Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3M4_LEIMU

TriTrypDb:

LmxM.32.0460

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.576
CLV_C14_Caspase3-7	190	194	PF00656	0.616
CLV_NRD_NRD_1	138	140	PF00675	0.592
CLV_NRD_NRD_1	248	250	PF00675	0.505
CLV_NRD_NRD_1	53	55	PF00675	0.688
CLV_PCSK_KEX2_1	137	139	PF00082	0.602
CLV_PCSK_KEX2_1	148	150	PF00082	0.410
CLV_PCSK_KEX2_1	248	250	PF00082	0.505
CLV_PCSK_KEX2_1	53	55	PF00082	0.646
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.497
CLV_PCSK_PC7_1	134	140	PF00082	0.554
CLV_PCSK_SKI1_1	199	203	PF00082	0.516
DEG_SPOP_SBC_1	185	189	PF00917	0.559
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.634
DOC_MAPK_gen_1	145	154	PF00069	0.359
DOC_MAPK_gen_1	234	243	PF00069	0.420
DOC_MAPK_MEF2A_6	145	154	PF00069	0.403
DOC_PP1_RVXF_1	240	246	PF00149	0.339
DOC_PP1_RVXF_1	265	272	PF00149	0.471
DOC_PP2B_LxvP_1	112	115	PF13499	0.545
DOC_PP2B_LxvP_1	80	83	PF13499	0.637
DOC_USP7_MATH_1	178	182	PF00917	0.614
DOC_USP7_MATH_1	197	201	PF00917	0.555
DOC_USP7_UBL2_3	96	100	PF12436	0.365
DOC_WW_Pin1_4	203	208	PF00397	0.637
LIG_14-3-3_CanoR_1	274	283	PF00244	0.542
LIG_14-3-3_CanoR_1	53	62	PF00244	0.662
LIG_Actin_WH2_2	228	244	PF00022	0.354
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.484
LIG_FHA_1	186	192	PF00498	0.711
LIG_FHA_1	69	75	PF00498	0.663
LIG_FHA_2	127	133	PF00498	0.459
LIG_FHA_2	185	191	PF00498	0.625
LIG_FHA_2	223	229	PF00498	0.390
LIG_FHA_2	73	79	PF00498	0.489
LIG_LIR_Gen_1	37	48	PF02991	0.490
LIG_LIR_Gen_1	6	14	PF02991	0.590
LIG_LIR_Nem_3	37	43	PF02991	0.489
LIG_LIR_Nem_3	6	10	PF02991	0.645
LIG_PCNA_PIPBox_1	150	159	PF02747	0.346
LIG_PDZ_Class_3	283	288	PF00595	0.609
LIG_SH2_STAT5	119	122	PF00017	0.457
LIG_SH2_STAT5	156	159	PF00017	0.447
LIG_SH2_STAT5	222	225	PF00017	0.433
LIG_SH2_STAT5	9	12	PF00017	0.659
LIG_SH3_1	29	35	PF00018	0.633
LIG_SH3_3	204	210	PF00018	0.624
LIG_SH3_3	29	35	PF00018	0.633
LIG_SUMO_SIM_par_1	69	75	PF11976	0.619
LIG_TRAF2_1	225	228	PF00917	0.482
LIG_TRAF2_1	230	233	PF00917	0.509
LIG_WRC_WIRS_1	4	9	PF05994	0.645
MOD_CDK_SPK_2	208	213	PF00069	0.588
MOD_CDK_SPxxK_3	208	215	PF00069	0.578
MOD_CK1_1	200	206	PF00069	0.666
MOD_CK1_1	208	214	PF00069	0.503
MOD_CK2_1	126	132	PF00069	0.446
MOD_CK2_1	222	228	PF00069	0.388
MOD_CK2_1	54	60	PF00069	0.579
MOD_GlcNHglycan	178	181	PF01048	0.586
MOD_GlcNHglycan	193	196	PF01048	0.617
MOD_GlcNHglycan	198	202	PF01048	0.592
MOD_GlcNHglycan	56	59	PF01048	0.546
MOD_GSK3_1	199	206	PF00069	0.532
MOD_GSK3_1	256	263	PF00069	0.464
MOD_GSK3_1	49	56	PF00069	0.657
MOD_GSK3_1	68	75	PF00069	0.485
MOD_NEK2_1	76	81	PF00069	0.506
MOD_PKA_1	53	59	PF00069	0.685
MOD_PKA_2	191	197	PF00069	0.534
MOD_PKA_2	260	266	PF00069	0.481
MOD_PKA_2	53	59	PF00069	0.639
MOD_PKB_1	272	280	PF00069	0.492
MOD_Plk_1	256	262	PF00069	0.580
MOD_Plk_1	68	74	PF00069	0.601
MOD_Plk_1	76	82	PF00069	0.566
MOD_Plk_4	39	45	PF00069	0.494
MOD_ProDKin_1	203	209	PF00069	0.631
TRG_DiLeu_BaEn_1	163	168	PF01217	0.366
TRG_ER_diArg_1	137	139	PF00400	0.611
TRG_ER_diArg_1	212	215	PF00400	0.564
TRG_ER_diArg_1	248	250	PF00400	0.503
TRG_NES_CRM1_1	78	93	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHC5	Leishmania donovani	84%	100%
A4HL81	Leishmania braziliensis	65%	100%
A4I8Q9	Leishmania infantum	84%	100%
Q4Q4G3	Leishmania major	85%	100%