PCSK_SKI1_1	405	409	PF00082	0.540
CLV_PCSK_SKI1_1	431	435	PF00082	0.507
CLV_PCSK_SKI1_1	509	513	PF00082	0.351
CLV_PCSK_SKI1_1	58	62	PF00082	0.627
CLV_PCSK_SKI1_1	595	599	PF00082	0.486
CLV_PCSK_SKI1_1	634	638	PF00082	0.495
CLV_PCSK_SKI1_1	678	682	PF00082	0.510
CLV_PCSK_SKI1_1	712	716	PF00082	0.491
DEG_APCC_DBOX_1	217	225	PF00400	0.586
DEG_APCC_DBOX_1	57	65	PF00400	0.602
DEG_Nend_UBRbox_3	1	3	PF02207	0.526
DEG_SCF_FBW7_1	157	162	PF00400	0.404
DOC_CDC14_PxL_1	445	453	PF14671	0.674
DOC_CYCLIN_RxL_1	709	717	PF00134	0.488
DOC_MAPK_gen_1	216	224	PF00069	0.581
DOC_MAPK_MEF2A_6	216	224	PF00069	0.581
DOC_PP1_RVXF_1	430	437	PF00149	0.561
DOC_PP2B_LxvP_1	49	52	PF13499	0.635
DOC_PP4_FxxP_1	390	393	PF00568	0.479
DOC_USP7_MATH_1	10	14	PF00917	0.520
DOC_USP7_MATH_1	129	133	PF00917	0.665
DOC_USP7_MATH_1	148	152	PF00917	0.379
DOC_USP7_MATH_1	250	254	PF00917	0.664
DOC_USP7_MATH_1	391	395	PF00917	0.657
DOC_USP7_MATH_1	467	471	PF00917	0.519
DOC_USP7_MATH_1	497	501	PF00917	0.547
DOC_USP7_MATH_1	537	541	PF00917	0.424
DOC_USP7_MATH_1	554	558	PF00917	0.447
DOC_USP7_MATH_1	853	857	PF00917	0.408
DOC_USP7_MATH_1	91	95	PF00917	0.632
DOC_USP7_UBL2_3	483	487	PF12436	0.531
DOC_WW_Pin1_4	12	17	PF00397	0.668
DOC_WW_Pin1_4	127	132	PF00397	0.595
DOC_WW_Pin1_4	155	160	PF00397	0.399
DOC_WW_Pin1_4	307	312	PF00397	0.645
DOC_WW_Pin1_4	415	420	PF00397	0.665
DOC_WW_Pin1_4	530	535	PF00397	0.551
LIG_14-3-3_CanoR_1	161	169	PF00244	0.633
LIG_14-3-3_CanoR_1	198	208	PF00244	0.726
LIG_14-3-3_CanoR_1	216	221	PF00244	0.575
LIG_14-3-3_CanoR_1	44	49	PF00244	0.648
LIG_14-3-3_CanoR_1	635	639	PF00244	0.549
LIG_14-3-3_CanoR_1	648	657	PF00244	0.469
LIG_14-3-3_CanoR_1	661	668	PF00244	0.450
LIG_14-3-3_CanoR_1	860	864	PF00244	0.474
LIG_Actin_WH2_2	359	377	PF00022	0.668
LIG_APCC_ABBA_1	144	149	PF00400	0.584
LIG_APCC_ABBA_1	240	245	PF00400	0.446
LIG_BIR_III_2	388	392	PF00653	0.485
LIG_BIR_III_4	99	103	PF00653	0.636
LIG_Clathr_ClatBox_1	703	707	PF01394	0.458
LIG_EVH1_1	49	53	PF00568	0.693
LIG_FHA_1	176	182	PF00498	0.443
LIG_FHA_1	202	208	PF00498	0.448
LIG_FHA_1	217	223	PF00498	0.589
LIG_FHA_1	35	41	PF00498	0.669
LIG_FHA_1	567	573	PF00498	0.535
LIG_FHA_1	618	624	PF00498	0.523
LIG_FHA_1	649	655	PF00498	0.496
LIG_FHA_1	715	721	PF00498	0.470
LIG_FHA_1	849	855	PF00498	0.306
LIG_FHA_2	262	268	PF00498	0.458
LIG_FHA_2	277	283	PF00498	0.422
LIG_FHA_2	689	695	PF00498	0.398
LIG_FHA_2	69	75	PF00498	0.465
LIG_FHA_2	751	757	PF00498	0.472
LIG_FHA_2	869	875	PF00498	0.474
LIG_Integrin_RGD_1	488	490	PF01839	0.316
LIG_LIR_Apic_2	388	393	PF02991	0.483
LIG_LIR_Gen_1	116	126	PF02991	0.423
LIG_LIR_Gen_1	717	726	PF02991	0.455
LIG_LIR_Gen_1	832	842	PF02991	0.507
LIG_LIR_Nem_3	11	17	PF02991	0.608
