HD_domain domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3M8_LEIMU

TriTrypDb:

LmxM.32.0500

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3M8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.383
CLV_NRD_NRD_1	32	34	PF00675	0.471
CLV_PCSK_KEX2_1	147	149	PF00082	0.409
CLV_PCSK_KEX2_1	250	252	PF00082	0.487
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.438
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.487
CLV_PCSK_SKI1_1	144	148	PF00082	0.448
CLV_PCSK_SKI1_1	250	254	PF00082	0.468
CLV_PCSK_SKI1_1	33	37	PF00082	0.423
CLV_PCSK_SKI1_1	62	66	PF00082	0.299
CLV_PCSK_SKI1_1	88	92	PF00082	0.301
DEG_APCC_DBOX_1	61	69	PF00400	0.298
DEG_Nend_UBRbox_2	1	3	PF02207	0.392
DOC_MAPK_DCC_7	248	257	PF00069	0.400
DOC_MAPK_gen_1	248	257	PF00069	0.444
DOC_MAPK_MEF2A_6	248	257	PF00069	0.400
DOC_PP1_RVXF_1	106	112	PF00149	0.299
DOC_PP2B_LxvP_1	265	268	PF13499	0.381
DOC_PP4_FxxP_1	110	113	PF00568	0.578
DOC_USP7_MATH_1	122	126	PF00917	0.308
DOC_USP7_MATH_1	164	168	PF00917	0.605
DOC_USP7_MATH_1	215	219	PF00917	0.692
DOC_WW_Pin1_4	297	302	PF00397	0.472
LIG_14-3-3_CanoR_1	11	16	PF00244	0.402
LIG_14-3-3_CanoR_1	203	210	PF00244	0.495
LIG_14-3-3_CanoR_1	33	42	PF00244	0.411
LIG_14-3-3_CanoR_1	86	91	PF00244	0.428
LIG_Actin_WH2_2	226	241	PF00022	0.508
LIG_CSL_BTD_1	110	113	PF09270	0.332
LIG_deltaCOP1_diTrp_1	7	15	PF00928	0.376
LIG_FHA_1	11	17	PF00498	0.420
LIG_FHA_1	128	134	PF00498	0.379
LIG_FHA_1	46	52	PF00498	0.367
LIG_FHA_2	133	139	PF00498	0.362
LIG_FHA_2	80	86	PF00498	0.360
LIG_FHA_2	89	95	PF00498	0.289
LIG_HCF-1_HBM_1	74	77	PF13415	0.360
LIG_LIR_Gen_1	167	177	PF02991	0.342
LIG_LIR_Gen_1	196	204	PF02991	0.374
LIG_LIR_Nem_3	167	173	PF02991	0.356
LIG_LIR_Nem_3	196	200	PF02991	0.364
LIG_Rb_LxCxE_1	188	205	PF01857	0.471
LIG_SH2_CRK	197	201	PF00017	0.479
LIG_SH2_CRK	61	65	PF00017	0.442
LIG_SH2_NCK_1	197	201	PF00017	0.414
LIG_SH2_NCK_1	299	303	PF00017	0.370
LIG_SH2_NCK_1	77	81	PF00017	0.431
LIG_SH2_STAP1	142	146	PF00017	0.452
LIG_SH2_STAT5	176	179	PF00017	0.450
LIG_SH2_STAT5	197	200	PF00017	0.339
LIG_SH2_STAT5	299	302	PF00017	0.438
LIG_SH2_STAT5	43	46	PF00017	0.484
LIG_SH3_3	109	115	PF00018	0.489
LIG_Sin3_3	95	102	PF02671	0.417
LIG_WRC_WIRS_1	87	92	PF05994	0.467
MOD_CK1_1	218	224	PF00069	0.544
MOD_CK2_1	88	94	PF00069	0.280
MOD_GlcNHglycan	123	127	PF01048	0.585
MOD_GlcNHglycan	17	20	PF01048	0.415
MOD_GlcNHglycan	204	207	PF01048	0.585
MOD_GlcNHglycan	217	220	PF01048	0.457
MOD_GlcNHglycan	260	263	PF01048	0.404
MOD_GSK3_1	11	18	PF00069	0.392
MOD_GSK3_1	162	169	PF00069	0.565
MOD_LATS_1	31	37	PF00433	0.465
MOD_NEK2_1	132	137	PF00069	0.397
MOD_NEK2_1	15	20	PF00069	0.403
MOD_NEK2_1	256	261	PF00069	0.416
MOD_NEK2_1	44	49	PF00069	0.524
MOD_OFUCOSY	194	199	PF10250	0.441
MOD_PIKK_1	127	133	PF00454	0.297
MOD_PKA_1	33	39	PF00069	0.458
MOD_PKA_2	10	16	PF00069	0.435
MOD_PKA_2	202	208	PF00069	0.532
MOD_Plk_1	195	201	PF00069	0.519
MOD_Plk_2-3	175	181	PF00069	0.313
MOD_Plk_4	11	17	PF00069	0.386
MOD_Plk_4	166	172	PF00069	0.518
MOD_Plk_4	286	292	PF00069	0.510
MOD_Plk_4	79	85	PF00069	0.319
MOD_ProDKin_1	297	303	PF00069	0.358
TRG_DiLeu_BaEn_1	272	277	PF01217	0.496
TRG_DiLeu_BaEn_1	37	42	PF01217	0.349
TRG_DiLeu_BaEn_1	94	99	PF01217	0.427
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.449
TRG_ENDOCYTIC_2	197	200	PF00928	0.454
TRG_ENDOCYTIC_2	61	64	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I587	Leptomonas seymouri	62%	99%
A0A0S4KI40	Bodo saltans	45%	100%
A0A1X0P0R2	Trypanosomatidae	42%	100%
A0A3R7LX07	Trypanosoma rangeli	45%	100%
A0A3S7X6G1	Leishmania donovani	89%	99%
A4HL85	Leishmania braziliensis	82%	100%
A4I8R3	Leishmania infantum	89%	99%
D0A4Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q4F9	Leishmania major	90%	100%
V5BKA1	Trypanosoma cruzi	42%	100%