LIG_LIR_Nem_3	116	121	PF02991	0.593
LIG_LIR_Nem_3	27	33	PF02991	0.628
LIG_LIR_Nem_3	717	722	PF02991	0.462
LIG_LIR_Nem_3	832	837	PF02991	0.475
LIG_LYPXL_SIV_4	730	738	PF13949	0.490
LIG_NRBOX	220	226	PF00104	0.593
LIG_NRBOX	362	368	PF00104	0.644
LIG_PDZ_Class_3	884	889	PF00595	0.520
LIG_Pex14_1	30	34	PF04695	0.548
LIG_PTAP_UEV_1	445	450	PF05743	0.606
LIG_Rb_LxCxE_1	874	889	PF01857	0.527
LIG_SH2_CRK	731	735	PF00017	0.477
LIG_SH2_NCK_1	147	151	PF00017	0.570
LIG_SH2_NCK_1	731	735	PF00017	0.477
LIG_SH2_PTP2	834	837	PF00017	0.489
LIG_SH2_SRC	147	150	PF00017	0.571
LIG_SH2_SRC	239	242	PF00017	0.455
LIG_SH2_SRC	565	568	PF00017	0.534
LIG_SH2_STAP1	731	735	PF00017	0.477
LIG_SH2_STAP1	861	865	PF00017	0.464
LIG_SH2_STAT5	239	242	PF00017	0.455
LIG_SH2_STAT5	34	37	PF00017	0.535
LIG_SH2_STAT5	565	568	PF00017	0.534
LIG_SH2_STAT5	774	777	PF00017	0.438
LIG_SH2_STAT5	834	837	PF00017	0.489
LIG_SH3_2	534	539	PF14604	0.417
LIG_SH3_3	4	10	PF00018	0.636
LIG_SH3_3	443	449	PF00018	0.682
LIG_SH3_3	47	53	PF00018	0.694
LIG_SH3_3	531	537	PF00018	0.417
LIG_SH3_3	611	617	PF00018	0.393
LIG_SH3_3	814	820	PF00018	0.454
LIG_SUMO_SIM_par_1	258	264	PF11976	0.422
LIG_SUMO_SIM_par_1	36	42	PF11976	0.668
LIG_SUMO_SIM_par_1	526	531	PF11976	0.551
LIG_SUMO_SIM_par_1	63	68	PF11976	0.594
LIG_SUMO_SIM_par_1	702	707	PF11976	0.461
LIG_TRAF2_1	557	560	PF00917	0.551
LIG_TRAF2_1	753	756	PF00917	0.477
LIG_TRFH_1	238	242	PF08558	0.453
LIG_WRC_WIRS_1	511	516	PF05994	0.224
LIG_WRC_WIRS_1	854	859	PF05994	0.478
LIG_WW_3	465	469	PF00397	0.707
MOD_CDK_SPxK_1	155	161	PF00069	0.401
MOD_CDK_SPxxK_3	307	314	PF00069	0.644
MOD_CK1_1	206	212	PF00069	0.574
MOD_CK1_1	228	234	PF00069	0.633
MOD_CK1_1	444	450	PF00069	0.595
MOD_CK1_1	740	746	PF00069	0.482
MOD_CK2_1	261	267	PF00069	0.442
MOD_CK2_1	554	560	PF00069	0.412
MOD_CK2_1	572	578	PF00069	0.338
MOD_CK2_1	679	685	PF00069	0.396
MOD_CK2_1	749	755	PF00069	0.459
MOD_CK2_1	868	874	PF00069	0.469
MOD_CK2_1	877	883	PF00069	0.414
MOD_GlcNHglycan	107	111	PF01048	0.489
MOD_GlcNHglycan	131	134	PF01048	0.573
MOD_GlcNHglycan	2	5	PF01048	0.660
MOD_GlcNHglycan	296	299	PF01048	0.654
MOD_GlcNHglycan	346	349	PF01048	0.651
MOD_GlcNHglycan	356	360	PF01048	0.581
MOD_GlcNHglycan	375	378	PF01048	0.441
MOD_GlcNHglycan	393	396	PF01048	0.534
MOD_GlcNHglycan	446	449	PF01048	0.667
MOD_GlcNHglycan	501	504	PF01048	0.392
MOD_GlcNHglycan	556	559	PF01048	0.295
MOD_GlcNHglycan	604	607	PF01048	0.347
MOD_GlcNHglycan	662	665	PF01048	0.538
MOD_GlcNHglycan	742	745	PF01048	0.475
MOD_GSK3_1	129	136	PF00069	0.670
MOD_GSK3_1	155	162	PF00069	0.527
MOD_GSK3_1	197	204	PF00069	0.602
MOD_GSK3_1	224	231	PF00069	0.613
MOD_GSK3_1	244	251	PF00069	0.418
MOD_GSK3_1	276	283	PF00069	0.501
MOD_GSK3_1	290	297	PF00069	0.574
MOD_GSK3_1	344	351	PF00069	0.598
MOD_GSK3_1	415	422	PF00069	0.699
MOD_GSK3_1	499	506	PF00069	0.325
MOD_GSK3_1	566	573	PF00069	0.531
MOD_GSK3_1	617	624	PF00069	0.529
MOD_GSK3_1	655	662	PF00069	0.559
MOD_GSK3_1	710	717	PF00069	0.485
MOD_GSK3_1	8	15	PF00069	0.597
MOD_N-GLC_1	422	427	PF02516	0.661
MOD_N-GLC_1	503	508	PF02516	0.224
MOD_NEK2_1	224	229	PF00069	0.648
MOD_NEK2_1	33	38	PF00069	0.626
MOD_NEK2_1	373	378	PF00069	0.557
MOD_NEK2_1	572	577	PF00069	0.530
MOD_NEK2_1	579	584	PF00069	0.428
MOD_NEK2_1	729	734	PF00069	0.473
MOD_NEK2_1	738	743	PF00069	0.384
MOD_NEK2_1	749	754	PF00069	0.238
MOD_NEK2_1	775	780	PF00069	0.442
MOD_NEK2_2	261	266	PF00069	0.300
MOD_OFUCOSY	645	652	PF10250	0.516
MOD_PIKK_1	572	578	PF00454	0.529
MOD_PIKK_1	590	596	PF00454	0.318
MOD_PKA_1	344	350	PF00069	0.595
MOD_PKA_1	634	640	PF00069	0.572
MOD_PKA_1	648	654	PF00069	0.484
MOD_PKA_2	197	203	PF00069	0.575
MOD_PKA_2	43	49	PF00069	0.692
MOD_PKA_2	467	473	PF00069	0.520
MOD_PKA_2	634	640	PF00069	0.572
MOD_PKA_2	648	654	PF00069	0.484
MOD_PKA_2	660	666	PF00069	0.439
MOD_PKA_2	859	865	PF00069	0.474
MOD_PKB_1	342	350	PF00069	0.512
MOD_Plk_1	106	112	PF00069	0.556
MOD_Plk_1	148	154	PF00069	0.574
MOD_Plk_1	244	250	PF00069	0.513
MOD_Plk_1	26	32	PF00069	0.639
MOD_Plk_1	503	509	PF00069	0.355
MOD_Plk_1	559	565	PF00069	0.412
MOD_Plk_2-3	68	74	PF00069	0.533
MOD_Plk_4	362	368	PF00069	0.644
MOD_Plk_4	44	50	PF00069	0.693
MOD_Plk_4	545	551	PF00069	0.412
MOD_Plk_4	561	567	PF00069	0.242
MOD_Plk_4	634	640	PF00069	0.562
MOD_Plk_4	853	859	PF00069	0.465
MOD_ProDKin_1	12	18	PF00069	0.668
MOD_ProDKin_1	127	133	PF00069	0.591
MOD_ProDKin_1	155	161	PF00069	0.401
MOD_ProDKin_1	307	313	PF00069	0.645
MOD_ProDKin_1	415	421	PF00069	0.666
MOD_ProDKin_1	530	536	PF00069	0.412
MOD_SUMO_for_1	680	683	PF00179	0.585
MOD_SUMO_rev_2	116	123	PF00179	0.545
MOD_SUMO_rev_2	682	689	PF00179	0.433
MOD_SUMO_rev_2	73	82	PF00179	0.446
TRG_DiLeu_BaEn_1	756	761	PF01217	0.512
TRG_DiLeu_BaEn_1	807	812	PF01217	0.507
TRG_DiLeu_BaEn_1	850	855	PF01217	0.443
TRG_DiLeu_BaEn_1	874	879	PF01217	0.490
TRG_DiLeu_BaLyEn_6	763	768	PF01217	0.493
TRG_ENDOCYTIC_2	387	390	PF00928	0.490
TRG_ENDOCYTIC_2	731	734	PF00928	0.484
TRG_ENDOCYTIC_2	774	777	PF00928	0.438
TRG_ENDOCYTIC_2	834	837	PF00928	0.489
TRG_ER_diArg_1	430	432	PF00400	0.657
TRG_ER_diArg_1	585	588	PF00400	0.426
TRG_ER_diArg_1	648	650	PF00400	0.599
TRG_ER_diArg_1	720	723	PF00400	0.404
TRG_ER_diArg_1	822	824	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6B7	Leishmania donovani	85%	89%
A4HL86	Leishmania braziliensis	70%	100%
A4I8R4	Leishmania infantum	85%	89%
Q4Q4F8	Leishmania major	85%	100%